CY1110145T1 - Αλκυλο-υποκατεστημενες ινδολοκινοξαλινες - Google Patents
Αλκυλο-υποκατεστημενες ινδολοκινοξαλινεςInfo
- Publication number
- CY1110145T1 CY1110145T1 CY20101100598T CY101100598T CY1110145T1 CY 1110145 T1 CY1110145 T1 CY 1110145T1 CY 20101100598 T CY20101100598 T CY 20101100598T CY 101100598 T CY101100598 T CY 101100598T CY 1110145 T1 CY1110145 T1 CY 1110145T1
- Authority
- CY
- Cyprus
- Prior art keywords
- alkyl
- lower alkyl
- indolokinoxalines
- substituted
- similar
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Abstract
Περιγράφονται νέες υποκατεστημένες ινδολοκινοξαλίνες του τύπου (I R2(I) Y όπου η R1 είναι υδρογόνο ή αντιπροσωπεύει έναν ή περισσότερους όμοιους ή διαφορετικούς υποκαταστάτες στις θέσεις 7 έως 10, επιλεγόμενους από την ομάδα αλογόνο, κατώτερο αλκύλιο/αλκοξυ ομάδα, υδροξυ ομάδα, τριφθορομεθύλιο, τριχλωρομεθύλιο, τριφθορομεθοξυ ομάδα, η R2 αντιπροσωπεύει όμοιους ή διαφορετικούς C1-C4 αλκυλο υποκατάστατες, η Χ είναι CO ή CH2, η Υ είναι OH, ΝΗ2, NH-(CH2)n-R3 όπου η R3 αντιπροσωπεύει κατώτερο αλκύλιο, OH, ΝΗ2, NHR4 ή NR5R6 όπου οι R4 , R5 και R6 είναι ανεξαρτήτως κατώτερο αλκύλιο ή κυκλοαλκύλιο και n είναι ακέραιος από 2 έως 4, με τον όρο ότι όταν η Χ είναι CH2, η Υ είναι ΟΗ ή ΝΗ-(CH2)n-OH, και φαρμακολογικώς αποδεκτά άλατα αυτών. Οι ενώσεις είναι χρήσιμες ως φαρμακευτικές ουσίες για την πρόληψη και/ή αγωγή αυτοάνοσων παθήσεων.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0401555A SE527639C2 (sv) | 2004-06-17 | 2004-06-17 | Alkylsubstituerade indolokinoxaliner |
| EP05742482A EP1756111B1 (en) | 2004-06-17 | 2005-05-18 | Alkyl substituted indoloquinoxalines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1110145T1 true CY1110145T1 (el) | 2015-01-14 |
Family
ID=32710074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100598T CY1110145T1 (el) | 2004-06-17 | 2010-06-29 | Αλκυλο-υποκατεστημενες ινδολοκινοξαλινες |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7589093B2 (el) |
| EP (1) | EP1756111B1 (el) |
| JP (1) | JP5038891B2 (el) |
| CN (1) | CN1976934B (el) |
| AT (1) | ATE462707T1 (el) |
| AU (1) | AU2005254919B2 (el) |
| BR (1) | BRPI0512086A (el) |
| CA (1) | CA2568592C (el) |
| CY (1) | CY1110145T1 (el) |
| DE (1) | DE602005020283D1 (el) |
| DK (1) | DK1756111T3 (el) |
| ES (1) | ES2342946T3 (el) |
| IL (1) | IL179171A (el) |
| MX (1) | MXPA06014170A (el) |
| NO (1) | NO20070289L (el) |
| NZ (1) | NZ551780A (el) |
| PL (1) | PL1756111T3 (el) |
| PT (1) | PT1756111E (el) |
| RU (1) | RU2369609C2 (el) |
| SE (1) | SE527639C2 (el) |
| SI (1) | SI1756111T1 (el) |
| WO (1) | WO2005123741A1 (el) |
| ZA (1) | ZA200700358B (el) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE529777C2 (sv) * | 2006-01-23 | 2007-11-20 | Vironova Ab | Nya föreningar och användning därav |
| JP5454750B2 (ja) | 2008-03-05 | 2014-03-26 | 東洋製罐株式会社 | 缶詰の内圧検査方法及びその装置 |
| EP2128160B1 (en) | 2008-04-30 | 2010-07-14 | Universität Duisburg-Essen | Indolo[2,3-b]-, Indeno[1,2-b]- and Indeno[2,1-b]pyrido[2,3-f] quinoxaline-3-carboxylic acids and esters, processes for their preparation and their use as antiviral, antibiotic and antitumor agents |
| EP2489354A1 (en) * | 2011-02-18 | 2012-08-22 | Vironova AB | Pharmaceutical formulation of B220 for topical treatment of herpes |
| CN103211960B (zh) * | 2012-01-18 | 2017-10-13 | 金士力佳友(天津)有限公司 | 具有降血糖作用的中药组合物、其应用及制备方法 |
| SG11201507310VA (en) * | 2013-03-15 | 2015-10-29 | Vironova Herpes Ab | Antiviral indolo[2,3-b]quinoxaline |
| US20230227456A1 (en) | 2020-06-10 | 2023-07-20 | Cyxone Ab | Oral formulation comprising a crystalline form of rabeximod |
| EP4164649A1 (en) | 2020-06-10 | 2023-04-19 | Cyxone AB | New use of rabeximod |
| CA3191963A1 (en) | 2020-09-21 | 2022-03-24 | Jan Bergman | Thionoester-derivative of rabeximod for the treatment of inflammatory and autoimmune disorders |
| US11643415B1 (en) | 2021-12-09 | 2023-05-09 | Cyxone Ab | Rabeximod compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE504862C2 (sv) * | 1994-12-27 | 1997-05-20 | Leif J I Lundblad | Användning av vissa indolo-§2,3b¤-kinoxaliner för framställning av ett läkemedel för skydd av DNA i initieringsfasen och/eller promotionsfasen av karcinogenes och för förhindrande av oxidativ stress i patienter med sjukdomar relaterade till fria radikaler |
| SE516067C2 (sv) * | 2000-02-18 | 2001-11-12 | Lundblad Leif J I | Användning av en förening för framställning av ett läkemedel |
| US6333327B2 (en) * | 2000-02-18 | 2001-12-25 | Leif J. I. Lundblad | Method for the treatment of Multiple Sclerosis |
-
2004
- 2004-06-17 SE SE0401555A patent/SE527639C2/sv not_active IP Right Cessation
-
2005
- 2005-05-18 SI SI200531030T patent/SI1756111T1/sl unknown
- 2005-05-18 US US11/143,935 patent/US7589093B2/en active Active
- 2005-05-18 EP EP05742482A patent/EP1756111B1/en active Active
- 2005-05-18 AT AT05742482T patent/ATE462707T1/de active
- 2005-05-18 DE DE602005020283T patent/DE602005020283D1/de active Active
- 2005-05-18 RU RU2007101497/04A patent/RU2369609C2/ru active
- 2005-05-18 AU AU2005254919A patent/AU2005254919B2/en not_active Ceased
- 2005-05-18 DK DK05742482.2T patent/DK1756111T3/da active
- 2005-05-18 CN CN200580019227XA patent/CN1976934B/zh active Active
- 2005-05-18 ZA ZA200700358A patent/ZA200700358B/xx unknown
- 2005-05-18 BR BRPI0512086-1A patent/BRPI0512086A/pt not_active IP Right Cessation
- 2005-05-18 JP JP2007516422A patent/JP5038891B2/ja active Active
- 2005-05-18 CA CA2568592A patent/CA2568592C/en not_active Expired - Fee Related
- 2005-05-18 PT PT05742482T patent/PT1756111E/pt unknown
- 2005-05-18 WO PCT/SE2005/000718 patent/WO2005123741A1/en active Application Filing
- 2005-05-18 ES ES05742482T patent/ES2342946T3/es active Active
- 2005-05-18 MX MXPA06014170A patent/MXPA06014170A/es active IP Right Grant
- 2005-05-18 PL PL05742482T patent/PL1756111T3/pl unknown
- 2005-05-18 NZ NZ551780A patent/NZ551780A/en not_active IP Right Cessation
-
2006
- 2006-11-09 IL IL179171A patent/IL179171A/en not_active IP Right Cessation
-
2007
- 2007-01-16 NO NO20070289A patent/NO20070289L/no not_active Application Discontinuation
-
2009
- 2009-07-01 US US12/496,261 patent/US8084453B2/en active Active
-
2010
- 2010-06-29 CY CY20101100598T patent/CY1110145T1/el unknown
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