PE115399A1 - Inhibidores aciclicos de la metaloproteasa - Google Patents

Inhibidores aciclicos de la metaloproteasa

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Publication number
PE115399A1
PE115399A1 PE1998000686A PE00068698A PE115399A1 PE 115399 A1 PE115399 A1 PE 115399A1 PE 1998000686 A PE1998000686 A PE 1998000686A PE 00068698 A PE00068698 A PE 00068698A PE 115399 A1 PE115399 A1 PE 115399A1
Authority
PE
Peru
Prior art keywords
alkyl
aciclic
metaloprotease
link
compound
Prior art date
Application number
PE1998000686A
Other languages
English (en)
Inventor
Yetunde Olabisi Taiwo
Michael George Natchus
Neil Gregory Almstead
Roger Gunnard Bookland
Rodney Dean Bush
Biswanath De
Rimma Sandler Bradley
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of PE115399A1 publication Critical patent/PE115399A1/es

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C07D207/408—Radicals containing only hydrogen and carbon atoms attached to ring carbon atoms
    • C07D207/412—Acyclic radicals containing more than six carbon atoms
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    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, A ES SO2Ar, COAr, CONHAr, PORAr; Ar ES UN MONOCICLO O BICICLO AROMATICO O HETEROAROMATICO; R1 ES ALQUILO o H; R2, R3 Y R4 SON H, ALQUILO, ARILO, HETEROARILO, ARILALQUILO, ALCOXIALQUILO, O R2 Y R3, R1 Y R2, R3 Y R4 FORMAN UN HETEROCICLO O HETEROCICLOALQUILO; X ES UN ENLACE, ALQUILO C1-C6, CO, O, N, S, SO, SO2; Y ES UN ENLACE, ALQUILO C1-C6, CO, CO2, CONH2, O, N, S, SO, SO2; Z ES H, COR4, COOR4, CONHR4, R4, CSR4, CSNHR4 Y SO2R4. EL COMPUESTO I ES UN INHIBIDOR DE METALOPROTEASA Y PUEDE SER UTIL PARA TRATAR UNA ENFERMEDAD COMO ARTRITIS, CANCER, DESORDENES CARDIOVASCULARES, DESORDENES CAPILARES, DESORDENES OCULARES, INFLAMACION Y ENFERMEDAD DE LAS ENCIAS
PE1998000686A 1997-07-31 1998-07-31 Inhibidores aciclicos de la metaloproteasa PE115399A1 (es)

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ZA986835B (en) 1999-02-01
BR9810841A (pt) 2001-07-10
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CN1265647A (zh) 2000-09-06
IL134273A0 (en) 2001-04-30
NO20000464D0 (no) 2000-01-28
AU8237698A (en) 1999-02-22
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WO1999006340A3 (en) 1999-09-30

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