ATE230398T1 - Substituierte heterocyklische derivate, verwendbar als plättchenaggregationshemmstoffe - Google Patents
Substituierte heterocyklische derivate, verwendbar als plättchenaggregationshemmstoffeInfo
- Publication number
- ATE230398T1 ATE230398T1 AT92922021T AT92922021T ATE230398T1 AT E230398 T1 ATE230398 T1 AT E230398T1 AT 92922021 T AT92922021 T AT 92922021T AT 92922021 T AT92922021 T AT 92922021T AT E230398 T1 ATE230398 T1 AT E230398T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted heterocyclic
- platele
- heterocyclic derivatives
- aggregation inhibitors
- derivatives usable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Lubricants (AREA)
- Electroluminescent Light Sources (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77787591A | 1991-10-15 | 1991-10-15 | |
| US88868692A | 1992-05-22 | 1992-05-22 | |
| PCT/US1992/008511 WO1993008164A1 (en) | 1991-10-15 | 1992-10-06 | Substituted heterocyclic derivatives useful as platelet aggregation inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE230398T1 true ATE230398T1 (de) | 2003-01-15 |
Family
ID=27119378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92922021T ATE230398T1 (de) | 1991-10-15 | 1992-10-06 | Substituierte heterocyklische derivate, verwendbar als plättchenaggregationshemmstoffe |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP0630366B1 (de) |
| JP (1) | JPH07500335A (de) |
| AT (1) | ATE230398T1 (de) |
| AU (1) | AU2867992A (de) |
| CA (1) | CA2115848A1 (de) |
| DE (1) | DE69232883T2 (de) |
| DK (1) | DK0630366T3 (de) |
| ES (1) | ES2191659T3 (de) |
| PT (1) | PT539343E (de) |
| WO (1) | WO1993008164A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993018058A1 (en) * | 1992-03-06 | 1993-09-16 | G.D. Searle & Co. | Peptides mimics useful as platelet aggregation inhibitors |
| US5314902A (en) * | 1993-01-27 | 1994-05-24 | Monsanto Company | Urea derivatives useful as platelet aggregation inhibitors |
| US5753659A (en) * | 1993-03-29 | 1998-05-19 | Zeneca Limited | Heterocyclic compouds |
| PL310889A1 (en) * | 1993-03-29 | 1996-01-08 | Zeneca Ltd | Heterocyclic derivatives as inhibitors of thrombocytes aggregation |
| NZ262942A (en) * | 1993-03-29 | 1997-07-27 | Zeneca Ltd | Pyridyl substituted piperazine and various other derivatives of azaheteroaryl substituted piperazines; pharmaceutical compositions |
| US5652242A (en) * | 1993-03-29 | 1997-07-29 | Zeneca Limited | Heterocyclic derivatives |
| US5750754A (en) * | 1993-03-29 | 1998-05-12 | Zeneca Limited | Heterocyclic compounds |
| EP0691953B1 (de) * | 1993-03-31 | 2000-08-02 | G.D. Searle & Co. | 1-amdinophenyl-pyrrolidone/piperidinone als blutblättchen-aggregations inhibitoren |
| GB9313268D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Chemical compounds |
| GB9313285D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Acid derivatives |
| US5463011A (en) * | 1993-06-28 | 1995-10-31 | Zeneca Limited | Acid derivatives |
| US5430043A (en) * | 1993-08-24 | 1995-07-04 | G. D. Searle & Co. | Platelet aggregation inhibitors |
| DE19515500A1 (de) * | 1995-04-27 | 1996-10-31 | Thomae Gmbh Dr K | Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5674894A (en) * | 1995-05-15 | 1997-10-07 | G.D. Searle & Co. | Amidine derivatives useful as platelet aggregation inhibitors and vasodilators |
| US6312893B1 (en) | 1996-01-23 | 2001-11-06 | Qiagen Genomics, Inc. | Methods and compositions for determining the sequence of nucleic acid molecules |
| US6613508B1 (en) | 1996-01-23 | 2003-09-02 | Qiagen Genomics, Inc. | Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques |
| US6027890A (en) | 1996-01-23 | 2000-02-22 | Rapigene, Inc. | Methods and compositions for enhancing sensitivity in the analysis of biological-based assays |
| US5942544A (en) * | 1996-02-22 | 1999-08-24 | Dupont Pharmaceuticals Company | α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors |
| US5872122A (en) * | 1997-10-16 | 1999-02-16 | Monsanto Company | Pyrimidinylamidino β-amino acid derivatives useful as inhibitors of platelet aggregation |
| EP1054871A2 (de) | 1998-04-01 | 2000-11-29 | Du Pont Pharmaceuticals Company | Pyrimidine und triazine als integrinantagonisten |
| US6037365A (en) * | 1998-09-25 | 2000-03-14 | G.D. Searle & Co. | Aminobenzamidinosuccinyl lactone derivatives useful as inhibitors of platelet aggregation |
| CA2585615C (en) * | 2004-11-03 | 2013-11-26 | F. Hoffmann-La Roche Ag | Dicarboxamide derivatives and their use as factor xa inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879313A (en) * | 1988-07-20 | 1989-11-07 | Mosanto Company | Novel platelet-aggregation inhibitors |
| US5039805A (en) * | 1988-12-08 | 1991-08-13 | Hoffmann-La Roche Inc. | Novel benzoic and phenylacetic acid derivatives |
| US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
| CA2037153A1 (en) * | 1990-03-09 | 1991-09-10 | Leo Alig | Acetic acid derivatives |
-
1992
- 1992-10-06 CA CA002115848A patent/CA2115848A1/en not_active Abandoned
- 1992-10-06 AU AU28679/92A patent/AU2867992A/en not_active Abandoned
- 1992-10-06 EP EP92922021A patent/EP0630366B1/de not_active Expired - Lifetime
- 1992-10-06 JP JP5507710A patent/JPH07500335A/ja not_active Ceased
- 1992-10-06 DE DE69232883T patent/DE69232883T2/de not_active Expired - Fee Related
- 1992-10-06 AT AT92922021T patent/ATE230398T1/de not_active IP Right Cessation
- 1992-10-06 ES ES92922021T patent/ES2191659T3/es not_active Expired - Lifetime
- 1992-10-06 WO PCT/US1992/008511 patent/WO1993008164A1/en active IP Right Grant
- 1992-10-06 DK DK92922021T patent/DK0630366T3/da active
- 1992-10-14 PT PT92870166T patent/PT539343E/pt unknown
- 1992-10-14 EP EP92870166A patent/EP0539343B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69232883D1 (de) | 2003-02-06 |
| JPH07500335A (ja) | 1995-01-12 |
| ES2191659T3 (es) | 2003-09-16 |
| WO1993008164A1 (en) | 1993-04-29 |
| EP0539343B1 (de) | 2000-07-26 |
| DE69232883T2 (de) | 2003-11-13 |
| EP0630366A1 (de) | 1994-12-28 |
| CA2115848A1 (en) | 1993-04-16 |
| EP0539343A1 (de) | 1993-04-28 |
| EP0630366B1 (de) | 2003-01-02 |
| PT539343E (pt) | 2000-12-29 |
| DK0630366T3 (da) | 2003-04-22 |
| AU2867992A (en) | 1993-05-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE230398T1 (de) | Substituierte heterocyklische derivate, verwendbar als plättchenaggregationshemmstoffe | |
| DE69427548D1 (de) | Heterozyklische Derivate als Plätchenaggregationsinhibitoren | |
| YU47992A (sh) | Derivati pirolidinona i piperidona | |
| ATE155143T1 (de) | 2-substituierte indan-2-mercaptoacetylamid- verbindungen mit enkephalinase und ace- hemmwirkung | |
| ATE114670T1 (de) | Phenylamidinderivate als plättchenaggregationsinhibitoren. | |
| EA199900242A1 (ru) | Аралкил- и аралкилиден-гетероциклические лактамы и имиды | |
| DE69428025D1 (de) | Proteinkinase C-Inhibitoren | |
| ATE150767T1 (de) | Kleine zyklische inhibitoren der blutplättchenaggregation | |
| ATE282025T1 (de) | Inhibitoren von c-amp phosphodiesterase | |
| ES2078257T3 (es) | Antagonistas de aminoacidos excitantes. | |
| ATE128985T1 (de) | Hydantoinderivate. | |
| FI941457A0 (fi) | Verihiutaleglyproteiini IIb/IIIa:n inhibiittoreina käyttökelpoisia syklisiä yhdisteitä | |
| NO871861L (no) | Fremgangsmaate for fremstilling av nye dopamin beta-hydroxylase inhibitorer. | |
| DE69414019D1 (de) | Bicyclische Stichstoff enthaltende Derivate als Prolyl-Endopeptidase Inhibitoren | |
| DE69326474D1 (de) | Neue 2-substituierte tricyclische derivate von indan-2-mercaptoacetylamid verwendbar als enkephalinase inhibitoren | |
| FI882358A (fi) | Cykliska antikoagulationspeptider. | |
| DE69202166D1 (de) | Verwendung von Tetrahydrothienopyridinderivate als Angiogenese-Inhibitoren. | |
| FI882359A0 (fi) | Cykliska antikoagulationspeptider. pi path slues6208 s880524 mlues6205 m881102 | |
| EA199800534A1 (ru) | ПРИМЕНЕНИЕ 2-ЭТИЛГЕКСИЛ-α-ЦИАНО-β, β-ДИФЕНИЛАКРИАТА ДЛЯ УЛУЧШЕНИЯ СТАБИЛЬНОСТИ КОСМЕТИЧЕСКИХ КОМПОЗИЦИЙ, СОДЕРЖАЩИХ П-МЕТИЛБЕНЗИЛИДЕНКАМФОРУВ СОЧЕТАНИИ С ДИБЕНЗОИЛМЕТАНОВЫМ ПРОИЗВОДНЫМ | |
| ATE223376T1 (de) | Bisarylcyclobutenderivate als cyclooxygenasehemmer | |
| ATE69220T1 (de) | Sechsgliedrige heterocyclische derivate von n'substituiertenn,n'-diacylhydrazinen. | |
| DK0552765T3 (da) | benzimidazoler, farmaceutiske præparater indeholdende disse og fremgangsmåde til deres fremstilling | |
| NO842345L (no) | Heksahydropyrrolo(2,1-a)isoquinolin-derivater. | |
| ES2183500T3 (es) | Nuevos compuestos y composiciones farmaceuticas que los contienen. | |
| DK0509593T3 (da) | Fungicide furanonderivater |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0630366 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |