DK0512829T3 - Fibrinogenreceptorantagonister - Google Patents
FibrinogenreceptorantagonisterInfo
- Publication number
- DK0512829T3 DK0512829T3 DK92304111.5T DK92304111T DK0512829T3 DK 0512829 T3 DK0512829 T3 DK 0512829T3 DK 92304111 T DK92304111 T DK 92304111T DK 0512829 T3 DK0512829 T3 DK 0512829T3
- Authority
- DK
- Denmark
- Prior art keywords
- fibrinogen
- inhibiting
- blood platelets
- aggregation
- chem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69690491A | 1991-05-07 | 1991-05-07 | |
US72054791A | 1991-06-25 | 1991-06-25 | |
US07/871,261 US5321034A (en) | 1991-05-07 | 1992-04-23 | Fibrinogen receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0512829T3 true DK0512829T3 (da) | 1998-05-11 |
Family
ID=27418647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK92304111.5T DK0512829T3 (da) | 1991-05-07 | 1992-05-07 | Fibrinogenreceptorantagonister |
Country Status (10)
Country | Link |
---|---|
US (1) | US5321034A (da) |
EP (1) | EP0512829B1 (da) |
JP (1) | JP2552986B2 (da) |
AT (1) | ATE163646T1 (da) |
CA (1) | CA2068054A1 (da) |
DE (1) | DE69224552T2 (da) |
DK (1) | DK0512829T3 (da) |
ES (1) | ES2112884T3 (da) |
GR (1) | GR3026277T3 (da) |
IE (1) | IE921462A1 (da) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6017877A (en) * | 1990-04-06 | 2000-01-25 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US6521594B1 (en) | 1990-04-06 | 2003-02-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5672585A (en) * | 1990-04-06 | 1997-09-30 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5780303A (en) * | 1990-04-06 | 1998-07-14 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
ATE188387T1 (de) * | 1991-02-08 | 2000-01-15 | Diatide Inc | Technetium-99m markierte polypeptide zur bildformung |
US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
US5645815A (en) | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
US5939412A (en) * | 1992-06-26 | 1999-08-17 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
US5968476A (en) * | 1992-05-21 | 1999-10-19 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
US5786373A (en) * | 1992-10-14 | 1998-07-28 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5648368A (en) * | 1992-12-01 | 1997-07-15 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
DE4309867A1 (de) * | 1993-03-26 | 1994-09-29 | Cassella Ag | Neue Harnstoffderivate, ihre Herstellung und Verwendung |
US5753659A (en) * | 1993-03-29 | 1998-05-19 | Zeneca Limited | Heterocyclic compouds |
US5652242A (en) * | 1993-03-29 | 1997-07-29 | Zeneca Limited | Heterocyclic derivatives |
US5750754A (en) * | 1993-03-29 | 1998-05-12 | Zeneca Limited | Heterocyclic compounds |
GB9406143D0 (en) * | 1993-03-29 | 1994-05-18 | Zeneca Ltd | Heterocyclic derivatives |
CA2155307A1 (en) * | 1993-03-29 | 1994-10-13 | Michael Garth Wayne | Heterocyclic compounds as platelet aggregation inhibitors |
ES2179076T3 (es) * | 1993-04-08 | 2003-01-16 | Diatide Inc | Compuestos marcados radiologicamente para reproducir trombos en imagenes. |
US5463011A (en) * | 1993-06-28 | 1995-10-31 | Zeneca Limited | Acid derivatives |
GB9313268D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Chemical compounds |
GB9313285D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Acid derivatives |
AU7862794A (en) * | 1993-10-19 | 1995-05-08 | Sumitomo Pharmaceuticals Company, Limited | 2,3-diaminopropionic acid derivative |
US5446056A (en) * | 1993-11-24 | 1995-08-29 | The Du Pont Merck Pharmaceutical Company | Isoxazoline compounds useful as fibrinogen receptor antagonists |
US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
US5523302A (en) * | 1993-11-24 | 1996-06-04 | The Du Pont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
US5563158A (en) * | 1993-12-28 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
MA23420A1 (fr) * | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
DE4405378A1 (de) * | 1994-02-19 | 1995-08-24 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
US5821241A (en) * | 1994-02-22 | 1998-10-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US6458784B1 (en) | 1994-06-29 | 2002-10-01 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
US5451578A (en) * | 1994-08-12 | 1995-09-19 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5525617A (en) * | 1994-08-24 | 1996-06-11 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5494921A (en) * | 1994-09-16 | 1996-02-27 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5602155A (en) * | 1995-01-17 | 1997-02-11 | G. D. Searle & Co. | Platelet aggregation inhibitors |
US5719144A (en) * | 1995-02-22 | 1998-02-17 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
ZA963391B (en) * | 1995-05-24 | 1997-10-29 | Du Pont Merck Pharma | Isoxazoline fibrinogen receptor antagonists. |
US5977101A (en) * | 1995-06-29 | 1999-11-02 | Smithkline Beecham Corporation | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity |
US5852045A (en) * | 1995-10-19 | 1998-12-22 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
EP0866705A4 (en) * | 1995-10-19 | 1999-03-03 | Merck & Co Inc | FIBRINOGENIC RECEPTOR ANTAGONISTS |
US5952306A (en) * | 1996-01-16 | 1999-09-14 | Merck & Co., Inc. | Integrin receptor antagonists |
US5981584A (en) * | 1997-02-06 | 1999-11-09 | Merck & Co., Inc. | Fibrinogen receptor antagonist prodrugs |
US6294549B1 (en) | 1997-07-23 | 2001-09-25 | Merck & Co., Inc. | Method for eliciting an αvβ5 or dual αvβ3/αvβ5 antagonizing effect |
US6623981B2 (en) * | 1998-01-27 | 2003-09-23 | Bristol-Myers Squibb Company | Detection of patients at risk for developing integrin antagonist/agonist mediated disease states |
US6117842A (en) * | 1998-03-09 | 2000-09-12 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
CA2386049A1 (en) | 1999-10-15 | 2001-04-26 | Daniel S. Gardner | Bicyclic and tricyclic amines as modulators of chemokine receptor activity |
US6784200B2 (en) * | 2000-10-13 | 2004-08-31 | Bristol-Myers Squibb Pharma Company | Bicyclic and tricyclic amines as modulators of chemokine receptor activity |
US11043823B2 (en) * | 2017-04-06 | 2021-06-22 | Tesla, Inc. | System and method for facilitating conditioning and testing of rechargeable battery cells |
CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2549999A1 (de) * | 1975-11-07 | 1977-05-12 | Boehringer Mannheim Gmbh | Piperidin-derivate und verfahren zu ihrer herstellung |
US4064125A (en) * | 1976-10-29 | 1977-12-20 | E. R. Squibb And Sons, Inc. | Substituted amides having antiinflammatory activity |
EP0021592B1 (en) * | 1979-05-23 | 1983-09-28 | BEECHAM - WUELFING GmbH & Co. KG | Phenylsulphonamide derivatives, a process for their preparation and their use as medicines |
US4611054A (en) * | 1985-04-29 | 1986-09-09 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
KR880007441A (ko) * | 1986-12-11 | 1988-08-27 | 알렌 제이.스피겔 | 스피로-치환된 글루타르아미드 이뇨제 |
US5039805A (en) * | 1988-12-08 | 1991-08-13 | Hoffmann-La Roche Inc. | Novel benzoic and phenylacetic acid derivatives |
CA2008116C (en) * | 1989-02-23 | 2001-11-20 | Thomas Weller | Glycine derivatives |
US5049548A (en) * | 1989-03-03 | 1991-09-17 | Merck & Co., Inc. | Renin-inhibitory di-, tri-, and tetrapeptides |
WO1991004746A1 (en) * | 1989-09-29 | 1991-04-18 | Rhone-Poulenc Rorer International (Holdings) Inc. | Anti-thrombotic peptides and pseudopeptides |
US5051405A (en) * | 1989-10-10 | 1991-09-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Anti-thrombotic peptides and pseudopeptides |
IL99538A0 (en) * | 1990-09-27 | 1992-08-18 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical compositions containing them |
NZ239846A (en) * | 1990-09-27 | 1994-11-25 | Merck & Co Inc | Sulphonamide derivatives and pharmaceutical compositions thereof |
IL99537A (en) * | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical preparations containing them |
-
1992
- 1992-04-23 US US07/871,261 patent/US5321034A/en not_active Expired - Fee Related
- 1992-05-06 CA CA002068054A patent/CA2068054A1/en not_active Abandoned
- 1992-05-07 DE DE69224552T patent/DE69224552T2/de not_active Expired - Fee Related
- 1992-05-07 EP EP92304111A patent/EP0512829B1/en not_active Expired - Lifetime
- 1992-05-07 DK DK92304111.5T patent/DK0512829T3/da active
- 1992-05-07 AT AT92304111T patent/ATE163646T1/de not_active IP Right Cessation
- 1992-05-07 ES ES92304111T patent/ES2112884T3/es not_active Expired - Lifetime
- 1992-05-07 JP JP4158498A patent/JP2552986B2/ja not_active Expired - Lifetime
- 1992-07-01 IE IE146292A patent/IE921462A1/en not_active Application Discontinuation
-
1998
- 1998-03-05 GR GR980400248T patent/GR3026277T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR3026277T3 (en) | 1998-06-30 |
DE69224552T2 (de) | 1998-10-01 |
DE69224552D1 (de) | 1998-04-09 |
CA2068054A1 (en) | 1992-11-08 |
JPH06247963A (ja) | 1994-09-06 |
IE921462A1 (en) | 1992-11-18 |
JP2552986B2 (ja) | 1996-11-13 |
ATE163646T1 (de) | 1998-03-15 |
EP0512829B1 (en) | 1998-03-04 |
EP0512829A1 (en) | 1992-11-11 |
ES2112884T3 (es) | 1998-04-16 |
US5321034A (en) | 1994-06-14 |
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