ES2179076T3 - Compuestos marcados radiologicamente para reproducir trombos en imagenes. - Google Patents
Compuestos marcados radiologicamente para reproducir trombos en imagenes.Info
- Publication number
- ES2179076T3 ES2179076T3 ES94921885T ES94921885T ES2179076T3 ES 2179076 T3 ES2179076 T3 ES 2179076T3 ES 94921885 T ES94921885 T ES 94921885T ES 94921885 T ES94921885 T ES 94921885T ES 2179076 T3 ES2179076 T3 ES 2179076T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- compounds
- methods
- thrombes
- pictures
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Surgical Instruments (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of Radiation (AREA)
Abstract
LA INVENCION SE REFIERE A AGENTES ESCINTIGRAFICOS, RADIOETIQUETADOS, PARA LA FORMACION DE IMAGENES, Y A METODOS Y REAGENTES PARA PRODUCIR TALES AGENTES. ESPECIFICAMENTE, LA INVENCION SE REFIERE A COMPUESTOS DE UNION ESPECIFICA, QUE INCLUYEN PEPTIDOS, QUE SE UNEN AL RECEPTOR DE LA PLAQUETAS QUE ES EL RECEPTOR GPIIB/IIIA DE LAS PLAQUETAS, A METODOS Y EQUIPOS PARA FABRICAR ESTOS COMPUESTOS, Y A METODOS PARA USAR TALES COMPUESTOS ETIQUETADOS CON TECNECIO 99M POR MEDIO DE UNA MOLECULA DE UNION DE RADIOETIQUETA COVALENTEMENTE UNIDA PARA FORMAR IMAGENES DE TROMBOS EN EL CUERPO DE UN MAMIFERO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4482593A | 1993-04-08 | 1993-04-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2179076T3 true ES2179076T3 (es) | 2003-01-16 |
Family
ID=21934541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94921885T Expired - Lifetime ES2179076T3 (es) | 1993-04-08 | 1994-04-08 | Compuestos marcados radiologicamente para reproducir trombos en imagenes. |
Country Status (13)
Country | Link |
---|---|
US (1) | US6056940A (es) |
EP (1) | EP0693941B1 (es) |
JP (1) | JP2954355B2 (es) |
AT (1) | ATE220926T1 (es) |
AU (1) | AU687080B2 (es) |
BR (1) | BR1100946A (es) |
CA (2) | CA2363780C (es) |
DE (1) | DE69431052T2 (es) |
DK (1) | DK0693941T3 (es) |
ES (1) | ES2179076T3 (es) |
SG (1) | SG49788A1 (es) |
WO (1) | WO1994023758A1 (es) |
ZA (1) | ZA942439B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR930703024A (ko) * | 1991-02-08 | 1993-11-29 | 리챠드 티. 딘 | 영상용 테크네튬-99m표지폴리펩티드 |
US5645815A (en) * | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
US7238340B1 (en) * | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
US5989519A (en) * | 1992-03-13 | 1999-11-23 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
US5968476A (en) * | 1992-05-21 | 1999-10-19 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
DE69529988T2 (de) * | 1994-05-02 | 2003-12-11 | Diatide Inc | Technetium-99m markierte bildformungsmittel |
US5753206A (en) * | 1995-06-07 | 1998-05-19 | Immunomedics, Inc. | Radiometal-binding analogues of luteinizing hormone releasing hormone |
AU725827B2 (en) * | 1996-07-12 | 2000-10-19 | Immunomedics Inc. | Radiometal-binding peptide analogues |
US5951981A (en) * | 1996-12-02 | 1999-09-14 | Diatide, Inc. | Thrombolytic agents with antithrombotic activity |
US5886142A (en) * | 1997-05-20 | 1999-03-23 | Thomas Jefferson University | Radiolabeled thrombus imaging agents |
DE10005631A1 (de) | 2000-02-09 | 2001-08-23 | Max Planck Gesellschaft | Arginin-Mimetika als Faktor X¶a¶-Inhibitoren |
CA2517823A1 (en) * | 2003-03-26 | 2004-10-14 | Cardiomind, Inc. | Implant delivery technologies |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4792525A (en) * | 1982-08-04 | 1988-12-20 | La Jolla Cancer Research Foundation | Tetrapeptide |
US4578079A (en) * | 1982-08-04 | 1986-03-25 | La Jolla Cancer Research Foundation | Tetrapeptide |
US5225181A (en) * | 1985-06-07 | 1993-07-06 | The Research Foundation Of State University Of New York | Radiolabeled antiplatelet monoclonal antibody for imaging in-vivo thrombi |
US4877868A (en) * | 1986-03-12 | 1989-10-31 | Neorx Corporation | Radionuclide antibody coupling |
WO1989002752A1 (en) * | 1987-09-25 | 1989-04-06 | Genentech, Inc. | Method of diagnosing blood clots using fibrin-binding proteins |
WO1989005150A1 (en) * | 1987-12-10 | 1989-06-15 | La Jolla Cancer Research Foundation | Conformationally stabilized cell adhesion peptides |
EP0381713B1 (en) * | 1988-04-29 | 1994-01-19 | Mallinckrodt, Inc. | Diaminedithiol chelating agents for radiopharmaceuticals |
US5196510A (en) * | 1988-12-29 | 1993-03-23 | Cytogen Corporation | Molecular recognition units |
US4986979A (en) * | 1989-03-14 | 1991-01-22 | Neorx Corporation | Imaging tissue sites of inflammation |
GB8914020D0 (en) * | 1989-06-19 | 1989-08-09 | Antisoma Ltd | Synthetic peptides for use in thrombus detection |
US5384309A (en) * | 1989-07-17 | 1995-01-24 | Genentech, Inc. | Cyclized peptides and their use as platelet aggregation inhibitors |
EP0410541A1 (en) * | 1989-07-28 | 1991-01-30 | Merck & Co. Inc. | Fibrinogen receptor antagonists |
EP0410537A1 (en) * | 1989-07-28 | 1991-01-30 | Merck & Co. Inc. | Fibrinogen receptor antagonists |
CA2021952A1 (en) * | 1989-07-28 | 1991-01-29 | Ruth F. Nutt | Fibrinogen receptor antagonists |
CA2021951A1 (en) * | 1989-07-28 | 1991-01-29 | Ruth F. Nutt | Fibrinogen receptor antagonists |
US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
US4952562A (en) * | 1989-09-29 | 1990-08-28 | Rorer Pharmaceutical Corporation | Anti-thrombotic peptides and pseudopeptides |
NZ235563A (en) * | 1989-10-13 | 1993-04-28 | Merck & Co Inc | Fibrinogen receptor antagonist and pharmaceutical composition |
NZ235564A (en) * | 1989-10-13 | 1993-10-26 | Merck & Co Inc | Fibrinogen receptor antagonist and pharmaceutical compositions |
AU6470590A (en) * | 1989-10-23 | 1991-04-26 | Smithkline Beecham Corporation | Cyclic anti-aggregatory peptides |
US5086069A (en) * | 1990-02-05 | 1992-02-04 | Rorer Pharmaceutical Corporation | Anti-thrombotic peptide and pseudopeptide derivatives |
IL97459A0 (en) * | 1990-03-09 | 1992-06-21 | Hybritech Inc | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
DK0527798T3 (da) * | 1990-04-06 | 1997-12-15 | Jolla Cancer Res Found | Fremgangsmåde og sammensætning til behandling af thrombose |
US5105327A (en) * | 1990-05-10 | 1992-04-14 | Uses, Inc. | Ac power conditioning circuit |
IL99537A (en) * | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical preparations containing them |
KR930703024A (ko) * | 1991-02-08 | 1993-11-29 | 리챠드 티. 딘 | 영상용 테크네튬-99m표지폴리펩티드 |
US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US5645815A (en) * | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
DE69200766T2 (de) * | 1991-03-06 | 1995-05-04 | Searle & Co | Phenylamidinderivate als plättchenaggregationsinhibitoren. |
JPH06509551A (ja) * | 1991-04-05 | 1994-10-27 | ジェネンテク,インコーポレイテッド | Gp II↓bIII↓aに対する高い特異性を有する血小板凝集阻害剤 |
US5321034A (en) * | 1991-05-07 | 1994-06-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5220050A (en) * | 1991-05-17 | 1993-06-15 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
PT100631B (pt) * | 1991-06-28 | 1999-06-30 | Smithkline Beecham Corp | Antagonistas biciclicos de fibrinogenio, seu uso e composicoes farmaceuticas que os contem |
US5250679A (en) * | 1991-10-18 | 1993-10-05 | Genentech, Inc. | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor |
US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
EP1004322B1 (en) * | 1992-05-21 | 2006-06-14 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
US5744120A (en) * | 1993-03-30 | 1998-04-28 | The Dupont Merick Pharmaceutical Company | Ternary radiopharmaceutical complexes |
US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
-
1994
- 1994-04-08 CA CA002363780A patent/CA2363780C/en not_active Expired - Fee Related
- 1994-04-08 US US08/535,170 patent/US6056940A/en not_active Expired - Fee Related
- 1994-04-08 AU AU72413/94A patent/AU687080B2/en not_active Ceased
- 1994-04-08 AT AT94921885T patent/ATE220926T1/de not_active IP Right Cessation
- 1994-04-08 ES ES94921885T patent/ES2179076T3/es not_active Expired - Lifetime
- 1994-04-08 CA CA002160120A patent/CA2160120A1/en not_active Abandoned
- 1994-04-08 DE DE69431052T patent/DE69431052T2/de not_active Expired - Fee Related
- 1994-04-08 EP EP94921885A patent/EP0693941B1/en not_active Expired - Lifetime
- 1994-04-08 WO PCT/US1994/003878 patent/WO1994023758A1/en active IP Right Grant
- 1994-04-08 JP JP6523329A patent/JP2954355B2/ja not_active Expired - Fee Related
- 1994-04-08 ZA ZA942439A patent/ZA942439B/xx unknown
- 1994-04-08 SG SG1996006000A patent/SG49788A1/en unknown
- 1994-04-08 DK DK94921885T patent/DK0693941T3/da active
-
1997
- 1997-05-14 BR BR1100946-2A patent/BR1100946A/pt active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ATE220926T1 (de) | 2002-08-15 |
AU7241394A (en) | 1994-11-08 |
DK0693941T3 (da) | 2002-10-14 |
DE69431052D1 (de) | 2002-08-29 |
EP0693941B1 (en) | 2002-07-24 |
ZA942439B (en) | 1996-01-08 |
JP2954355B2 (ja) | 1999-09-27 |
AU687080B2 (en) | 1998-02-19 |
JPH08508999A (ja) | 1996-09-24 |
US6056940A (en) | 2000-05-02 |
WO1994023758A1 (en) | 1994-10-27 |
BR1100946A (pt) | 2000-08-08 |
SG49788A1 (en) | 1998-06-15 |
CA2363780A1 (en) | 1994-10-27 |
EP0693941A1 (en) | 1996-01-31 |
CA2363780C (en) | 2003-01-07 |
DE69431052T2 (de) | 2003-03-13 |
CA2160120A1 (en) | 1994-10-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2179076T3 (es) | Compuestos marcados radiologicamente para reproducir trombos en imagenes. | |
ATE184203T1 (de) | Technetium-99m-markierte peptide zur bilderzeugung | |
ES2150945T3 (es) | Peptidos marcados con tecnecio-99m para obtencion de imagenes de trombos. | |
DK0644778T3 (da) | Technetium-99-mærkede peptider til imagografi | |
EP0873361A4 (en) | Nuclear receptor ligands and ligand binding domains | |
SE9001521D0 (sv) | System och metod foer rekonstruktion av leder, i synnerhet handleder | |
ES2141102T3 (es) | Polipeptidos marcados con tecnecio-99m para la generacion de imagenes. | |
TR200002257T2 (tr) | Nükleer reseptör ligandları ve ligand bağlanma domainleri. | |
AU598183B2 (en) | Coupling agents for radiolabeled antibody fragments | |
CA2156390A1 (en) | Technetium-99m labeled peptides for diagnostic imaging | |
NO931631L (no) | Kompleksdannende midler og maalsoeking av radioaktive immunoreagenser nyttige innen terapeutiske og diagnostiske bildedannende sammensetninger og fremgangsmetoder | |
PT772459E (pt) | Agentes de imagem marcados tecnecio-99m | |
NO972028L (no) | Kjemiske forbindelser og antikonsepsjonsmidler inneholdende disse | |
ZA952206B (en) | Scintigraphic imaging agents | |
EP0713513A4 (en) | TRIS (ISONITRILE) COPPER (I) SULPHATE COMPLEXES FOR THE PREPARATION OF RADIONUCLIDES | |
WO1995025720B1 (en) | Piperidyl-4-substituted thyrosine derivatives as scintigraphic imaging agents for the diagnosis of thrombosis | |
ATE134988T1 (de) | Neue vorangeordnete sechszähnige liganden verwendbar in röntgenologischen bildformenden wirkstoffen |