CO4920240A1 - Compuestos inhibidores de metaloproteasa diheterociclicos, composiciones farmaceuticas que los contienen y metodos para su utilizacion - Google Patents

Compuestos inhibidores de metaloproteasa diheterociclicos, composiciones farmaceuticas que los contienen y metodos para su utilizacion

Info

Publication number
CO4920240A1
CO4920240A1 CO97049501A CO97049501A CO4920240A1 CO 4920240 A1 CO4920240 A1 CO 4920240A1 CO 97049501 A CO97049501 A CO 97049501A CO 97049501 A CO97049501 A CO 97049501A CO 4920240 A1 CO4920240 A1 CO 4920240A1
Authority
CO
Colombia
Prior art keywords
pharmaceutical compositions
metaloprotease
dihetero
cyclic
methods
Prior art date
Application number
CO97049501A
Other languages
English (en)
Inventor
Pikul Stanislaw
Kelly Lynn Mcdow-Dunham
Gregory Almstead Neil
De Biswanath
Michael George Natchus
Olabisi Taiwo Yetunde
Sandler Bradley Rimma
Thomas Lee Cupps
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of CO4920240A1 publication Critical patent/CO4920240A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/06—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Abstract

La presente invención se relaciona con compuestos de lafórmula o un isómero, diestereómero o enantiómero óptico del mismo, o una sal farmacéuticamente aceptable o amida biohidrolizable, éster o imida de ellos, los cuales son útiles como inhibidores de metaloproteasas.También se relaciona con composiciones farmacéuticas que comprenden una cantidad segura y efectiva de dicho compuesto y un portador farmacéuticamente aceptable, así como con un método para prevenir o tratar una enfermedad asociada con actividad indeseable de metaloproteasa a través de la administración del mencionado compuesto.
CO97049501A 1996-08-28 1997-08-27 Compuestos inhibidores de metaloproteasa diheterociclicos, composiciones farmaceuticas que los contienen y metodos para su utilizacion CO4920240A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2484696P 1996-08-28 1996-08-28

Publications (1)

Publication Number Publication Date
CO4920240A1 true CO4920240A1 (es) 2000-05-29

Family

ID=21822698

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97049501A CO4920240A1 (es) 1996-08-28 1997-08-27 Compuestos inhibidores de metaloproteasa diheterociclicos, composiciones farmaceuticas que los contienen y metodos para su utilizacion

Country Status (25)

Country Link
US (2) US6121258A (es)
EP (1) EP0923561B1 (es)
JP (1) JP3347331B2 (es)
KR (1) KR20000035920A (es)
CN (1) CN1228772A (es)
AR (1) AR009457A1 (es)
AT (1) ATE226573T1 (es)
AU (1) AU734834B2 (es)
BR (1) BR9712085A (es)
CA (1) CA2263917A1 (es)
CO (1) CO4920240A1 (es)
CZ (1) CZ62699A3 (es)
DE (1) DE69716615T2 (es)
DK (1) DK0923561T3 (es)
HU (1) HUP0000210A3 (es)
ID (1) ID18416A (es)
IL (1) IL128664A (es)
NO (1) NO314934B1 (es)
NZ (1) NZ334254A (es)
PE (1) PE2599A1 (es)
PL (1) PL331795A1 (es)
SK (1) SK25799A3 (es)
TR (1) TR199900382T2 (es)
WO (1) WO1998008823A1 (es)
ZA (1) ZA977696B (es)

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US6339101B1 (en) * 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
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OA11722A (en) * 1998-12-02 2005-01-25 Pfizer Prod Inc Methods and compositions for restoring conformational stability of a protein of the p53 family.
EP1147085B1 (en) 1999-01-27 2005-11-16 Wyeth Holdings Corporation Alkynyl containing hydroxamic acid derivatives, their preparation and their use as matrix metalloproteinase (mmp) inhibitors / tnf-alpha converting enzyme (tace) inhibitors
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US6753337B2 (en) 1999-01-27 2004-06-22 Wyeth Holdings Corporation Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
US6544984B1 (en) 1999-01-27 2003-04-08 American Cyanamid Company 2,3,4,5-tetrahydro-1H-(1,4)benzodiazepine-3-hydroxamic acids
NZ513831A (en) 1999-03-03 2001-09-28 Procter & Gamble Alkenyl- and alkynyl-containing metalloprotease inhibitors
KR20010102485A (ko) 1999-03-03 2001-11-15 데이비드 엠 모이어 디헤테로-치환된 메탈로프로테아제 저해제
EP1259499A1 (en) * 2000-02-21 2002-11-27 Fujisawa Pharmaceutical Co., Ltd. Thiazepinyl hydroxamic acid derivatives as matrix metalloproteinase inhibitors
US8283135B2 (en) 2000-06-30 2012-10-09 The Procter & Gamble Company Oral care compositions containing combinations of anti-bacterial and host-response modulating agents
DE60134854D1 (de) 2000-06-30 2008-08-28 Procter & Gamble Orale zubereitungen, die wirtsantwortmodulierenden wirkstoffe enthalten
JP2005500270A (ja) * 2001-05-29 2005-01-06 ギルフォード ファーマシュウティカルズ インコーポレイテッド 手術の結果として発生した神経損傷を治療するための方法
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Also Published As

Publication number Publication date
CN1228772A (zh) 1999-09-15
JP2000516953A (ja) 2000-12-19
BR9712085A (pt) 2000-10-24
NZ334254A (en) 2000-11-24
HUP0000210A3 (en) 2001-07-30
NO990759L (no) 1999-04-27
PL331795A1 (en) 1999-08-02
US6121258A (en) 2000-09-19
PE2599A1 (es) 1999-03-03
IL128664A (en) 2003-07-06
AR009457A1 (es) 2000-04-26
SK25799A3 (en) 1999-12-10
WO1998008823A1 (en) 1998-03-05
KR20000035920A (ko) 2000-06-26
AU4153097A (en) 1998-03-19
ZA977696B (en) 1998-02-23
TR199900382T2 (xx) 1999-05-21
JP3347331B2 (ja) 2002-11-20
CA2263917A1 (en) 1998-03-05
ID18416A (id) 1998-04-09
NO314934B1 (no) 2003-06-16
DE69716615T2 (de) 2003-06-18
EP0923561A1 (en) 1999-06-23
CZ62699A3 (cs) 1999-07-14
EP0923561B1 (en) 2002-10-23
DK0923561T3 (da) 2003-02-24
HUP0000210A2 (hu) 2001-04-28
ATE226573T1 (de) 2002-11-15
US6399598B1 (en) 2002-06-04
IL128664A0 (en) 2000-01-31
NO990759D0 (no) 1999-02-18
DE69716615D1 (de) 2002-11-28
AU734834B2 (en) 2001-06-21

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