YU47992A - Derivati pirolidinona i piperidona - Google Patents

Derivati pirolidinona i piperidona

Info

Publication number
YU47992A
YU47992A YU47992A YU47992A YU47992A YU 47992 A YU47992 A YU 47992A YU 47992 A YU47992 A YU 47992A YU 47992 A YU47992 A YU 47992A YU 47992 A YU47992 A YU 47992A
Authority
YU
Yugoslavia
Prior art keywords
piperlidinon
piperidona
derivative
inhibiting
blood platelets
Prior art date
Application number
YU47992A
Other languages
English (en)
Inventor
M.E. Duggan
G. Hartman
M.S. Egbertson
N. Ihle
L.M. Turchi
W.F. Hoffman
Original Assignee
Merck And Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck And Co. Inc. filed Critical Merck And Co. Inc.
Publication of YU47992A publication Critical patent/YU47992A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Pronalazak se odnosi na jedinjenja koja su derivati pirolidinona i piperidona i imaju formulu: O R X-(CH2)m-Y-(CH2)k-C-NH-CH-CH-Z R1 (I) u kojoj Y je supstituisani pirolidinon ili piperidon u kojima su heterociklični atomi azota supstituisani. Definicije supstituenata izložene su u patentnim zahtevima. Jedinjenja predložena pronalaskom, kao antagonisti receptora fibrinogena de jstvuju inhibirajući na vezivanje fibrinogena za krvne pločice i sprečavaju agregaciju krvnih pločica. Pronalazak obuhvata delotvorne ali netoksične količine napred navedenih derivata.
YU47992A 1991-05-07 1992-05-06 Derivati pirolidinona i piperidona YU47992A (sh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69689391A 1991-05-07 1991-05-07
US72035791A 1991-06-25 1991-06-25
US87126292A 1992-04-23 1992-04-23

Publications (1)

Publication Number Publication Date
YU47992A true YU47992A (sh) 1995-03-27

Family

ID=27418643

Family Applications (1)

Application Number Title Priority Date Filing Date
YU47992A YU47992A (sh) 1991-05-07 1992-05-06 Derivati pirolidinona i piperidona

Country Status (20)

Country Link
US (2) US5281585A (sh)
EP (1) EP0512831B1 (sh)
JP (1) JP2531562B2 (sh)
KR (1) KR920021531A (sh)
CN (1) CN1067883A (sh)
AT (1) ATE184874T1 (sh)
AU (1) AU647618B2 (sh)
BG (1) BG98194A (sh)
CA (1) CA2068064C (sh)
DE (1) DE69230013T2 (sh)
ES (1) ES2137175T3 (sh)
FI (1) FI934894A0 (sh)
HU (1) HUT68769A (sh)
IE (1) IE921463A1 (sh)
IL (1) IL101779A0 (sh)
MX (1) MXPA92002103A (sh)
NO (1) NO933999D0 (sh)
NZ (1) NZ242609A (sh)
WO (1) WO1992019595A1 (sh)
YU (1) YU47992A (sh)

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Also Published As

Publication number Publication date
HU9303145D0 (en) 1994-01-28
NZ242609A (en) 1995-04-27
IE921463A1 (en) 1992-11-18
EP0512831A1 (en) 1992-11-11
US5281585A (en) 1994-01-25
NO933999L (no) 1993-11-05
EP0512831B1 (en) 1999-09-22
CA2068064C (en) 2001-01-02
BG98194A (bg) 1994-09-30
JP2531562B2 (ja) 1996-09-04
HUT68769A (en) 1995-07-28
FI934894A (fi) 1993-11-05
US5455243A (en) 1995-10-03
AU647618B2 (en) 1994-03-24
CN1067883A (zh) 1993-01-13
ES2137175T3 (es) 1999-12-16
IL101779A0 (en) 1992-12-30
ATE184874T1 (de) 1999-10-15
AU1611192A (en) 1992-11-12
NO933999D0 (no) 1993-11-05
JPH069525A (ja) 1994-01-18
DE69230013T2 (de) 2000-04-27
DE69230013D1 (de) 1999-10-28
KR920021531A (ko) 1992-12-18
WO1992019595A1 (en) 1992-11-12
MXPA92002103A (es) 2005-08-25
CA2068064A1 (en) 1992-11-08
FI934894A0 (fi) 1993-11-05

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