AR012264A1 - Compuesto, composicion farmaceutica y metodo para obtener la composicion para prevenir o evitar una enfermedad asociada a actividad metaloproteasicaindeseada - Google Patents

Compuesto, composicion farmaceutica y metodo para obtener la composicion para prevenir o evitar una enfermedad asociada a actividad metaloproteasicaindeseada

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Publication number
AR012264A1
AR012264A1 ARP980103788A ARP980103788A AR012264A1 AR 012264 A1 AR012264 A1 AR 012264A1 AR P980103788 A ARP980103788 A AR P980103788A AR P980103788 A ARP980103788 A AR P980103788A AR 012264 A1 AR012264 A1 AR 012264A1
Authority
AR
Argentina
Prior art keywords
composition
activity
undesiated
metaloproteasical
avoid
Prior art date
Application number
ARP980103788A
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English (en)
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of AR012264A1 publication Critical patent/AR012264A1/es

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C07D207/408—Radicals containing only hydrogen and carbon atoms attached to ring carbon atoms
    • C07D207/412—Acyclic radicals containing more than six carbon atoms
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    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/36—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

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Abstract

Compuestos de la formula (I), como se describe en las reivindicaciones, o un isomero, diastereomero o enantiomero de éstos, o una sal farmacéuticamenteaceptable, o amida, éster, o imida biohidrolizable de éstos son utiles como inhibidoresde las metaloproteasas. También se revelan composicionesfarmacéuticas y métodos de tratar enfermedades, trastornos y condiciones que se caracterizan por la actividad de la metaloproteasa utilizando los compuestoso las composiciones farmacéuticasq ue los contienen.
ARP980103788A 1997-07-31 1998-07-31 Compuesto, composicion farmaceutica y metodo para obtener la composicion para prevenir o evitar una enfermedad asociada a actividad metaloproteasicaindeseada AR012264A1 (es)

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WO1999006340A3 (en) 1999-09-30
CN1265647A (zh) 2000-09-06
JP2001513484A (ja) 2001-09-04
NZ503945A (en) 2002-11-26
HUP0004595A2 (hu) 2001-08-28
HUP0004595A3 (en) 2001-12-28
NO20000464D0 (no) 2000-01-28
AU746877B2 (en) 2002-05-02
EP1009737A2 (en) 2000-06-21
KR20010022499A (ko) 2001-03-15
AU8237698A (en) 1999-02-22
CA2298617A1 (en) 1999-02-11
ZA986835B (en) 1999-02-01
BR9810841A (pt) 2001-07-10
US6218389B1 (en) 2001-04-17
IL134273A0 (en) 2001-04-30
PE115399A1 (es) 2000-02-02
WO1999006340A2 (en) 1999-02-11
NO20000464L (no) 2000-03-30

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