DE69415154D1 - Chimäre selektine erhältlich durch domänenaustauch und ihre verwendungen - Google Patents

Chimäre selektine erhältlich durch domänenaustauch und ihre verwendungen

Info

Publication number
DE69415154D1
DE69415154D1 DE69415154T DE69415154T DE69415154D1 DE 69415154 D1 DE69415154 D1 DE 69415154D1 DE 69415154 T DE69415154 T DE 69415154T DE 69415154 T DE69415154 T DE 69415154T DE 69415154 D1 DE69415154 D1 DE 69415154D1
Authority
DE
Germany
Prior art keywords
polypeptides
lectin
peptides
domains
chimeral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69415154T
Other languages
English (en)
Other versions
DE69415154T2 (de
Inventor
Thomas F Tedder
Geoffrey S Kansas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Application granted granted Critical
Publication of DE69415154D1 publication Critical patent/DE69415154D1/de
Publication of DE69415154T2 publication Critical patent/DE69415154T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C07K14/70564—Selectins, e.g. CD62
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C07K16/2854—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physiology (AREA)
DE69415154T 1993-01-25 1994-01-25 Chimäre selektine erhältlich durch domänenaustauch und ihre verwendungen Expired - Fee Related DE69415154T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US845993A 1993-01-25 1993-01-25
PCT/US1994/000909 WO1994017193A2 (en) 1993-01-25 1994-01-25 Chimeric l- and p-selectin by exchange of domains - uses thereof

Publications (2)

Publication Number Publication Date
DE69415154D1 true DE69415154D1 (de) 1999-01-21
DE69415154T2 DE69415154T2 (de) 1999-07-29

Family

ID=21731721

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69415154T Expired - Fee Related DE69415154T2 (de) 1993-01-25 1994-01-25 Chimäre selektine erhältlich durch domänenaustauch und ihre verwendungen

Country Status (14)

Country Link
US (2) US5808025A (de)
EP (1) EP0689599B1 (de)
JP (1) JPH08506017A (de)
AT (1) ATE174344T1 (de)
AU (1) AU694933B2 (de)
CA (1) CA2153802A1 (de)
DE (1) DE69415154T2 (de)
DK (1) DK0689599T3 (de)
ES (1) ES2126742T3 (de)
GR (1) GR3029640T3 (de)
HK (1) HK1011382A1 (de)
NZ (1) NZ261991A (de)
SG (1) SG48892A1 (de)
WO (1) WO1994017193A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728802A (en) * 1992-05-06 1998-03-17 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 (ELAM-1)
US5648458A (en) * 1992-05-06 1997-07-15 Affymax Technologies N.V. Peptides and compounds that bind to ELAM-1
US5643873A (en) * 1992-05-06 1997-07-01 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1
US20020040008A1 (en) * 1995-01-24 2002-04-04 Wagner Denisa D. Method for treating and preventing atherosclerosis
US20040116333A1 (en) 2001-08-03 2004-06-17 Rong-Hwa Lin Modulators of P-selectin glycoprotein ligand 1
US7744888B2 (en) 2001-08-03 2010-06-29 Abgenomics Cooperatief U.A. Methods of modulating T cell or natural killer cell activity with anti-P-selectin glycoprotein ligand 1 antibodies
US7169376B2 (en) * 2004-06-10 2007-01-30 Chevron U.S.A. Inc. Method for making hydrogen using a gold containing water-gas shift catalyst
UY28886A1 (es) 2004-05-10 2005-12-30 Boehringer Ingelheim Int Anticuerpos que consisten en polipéptidos y derivados conprendiendo tres secuencias conteniendo respectivamente los siguientes números de seq. id: 1-3 y 4-6; 7-9 y 10-12 y 13-15 ó 16-18
EP1751300B1 (de) * 2004-05-11 2017-11-08 AbGenomics Coöperatief U.A. T-zelltod induzierende epitope
BR112013031892A2 (pt) 2011-06-13 2016-11-22 Abgenomics Cooperatief Ua anticorpos anti-psgl-1 e seu uso

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783330A (en) * 1984-11-15 1988-11-08 New England Medical Center Hospitals, Inc. Monoclonal antibodies to activated platelets
US5081034A (en) * 1988-11-14 1992-01-14 Brigham & Women's Hospital Cloned genes which encode elam-1
US5098833A (en) * 1989-02-23 1992-03-24 Genentech, Inc. DNA sequence encoding a functional domain of a lymphocyte homing receptor
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US5216131A (en) * 1989-02-23 1993-06-01 Genentech, Inc. Lymphocyte homing receptors
US5026537A (en) * 1989-04-06 1991-06-25 Centocor, Inc. Methods for imaging atherosclerotic plaque
WO1991007993A1 (en) * 1989-11-30 1991-06-13 Mathew Vadas Anti-inflammatory and anti-adhesive factors
US5709859A (en) * 1991-01-24 1998-01-20 Bristol-Myers Squibb Company Mixed specificity fusion proteins
WO1992020712A1 (en) * 1991-05-15 1992-11-26 Dana-Farber Cancer Institute, Inc. Leukocyte-associated cell surface protein

Also Published As

Publication number Publication date
SG48892A1 (en) 1998-05-18
AU6128494A (en) 1994-08-15
US5808025A (en) 1998-09-15
EP0689599B1 (de) 1998-12-09
WO1994017193A2 (en) 1994-08-04
AU694933B2 (en) 1998-08-06
HK1011382A1 (en) 1999-07-09
DE69415154T2 (de) 1999-07-29
CA2153802A1 (en) 1994-08-04
DK0689599T3 (da) 1999-08-16
US5834425A (en) 1998-11-10
WO1994017193A3 (en) 1994-11-10
JPH08506017A (ja) 1996-07-02
NZ261991A (en) 1998-04-27
ES2126742T3 (es) 1999-04-01
GR3029640T3 (en) 1999-06-30
ATE174344T1 (de) 1998-12-15
EP0689599A1 (de) 1996-01-03

Similar Documents

Publication Publication Date Title
TR200002257T2 (tr) Nükleer reseptör ligandları ve ligand bağlanma domainleri.
DK0584082T3 (da) Domæner i den ekstracellulære region af humane blodpladeafledte vækstfaktorreceptorpolypeptider
DE69415154D1 (de) Chimäre selektine erhältlich durch domänenaustauch und ihre verwendungen
DK1102596T3 (da) Peptidantagonister af zonulin og fremgangsmåder til anvendelse heraf
WO1997021993A3 (en) Nuclear receptor ligands and ligand binding domains
DK0842273T3 (da) Receptorligand VGEF-C
BR0314092A (pt) proteìnas de fusão de transferrina modificadas
IL100731A (en) Mixed specificity fusion protein and pharmaceutical composition containing it
NO20003534D0 (no) Progesteronreseptor-modulatorforbindelser, farmasøytiske sammensetninger inneholdende disse og anvendelsen av forbindelsene
DK1129186T3 (da) Et faktor VIII-polypeptid med faktor VIII:C-aktivitet
EP0504327A4 (en) Therapeutic uses of the hypervariable region of monoclonal antibody m195 and constructs thereof
NZ509536A (en) Antithrombotic agent and humanized anti-von willebrand factor monoclonal antibody
IL99580A0 (en) Antagonists of human gamma interferon
DK407987A (da) Apolipoprotein b-specifikke monoklonale antistoffer og hybridomer, som producerer disse antistoffer
AU4157501A (en) Her-2 binding antagonists
DE69427484D1 (de) Angiotensin ii rezeptor typ i spezifische monoklonale antikörper und hybridoma
DE69115104D1 (de) Composition comprising at least two different antibodies or fragments thereof.
KR920701127A (ko) 단백질에 금속 이온을 부착하기 위한 킬레이트제
DK1019500T3 (da) IFN receptor 1-bindende proteiner, DNA, som koder for dem, og fremgangsmåder til modulering af cellulært respons på interferoner
CA2219961A1 (en) Vasopermeability enhancing peptide of human interleukin-2 and immunoconjugates thereof
ATE28450T1 (de) (alkylsulfonyl)methansulfonate als antikrebsmittel.
EA200400384A1 (ru) Растворимый рецептор т-клетки
NO940797L (no) Reseptorderivater som har bindingseter for human-rhinovirus
EP1326076A3 (de) Verfahren zur Identifizierung von Liganden oder Modulatoren von 2871 G-Protein gekoppelten Rezeptoren

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee