DK1757610T3 - Kondenseret pyrimidinderivat og xanthinoxidaseinhibitor - Google Patents
Kondenseret pyrimidinderivat og xanthinoxidaseinhibitorInfo
- Publication number
- DK1757610T3 DK1757610T3 DK05751417.6T DK05751417T DK1757610T3 DK 1757610 T3 DK1757610 T3 DK 1757610T3 DK 05751417 T DK05751417 T DK 05751417T DK 1757610 T3 DK1757610 T3 DK 1757610T3
- Authority
- DK
- Denmark
- Prior art keywords
- xanthine oxidase
- oxidase inhibitor
- pyrimidine derivative
- carbon atoms
- condensed pyrimidine
- Prior art date
Links
- 229940123769 Xanthine oxidase inhibitor Drugs 0.000 title abstract 2
- 239000003064 xanthine oxidase inhibitor Substances 0.000 title abstract 2
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004175798 | 2004-06-14 | ||
| PCT/JP2005/011188 WO2005121153A1 (ja) | 2004-06-14 | 2005-06-13 | 縮合ピリミジン誘導体、及びキサンチンオキシダーゼ阻害剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1757610T3 true DK1757610T3 (da) | 2011-08-01 |
Family
ID=35503006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05751417.6T DK1757610T3 (da) | 2004-06-14 | 2005-06-13 | Kondenseret pyrimidinderivat og xanthinoxidaseinhibitor |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7598254B2 (da) |
| EP (1) | EP1757610B1 (da) |
| JP (3) | JP4914210B2 (da) |
| CN (1) | CN1993367B (da) |
| AT (1) | ATE512154T1 (da) |
| DK (1) | DK1757610T3 (da) |
| ES (1) | ES2367118T3 (da) |
| PL (1) | PL1757610T3 (da) |
| PT (1) | PT1757610E (da) |
| WO (1) | WO2005121153A1 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4914210B2 (ja) * | 2004-06-14 | 2012-04-11 | 日本ケミファ株式会社 | 縮合ピリミジン誘導体、及びキサンチンオキシダーゼ阻害剤 |
| US20090149452A1 (en) * | 2005-07-01 | 2009-06-11 | Nippon Chemiphar Co., Ltd. | Xanthine oxidase inhibitor |
| US20100234399A1 (en) * | 2006-06-22 | 2010-09-16 | Nippon Chemiphar Co., Ltd. | Agent for overcoming resistance to anti-cancer agent |
| WO2014065275A1 (ja) | 2012-10-23 | 2014-05-01 | 国立大学法人福井大学 | 腫瘍融解症候群の治療薬及び予防薬 |
| CN103848798B (zh) | 2012-11-30 | 2016-01-06 | 镇江新元素医药科技有限公司 | 2-芳基硒唑化合物及其药物组合物 |
| TW201536284A (zh) | 2013-05-31 | 2015-10-01 | Teijin Pharma Ltd | 使用黃嘌呤氧化酶抑制劑之治療方法與組成物 |
| CN107427517B (zh) * | 2015-02-24 | 2021-11-16 | 国立大学法人鸟取大学 | 用于痴呆症的预防及/或治疗的医药 |
| TWI780270B (zh) | 2017-11-28 | 2022-10-11 | 靜岡縣公立大學法人 | 固體分散體 |
| JP2021127289A (ja) * | 2018-04-27 | 2021-09-02 | 日本ケミファ株式会社 | 縮合ピリミジン誘導体 |
| EP3981470A4 (en) * | 2019-06-04 | 2023-07-19 | Nippon Chemiphar Co., Ltd. | ENTERIC COATED FORMULATION COMPRISING A XANTHINE OXIDASE INHIBITOR |
| WO2020246528A1 (ja) | 2019-06-04 | 2020-12-10 | 日本ケミファ株式会社 | 痛風又は高尿酸血症の治療薬 |
| WO2022124325A1 (ja) | 2020-12-08 | 2022-06-16 | 国立大学法人東京大学 | 細胞内ａｔｐ増強剤 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6421431A (en) | 1987-07-16 | 1989-01-24 | Fuji Photo Film Co Ltd | Film carrying device |
| JP2691317B2 (ja) * | 1989-08-25 | 1997-12-17 | 株式会社大塚製薬工場 | ４―ヒドロキシ―８―（３―低級アルコキシ―４―フェニルスルフィニルフェニル）ピラゾロ〔１，５―ａ〕―１，３，５―トリアジン光学活性体の塩類及びその製造方法 |
| CA2073981C (en) * | 1990-11-30 | 2002-01-08 | Shiro Kondo | 2-arylthiazole derivatives and pharmaceutical composition thereof |
| ID21775A (id) * | 1996-10-25 | 1999-07-22 | Yoshitomi Pharmaceutical | Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya |
| JP2000001431A (ja) * | 1998-06-15 | 2000-01-07 | Kotobuki Seiyaku Kk | 尿酸排泄剤 |
| PT1452528E (pt) * | 2001-11-16 | 2008-10-14 | Nippon Chemiphar Co | Inibidores de xantina-oxidase |
| JP4914210B2 (ja) * | 2004-06-14 | 2012-04-11 | 日本ケミファ株式会社 | 縮合ピリミジン誘導体、及びキサンチンオキシダーゼ阻害剤 |
-
2005
- 2005-06-13 JP JP2006514620A patent/JP4914210B2/ja active Active
- 2005-06-13 DK DK05751417.6T patent/DK1757610T3/da active
- 2005-06-13 WO PCT/JP2005/011188 patent/WO2005121153A1/ja active Application Filing
- 2005-06-13 PT PT05751417T patent/PT1757610E/pt unknown
- 2005-06-13 CN CN2005800267399A patent/CN1993367B/zh active Active
- 2005-06-13 US US11/629,277 patent/US7598254B2/en active Active
- 2005-06-13 PL PL05751417T patent/PL1757610T3/pl unknown
- 2005-06-13 AT AT05751417T patent/ATE512154T1/de active
- 2005-06-13 EP EP05751417A patent/EP1757610B1/en active Active
- 2005-06-13 ES ES05751417T patent/ES2367118T3/es active Active
-
2011
- 2011-12-16 JP JP2011276232A patent/JP5456757B2/ja active Active
-
2013
- 2013-06-03 JP JP2013117370A patent/JP5554439B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP5554439B2 (ja) | 2014-07-23 |
| ES2367118T3 (es) | 2011-10-28 |
| ATE512154T1 (de) | 2011-06-15 |
| JP2012092128A (ja) | 2012-05-17 |
| WO2005121153A1 (ja) | 2005-12-22 |
| PT1757610E (pt) | 2011-08-24 |
| US20070293512A1 (en) | 2007-12-20 |
| JP5456757B2 (ja) | 2014-04-02 |
| PL1757610T3 (pl) | 2011-10-31 |
| EP1757610B1 (en) | 2011-06-08 |
| JPWO2005121153A1 (ja) | 2008-04-10 |
| JP4914210B2 (ja) | 2012-04-11 |
| CN1993367B (zh) | 2012-05-30 |
| CN1993367A (zh) | 2007-07-04 |
| EP1757610A1 (en) | 2007-02-28 |
| US7598254B2 (en) | 2009-10-06 |
| EP1757610A4 (en) | 2009-06-24 |
| JP2013189460A (ja) | 2013-09-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1757610T3 (da) | Kondenseret pyrimidinderivat og xanthinoxidaseinhibitor | |
| ATE404541T1 (de) | Xanthinoxidaseinhibitoren | |
| DE602006007012D1 (de) | Pyridinderivate als dipeptedyl-peptidase-hemmer | |
| EP1338595A3 (en) | Xanthine derivatives as DPP-IV inhibitors | |
| WO2006062984A3 (en) | Inhibitors of protein kinases | |
| WO2007026920A3 (en) | Amide derivatives as rock inhibitors | |
| WO2006123165A3 (en) | Pyrimidine derivatives as hsp90 inhibitors | |
| PE20080835A1 (es) | Derivados novedosos de aminopiridina que tienen accion inhibidora selectiva sobre aurora a | |
| CY1111922T1 (el) | 1-ετεροκυκλυλσουλφονυλ, 2-αμινομεθυλ, 5-(ετερο-)αρυλ υποκατεστημενα 1-η-πυρρολιου παραγωγα ως αναστολεις εκκρισης οξεος | |
| WO2006062982A3 (en) | Urea inhibitors of map kinases | |
| ATE449099T1 (de) | Derivate des 2-trifluormethyl-6-aminopurins als phosphodiesterase 4 inhibitoren | |
| AR042602A1 (es) | Compuestos de 1,2,4-triazol | |
| DK1263740T3 (da) | Pyrimidin-4-on-derivat som LDL-PLA2-inhibitor | |
| ATE388146T1 (de) | 1-isopropyl-2-oxo-1,2-dihydropyridin-3- carbonsäureamidderivate mit agonistischer wirkung am 5-ht4-rezeptor | |
| EA200701779A1 (ru) | Производные (1,5-дифенил-1н-пиразол-3-ил)оксадиазола, их получение и их применение в терапии | |
| BR0013041A (pt) | Composto heterociclico e composição farmacêutica para tratar e prevenir doenças mediadas por cgmp-pde, seu uso e método | |
| WO2008076779A3 (en) | 2-(piperidin-4-yl0xy)pyrimidin-4-amine derivatives as deoxycytidine kinase inhibitors for the treatment of cancer | |
| ATE553077T1 (de) | Peptidaseinhibitoren | |
| RS51085B (sr) | Derivati dioksan-2-alkilkarbamata, postupak za njihovo dobijanje i primena istih u terapeuticima | |
| PE20011115A1 (es) | Etanos tri-aril-sustituidos inhibidores de pde4 | |
| WO2008126901A1 (ja) | 含窒素複素環化合物およびそれを含有する医薬組成物 | |
| ATE457314T1 (de) | Antibiotische spiroderivate | |
| ATE172452T1 (de) | Bicyclische stichstoff enthaltende derivate als prolyl-endopeptidase inhibitoren | |
| EA200600018A1 (ru) | Производные никотинамида, полезные в качестве ингибиторов фдэ4 | |
| ATE445619T1 (de) | Pyridinylpyrazolopyrimidinon-derivate als pde 7 inhibitoren |