SV1997000038A - Inhibicion de matrices metaloproteasas mediante acidos 2-(omega-aroilalkil)-4-biaril-4-oxobutirico - Google Patents

Inhibicion de matrices metaloproteasas mediante acidos 2-(omega-aroilalkil)-4-biaril-4-oxobutirico

Info

Publication number
SV1997000038A
SV1997000038A SV1997000038A SV1997000038A SV1997000038A SV 1997000038 A SV1997000038 A SV 1997000038A SV 1997000038 A SV1997000038 A SV 1997000038A SV 1997000038 A SV1997000038 A SV 1997000038A SV 1997000038 A SV1997000038 A SV 1997000038A
Authority
SV
El Salvador
Prior art keywords
present
activity
compounds
pharmaceutical compositions
methods
Prior art date
Application number
SV1997000038A
Other languages
English (en)
Inventor
William J Scott
Margaret A Popp
David S Hartsough
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of SV1997000038A publication Critical patent/SV1997000038A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION PRESENTA COMPOSICIONES FARMACEUTIAS Y METODOS PARA TRATAR CIERTOS TRASTORNOS, QUE COMPRENDEN ADMIISTRAR UNA CANTIDAD DE UN COMPUESTO O COMPOSICION DE LA PRESENTE INVENCION QUE SEA EFICAZ PARA INHIBIR LA ACTIVIDAD DE POR LO MENOS UNA METALOPROTEASA DE MATRIZ, QUE DA COMO RESULTADO LA OBTENCION DEL EFECTO DESEADO. LOS COMPUESTOS DE LA PRESENTE INVENCION TIENEN LA FORMULA GENERALIZADA (VER FORMULA) DONDE V ES 1,2,3,O 4 Y AR REPRESENTA UNA PORCION AROMATICA SUSTITUIDA. ESTOS COMPUESTOS SON UTILES PARA INHIBIR LAS METALOPROTEASAS DE MATRIZ, Y COMO L A OSTEOARTRITIS, ARTRITISREUMATOIDEA, ARTRITIS SEPTICA, ENFERMEDAD PRIODONTAL, ULCERA DE CORNEA, PROTEINURIA, ENFERMEDAD DE ANEURISMA AORTICO, EPIDERMOLISIS VESICULAR DISTROFICA, TRASTORNOS QUE PRODUCEN RESPUESTAS INFLAMATORIAS, OSTEOPENIAS EN LS QUE MEDIA LA ACTIVIDAD DE LAS MMP, ENFERMEDAD DE LA ARTICULACION TEMPOROMANDIBULAR, ENFERMEDADES DESMIELINIZANTES DEL SISTEMA NERVIOSO, METASTASIS DE TUMORES O PERDIDA DE CARTILAGO POSTERIOR A LA LESION ARTICULAR TRAUMATICA, Y TROMBOSIS CORONARIA POR RUPTURA DE PLACA ATEROSCLEROTICA. LA PRESENTE INVENCION PRESENTA ADIMISMO COMPOSICIONES FARMACEUTICAS Y METODOS PAARA TRATAR DICHAS AFECCIONES.
SV1997000038A 1996-05-15 1997-05-12 Inhibicion de matrices metaloproteasas mediante acidos 2-(omega-aroilalkil)-4-biaril-4-oxobutirico SV1997000038A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64502996A 1996-05-15 1996-05-15

Publications (1)

Publication Number Publication Date
SV1997000038A true SV1997000038A (es) 1998-09-01

Family

ID=24587374

Family Applications (1)

Application Number Title Priority Date Filing Date
SV1997000038A SV1997000038A (es) 1996-05-15 1997-05-12 Inhibicion de matrices metaloproteasas mediante acidos 2-(omega-aroilalkil)-4-biaril-4-oxobutirico

Country Status (22)

Country Link
EP (1) EP0904260B1 (es)
JP (1) JP3524556B2 (es)
CN (1) CN1119313C (es)
AR (1) AR007099A1 (es)
AT (1) ATE224350T1 (es)
AU (1) AU715877B2 (es)
BR (1) BR9709078A (es)
CA (1) CA2254750C (es)
CO (1) CO5011071A1 (es)
DE (1) DE69715619T2 (es)
ES (1) ES2184092T3 (es)
HN (1) HN1997000070A (es)
HR (1) HRP970242A2 (es)
ID (1) ID17938A (es)
PA (1) PA8429601A1 (es)
PE (1) PE66198A1 (es)
SV (1) SV1997000038A (es)
TN (1) TNSN97081A1 (es)
TW (1) TW457231B (es)
WO (1) WO1997043240A1 (es)
YU (1) YU18397A (es)
ZA (1) ZA974028B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6288063B1 (en) 1998-05-27 2001-09-11 Bayer Corporation Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors
EP1031349A1 (en) * 1999-02-25 2000-08-30 Bayer Aktiengesellschaft Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases
WO2015150363A1 (de) 2014-04-03 2015-10-08 Bayer Pharma Aktiengesellschaft 2,5-disubstituierte cyclopentancarbonsäuren und ihre verwendung
CN106661008A (zh) 2014-04-03 2017-05-10 拜耳制药股份公司 用于治疗呼吸道疾病的2,5‑二取代的环戊烷甲酸
US20170119776A1 (en) 2014-04-03 2017-05-04 Bayer Pharma Aktiengesellschaft Chiral 2,5-disubstituted cyclopentanecarboxylic acid derivatives and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS243570B1 (en) * 1984-08-31 1986-06-12 Miroslav Kuchar Omega-aryloxoalkane acids
GB9101468D0 (en) * 1991-01-23 1991-03-06 Ciba Geigy Coating compositions
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors

Also Published As

Publication number Publication date
EP0904260B1 (en) 2002-09-18
EP0904260A1 (en) 1999-03-31
JP2001509783A (ja) 2001-07-24
AR007099A1 (es) 1999-10-13
ES2184092T3 (es) 2003-04-01
WO1997043240A1 (en) 1997-11-20
ID17938A (id) 1998-02-12
CO5011071A1 (es) 2001-02-28
CN1119313C (zh) 2003-08-27
CA2254750C (en) 2003-09-30
JP3524556B2 (ja) 2004-05-10
CN1234791A (zh) 1999-11-10
YU18397A (en) 1999-11-22
CA2254750A1 (en) 1997-11-20
AU3010497A (en) 1997-12-05
ZA974028B (en) 1998-02-19
ATE224350T1 (de) 2002-10-15
PE66198A1 (es) 1998-10-23
DE69715619D1 (de) 2002-10-24
DE69715619T2 (de) 2003-01-16
HRP970242A2 (en) 1998-04-30
HN1997000070A (es) 1997-09-08
TW457231B (en) 2001-10-01
AU715877B2 (en) 2000-02-10
BR9709078A (pt) 1999-08-03
PA8429601A1 (es) 2000-05-24
TNSN97081A1 (fr) 2005-03-15

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