EA200100867A1 - Сульфаматогидроксамовая кислота как ингибитор металлопротеаз - Google Patents

Сульфаматогидроксамовая кислота как ингибитор металлопротеаз

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Publication number
EA200100867A1
EA200100867A1 EA200100867A EA200100867A EA200100867A1 EA 200100867 A1 EA200100867 A1 EA 200100867A1 EA 200100867 A EA200100867 A EA 200100867A EA 200100867 A EA200100867 A EA 200100867A EA 200100867 A1 EA200100867 A1 EA 200100867A1
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EA
Eurasian Patent Office
Prior art keywords
acid
sulfamatogidroxamic
metalloproteas
inhibitor
compounds
Prior art date
Application number
EA200100867A
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English (en)
Other versions
EA005500B1 (ru
Inventor
Гари А. Де Крещенцо
Джозеф Дж. Рико
Терри Л. Бем
Джеффри Н. Кэррол
Даррен Дж. Кассав
Дебора А. Мишке
Original Assignee
Дж.Д.Сирл Энд Ко.
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Publication date
Application filed by Дж.Д.Сирл Энд Ко. filed Critical Дж.Д.Сирл Энд Ко.
Publication of EA200100867A1 publication Critical patent/EA200100867A1/ru
Publication of EA005500B1 publication Critical patent/EA005500B1/ru

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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Раскрыты соединения сульфаматогидроксамовой кислоты, которые, inter alia, угнетают активность матричных металлопротеаз, а также способ получения упомянутых соединений и промежуточных соединений, используемых при синтезировании упомянутых соединений, а также способ лечения, который включает введение хозяину, имеющему состояние, связанное с патологической активностью матричной металлопротеазы, предусматриваемого соединения сульфаматогидроксамовой кислоты в количестве, эффективном для подавления матричной металлопротеазы.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100867A 1999-02-08 2000-02-07 Сульфаматогидроксамовая кислота как ингибитор металлопротеаз EA005500B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11918199P 1999-02-08 1999-02-08
PCT/US2000/003061 WO2000046221A1 (en) 1999-02-08 2000-02-07 Sulfamato hydroxamic acid metalloprotease inhibitor

Publications (2)

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EA200100867A1 true EA200100867A1 (ru) 2002-04-25
EA005500B1 EA005500B1 (ru) 2005-02-24

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US (3) US6448250B1 (ru)
EP (1) EP1157021A1 (ru)
JP (1) JP2002536373A (ru)
KR (1) KR20010102000A (ru)
CN (1) CN1216056C (ru)
AP (1) AP2001002240A0 (ru)
AR (1) AR036585A1 (ru)
AU (1) AU775701B2 (ru)
BG (1) BG105788A (ru)
BR (1) BR0008440A (ru)
CA (1) CA2362230A1 (ru)
CZ (1) CZ20012849A3 (ru)
EA (1) EA005500B1 (ru)
EE (1) EE200100410A (ru)
GE (1) GEP20043238B (ru)
HK (1) HK1049660B (ru)
HR (1) HRP20010660A2 (ru)
HU (1) HUP0200119A3 (ru)
IL (1) IL144783A0 (ru)
IS (1) IS6039A (ru)
MX (1) MXPA01007987A (ru)
NO (1) NO20013850L (ru)
PL (1) PL350193A1 (ru)
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ZA (1) ZA200106492B (ru)

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NO20013850L (no) 2001-09-19
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WO2000046221A1 (en) 2000-08-10
HUP0200119A3 (en) 2003-04-28
JP2002536373A (ja) 2002-10-29
US6448250B1 (en) 2002-09-10
AU775701B2 (en) 2004-08-12
EE200100410A (et) 2002-12-16
EA005500B1 (ru) 2005-02-24
KR20010102000A (ko) 2001-11-15
BG105788A (bg) 2002-02-28
HUP0200119A2 (en) 2002-06-29
NO20013850D0 (no) 2001-08-07
HK1049660A1 (en) 2003-05-23
PL350193A1 (en) 2002-11-18
AU2757400A (en) 2000-08-25
EP1157021A1 (en) 2001-11-28
IS6039A (is) 2001-08-07
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US6372758B1 (en) 2002-04-16
ZA200106492B (en) 2003-05-07
CZ20012849A3 (cs) 2002-05-15
AR036585A1 (es) 2004-09-22
YU57101A (sh) 2005-06-10
CN1362954A (zh) 2002-08-07
HK1049660B (zh) 2006-05-12
IL144783A0 (en) 2002-06-30
CN1216056C (zh) 2005-08-24
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US6492367B1 (en) 2002-12-10
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