SV1997000037A - Inhibisor de matrices de metaloproteasas mediante compuestos sustituidos de fenalquilo, - Google Patents
Inhibisor de matrices de metaloproteasas mediante compuestos sustituidos de fenalquilo,Info
- Publication number
- SV1997000037A SV1997000037A SV1997000037A SV1997000037A SV1997000037A SV 1997000037 A SV1997000037 A SV 1997000037A SV 1997000037 A SV1997000037 A SV 1997000037A SV 1997000037 A SV1997000037 A SV 1997000037A SV 1997000037 A SV1997000037 A SV 1997000037A
- Authority
- SV
- El Salvador
- Prior art keywords
- disorders
- metaloprotease
- diseases
- alnoria
- mmp
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE RELACIONA CON COMPUESTOS DE INHIBIDORES DE LA METALOPROTEASA DE MATRIZ, COMPOSICIONES FARMACEUTICAS DE LOS MISMOS Y UN METODO DE TRATAMIENTO DE ENFERMEDADES MEDIANTE EL USO DE DICHOS COMPUESTOS DE LA PRESENTE INVENCION TIENE LA FROMULA GENERAL I, ESTOS COMPUESTOS SON UTILES PARA INHIBIR LAS METALOPROTEASA DE MATRIZ Y POR LO TANTO, PARA COMBATIR LOS TRASTORNOS DE LOS CUALES CONTRIBUYEN LAS MMP, TALES COMO LA OSTEOARTRITIS, LA ARTRITIS REUMATOIDEA, LA ARTRITIS SEPTICA, LAS ENFEREMEDADES PERIODONTALES, LAS ULCERAS DE CORNEA, LA PROTEINURIA, AL ENFERMEDAD DE NEURISMA AORTICA, LA EPIDERMOLISIS DISTROFICA, LOS TRASTORNOS QUE PRODUCEN RESPUESTAS INFLAMATORIAS, LAS OSTEOPENIAS EN LAS QUE MEDIA LA ACTIVIDAD DE MMP, LA ENFERMEDAD DE LA ATICULACION TEMPOROANDIBULAR, LAS ENFERMEDADES DESMIELIZANTES DEL SISTEMA NERVIOSO; LAS METASTASIS DE TUMORES O LA PERDIDA DEGENERATIVA DE CARTILAGOS A LA LESION ARTICULAR TRAUMATICA Y TROMBOSIS CORONARIA POR RUPTURA DE PLACA ATEROESCLEROTICA, ASIMISMO ESTE INVENTO PRESENTA COMPOSICIONES FARMACEUTICAS Y METODOS PARA TRATAR DICHOS TRASTORNOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64502696A | 1996-05-15 | 1996-05-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SV1997000037A true SV1997000037A (es) | 1999-01-14 |
Family
ID=24587359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SV1997000037A SV1997000037A (es) | 1996-05-15 | 1997-05-12 | Inhibisor de matrices de metaloproteasas mediante compuestos sustituidos de fenalquilo, |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0907632B1 (es) |
| JP (1) | JP3305328B2 (es) |
| CN (1) | CN1124255C (es) |
| AR (1) | AR007100A1 (es) |
| AT (1) | ATE229497T1 (es) |
| AU (1) | AU727899B2 (es) |
| BR (1) | BR9709084A (es) |
| CA (1) | CA2253870C (es) |
| CO (1) | CO5070565A1 (es) |
| DE (1) | DE69717811T2 (es) |
| DK (1) | DK0907632T3 (es) |
| ES (1) | ES2188943T3 (es) |
| HN (1) | HN1997000071A (es) |
| HR (1) | HRP970243B1 (es) |
| ID (1) | ID17424A (es) |
| PA (1) | PA8429801A1 (es) |
| PE (1) | PE66298A1 (es) |
| PT (1) | PT907632E (es) |
| SV (1) | SV1997000037A (es) |
| TN (1) | TNSN97082A1 (es) |
| TW (1) | TW363056B (es) |
| WO (1) | WO1997043247A1 (es) |
| YU (1) | YU18497A (es) |
| ZA (1) | ZA974029B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6288063B1 (en) * | 1998-05-27 | 2001-09-11 | Bayer Corporation | Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors |
| KR20010101325A (ko) | 1998-12-30 | 2001-11-14 | 빌프리더 하이더 | 치환된 4-비아릴부티르산 유도체 및 5-비아릴펜탄산유도체의 호흡기 질환 치료용 매트릭스 메탈로프로테아제저해제로서의 용도 |
| EP1031349A1 (en) * | 1999-02-25 | 2000-08-30 | Bayer Aktiengesellschaft | Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases |
| US7141607B1 (en) | 2000-03-10 | 2006-11-28 | Insite Vision Incorporated | Methods and compositions for treating and inhibiting retinal neovascularization |
| FR2901320B1 (fr) * | 2006-05-17 | 2008-07-04 | Univ Savoie Etablissement Publ | Dispositif miniaturise apte a fonctionner comme moteur ou refroidisseur selon un cycle thermodynamique de stirling |
| WO2015150362A2 (de) | 2014-04-03 | 2015-10-08 | Bayer Pharma Aktiengesellschaft | Chirale 2,5-disubstituierte cyclopentancarbonsäure-derivate und ihre verwendung |
| CA2944614A1 (en) | 2014-04-03 | 2015-10-08 | Bayer Pharma Aktiengesellschaft | 2,5-disubstituted cyclopentane carboxylic acids for the treatment of respiratoy tract diseases |
| WO2015150363A1 (de) | 2014-04-03 | 2015-10-08 | Bayer Pharma Aktiengesellschaft | 2,5-disubstituierte cyclopentancarbonsäuren und ihre verwendung |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3784701A (en) * | 1970-09-21 | 1974-01-08 | American Cyanamid Co | Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain |
| DE2112716A1 (de) * | 1971-03-17 | 1972-10-05 | Thomae Gmbh Dr K | Neue 4-(4-Biphenylyl)-4-oxobuttersaeuren,ihre Salze und ihre Ester |
| US5789434A (en) * | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
-
1997
- 1997-05-09 ZA ZA9704029A patent/ZA974029B/xx unknown
- 1997-05-09 TN TNTNSN97082A patent/TNSN97082A1/fr unknown
- 1997-05-09 HR HR970243A patent/HRP970243B1/xx not_active IP Right Cessation
- 1997-05-09 CO CO97025183A patent/CO5070565A1/es unknown
- 1997-05-12 ES ES97923621T patent/ES2188943T3/es not_active Expired - Lifetime
- 1997-05-12 AR ARP970101980A patent/AR007100A1/es unknown
- 1997-05-12 PE PE1997000366A patent/PE66298A1/es not_active Application Discontinuation
- 1997-05-12 CN CN97196457A patent/CN1124255C/zh not_active Expired - Fee Related
- 1997-05-12 PT PT97923621T patent/PT907632E/pt unknown
- 1997-05-12 HN HN1997000071A patent/HN1997000071A/es unknown
- 1997-05-12 CA CA002253870A patent/CA2253870C/en not_active Expired - Fee Related
- 1997-05-12 YU YU18497A patent/YU18497A/sr unknown
- 1997-05-12 BR BR9709084A patent/BR9709084A/pt not_active Application Discontinuation
- 1997-05-12 WO PCT/US1997/007919 patent/WO1997043247A1/en active IP Right Grant
- 1997-05-12 PA PA19978429801A patent/PA8429801A1/es unknown
- 1997-05-12 JP JP54097997A patent/JP3305328B2/ja not_active Expired - Fee Related
- 1997-05-12 DK DK97923621T patent/DK0907632T3/da active
- 1997-05-12 EP EP97923621A patent/EP0907632B1/en not_active Expired - Lifetime
- 1997-05-12 SV SV1997000037A patent/SV1997000037A/es not_active Application Discontinuation
- 1997-05-12 TW TW086106288A patent/TW363056B/zh active
- 1997-05-12 AU AU29385/97A patent/AU727899B2/en not_active Ceased
- 1997-05-12 AT AT97923621T patent/ATE229497T1/de not_active IP Right Cessation
- 1997-05-12 DE DE69717811T patent/DE69717811T2/de not_active Expired - Fee Related
- 1997-05-14 ID IDP971605A patent/ID17424A/id unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69717811T2 (de) | 2003-05-28 |
| CA2253870C (en) | 2004-01-06 |
| EP0907632A1 (en) | 1999-04-14 |
| ATE229497T1 (de) | 2002-12-15 |
| AU727899B2 (en) | 2001-01-04 |
| JPH11510517A (ja) | 1999-09-14 |
| CO5070565A1 (es) | 2001-08-28 |
| HN1997000071A (es) | 1997-06-18 |
| HRP970243B1 (en) | 2002-06-30 |
| PT907632E (pt) | 2003-04-30 |
| AU2938597A (en) | 1997-12-05 |
| CN1225624A (zh) | 1999-08-11 |
| BR9709084A (pt) | 1999-08-03 |
| ZA974029B (en) | 1998-02-19 |
| TW363056B (en) | 1999-07-01 |
| CN1124255C (zh) | 2003-10-15 |
| TNSN97082A1 (fr) | 2005-03-15 |
| DE69717811D1 (en) | 2003-01-23 |
| AR007100A1 (es) | 1999-10-13 |
| CA2253870A1 (en) | 1997-11-20 |
| PA8429801A1 (es) | 2000-05-24 |
| WO1997043247A1 (en) | 1997-11-20 |
| ID17424A (id) | 1997-12-24 |
| JP3305328B2 (ja) | 2002-07-22 |
| DK0907632T3 (da) | 2003-04-07 |
| PE66298A1 (es) | 1998-10-23 |
| HRP970243A2 (en) | 1998-04-30 |
| YU18497A (en) | 1999-11-22 |
| ES2188943T3 (es) | 2003-07-01 |
| EP0907632B1 (en) | 2002-12-11 |
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