HN1997000070A - Inhibición de las metaloproteinasas de matriz por acidos 2-((1)-aroilalquil) -4-biaril-4-oxoburiticos - Google Patents
Inhibición de las metaloproteinasas de matriz por acidos 2-((1)-aroilalquil) -4-biaril-4-oxoburiticosInfo
- Publication number
- HN1997000070A HN1997000070A HN1997000070A HN1997000070A HN1997000070A HN 1997000070 A HN1997000070 A HN 1997000070A HN 1997000070 A HN1997000070 A HN 1997000070A HN 1997000070 A HN1997000070 A HN 1997000070A HN 1997000070 A HN1997000070 A HN 1997000070A
- Authority
- HN
- Honduras
- Prior art keywords
- result
- aroylalkyl
- biaryl
- acids
- oxoburitics
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
Abstract
ESTA INVENCIÓN PRESENTA COMPOSICIONES FARMACEUTICAS Y METODOS PARA TRATAR CIERTOS TRASTORNOS,QUE COMPRENDEN ADMINISTRAR UNA CANTIDAD DE UN COMPUESTO O COMPOSICIÓN DE LA PRESENTE INVENCIÓN QUE SEA EFICAZ PARA INHIBIR LA ACTIVIDAD DE POR LO MENOS UNA METALOPROTEASA DE MATRIZ, QUE DA COMO RESULTADO LA OBTENCIÓN DEL EFECTO DESEADO.LOS COMPUESTOS DE LA PRESENTE INVENCIÓN TIENEN LA FORMULA GENERALIZADA. ESTA INVENCIÓN SE RELACIONA CON INHIBIDORES DE ENZIMAS Y,MAS ESPECIFICAMENTE CON NOVEDOSOS COMPUESTOS DE ÁCIDOS 2-((r)-AROILALQUIL)-4-BIARIL-4-OXIBUTRICOS O DERIVADOS DE LOS MISMOS PARA INHIBIR LAS METALOPROTEASAS DE LA MATRIZ (CONOCIDAS TAMBIEN COMO MMP-1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64502996A | 1996-05-15 | 1996-05-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
HN1997000070A true HN1997000070A (es) | 1997-09-08 |
Family
ID=24587374
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HN1997000070A HN1997000070A (es) | 1996-05-15 | 1997-05-12 | Inhibición de las metaloproteinasas de matriz por acidos 2-((1)-aroilalquil) -4-biaril-4-oxoburiticos |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0904260B1 (es) |
JP (1) | JP3524556B2 (es) |
CN (1) | CN1119313C (es) |
AR (1) | AR007099A1 (es) |
AT (1) | ATE224350T1 (es) |
AU (1) | AU715877B2 (es) |
BR (1) | BR9709078A (es) |
CA (1) | CA2254750C (es) |
CO (1) | CO5011071A1 (es) |
DE (1) | DE69715619T2 (es) |
ES (1) | ES2184092T3 (es) |
HN (1) | HN1997000070A (es) |
HR (1) | HRP970242A2 (es) |
ID (1) | ID17938A (es) |
PA (1) | PA8429601A1 (es) |
PE (1) | PE66198A1 (es) |
SV (1) | SV1997000038A (es) |
TN (1) | TNSN97081A1 (es) |
TW (1) | TW457231B (es) |
WO (1) | WO1997043240A1 (es) |
YU (1) | YU18397A (es) |
ZA (1) | ZA974028B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6288063B1 (en) | 1998-05-27 | 2001-09-11 | Bayer Corporation | Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors |
EP1031349A1 (en) * | 1999-02-25 | 2000-08-30 | Bayer Aktiengesellschaft | Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases |
WO2015150350A1 (de) | 2014-04-03 | 2015-10-08 | Bayer Pharma Aktiengesellschaft | 2,5-disubstituierte cyclopentancarbonsäuren zur behandlung von atemwegserkrankungen |
WO2015150363A1 (de) | 2014-04-03 | 2015-10-08 | Bayer Pharma Aktiengesellschaft | 2,5-disubstituierte cyclopentancarbonsäuren und ihre verwendung |
US20170119776A1 (en) | 2014-04-03 | 2017-05-04 | Bayer Pharma Aktiengesellschaft | Chiral 2,5-disubstituted cyclopentanecarboxylic acid derivatives and use thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS243570B1 (en) * | 1984-08-31 | 1986-06-12 | Miroslav Kuchar | Omega-aryloxoalkane acids |
GB9101468D0 (en) * | 1991-01-23 | 1991-03-06 | Ciba Geigy | Coating compositions |
US5789434A (en) * | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
-
1997
- 1997-05-09 HR HR08/645,029A patent/HRP970242A2/xx not_active Application Discontinuation
- 1997-05-09 CO CO97025187A patent/CO5011071A1/es unknown
- 1997-05-09 ZA ZA9704028A patent/ZA974028B/xx unknown
- 1997-05-09 TN TNTNSN97081A patent/TNSN97081A1/fr unknown
- 1997-05-12 BR BR9709078A patent/BR9709078A/pt not_active IP Right Cessation
- 1997-05-12 PA PA19978429601A patent/PA8429601A1/es unknown
- 1997-05-12 CA CA002254750A patent/CA2254750C/en not_active Expired - Fee Related
- 1997-05-12 AR ARP970101979A patent/AR007099A1/es unknown
- 1997-05-12 WO PCT/US1997/008608 patent/WO1997043240A1/en active IP Right Grant
- 1997-05-12 PE PE1997000364A patent/PE66198A1/es not_active Application Discontinuation
- 1997-05-12 JP JP54119597A patent/JP3524556B2/ja not_active Expired - Fee Related
- 1997-05-12 ES ES97924788T patent/ES2184092T3/es not_active Expired - Lifetime
- 1997-05-12 AU AU30104/97A patent/AU715877B2/en not_active Ceased
- 1997-05-12 YU YU18397A patent/YU18397A/sr unknown
- 1997-05-12 CN CN97196453A patent/CN1119313C/zh not_active Expired - Fee Related
- 1997-05-12 AT AT97924788T patent/ATE224350T1/de not_active IP Right Cessation
- 1997-05-12 EP EP97924788A patent/EP0904260B1/en not_active Expired - Lifetime
- 1997-05-12 SV SV1997000038A patent/SV1997000038A/es not_active Application Discontinuation
- 1997-05-12 TW TW086106287A patent/TW457231B/zh not_active IP Right Cessation
- 1997-05-12 HN HN1997000070A patent/HN1997000070A/es unknown
- 1997-05-12 DE DE69715619T patent/DE69715619T2/de not_active Expired - Fee Related
- 1997-05-14 ID IDP971608A patent/ID17938A/id unknown
Also Published As
Publication number | Publication date |
---|---|
YU18397A (en) | 1999-11-22 |
CN1119313C (zh) | 2003-08-27 |
TW457231B (en) | 2001-10-01 |
PE66198A1 (es) | 1998-10-23 |
ATE224350T1 (de) | 2002-10-15 |
DE69715619T2 (de) | 2003-01-16 |
AU715877B2 (en) | 2000-02-10 |
WO1997043240A1 (en) | 1997-11-20 |
BR9709078A (pt) | 1999-08-03 |
EP0904260B1 (en) | 2002-09-18 |
EP0904260A1 (en) | 1999-03-31 |
AU3010497A (en) | 1997-12-05 |
AR007099A1 (es) | 1999-10-13 |
JP2001509783A (ja) | 2001-07-24 |
ES2184092T3 (es) | 2003-04-01 |
CA2254750A1 (en) | 1997-11-20 |
PA8429601A1 (es) | 2000-05-24 |
TNSN97081A1 (fr) | 2005-03-15 |
HRP970242A2 (en) | 1998-04-30 |
CO5011071A1 (es) | 2001-02-28 |
CN1234791A (zh) | 1999-11-10 |
CA2254750C (en) | 2003-09-30 |
SV1997000038A (es) | 1998-09-01 |
DE69715619D1 (de) | 2002-10-24 |
JP3524556B2 (ja) | 2004-05-10 |
ID17938A (id) | 1998-02-12 |
ZA974028B (en) | 1998-02-19 |
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