DE69414019D1 - Bicyclische Stichstoff enthaltende Derivate als Prolyl-Endopeptidase Inhibitoren - Google Patents

Bicyclische Stichstoff enthaltende Derivate als Prolyl-Endopeptidase Inhibitoren

Info

Publication number
DE69414019D1
DE69414019D1 DE69414019T DE69414019T DE69414019D1 DE 69414019 D1 DE69414019 D1 DE 69414019D1 DE 69414019 T DE69414019 T DE 69414019T DE 69414019 T DE69414019 T DE 69414019T DE 69414019 D1 DE69414019 D1 DE 69414019D1
Authority
DE
Germany
Prior art keywords
derivatives containing
prolyl endopeptidase
endopeptidase inhibitors
group
containing bicyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69414019T
Other languages
English (en)
Other versions
DE69414019T2 (de
Inventor
Nanteuil Guillaume De
Bernard Portevin
Georges Remond
Jean Lepagnol
Veronique Heidet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of DE69414019D1 publication Critical patent/DE69414019D1/de
Publication of DE69414019T2 publication Critical patent/DE69414019T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69414019T 1993-03-24 1994-03-17 Bicyclische Stichstoff enthaltende Derivate als Prolyl-Endopeptidase Inhibitoren Expired - Fee Related DE69414019T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9303363A FR2703050B1 (fr) 1993-03-24 1993-03-24 Nouveaux dérivés bicycliques azotés, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Publications (2)

Publication Number Publication Date
DE69414019D1 true DE69414019D1 (de) 1998-11-26
DE69414019T2 DE69414019T2 (de) 1999-06-10

Family

ID=9445279

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69414019T Expired - Fee Related DE69414019T2 (de) 1993-03-24 1994-03-17 Bicyclische Stichstoff enthaltende Derivate als Prolyl-Endopeptidase Inhibitoren

Country Status (11)

Country Link
US (1) US5506237A (de)
EP (1) EP0618193B1 (de)
JP (1) JPH072853A (de)
AT (1) ATE172452T1 (de)
AU (1) AU671347B2 (de)
CA (1) CA2119662C (de)
DE (1) DE69414019T2 (de)
DK (1) DK0618193T3 (de)
ES (1) ES2126075T3 (de)
FR (1) FR2703050B1 (de)
NZ (1) NZ260159A (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19616509A1 (de) * 1996-04-25 1998-01-15 Asta Medica Ag Neue spezifische Immunophilin-Liganden als Antiasthmatika, Immunsuppressiva
FR2748026B1 (fr) * 1996-04-26 1998-06-05 Adir Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6828460B2 (en) 1999-03-22 2004-12-07 Pfizer Inc. Resorcinol derivatives
US7371871B2 (en) 2003-05-05 2008-05-13 Probiodrug Ag Inhibitors of glutaminyl cyclase
CA2544573A1 (en) 2003-11-03 2005-06-02 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
CA2554809C (en) 2004-02-05 2014-04-29 Probiodrug Ag Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase
MX2008011647A (es) * 2006-03-15 2008-09-22 Actelion Pharmaceuticals Ltd Derivados de tetrahidroisoquinolina para mejorar la funcion de la memoria.
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
SI2091948T1 (sl) 2006-11-30 2012-07-31 Probiodrug Ag Novi inhibitorji glutaminil ciklaze
ZA200905537B (en) 2007-03-01 2010-10-27 Probiodrug Ag New use of glutaminyl cyclase inhibitors
EP2142514B1 (de) 2007-04-18 2014-12-24 Probiodrug AG Thioharnstoffderivate als glutaminylcyclaseinhibitoren
ES2548913T3 (es) 2009-09-11 2015-10-21 Probiodrug Ag Derivados heterocíclicos como inhibidores de glutaminil ciclasa
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
JP5688745B2 (ja) 2010-03-10 2015-03-25 プロビオドルグ エージー グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
WO2012123563A1 (en) 2011-03-16 2012-09-20 Probiodrug Ag Benz imidazole derivatives as inhibitors of glutaminyl cyclase
US9115082B2 (en) * 2012-01-18 2015-08-25 Catherine Yang Dipeptidyl-peptidase-IV inhibitors for treatment of type 2 diabetes complex with hypertension
EP3461819B1 (de) 2017-09-29 2020-05-27 Probiodrug AG Hemmer der glutaminylcyclase

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1320734C (en) * 1986-02-04 1993-07-27 Suntory Limited Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same
ES2058089T3 (es) * 1986-11-20 1994-11-01 Ono Pharmaceutical Co Un procedimiento para la preparacion de un nuevo derivado de prolinal.
DE3742431A1 (de) * 1987-12-15 1989-07-13 Hoechst Ag Neue derivate cyclischer aminosaeuren, verfahren zu ihrer herstellung, sie enthaltende mittel und deren verwendung
JPH01250370A (ja) * 1987-12-23 1989-10-05 Zeria Pharmaceut Co Ltd 新規アミノ酸イミド誘導体、製法ならびに用途
FR2672598A1 (fr) * 1991-02-11 1992-08-14 Adir Nouveaux inhibiteurs de n-myristoyltransferase, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2681864B1 (fr) * 1991-09-27 1995-03-31 Adir Nouveaux derives bicycliques azotes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
CA2119662A1 (fr) 1994-09-25
AU5795694A (en) 1994-09-29
FR2703050A1 (fr) 1994-09-30
NZ260159A (en) 1995-01-27
EP0618193B1 (de) 1998-10-21
DE69414019T2 (de) 1999-06-10
ES2126075T3 (es) 1999-03-16
JPH072853A (ja) 1995-01-06
DK0618193T3 (da) 1999-06-28
US5506237A (en) 1996-04-09
FR2703050B1 (fr) 1995-04-28
AU671347B2 (en) 1996-08-22
EP0618193A1 (de) 1994-10-05
CA2119662C (fr) 2001-10-09
ATE172452T1 (de) 1998-11-15

Similar Documents

Publication Publication Date Title
DE69414019D1 (de) Bicyclische Stichstoff enthaltende Derivate als Prolyl-Endopeptidase Inhibitoren
EA200100755A1 (ru) 4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты
ATE169914T1 (de) Piperazin-derivate und ihre verwendung als calmodulin-inhibitoren
DK1105393T3 (da) Bicykliske piperidin- og piperazinforbindelser med 5-HT6-receptoraffinitet
DE69835430D1 (de) Sulfonamidderivate, ihre herstellung und verwendung
DK1452528T3 (da) Xanthinoxidaserinhibitorer
DE69418789D1 (de) 2-(Piperidin-4-yl, Pyridin-4-yl und Tetrahydropyridin-4-yl)-benzofuran-7-carbamat Derivate, ihre Herstellung und Verwendung als Acetylcholinesterase Inhibitoren
EA200000614A1 (ru) 2,3-замещенные соединения индола в качестве ингибиторов сох-2
DK0565377T3 (da) Terapeutiske midler til behandling af Parkinsons sygdom
ATE230398T1 (de) Substituierte heterocyklische derivate, verwendbar als plättchenaggregationshemmstoffe
ATE182889T1 (de) Bicyclische amidinderivate als no-synthetase inhibitoren
DE3783754D1 (de) Prolin-derivate.
DE69202166D1 (de) Verwendung von Tetrahydrothienopyridinderivate als Angiogenese-Inhibitoren.
NO902336L (no) Antispasmotiske midler.
DE3776044D1 (de) Pyridazinon-derivate.
DK0844241T3 (da) Inhibitor af narkotisk analgetisk afhængighed/resistensudvikling
DE68927599D1 (de) Hydantoin-Derivate
DE69529807D1 (de) Neue Parabansäure-Derivate als Aldose-Reduktase Inhibitoren
TW429147B (en) Pharmaceutical composition for the treatment of CNS disorders
DE69103454D1 (de) Merkapto- oder Acylthio-trifluoromethylamidderivate und ihre Verwendung.
DE60239324D1 (de) Phenyl- und pyridyl-piperidine mit tnf-wirkung
ECSP920822A (es) Composiciones heterocyclicas

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LES LABORATOIRES SERVIER, NEUILLY SUR SEINE, FR

8339 Ceased/non-payment of the annual fee