GT200300034A - Derivados de nicotinamida y una sal de tiotropio en combinacion para el tratamiento de enfermedades - Google Patents
Derivados de nicotinamida y una sal de tiotropio en combinacion para el tratamiento de enfermedadesInfo
- Publication number
- GT200300034A GT200300034A GT200300034A GT200300034A GT200300034A GT 200300034 A GT200300034 A GT 200300034A GT 200300034 A GT200300034 A GT 200300034A GT 200300034 A GT200300034 A GT 200300034A GT 200300034 A GT200300034 A GT 200300034A
- Authority
- GT
- Guatemala
- Prior art keywords
- tiotropio
- diseases
- salt
- treatment
- combination
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
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Abstract
LA PRESENTE INVENCION SE REFIERE A UN COMPUESTO DE FORMULA GENERAL I EN DONDE R1,R2,R3,R4,X,Y,M,N, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS SON INHIBIDORES DE PDE4 DE LA FAMILIA DE LA NICOTINAMIDA POR LO QUE SON DE UTILIDAD EN NUMEROSAS PATOLOGIAS, TRASTORNOS Y AFECCIONES INFLAMATORIAS, ALERGICAS Y RESPIRATORIAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0203193.8A GB0203193D0 (en) | 2002-02-11 | 2002-02-11 | Nicotinamide derivatives useful as pde4 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
GT200300034A true GT200300034A (es) | 2003-09-11 |
Family
ID=9930842
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT200300033A GT200300033A (es) | 2002-02-11 | 2003-02-10 | Derivados de nicotinamida utiles como inhibidores de pde4 |
GT200300034A GT200300034A (es) | 2002-02-11 | 2003-02-10 | Derivados de nicotinamida y una sal de tiotropio en combinacion para el tratamiento de enfermedades |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT200300033A GT200300033A (es) | 2002-02-11 | 2003-02-10 | Derivados de nicotinamida utiles como inhibidores de pde4 |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1476157A1 (es) |
JP (1) | JP2005522449A (es) |
AR (1) | AR038404A1 (es) |
AU (2) | AU2003245812A1 (es) |
BR (1) | BR0307574A (es) |
CA (1) | CA2475708A1 (es) |
GB (1) | GB0203193D0 (es) |
GT (2) | GT200300033A (es) |
HN (1) | HN2003000062A (es) |
MX (1) | MXPA04007736A (es) |
PA (2) | PA8566601A1 (es) |
PE (2) | PE20030921A1 (es) |
SV (1) | SV2004001481A (es) |
TW (2) | TW200304824A (es) |
UY (2) | UY27658A1 (es) |
WO (2) | WO2003068232A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
US6878714B2 (en) | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
EP1476158B1 (en) | 2002-02-11 | 2007-11-14 | Pfizer Limited | Nicotinamide derivatives useful as pde4 inhibitors |
US7307088B2 (en) | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
GB0317516D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
US7153870B2 (en) | 2003-07-25 | 2006-12-26 | Pfizer Inc. | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0317509D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0317482D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
GB0317484D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
WO2005026132A1 (ja) * | 2003-09-17 | 2005-03-24 | Nippon Shinyaku Co., Ltd. | ホスホジエステラーゼのcAMP基質特異的阻害剤 |
CN100549010C (zh) | 2003-11-03 | 2009-10-14 | 贝林格尔.英格海姆国际有限公司 | 制备噻托铵盐类的方法,噻托铵盐类及含有该盐类的医药制剂 |
JP2007517820A (ja) * | 2004-01-09 | 2007-07-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | スコピンエステル及びニコチンアミド誘導体を基にした新規な医薬組成物 |
WO2006106711A1 (ja) * | 2005-03-30 | 2006-10-12 | Eisai R & D Management Co., Ltd. | ピリジン誘導体を含有する抗真菌剤 |
CA2617101A1 (en) * | 2005-08-08 | 2007-02-15 | Boehringer Ingelheim International Gmbh | Method for the protection against the risk of cardiac disorders comprising administration of tiotropium salts |
DE102005049429A1 (de) | 2005-10-15 | 2007-04-19 | Cognis Ip Management Gmbh | Verfahren zur Ausrüstung von Textilien |
RU2008119322A (ru) * | 2005-10-19 | 2009-11-27 | Рэнбакси Лабораториз Лимитед (In) | Композиции ингибиторов фосфодиэстеразы iv типа |
US8247556B2 (en) | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
TWI385169B (zh) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
PL2068873T3 (pl) * | 2006-09-14 | 2012-05-31 | Bridge Bioresearch Rights Jersey Ltd | Mediowane przez izoniazyd gojenie ran i owrzodzeń |
US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
CN109020825B (zh) * | 2017-06-12 | 2021-03-19 | 重庆医科大学 | 抗流感病毒化合物及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3931041C2 (de) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
IL132033A0 (en) * | 1997-04-04 | 2001-03-19 | Pfizer Prod Inc | Nicotinamide derivatives |
-
2002
- 2002-02-11 GB GBGB0203193.8A patent/GB0203193D0/en not_active Ceased
-
2003
- 2003-02-03 MX MXPA04007736A patent/MXPA04007736A/es active IP Right Grant
- 2003-02-03 WO PCT/IB2003/000377 patent/WO2003068232A1/en not_active Application Discontinuation
- 2003-02-03 AU AU2003245812A patent/AU2003245812A1/en not_active Abandoned
- 2003-02-03 CA CA002475708A patent/CA2475708A1/en not_active Abandoned
- 2003-02-03 AU AU2003202116A patent/AU2003202116A1/en not_active Abandoned
- 2003-02-03 WO PCT/IB2003/000379 patent/WO2003068234A1/en not_active Application Discontinuation
- 2003-02-03 EP EP03700974A patent/EP1476157A1/en not_active Withdrawn
- 2003-02-03 JP JP2003567414A patent/JP2005522449A/ja not_active Withdrawn
- 2003-02-03 BR BR0307574-5A patent/BR0307574A/pt not_active IP Right Cessation
- 2003-02-06 TW TW092102415A patent/TW200304824A/zh unknown
- 2003-02-06 TW TW092102422A patent/TW200307545A/zh unknown
- 2003-02-10 AR ARP030100406A patent/AR038404A1/es not_active Application Discontinuation
- 2003-02-10 GT GT200300033A patent/GT200300033A/es unknown
- 2003-02-10 HN HN2003000062A patent/HN2003000062A/es unknown
- 2003-02-10 SV SV2003001481A patent/SV2004001481A/es not_active Application Discontinuation
- 2003-02-10 GT GT200300034A patent/GT200300034A/es unknown
- 2003-02-11 UY UY27658A patent/UY27658A1/es not_active Application Discontinuation
- 2003-02-11 PE PE2003000148A patent/PE20030921A1/es not_active Application Discontinuation
- 2003-02-11 PA PA20038566601A patent/PA8566601A1/es unknown
- 2003-02-11 PE PE2003000149A patent/PE20030860A1/es not_active Application Discontinuation
- 2003-02-11 PA PA20038566501A patent/PA8566501A1/es unknown
- 2003-02-11 UY UY27657A patent/UY27657A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2003068234A1 (en) | 2003-08-21 |
CA2475708A1 (en) | 2003-08-21 |
TW200304824A (en) | 2003-10-16 |
JP2005522449A (ja) | 2005-07-28 |
HN2003000062A (es) | 2003-09-24 |
PE20030860A1 (es) | 2003-10-25 |
AU2003245812A1 (en) | 2003-09-04 |
GT200300033A (es) | 2003-10-11 |
UY27657A1 (es) | 2003-09-30 |
AR038404A1 (es) | 2005-01-12 |
UY27658A1 (es) | 2003-09-30 |
EP1476157A1 (en) | 2004-11-17 |
AU2003202116A1 (en) | 2003-09-04 |
PA8566501A1 (es) | 2003-11-12 |
GB0203193D0 (en) | 2002-03-27 |
PA8566601A1 (es) | 2003-11-12 |
SV2004001481A (es) | 2004-05-07 |
BR0307574A (pt) | 2004-12-21 |
MXPA04007736A (es) | 2004-10-15 |
PE20030921A1 (es) | 2003-11-05 |
WO2003068232A1 (en) | 2003-08-21 |
TW200307545A (en) | 2003-12-16 |
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