DE69422615D1 - Fibrinogenrezeptorantagonisten - Google Patents

Fibrinogenrezeptorantagonisten

Info

Publication number
DE69422615D1
DE69422615D1 DE69422615T DE69422615T DE69422615D1 DE 69422615 D1 DE69422615 D1 DE 69422615D1 DE 69422615 T DE69422615 T DE 69422615T DE 69422615 T DE69422615 T DE 69422615T DE 69422615 D1 DE69422615 D1 DE 69422615D1
Authority
DE
Germany
Prior art keywords
receptor antagonists
fibrinogen receptor
fibrinogen
image
blood platelets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69422615T
Other languages
English (en)
Other versions
DE69422615T2 (de
Inventor
A Claremon
Nigel Liverton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE69422615D1 publication Critical patent/DE69422615D1/de
Application granted granted Critical
Publication of DE69422615T2 publication Critical patent/DE69422615T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
DE69422615T 1993-04-05 1994-03-29 Fibrinogenrezeptorantagonisten Expired - Fee Related DE69422615T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/042,963 US5441952A (en) 1993-04-05 1993-04-05 Fibrinogen receptor antagonists
PCT/US1994/003400 WO1994022825A1 (en) 1993-04-05 1994-03-29 Fibrinogen receptor antagonists

Publications (2)

Publication Number Publication Date
DE69422615D1 true DE69422615D1 (de) 2000-02-17
DE69422615T2 DE69422615T2 (de) 2000-08-03

Family

ID=21924701

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69422615T Expired - Fee Related DE69422615T2 (de) 1993-04-05 1994-03-29 Fibrinogenrezeptorantagonisten

Country Status (8)

Country Link
US (1) US5441952A (de)
EP (1) EP0693067B1 (de)
JP (1) JPH08508501A (de)
AT (1) ATE188692T1 (de)
AU (1) AU683882B2 (de)
CA (1) CA2159482A1 (de)
DE (1) DE69422615T2 (de)
WO (1) WO1994022825A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0796252A4 (de) * 1994-12-09 1998-02-04 Smithkline Beecham Corp Bicyclische fibrinogen antagonisten
DE69633245T2 (de) 1995-09-29 2005-09-08 Eli Lilly And Co., Indianapolis Spiroverbindungen als Inhibitoren der Fibrinogen-abhängigen Blutplättchenaggregation
US6011029A (en) * 1996-02-26 2000-01-04 Bristol-Myers Squibb Company Inhibitors of farnesyl protein transferase
US6686350B1 (en) 1996-07-25 2004-02-03 Biogen, Inc. Cell adhesion inhibitors
JP2000516596A (ja) * 1996-07-25 2000-12-12 バイオジェン，インコーポレイテッド 細胞接着インヒビター
US6265418B1 (en) * 1997-07-31 2001-07-24 Ube Industries, Ltd. N-acylamino acid amide compounds and intermediates for preparation thereof
US6623981B2 (en) * 1998-01-27 2003-09-23 Bristol-Myers Squibb Company Detection of patients at risk for developing integrin antagonist/agonist mediated disease states
HUP0402003A3 (en) 2001-11-13 2005-06-28 Dimensional Pharm Inc Substituted 1,4-benzodiazepines, pharmaceutical compositions containing them and uses thereof
EP1591120A4 (de) * 2003-01-28 2009-06-10 Takeda Chemical Industries Ltd Rezeptor-agonisten
US9416132B2 (en) 2011-07-21 2016-08-16 Tolero Pharmaceuticals, Inc. Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors
WO2020167990A1 (en) 2019-02-12 2020-08-20 Tolero Pharmaceuticals, Inc. Formulations comprising heterocyclic protein kinase inhibitors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4313947A (en) * 1974-06-24 1982-02-02 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting 2-oxyindoles, their compositions and method of use
DE2549999A1 (de) * 1975-11-07 1977-05-12 Boehringer Mannheim Gmbh Piperidin-derivate und verfahren zu ihrer herstellung
US4064125A (en) * 1976-10-29 1977-12-20 E. R. Squibb And Sons, Inc. Substituted amides having antiinflammatory activity
EP0021592B1 (de) * 1979-05-23 1983-09-28 BEECHAM - WUELFING GmbH & Co. KG Benzolsulfonamid-Derivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Medikamente
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
KR880007441A (ko) * 1986-12-11 1988-08-27 알렌 제이.스피겔 스피로-치환된 글루타르아미드 이뇨제
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
US5084466A (en) * 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
NZ234264A (en) * 1989-06-29 1993-05-26 Warner Lambert Co N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives, and pharmaceutical compositions
NZ239846A (en) * 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
ES2190428T3 (es) * 1991-06-28 2003-08-01 Smithkline Beecham Corp Antagonistas biciclicos de fibrinogeno.

Also Published As

Publication number Publication date
US5441952A (en) 1995-08-15
WO1994022825A1 (en) 1994-10-13
EP0693067B1 (de) 2000-01-12
AU6621894A (en) 1994-10-24
CA2159482A1 (en) 1994-10-13
EP0693067A1 (de) 1996-01-24
ATE188692T1 (de) 2000-01-15
EP0693067A4 (de) 1995-12-12
JPH08508501A (ja) 1996-09-10
DE69422615T2 (de) 2000-08-03
AU683882B2 (en) 1997-11-27

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee