YU47992A - Derivati pirolidinona i piperidona - Google Patents
Derivati pirolidinona i piperidonaInfo
- Publication number
- YU47992A YU47992A YU47992A YU47992A YU47992A YU 47992 A YU47992 A YU 47992A YU 47992 A YU47992 A YU 47992A YU 47992 A YU47992 A YU 47992A YU 47992 A YU47992 A YU 47992A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- piperlidinon
- piperidona
- derivative
- inhibiting
- blood platelets
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Materials For Medical Uses (AREA)
Abstract
Pronalazak se odnosi na jedinjenja koja su derivati pirolidinona i piperidona i imaju formulu: O R X-(CH2)m-Y-(CH2)k-C-NH-CH-CH-Z R1 (I) u kojoj Y je supstituisani pirolidinon ili piperidon u kojima su heterociklični atomi azota supstituisani. Definicije supstituenata izložene su u patentnim zahtevima. Jedinjenja predložena pronalaskom, kao antagonisti receptora fibrinogena de jstvuju inhibirajući na vezivanje fibrinogena za krvne pločice i sprečavaju agregaciju krvnih pločica. Pronalazak obuhvata delotvorne ali netoksične količine napred navedenih derivata.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69689391A | 1991-05-07 | 1991-05-07 | |
US72035791A | 1991-06-25 | 1991-06-25 | |
US87126292A | 1992-04-23 | 1992-04-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU47992A true YU47992A (sh) | 1995-03-27 |
Family
ID=27418643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU47992A YU47992A (sh) | 1991-05-07 | 1992-05-06 | Derivati pirolidinona i piperidona |
Country Status (20)
Country | Link |
---|---|
US (2) | US5281585A (sh) |
EP (1) | EP0512831B1 (sh) |
JP (1) | JP2531562B2 (sh) |
KR (1) | KR920021531A (sh) |
CN (1) | CN1067883A (sh) |
AT (1) | ATE184874T1 (sh) |
AU (1) | AU647618B2 (sh) |
BG (1) | BG98194A (sh) |
CA (1) | CA2068064C (sh) |
DE (1) | DE69230013T2 (sh) |
ES (1) | ES2137175T3 (sh) |
FI (1) | FI934894A (sh) |
HU (1) | HUT68769A (sh) |
IE (1) | IE921463A1 (sh) |
IL (1) | IL101779A0 (sh) |
MX (1) | MXPA92002103A (sh) |
NO (1) | NO933999L (sh) |
NZ (1) | NZ242609A (sh) |
WO (1) | WO1992019595A1 (sh) |
YU (1) | YU47992A (sh) |
Families Citing this family (112)
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NZ234264A (en) * | 1989-06-29 | 1993-05-26 | Warner Lambert Co | N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives, and pharmaceutical compositions |
US5064814A (en) * | 1990-04-05 | 1991-11-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Anti-thrombotic peptide and pseudopeptide derivatives |
NZ239876A (en) * | 1990-09-27 | 1993-12-23 | Merck & Co Inc | Glycyl-b-alanine derivatives and pharmaceutical compositions thereof. |
IL99537A (en) * | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical preparations containing them |
-
1992
- 1992-04-27 WO PCT/US1992/003463 patent/WO1992019595A1/en not_active Application Discontinuation
- 1992-04-27 HU HU9303145A patent/HUT68769A/hu unknown
- 1992-05-05 NZ NZ242609A patent/NZ242609A/en unknown
- 1992-05-05 IL IL101779A patent/IL101779A0/xx unknown
- 1992-05-06 YU YU47992A patent/YU47992A/sh unknown
- 1992-05-06 CN CN92104545A patent/CN1067883A/zh active Pending
- 1992-05-06 CA CA002068064A patent/CA2068064C/en not_active Expired - Fee Related
- 1992-05-06 MX MXPA92002103A patent/MXPA92002103A/es unknown
- 1992-05-07 AU AU16111/92A patent/AU647618B2/en not_active Ceased
- 1992-05-07 EP EP92304113A patent/EP0512831B1/en not_active Expired - Lifetime
- 1992-05-07 JP JP4158496A patent/JP2531562B2/ja not_active Expired - Lifetime
- 1992-05-07 DE DE69230013T patent/DE69230013T2/de not_active Expired - Fee Related
- 1992-05-07 KR KR1019920007683A patent/KR920021531A/ko not_active Application Discontinuation
- 1992-05-07 ES ES92304113T patent/ES2137175T3/es not_active Expired - Lifetime
- 1992-05-07 AT AT92304113T patent/ATE184874T1/de active
- 1992-07-01 IE IE146392A patent/IE921463A1/en not_active Application Discontinuation
- 1992-11-06 US US07/972,668 patent/US5281585A/en not_active Expired - Fee Related
-
1993
- 1993-11-02 BG BG98194A patent/BG98194A/bg unknown
- 1993-11-05 NO NO933999A patent/NO933999L/no unknown
- 1993-11-05 FI FI934894A patent/FI934894A/fi unknown
- 1993-12-20 US US08/169,947 patent/US5455243A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
BG98194A (bg) | 1994-09-30 |
JP2531562B2 (ja) | 1996-09-04 |
MXPA92002103A (es) | 2005-08-25 |
DE69230013T2 (de) | 2000-04-27 |
IE921463A1 (en) | 1992-11-18 |
AU1611192A (en) | 1992-11-12 |
ES2137175T3 (es) | 1999-12-16 |
AU647618B2 (en) | 1994-03-24 |
KR920021531A (ko) | 1992-12-18 |
CA2068064A1 (en) | 1992-11-08 |
FI934894A0 (fi) | 1993-11-05 |
CN1067883A (zh) | 1993-01-13 |
EP0512831A1 (en) | 1992-11-11 |
NZ242609A (en) | 1995-04-27 |
US5455243A (en) | 1995-10-03 |
HU9303145D0 (en) | 1994-01-28 |
US5281585A (en) | 1994-01-25 |
EP0512831B1 (en) | 1999-09-22 |
CA2068064C (en) | 2001-01-02 |
HUT68769A (en) | 1995-07-28 |
ATE184874T1 (de) | 1999-10-15 |
NO933999D0 (no) | 1993-11-05 |
WO1992019595A1 (en) | 1992-11-12 |
NO933999L (no) | 1993-11-05 |
FI934894A (fi) | 1993-11-05 |
IL101779A0 (en) | 1992-12-30 |
DE69230013D1 (de) | 1999-10-28 |
JPH069525A (ja) | 1994-01-18 |
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