BR9709084A - Composto de inibição de metaloproteinase de matriz composição tendo atividade de inibição de metaloprotease de matriz e processos para inibir a atividade de metaloprotease de matriz em um mamífero e para tratar mamíferos - Google Patents

Composto de inibição de metaloproteinase de matriz composição tendo atividade de inibição de metaloprotease de matriz e processos para inibir a atividade de metaloprotease de matriz em um mamífero e para tratar mamíferos

Info

Publication number
BR9709084A
BR9709084A BR9709084A BR9709084A BR9709084A BR 9709084 A BR9709084 A BR 9709084A BR 9709084 A BR9709084 A BR 9709084A BR 9709084 A BR9709084 A BR 9709084A BR 9709084 A BR9709084 A BR 9709084A
Authority
BR
Brazil
Prior art keywords
inhibiting
activity
matrix
matrix metalloprotease
mammal
Prior art date
Application number
BR9709084A
Other languages
English (en)
Inventor
Donald J Wolanin
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of BR9709084A publication Critical patent/BR9709084A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
BR9709084A 1996-05-15 1997-05-12 Composto de inibição de metaloproteinase de matriz composição tendo atividade de inibição de metaloprotease de matriz e processos para inibir a atividade de metaloprotease de matriz em um mamífero e para tratar mamíferos BR9709084A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64502696A 1996-05-15 1996-05-15
PCT/US1997/007919 WO1997043247A1 (en) 1996-05-15 1997-05-12 Inhibition of matrix metalloproteases by substituted phenethyl compounds

Publications (1)

Publication Number Publication Date
BR9709084A true BR9709084A (pt) 1999-08-03

Family

ID=24587359

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9709084A BR9709084A (pt) 1996-05-15 1997-05-12 Composto de inibição de metaloproteinase de matriz composição tendo atividade de inibição de metaloprotease de matriz e processos para inibir a atividade de metaloprotease de matriz em um mamífero e para tratar mamíferos

Country Status (24)

Country Link
EP (1) EP0907632B1 (pt)
JP (1) JP3305328B2 (pt)
CN (1) CN1124255C (pt)
AR (1) AR007100A1 (pt)
AT (1) ATE229497T1 (pt)
AU (1) AU727899B2 (pt)
BR (1) BR9709084A (pt)
CA (1) CA2253870C (pt)
CO (1) CO5070565A1 (pt)
DE (1) DE69717811T2 (pt)
DK (1) DK0907632T3 (pt)
ES (1) ES2188943T3 (pt)
HN (1) HN1997000071A (pt)
HR (1) HRP970243B1 (pt)
ID (1) ID17424A (pt)
PA (1) PA8429801A1 (pt)
PE (1) PE66298A1 (pt)
PT (1) PT907632E (pt)
SV (1) SV1997000037A (pt)
TN (1) TNSN97082A1 (pt)
TW (1) TW363056B (pt)
WO (1) WO1997043247A1 (pt)
YU (1) YU18497A (pt)
ZA (1) ZA974029B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6288063B1 (en) * 1998-05-27 2001-09-11 Bayer Corporation Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors
JP2002534404A (ja) 1998-12-30 2002-10-15 バイエル アクチェンゲゼルシャフト 呼吸器疾患の治療のためのマトリックスメタロプロテアーゼ阻害剤としての置換４−ビアリール酪酸および５−ビアリールペンタン酸誘導体の使用
EP1031349A1 (en) * 1999-02-25 2000-08-30 Bayer Aktiengesellschaft Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases
US7141607B1 (en) 2000-03-10 2006-11-28 Insite Vision Incorporated Methods and compositions for treating and inhibiting retinal neovascularization
FR2901320B1 (fr) * 2006-05-17 2008-07-04 Univ Savoie Etablissement Publ Dispositif miniaturise apte a fonctionner comme moteur ou refroidisseur selon un cycle thermodynamique de stirling
US20170022171A1 (en) 2014-04-03 2017-01-26 Bayer Pharma Aktiengesellschaft 2,5-disubstituted cyclopentanecarboxylic acids and their use
CN106458938A (zh) 2014-04-03 2017-02-22 拜耳制药股份公司 手性2,5‑二取代的环戊烷甲酸衍生物及其用途
US20170114049A1 (en) 2014-04-03 2017-04-27 Bayer Pharma Aktiengesellschaft 2,5-disubstituted cyclopentane carboxylic acids for the treatment of respiratory tract diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3784701A (en) * 1970-09-21 1974-01-08 American Cyanamid Co Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain
DE2112716A1 (de) * 1971-03-17 1972-10-05 Thomae Gmbh Dr K Neue 4-(4-Biphenylyl)-4-oxobuttersaeuren,ihre Salze und ihre Ester
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors

Also Published As

Publication number Publication date
PA8429801A1 (es) 2000-05-24
PE66298A1 (es) 1998-10-23
YU18497A (en) 1999-11-22
JPH11510517A (ja) 1999-09-14
JP3305328B2 (ja) 2002-07-22
ATE229497T1 (de) 2002-12-15
TW363056B (en) 1999-07-01
DE69717811T2 (de) 2003-05-28
CA2253870A1 (en) 1997-11-20
WO1997043247A1 (en) 1997-11-20
TNSN97082A1 (fr) 2005-03-15
CN1225624A (zh) 1999-08-11
CN1124255C (zh) 2003-10-15
HN1997000071A (es) 1997-06-18
SV1997000037A (es) 1999-01-14
CO5070565A1 (es) 2001-08-28
ES2188943T3 (es) 2003-07-01
CA2253870C (en) 2004-01-06
EP0907632A1 (en) 1999-04-14
HRP970243A2 (en) 1998-04-30
EP0907632B1 (en) 2002-12-11
ZA974029B (en) 1998-02-19
AR007100A1 (es) 1999-10-13
ID17424A (id) 1997-12-24
PT907632E (pt) 2003-04-30
AU727899B2 (en) 2001-01-04
DK0907632T3 (da) 2003-04-07
DE69717811D1 (en) 2003-01-23
AU2938597A (en) 1997-12-05
HRP970243B1 (en) 2002-06-30

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Legal Events

Date Code Title Description
FB36 Technical and formal requirements: requirement - article 36 of industrial property law
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements