DE69216674D1 - Biguanidederivate, Verfahren zu ihrer Herstellung und diese enthaltende Desinfektionsmittel - Google Patents

Biguanidederivate, Verfahren zu ihrer Herstellung und diese enthaltende Desinfektionsmittel

Info

Publication number
DE69216674D1
DE69216674D1 DE69216674T DE69216674T DE69216674D1 DE 69216674 D1 DE69216674 D1 DE 69216674D1 DE 69216674 T DE69216674 T DE 69216674T DE 69216674 T DE69216674 T DE 69216674T DE 69216674 D1 DE69216674 D1 DE 69216674D1
Authority
DE
Germany
Prior art keywords
processes
preparation
biguanide derivatives
disinfectants containing
biguanide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69216674T
Other languages
English (en)
Other versions
DE69216674T2 (de
Inventor
Hiroshi Ishikawa
Koichi Yasumura
Hidetsugu Tsubouchi
Yukio Higuchi
Hisashi Tamaoka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP3073202A external-priority patent/JPH04308562A/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of DE69216674D1 publication Critical patent/DE69216674D1/de
Application granted granted Critical
Publication of DE69216674T2 publication Critical patent/DE69216674T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • C07C279/265—X and Y being nitrogen atoms, i.e. biguanides containing two or more biguanide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
DE69216674T 1991-04-05 1992-04-03 Biguanidederivate, Verfahren zu ihrer Herstellung und diese enthaltende Desinfektionsmittel Expired - Lifetime DE69216674T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP3073202A JPH04308562A (ja) 1991-04-05 1991-04-05 ビスビグアナイド誘導体とこの誘導体を含有した消毒薬
JP14764491 1991-06-19
JP22430691 1991-09-04

Publications (2)

Publication Number Publication Date
DE69216674D1 true DE69216674D1 (de) 1997-02-27
DE69216674T2 DE69216674T2 (de) 1997-05-28

Family

ID=27301157

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69216674T Expired - Lifetime DE69216674T2 (de) 1991-04-05 1992-04-03 Biguanidederivate, Verfahren zu ihrer Herstellung und diese enthaltende Desinfektionsmittel

Country Status (13)

Country Link
US (1) US5376686A (de)
EP (1) EP0507317B1 (de)
KR (1) KR100195548B1 (de)
CN (1) CN1038248C (de)
AT (1) ATE147725T1 (de)
AU (1) AU651184B2 (de)
CA (1) CA2064664C (de)
DE (1) DE69216674T2 (de)
DK (1) DK0507317T3 (de)
ES (1) ES2099176T3 (de)
GR (1) GR3022353T3 (de)
HK (1) HK1007310A1 (de)
MX (1) MX9201564A (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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GB9506841D0 (en) * 1995-04-03 1995-05-24 Unilever Plc Deodorant compositions
DE59802860D1 (de) * 1997-10-18 2002-02-28 Ddg Dental Devices Gmbh Desinfektionsmittel
ZA9811445B (en) 1997-12-19 1999-08-16 Alcon Lab Inc Aminobiguanides and the use thereof to disinfect contact lenses and preserve pharmaceutical compositions.
EP1435932A4 (de) * 2001-09-21 2006-12-06 Message Pharmaceuticals Inc Hemmer von rnase-p-proteinen als antibakterielle verbindungen
US7256218B2 (en) 2002-11-22 2007-08-14 Jacobus Pharmaceutical Company, Inc. Biguanide and dihydrotriazine derivatives
TW200509893A (en) * 2003-05-28 2005-03-16 Otsuka Pharma Co Ltd A composition for sterilizing and/ or disinfecting
DE602004031523D1 (de) * 2003-05-28 2011-04-07 Otsuka Pharma Co Ltd Wässrige olanexidin-lösung, herstellungsverfahren dafür und desinfektionsmittel
EP1827562A2 (de) 2004-11-17 2007-09-05 Otsuka America Pharmaceutical, Inc. Flüssigkeitsapplikationsgerät und verfahren
TWI385143B (zh) 2006-08-30 2013-02-11 Otsuka Pharma Co Ltd １-（３，４-二氯苯甲基）-５-辛基雙胍或其鹽之製造方法
TWI492786B (zh) * 2008-05-19 2015-07-21 Otsuka America Pharmaceutical Inc 製造剪切敏感材料之溶液的方法與裝置
KR101083300B1 (ko) * 2008-10-13 2011-11-14 한국화학연구원 Ｎ1-벤조［1,3］다이옥솔-5-일메틸-ｎ2-치환된 바이구아나이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 약학 조성물
TWI524875B (zh) 2008-12-30 2016-03-11 大塚製藥工場股份有限公司 用於施加流體的施加器裝置和系統、和設置在施加器裝置中的流體盛裝容器
TWI556845B (zh) 2008-12-30 2016-11-11 大塚美國製藥股份有限公司 施加流體的裝置和方法
KR101285719B1 (ko) * 2010-01-06 2013-07-18 한올바이오파마주식회사 바이구아나이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 약학 조성물
US8933055B2 (en) 2010-09-22 2015-01-13 Ecolab Usa Inc. Antimicrobial compositions containing cationic active ingredients and quaternary sugar derived surfactants
CN102584638B (zh) * 2012-01-19 2014-06-11 山东省农业科学院中心实验室 一种n-(取代苯基) 六亚甲基双胍盐酸盐及其合成方法
CN102993057B (zh) * 2012-12-04 2014-09-17 甘肃省化工研究院 1,6-双氰基胍基己烷的合成方法
US9956153B2 (en) 2014-08-01 2018-05-01 Ecolab Usa Inc. Antimicrobial foaming compositions containing cationic active ingredients
KR102216701B1 (ko) 2014-11-20 2021-02-18 이뮤노메트테라퓨틱스 인코포레이티드 바이구아나이드 화합물 및 이의 용도
DK3347342T3 (da) * 2015-09-11 2019-07-15 Bayer Cropscience Ag Fremgangsmåde til fremstilling af biguanidin-salte og s-triaziner
WO2018193904A1 (ja) 2017-04-19 2018-10-25 株式会社大塚製薬工場 抗炎症剤
CN107668062B (zh) * 2017-10-27 2021-03-09 金英花 基于透明质酸的奥兰西丁水溶液及其制备方法和应用
CN107646862B (zh) * 2017-10-27 2021-05-07 江苏食品药品职业技术学院 基于抗坏血酸的奥兰西丁水溶液及其制备方法和应用
CN112351684B (zh) * 2018-07-18 2022-09-23 株式会社大塚制药工场 消毒用组合物
CN110615886A (zh) * 2019-09-05 2019-12-27 哈尔滨工程大学 一种双胍衍生物抗菌型环氧树脂固化剂及其制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US403243A (en) * 1889-05-14 Vehicle-spring
US2467371A (en) * 1944-05-10 1949-04-19 Ici Ltd Biguanide derivatives
GB577843A (en) * 1944-05-10 1946-06-03 Francis Henry Swinden Curd Biguanide derivatives
US2455896A (en) * 1945-10-12 1948-12-07 American Cyanamid Co 1-aryl, 5-alkyl, biguanides
FR1015134A (fr) * 1948-01-28 1952-08-27 Ici Ltd Fabrication de dérivés de la biguanide
US2544827A (en) * 1948-08-20 1951-03-13 Ici Ltd Manufacture of biguanide derivatives
BE612529A (de) * 1961-01-13
NL273482A (de) * 1961-01-18
BR6568736D0 (pt) * 1964-04-09 1973-08-14 Drug Inc Sterling Processo para preparar uma bisguanida
US3403243A (en) * 1965-05-27 1968-09-24 Tasope Ltd Radiant burn-in unit for photoengraving plates
US3366650A (en) * 1965-10-07 1968-01-30 Squibb & Sons Inc Tetra-and penta-fluoro-phenyl- and phenylalkyl-biguanides and salts thereof
DE2009743A1 (de) * 1970-03-03 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Substituierte Biguanide mit antihyperglykämischer Wirkung
US3879541A (en) * 1970-03-03 1975-04-22 Bayer Ag Antihyperglycemic methods and compositions
DE2009738A1 (de) * 1970-03-03 1971-09-16 Farbenfabriken Bayer Aktiengesell schaft, 5090 Leverkusen Substituierte Biguanide mit antihyper glykamischer Wirkung
US3996232A (en) * 1970-11-23 1976-12-07 William H. Rorer, Inc. 1,5-Disubstituted biguanides
US3891705A (en) * 1971-10-14 1975-06-24 Rorer Inc William H S-triazines
US4183958A (en) * 1978-09-26 1980-01-15 Gaf Corporation Fungicidal 1-(alkoxyphenyl)-5-(substituted phenyl) biguanide compounds
GB8327561D0 (en) * 1983-10-14 1983-11-16 Ici Plc Contraceptive methods
US4567174A (en) * 1984-05-07 1986-01-28 Imperial Chemical Industries Plc Bis(1-substituted biguanide) derivatives

Also Published As

Publication number Publication date
EP0507317B1 (de) 1997-01-15
DE69216674T2 (de) 1997-05-28
CN1038248C (zh) 1998-05-06
CA2064664C (en) 2000-01-11
DK0507317T3 (da) 1997-02-03
EP0507317A3 (en) 1993-02-24
US5376686A (en) 1994-12-27
ES2099176T3 (es) 1997-05-16
AU651184B2 (en) 1994-07-14
CN1065453A (zh) 1992-10-21
EP0507317A2 (de) 1992-10-07
ATE147725T1 (de) 1997-02-15
MX9201564A (es) 1994-03-31
KR920019731A (ko) 1992-11-19
AU1401692A (en) 1992-10-08
HK1007310A1 (en) 1999-04-09
CA2064664A1 (en) 1992-10-06
GR3022353T3 (en) 1997-04-30
KR100195548B1 (ko) 1999-06-15

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