TR200002257T2 - Nükleer reseptör ligandları ve ligand bağlanma domainleri. - Google Patents
Nükleer reseptör ligandları ve ligand bağlanma domainleri.Info
- Publication number
- TR200002257T2 TR200002257T2 TR2000/02257T TR200002257T TR200002257T2 TR 200002257 T2 TR200002257 T2 TR 200002257T2 TR 2000/02257 T TR2000/02257 T TR 2000/02257T TR 200002257 T TR200002257 T TR 200002257T TR 200002257 T2 TR200002257 T2 TR 200002257T2
- Authority
- TR
- Turkey
- Prior art keywords
- nuclear receptor
- ligand binding
- binding domains
- receptor ligands
- nuclear
- Prior art date
Links
- 108020005497 Nuclear hormone receptor Proteins 0.000 title abstract 4
- 102000006255 nuclear receptors Human genes 0.000 title abstract 4
- 108020004017 nuclear receptors Proteins 0.000 title abstract 4
- 239000003446 ligand Substances 0.000 title abstract 3
- 108020001756 ligand binding domains Proteins 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 238000000205 computational method Methods 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 102000004217 thyroid hormone receptors Human genes 0.000 abstract 1
- 108090000721 thyroid hormone receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
- G16B15/30—Drug targeting using structural data; Docking or binding prediction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/723—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Theoretical Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medical Informatics (AREA)
Abstract
Mevcut bulus, özellikle Tiroit reseptörü (bundan sonra ''TR'' olarak ifade edilecektir) gibi nükleer reseptörlerin 3 boyutlu yapisi esasinda nükleer reseptör sentetik ligandlarinin meydana getirilmesi için kompozisyon ve özellikle komputasyonel yöntemler gibi yöntemler temin eder. Ayrica temin edilenler, kristaller, nükleer reseptör sentetik ligandlari ve ilgili yöntemleri içerir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/980,115 US6266622B1 (en) | 1995-12-13 | 1997-11-26 | Nuclear receptor ligands and ligand binding domains |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200002257T2 true TR200002257T2 (tr) | 2000-12-21 |
Family
ID=25527367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/02257T TR200002257T2 (tr) | 1997-11-26 | 1998-11-25 | Nükleer reseptör ligandları ve ligand bağlanma domainleri. |
Country Status (11)
Country | Link |
---|---|
US (2) | US6266622B1 (tr) |
EP (1) | EP1034184A2 (tr) |
JP (1) | JP2001524489A (tr) |
KR (1) | KR20010032544A (tr) |
CN (1) | CN1290161A (tr) |
AU (1) | AU763452B2 (tr) |
BR (1) | BR9815061A (tr) |
CA (1) | CA2314096A1 (tr) |
MX (1) | MXPA00005241A (tr) |
TR (1) | TR200002257T2 (tr) |
WO (1) | WO1999026966A2 (tr) |
Families Citing this family (31)
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US6965850B2 (en) * | 1998-03-30 | 2005-11-15 | The Regents Of The University Of California | Methods for modulating nuclear receptor coactivator binding |
WO2000052050A2 (en) * | 1999-03-01 | 2000-09-08 | Karo Bio Ab | Homology models of the glucocorticoid receptor |
US20040033600A1 (en) | 2001-03-21 | 2004-02-19 | Palli Subba Reddy | Ecdysone receptor-based inducible gene expression system |
DE10024939A1 (de) | 2000-05-19 | 2001-11-29 | Bayer Ag | Neue Diphenylmethanderivate für Arzneimittel |
DE10038007A1 (de) | 2000-08-04 | 2002-02-14 | Bayer Ag | Neue Amino-und Amido-Diphenylether für Arzneimittel |
DE10046029A1 (de) | 2000-09-18 | 2002-03-28 | Bayer Ag | Indazole |
US8105825B2 (en) | 2000-10-03 | 2012-01-31 | Intrexon Corporation | Multiple inducible gene regulation system |
CA2433100A1 (en) | 2000-12-27 | 2002-07-04 | Helmut Haning | Indole derivatives as ligands of thyroid receptors |
WO2002066615A2 (en) * | 2001-02-20 | 2002-08-29 | Rheogene, Inc. | Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
AU2002306550B2 (en) | 2001-02-20 | 2007-10-25 | Intrexon Corporation | Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
ES2392508T3 (es) | 2001-02-20 | 2012-12-11 | Intrexon Corporation | Receptores X retinoides quiméricos y su uso en un sistema inducible de expresión génica basado en receptores de ecdisona novedoso |
US9493540B2 (en) | 2001-02-20 | 2016-11-15 | Intrexon Corporation | Ecdysone receptor/invertebrate retinoid X receptor-based inducible gene expression system |
US6777442B2 (en) | 2001-03-12 | 2004-08-17 | Bayer Aktiengesellschaft | Diphenyl derivatives |
US20030027315A1 (en) * | 2001-09-24 | 2003-02-06 | Ada Yonath | Methods of growing crystals of free and antibiotic complexed large ribosomal subunits, and methods of rationally designing or identifying antibiotics using structure coordinate data derived from such crystals |
WO2003027289A1 (en) | 2001-09-26 | 2003-04-03 | Rheo Gene Holdings, Inc. | Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof |
US7302347B2 (en) * | 2002-12-10 | 2007-11-27 | The Regents Of The University Of California | Method for creating specific, high affinity nuclear receptor pharmaceuticals |
WO2004052302A2 (en) * | 2002-12-10 | 2004-06-24 | The Regents Of The University Of California | A method for creating specific, high affinity nuclear receptor pharmaceuticals |
EP1587822A4 (en) * | 2003-01-22 | 2006-04-19 | Merck & Co Inc | PEROXISOME-PROPERATOR-ACTIVATED RECEPTOR |
GB0302446D0 (en) * | 2003-02-03 | 2003-03-05 | Imp College Innovations Ltd | Screening for modulators of fat storage |
EP1658036A2 (en) * | 2003-08-26 | 2006-05-24 | Board of Regents of the University of Texas System | Estrogen receptor modulators and uses thereof |
US20070087352A9 (en) * | 2003-11-06 | 2007-04-19 | Robert Fletterick | Inhibitors for androgen antagonist refractory prostate cancer |
JP2007512359A (ja) * | 2003-11-19 | 2007-05-17 | メタバシス・セラピューティクス・インコーポレイテッド | 新規なリン含有甲状腺ホルモン様物質 |
US7935510B2 (en) | 2004-04-30 | 2011-05-03 | Intrexon Corporation | Mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
US20060032110A1 (en) * | 2004-08-16 | 2006-02-16 | Keng-Ming Yang | Trapping device |
MX2007014502A (es) | 2005-05-26 | 2008-02-07 | Metabasis Therapeutics Inc | Tiromimeticos para el tratamiento de enfermedades del higado graso. |
WO2006128056A2 (en) * | 2005-05-26 | 2006-11-30 | Metabasis Therapeutics, Inc. | Novel phosphinic acid-containing thyromimetics |
CN101291640A (zh) * | 2005-06-24 | 2008-10-22 | 托马斯·拉文 | 甲状腺素化合物用于人体烧伤和脂肪沉积的治疗 |
WO2010122980A1 (ja) | 2009-04-20 | 2010-10-28 | 田辺三菱製薬株式会社 | 新規甲状腺ホルモンβ受容体作動薬 |
JP2020500199A (ja) | 2016-11-21 | 2020-01-09 | バイキング・セラピューティクス・インコーポレイテッド | グリコーゲン蓄積症の治療方法 |
EA201992703A1 (ru) | 2017-06-05 | 2020-04-15 | Вайкинг Терапьютикс, Инк. | Композиции для лечения фиброза |
CN112135832A (zh) | 2018-03-22 | 2020-12-25 | 维京治疗公司 | 化合物的晶型和制备化合物的晶型的方法 |
Family Cites Families (21)
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US3046306A (en) * | 1959-06-24 | 1962-07-24 | Warner Lambert Pharmaceutical | Process of preparing triiodinated analogs of thyronine |
US5061798A (en) * | 1985-01-18 | 1991-10-29 | Smith Kline & French Laboratories, Ltd. | Benzyl pyridyl and pyridazinyl compounds |
GB8501372D0 (en) * | 1985-01-18 | 1985-02-20 | Smith Kline French Lab | Chemical compounds |
US4741897A (en) * | 1986-07-08 | 1988-05-03 | Baxter Travenol | Thyroxine analogs and reagents for thyroid hormone assays |
US5071773A (en) * | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
US5171671A (en) * | 1987-12-02 | 1992-12-15 | The Salk Institute For Biological Studies | Retinoic acid receptor composition |
JP2708456B2 (ja) * | 1988-03-31 | 1998-02-04 | 武田薬品工業株式会社 | 自動合成装置 |
US5025388A (en) * | 1988-08-26 | 1991-06-18 | Cramer Richard D Iii | Comparative molecular field analysis (CoMFA) |
US5438126A (en) * | 1989-09-11 | 1995-08-01 | Arch Development Corporation | Human thyroid hormone receptor DNA |
US5116828A (en) * | 1989-10-26 | 1992-05-26 | Nippon Zoki Pharmaceutical Co., Ltd. | Pharmaceutical composition for treatment of osteoporosis |
US5403925A (en) * | 1989-12-13 | 1995-04-04 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleic acids encoding mammalian H-2RIIBP or RXR.sub.β and uses thereof |
JPH05503691A (ja) * | 1989-12-29 | 1993-06-17 | ユニバーシティ・テクノロジーズ・インターナショナル・インコーポレイテッド | アゴニストおよびアンタゴニストを含む生物学的に活性なリガンドの3次構造モデルの設計方法およびアンギオテンシンに基づいた新規合成アンタゴニスト |
US5284999A (en) * | 1990-04-05 | 1994-02-08 | Brigham And Women's Hospital | DNA encoding a pituitary-specific thyroid hormone receptor |
US5322933A (en) * | 1992-05-07 | 1994-06-21 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Crystal structure of TGF-β-2 |
US5284971A (en) * | 1992-07-16 | 1994-02-08 | Syntex (U.S.A.) Inc. | 4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents |
US5466861A (en) * | 1992-11-25 | 1995-11-14 | Sri International | Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors |
US5463564A (en) * | 1994-09-16 | 1995-10-31 | 3-Dimensional Pharmaceuticals, Inc. | System and method of automatically generating chemical compounds with desired properties |
EP0873361B1 (en) * | 1995-12-13 | 2006-11-02 | The Regents Of The University Of California | Crystals of the ligand-binding domain of the thyroid hormone receptor complexed to a ligand |
JP3345428B2 (ja) * | 1996-08-20 | 2002-11-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 合成甲状腺ホルマン組成物を使用した眼の処置 |
US5883294A (en) * | 1997-06-18 | 1999-03-16 | The Regeants Of The University Of California | Selective thyroid hormone analogs |
US20040137518A1 (en) * | 2002-01-31 | 2004-07-15 | Lambert Millard Hurst | CRYSTALLIZED PPARa LIGAND BINDING DOMAIN POLYPEPTIDE AND SCREENING METHODS EMPLOYING SAME |
-
1997
- 1997-11-26 US US08/980,115 patent/US6266622B1/en not_active Expired - Lifetime
-
1998
- 1998-11-25 TR TR2000/02257T patent/TR200002257T2/tr unknown
- 1998-11-25 EP EP98962849A patent/EP1034184A2/en not_active Withdrawn
- 1998-11-25 WO PCT/US1998/025296 patent/WO1999026966A2/en not_active Application Discontinuation
- 1998-11-25 CA CA002314096A patent/CA2314096A1/en not_active Abandoned
- 1998-11-25 AU AU17999/99A patent/AU763452B2/en not_active Ceased
- 1998-11-25 CN CN98812828A patent/CN1290161A/zh active Pending
- 1998-11-25 MX MXPA00005241A patent/MXPA00005241A/es not_active Application Discontinuation
- 1998-11-25 KR KR1020007005787A patent/KR20010032544A/ko not_active Application Discontinuation
- 1998-11-25 BR BR9815061-8A patent/BR9815061A/pt not_active IP Right Cessation
- 1998-11-25 JP JP2000522122A patent/JP2001524489A/ja active Pending
-
2004
- 2004-04-16 US US10/827,121 patent/US20070027215A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO1999026966A3 (en) | 2000-01-20 |
CA2314096A1 (en) | 1999-06-03 |
US6266622B1 (en) | 2001-07-24 |
WO1999026966A2 (en) | 1999-06-03 |
AU1799999A (en) | 1999-06-15 |
KR20010032544A (ko) | 2001-04-25 |
AU763452B2 (en) | 2003-07-24 |
JP2001524489A (ja) | 2001-12-04 |
EP1034184A2 (en) | 2000-09-13 |
MXPA00005241A (es) | 2002-08-06 |
BR9815061A (pt) | 2001-11-20 |
CN1290161A (zh) | 2001-04-04 |
US20070027215A1 (en) | 2007-02-01 |
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