PA8566601A1 - Derivados de nicotinamida utiles como inhibidores de pde4 - Google Patents
Derivados de nicotinamida utiles como inhibidores de pde4Info
- Publication number
- PA8566601A1 PA8566601A1 PA20038566601A PA8566601A PA8566601A1 PA 8566601 A1 PA8566601 A1 PA 8566601A1 PA 20038566601 A PA20038566601 A PA 20038566601A PA 8566601 A PA8566601 A PA 8566601A PA 8566601 A1 PA8566601 A1 PA 8566601A1
- Authority
- PA
- Panama
- Prior art keywords
- derivatives
- useful
- pde4 inhibitors
- nicotinamide derivatives
- disorders
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
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Abstract
LA INVENCION SE REFIERE A DERIVADOS DE NICOTINAMIDA Y A PROCEDIMIENTOS PARA LA PREPARACION DE DICHOS DERIVADOS, A LOS INTERMEDIOS UTILIZADOS EN LA PREPARACION DE DICHOS DERIVADOS, A COMPOSICIONES QUE CONTIENEN DICHOS DERIVADOS Y A LOS USOS DE DICHOS DERIVADOS, LOS DERIVADOS DE NICOTINAMIDA DE ACUERDO CON LA PRESENTE INVENCION SON UTILES EN NUMEROSAS ENFERMEDADES, TRASTORNOS Y AFECCIONES, EN PARTICULAR ENFERMEDADES, TRASTORNOS Y AFECCIONES INFLAMATORIAS, ALERGICAS Y RESPIRATORIAS, ASI COMO PARA CURAR HERIDAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0203193.8A GB0203193D0 (en) | 2002-02-11 | 2002-02-11 | Nicotinamide derivatives useful as pde4 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8566601A1 true PA8566601A1 (es) | 2003-11-12 |
Family
ID=9930842
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20038566501A PA8566501A1 (es) | 2002-02-11 | 2003-02-11 | Derivados de nicotinamida y una sal de tiotropio en combinacion para el tratamiento de enfermedades |
PA20038566601A PA8566601A1 (es) | 2002-02-11 | 2003-02-11 | Derivados de nicotinamida utiles como inhibidores de pde4 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20038566501A PA8566501A1 (es) | 2002-02-11 | 2003-02-11 | Derivados de nicotinamida y una sal de tiotropio en combinacion para el tratamiento de enfermedades |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1476157A1 (es) |
JP (1) | JP2005522449A (es) |
AR (1) | AR038404A1 (es) |
AU (2) | AU2003202116A1 (es) |
BR (1) | BR0307574A (es) |
CA (1) | CA2475708A1 (es) |
GB (1) | GB0203193D0 (es) |
GT (2) | GT200300034A (es) |
HN (1) | HN2003000062A (es) |
MX (1) | MXPA04007736A (es) |
PA (2) | PA8566501A1 (es) |
PE (2) | PE20030921A1 (es) |
SV (1) | SV2004001481A (es) |
TW (2) | TW200307545A (es) |
UY (2) | UY27657A1 (es) |
WO (2) | WO2003068234A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6878714B2 (en) | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
EA008939B1 (ru) | 2002-02-11 | 2007-10-26 | Пфайзер Инк. | Производные никотинамида, полезные в качестве ингибиторов pde4 |
US7307088B2 (en) | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
GB0317516D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0317484D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
US7153870B2 (en) | 2003-07-25 | 2006-12-26 | Pfizer Inc. | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0317509D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0317482D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
WO2005026132A1 (ja) * | 2003-09-17 | 2005-03-24 | Nippon Shinyaku Co., Ltd. | ホスホジエステラーゼのcAMP基質特異的阻害剤 |
KR20060117334A (ko) | 2003-11-03 | 2006-11-16 | 베링거 인겔하임 인터내셔날 게엠베하 | 티오트로피움 염의 제조방법, 티오트로피움 염 및 이를함유하는 약제학적 조성물 |
EP1706118A1 (en) * | 2004-01-09 | 2006-10-04 | Boehringer Ingelheim International GmbH | New pharmaceutical compositions based on a scopineester and nicotinamide derivatives |
JP4874958B2 (ja) * | 2005-03-30 | 2012-02-15 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピリジン誘導体を含有する抗真菌剤 |
CA2617101A1 (en) * | 2005-08-08 | 2007-02-15 | Boehringer Ingelheim International Gmbh | Method for the protection against the risk of cardiac disorders comprising administration of tiotropium salts |
DE102005049429A1 (de) | 2005-10-15 | 2007-04-19 | Cognis Ip Management Gmbh | Verfahren zur Ausrüstung von Textilien |
JP2009512677A (ja) * | 2005-10-19 | 2009-03-26 | ランバクシー ラボラトリーズ リミテッド | ホスホジエステラーゼタイプiv阻害剤の組成物 |
US8247556B2 (en) | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
TWI385169B (zh) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
US20100184811A1 (en) * | 2006-09-14 | 2010-07-22 | Finn Buxbom | Isoniazid mediated healing of wounds and ulcers |
US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
CN109020825B (zh) * | 2017-06-12 | 2021-03-19 | 重庆医科大学 | 抗流感病毒化合物及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3931041C2 (de) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
HUP0001243A3 (en) * | 1997-04-04 | 2000-10-30 | Pfizer Prod Inc | Nicotinamide derivatives and pharmaceutical compositions containing them |
-
2002
- 2002-02-11 GB GBGB0203193.8A patent/GB0203193D0/en not_active Ceased
-
2003
- 2003-02-03 JP JP2003567414A patent/JP2005522449A/ja not_active Withdrawn
- 2003-02-03 AU AU2003202116A patent/AU2003202116A1/en not_active Abandoned
- 2003-02-03 MX MXPA04007736A patent/MXPA04007736A/es active IP Right Grant
- 2003-02-03 BR BR0307574-5A patent/BR0307574A/pt not_active IP Right Cessation
- 2003-02-03 WO PCT/IB2003/000379 patent/WO2003068234A1/en not_active Application Discontinuation
- 2003-02-03 WO PCT/IB2003/000377 patent/WO2003068232A1/en not_active Application Discontinuation
- 2003-02-03 EP EP03700974A patent/EP1476157A1/en not_active Withdrawn
- 2003-02-03 CA CA002475708A patent/CA2475708A1/en not_active Abandoned
- 2003-02-03 AU AU2003245812A patent/AU2003245812A1/en not_active Abandoned
- 2003-02-06 TW TW092102422A patent/TW200307545A/zh unknown
- 2003-02-06 TW TW092102415A patent/TW200304824A/zh unknown
- 2003-02-10 SV SV2003001481A patent/SV2004001481A/es not_active Application Discontinuation
- 2003-02-10 GT GT200300034A patent/GT200300034A/es unknown
- 2003-02-10 AR ARP030100406A patent/AR038404A1/es not_active Application Discontinuation
- 2003-02-10 HN HN2003000062A patent/HN2003000062A/es unknown
- 2003-02-10 GT GT200300033A patent/GT200300033A/es unknown
- 2003-02-11 PE PE2003000148A patent/PE20030921A1/es not_active Application Discontinuation
- 2003-02-11 UY UY27657A patent/UY27657A1/es not_active Application Discontinuation
- 2003-02-11 PE PE2003000149A patent/PE20030860A1/es not_active Application Discontinuation
- 2003-02-11 PA PA20038566501A patent/PA8566501A1/es unknown
- 2003-02-11 PA PA20038566601A patent/PA8566601A1/es unknown
- 2003-02-11 UY UY27658A patent/UY27658A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2003068234A1 (en) | 2003-08-21 |
GT200300033A (es) | 2003-10-11 |
AU2003245812A1 (en) | 2003-09-04 |
PA8566501A1 (es) | 2003-11-12 |
BR0307574A (pt) | 2004-12-21 |
HN2003000062A (es) | 2003-09-24 |
AU2003202116A1 (en) | 2003-09-04 |
TW200304824A (en) | 2003-10-16 |
UY27658A1 (es) | 2003-09-30 |
TW200307545A (en) | 2003-12-16 |
GT200300034A (es) | 2003-09-11 |
PE20030860A1 (es) | 2003-10-25 |
EP1476157A1 (en) | 2004-11-17 |
UY27657A1 (es) | 2003-09-30 |
MXPA04007736A (es) | 2004-10-15 |
PE20030921A1 (es) | 2003-11-05 |
JP2005522449A (ja) | 2005-07-28 |
CA2475708A1 (en) | 2003-08-21 |
AR038404A1 (es) | 2005-01-12 |
SV2004001481A (es) | 2004-05-07 |
GB0203193D0 (en) | 2002-03-27 |
WO2003068232A1 (en) | 2003-08-21 |
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