PA8429801A1 - Inhibicion de las metaloproteasas de matriz por compuestos de fenetilo sustituido - Google Patents
Inhibicion de las metaloproteasas de matriz por compuestos de fenetilo sustituidoInfo
- Publication number
- PA8429801A1 PA8429801A1 PA19978429801A PA8429801A PA8429801A1 PA 8429801 A1 PA8429801 A1 PA 8429801A1 PA 19978429801 A PA19978429801 A PA 19978429801A PA 8429801 A PA8429801 A PA 8429801A PA 8429801 A1 PA8429801 A1 PA 8429801A1
- Authority
- PA
- Panama
- Prior art keywords
- compounds
- disease
- disorders
- substituted
- matrix
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE PRESENTAN COMPUESTOS INHIBIDORES DE LA METALOPROTEASA DE MATRIZ, COMPOSICIONES FARMACEUTICAS DE LOS MISMOS Y UN METODO DE TRATAMIENTO DE ENFERMEDADES MEDIANTE EL USO DE DICHOS COMPUESTOS. LOS COMPUESTOS DE LA PRESENTE INVENCION TIENE LA FORMULA GENERALIZADA: DONDE R25 ES UNA PORCION FENILETILO SUSTITUIDA. ESTOS COMPUESTOS SON UTILES PARA INHIBIR LAS METALOPROTEASAS DE MATRIZ Y, POR LO TANTO, PARA COMBATIR LOS TRASTORNOS A LOS CUALES CONTRIBUYEN LAS MMP, TALES COMO LA OSTEOARTRITIS, LA ARTRITIS REUMATOIDEA, LA ARTRITIS SEPTICA, LAS ENFERMEDADES PERIODONTALES, LAS ULCERAS DE CORNEA, LA PROTEINURIA, LA ENFERMEDAD DE ANEURISMA AORTICO, LA EPIDERMOLISIS VESICULAR DISTROFICA, LOS TRASTORNOS QUE PRODUCEN RESPUESTAS INFLAMATORIAS, LAS OSTEOPENIAS EN LAS QUE MEDIA LA ACTIVIDAD DE MMP, LA ENFERMEDAD DE LA ARTICULACION TEMPOROMANDIBULAR, LAS ENFERMEDADES DESMIELINIZANTES DEL SISTEMA NERVIOSO; LAS METASTASIS DE TUMORES O LA PERDIDA DEGENERATIVA DE CARTILAGO POSTERIOR A LA LESION ARTICULAR TRAUMATICA, Y LA TROMBOSIS CORONARIA POR RUPTURA DE PLACA ATEROESCLEROTICA. LA PRESENTE INVENCION SE RELACIONA ASIMISMO CON COMPOSICIONES FARMACEUTICAS Y METODOS PARA TRATAR DICHOS TRASTORNOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64502696A | 1996-05-15 | 1996-05-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8429801A1 true PA8429801A1 (es) | 2000-05-24 |
Family
ID=24587359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA19978429801A PA8429801A1 (es) | 1996-05-15 | 1997-05-12 | Inhibicion de las metaloproteasas de matriz por compuestos de fenetilo sustituido |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0907632B1 (es) |
| JP (1) | JP3305328B2 (es) |
| CN (1) | CN1124255C (es) |
| AR (1) | AR007100A1 (es) |
| AT (1) | ATE229497T1 (es) |
| AU (1) | AU727899B2 (es) |
| BR (1) | BR9709084A (es) |
| CA (1) | CA2253870C (es) |
| CO (1) | CO5070565A1 (es) |
| DE (1) | DE69717811T2 (es) |
| DK (1) | DK0907632T3 (es) |
| ES (1) | ES2188943T3 (es) |
| HN (1) | HN1997000071A (es) |
| HR (1) | HRP970243B1 (es) |
| ID (1) | ID17424A (es) |
| PA (1) | PA8429801A1 (es) |
| PE (1) | PE66298A1 (es) |
| PT (1) | PT907632E (es) |
| SV (1) | SV1997000037A (es) |
| TN (1) | TNSN97082A1 (es) |
| TW (1) | TW363056B (es) |
| WO (1) | WO1997043247A1 (es) |
| YU (1) | YU18497A (es) |
| ZA (1) | ZA974029B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6288063B1 (en) * | 1998-05-27 | 2001-09-11 | Bayer Corporation | Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors |
| EP1140768A1 (en) | 1998-12-30 | 2001-10-10 | Bayer Aktiengesellschaft | Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors for the treatment of respiratory diseases |
| EP1031349A1 (en) * | 1999-02-25 | 2000-08-30 | Bayer Aktiengesellschaft | Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases |
| US7141607B1 (en) | 2000-03-10 | 2006-11-28 | Insite Vision Incorporated | Methods and compositions for treating and inhibiting retinal neovascularization |
| FR2901320B1 (fr) * | 2006-05-17 | 2008-07-04 | Univ Savoie Etablissement Publ | Dispositif miniaturise apte a fonctionner comme moteur ou refroidisseur selon un cycle thermodynamique de stirling |
| CA2944614A1 (en) | 2014-04-03 | 2015-10-08 | Bayer Pharma Aktiengesellschaft | 2,5-disubstituted cyclopentane carboxylic acids for the treatment of respiratoy tract diseases |
| EP3126339A1 (de) | 2014-04-03 | 2017-02-08 | Bayer Pharma Aktiengesellschaft | 2,5-disubstituierte cyclopentancarbonsäuren und ihre verwendung |
| JP2017511319A (ja) | 2014-04-03 | 2017-04-20 | バイエル ファーマ アクチエンゲゼルシャフト | キラル２，５−ジ置換されたシクロペンタンカルボン酸誘導体およびそれの使用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3784701A (en) * | 1970-09-21 | 1974-01-08 | American Cyanamid Co | Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain |
| DE2112716A1 (de) * | 1971-03-17 | 1972-10-05 | Thomae Gmbh Dr K | Neue 4-(4-Biphenylyl)-4-oxobuttersaeuren,ihre Salze und ihre Ester |
| US5789434A (en) * | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
-
1997
- 1997-05-09 CO CO97025183A patent/CO5070565A1/es unknown
- 1997-05-09 HR HR970243A patent/HRP970243B1/xx not_active IP Right Cessation
- 1997-05-09 ZA ZA9704029A patent/ZA974029B/xx unknown
- 1997-05-09 TN TNTNSN97082A patent/TNSN97082A1/fr unknown
- 1997-05-12 TW TW086106288A patent/TW363056B/zh active
- 1997-05-12 JP JP54097997A patent/JP3305328B2/ja not_active Expired - Fee Related
- 1997-05-12 AU AU29385/97A patent/AU727899B2/en not_active Ceased
- 1997-05-12 WO PCT/US1997/007919 patent/WO1997043247A1/en active IP Right Grant
- 1997-05-12 CA CA002253870A patent/CA2253870C/en not_active Expired - Fee Related
- 1997-05-12 YU YU18497A patent/YU18497A/sr unknown
- 1997-05-12 PA PA19978429801A patent/PA8429801A1/es unknown
- 1997-05-12 EP EP97923621A patent/EP0907632B1/en not_active Expired - Lifetime
- 1997-05-12 BR BR9709084A patent/BR9709084A/pt not_active Application Discontinuation
- 1997-05-12 HN HN1997000071A patent/HN1997000071A/es unknown
- 1997-05-12 PT PT97923621T patent/PT907632E/pt unknown
- 1997-05-12 AR ARP970101980A patent/AR007100A1/es unknown
- 1997-05-12 AT AT97923621T patent/ATE229497T1/de not_active IP Right Cessation
- 1997-05-12 ES ES97923621T patent/ES2188943T3/es not_active Expired - Lifetime
- 1997-05-12 DE DE69717811T patent/DE69717811T2/de not_active Expired - Fee Related
- 1997-05-12 SV SV1997000037A patent/SV1997000037A/es not_active Application Discontinuation
- 1997-05-12 CN CN97196457A patent/CN1124255C/zh not_active Expired - Fee Related
- 1997-05-12 PE PE1997000366A patent/PE66298A1/es not_active Application Discontinuation
- 1997-05-12 DK DK97923621T patent/DK0907632T3/da active
- 1997-05-14 ID IDP971605A patent/ID17424A/id unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0907632A1 (en) | 1999-04-14 |
| PE66298A1 (es) | 1998-10-23 |
| CA2253870A1 (en) | 1997-11-20 |
| HRP970243A2 (en) | 1998-04-30 |
| AU2938597A (en) | 1997-12-05 |
| TW363056B (en) | 1999-07-01 |
| SV1997000037A (es) | 1999-01-14 |
| HN1997000071A (es) | 1997-06-18 |
| JP3305328B2 (ja) | 2002-07-22 |
| AR007100A1 (es) | 1999-10-13 |
| DE69717811T2 (de) | 2003-05-28 |
| DK0907632T3 (da) | 2003-04-07 |
| EP0907632B1 (en) | 2002-12-11 |
| ATE229497T1 (de) | 2002-12-15 |
| ID17424A (id) | 1997-12-24 |
| ZA974029B (en) | 1998-02-19 |
| DE69717811D1 (en) | 2003-01-23 |
| YU18497A (en) | 1999-11-22 |
| CN1124255C (zh) | 2003-10-15 |
| JPH11510517A (ja) | 1999-09-14 |
| HRP970243B1 (en) | 2002-06-30 |
| BR9709084A (pt) | 1999-08-03 |
| CN1225624A (zh) | 1999-08-11 |
| AU727899B2 (en) | 2001-01-04 |
| ES2188943T3 (es) | 2003-07-01 |
| WO1997043247A1 (en) | 1997-11-20 |
| CO5070565A1 (es) | 2001-08-28 |
| TNSN97082A1 (fr) | 2005-03-15 |
| CA2253870C (en) | 2004-01-06 |
| PT907632E (pt) | 2003-04-30 |
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