BR9709084A - Composto de inibição de metaloproteinase de matriz composição tendo atividade de inibição de metaloprotease de matriz e processos para inibir a atividade de metaloprotease de matriz em um mamífero e para tratar mamíferos - Google Patents
Composto de inibição de metaloproteinase de matriz composição tendo atividade de inibição de metaloprotease de matriz e processos para inibir a atividade de metaloprotease de matriz em um mamífero e para tratar mamíferosInfo
- Publication number
- BR9709084A BR9709084A BR9709084A BR9709084A BR9709084A BR 9709084 A BR9709084 A BR 9709084A BR 9709084 A BR9709084 A BR 9709084A BR 9709084 A BR9709084 A BR 9709084A BR 9709084 A BR9709084 A BR 9709084A
- Authority
- BR
- Brazil
- Prior art keywords
- inhibiting
- activity
- matrix
- matrix metalloprotease
- mammal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64502696A | 1996-05-15 | 1996-05-15 | |
PCT/US1997/007919 WO1997043247A1 (en) | 1996-05-15 | 1997-05-12 | Inhibition of matrix metalloproteases by substituted phenethyl compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9709084A true BR9709084A (pt) | 1999-08-03 |
Family
ID=24587359
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9709084A BR9709084A (pt) | 1996-05-15 | 1997-05-12 | Composto de inibição de metaloproteinase de matriz composição tendo atividade de inibição de metaloprotease de matriz e processos para inibir a atividade de metaloprotease de matriz em um mamífero e para tratar mamíferos |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP0907632B1 (pt) |
JP (1) | JP3305328B2 (pt) |
CN (1) | CN1124255C (pt) |
AR (1) | AR007100A1 (pt) |
AT (1) | ATE229497T1 (pt) |
AU (1) | AU727899B2 (pt) |
BR (1) | BR9709084A (pt) |
CA (1) | CA2253870C (pt) |
CO (1) | CO5070565A1 (pt) |
DE (1) | DE69717811T2 (pt) |
DK (1) | DK0907632T3 (pt) |
ES (1) | ES2188943T3 (pt) |
HN (1) | HN1997000071A (pt) |
HR (1) | HRP970243B1 (pt) |
ID (1) | ID17424A (pt) |
PA (1) | PA8429801A1 (pt) |
PE (1) | PE66298A1 (pt) |
PT (1) | PT907632E (pt) |
SV (1) | SV1997000037A (pt) |
TN (1) | TNSN97082A1 (pt) |
TW (1) | TW363056B (pt) |
WO (1) | WO1997043247A1 (pt) |
YU (1) | YU18497A (pt) |
ZA (1) | ZA974029B (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6288063B1 (en) * | 1998-05-27 | 2001-09-11 | Bayer Corporation | Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors |
JP2002534404A (ja) | 1998-12-30 | 2002-10-15 | バイエル アクチェンゲゼルシャフト | 呼吸器疾患の治療のためのマトリックスメタロプロテアーゼ阻害剤としての置換4−ビアリール酪酸および5−ビアリールペンタン酸誘導体の使用 |
EP1031349A1 (en) * | 1999-02-25 | 2000-08-30 | Bayer Aktiengesellschaft | Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases |
US7141607B1 (en) | 2000-03-10 | 2006-11-28 | Insite Vision Incorporated | Methods and compositions for treating and inhibiting retinal neovascularization |
FR2901320B1 (fr) * | 2006-05-17 | 2008-07-04 | Univ Savoie Etablissement Publ | Dispositif miniaturise apte a fonctionner comme moteur ou refroidisseur selon un cycle thermodynamique de stirling |
US20170022171A1 (en) | 2014-04-03 | 2017-01-26 | Bayer Pharma Aktiengesellschaft | 2,5-disubstituted cyclopentanecarboxylic acids and their use |
CN106458938A (zh) | 2014-04-03 | 2017-02-22 | 拜耳制药股份公司 | 手性2,5‑二取代的环戊烷甲酸衍生物及其用途 |
US20170114049A1 (en) | 2014-04-03 | 2017-04-27 | Bayer Pharma Aktiengesellschaft | 2,5-disubstituted cyclopentane carboxylic acids for the treatment of respiratory tract diseases |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3784701A (en) * | 1970-09-21 | 1974-01-08 | American Cyanamid Co | Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain |
DE2112716A1 (de) * | 1971-03-17 | 1972-10-05 | Thomae Gmbh Dr K | Neue 4-(4-Biphenylyl)-4-oxobuttersaeuren,ihre Salze und ihre Ester |
US5789434A (en) * | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
-
1997
- 1997-05-09 HR HR970243A patent/HRP970243B1/xx not_active IP Right Cessation
- 1997-05-09 ZA ZA9704029A patent/ZA974029B/xx unknown
- 1997-05-09 TN TNTNSN97082A patent/TNSN97082A1/fr unknown
- 1997-05-09 CO CO97025183A patent/CO5070565A1/es unknown
- 1997-05-12 BR BR9709084A patent/BR9709084A/pt not_active Application Discontinuation
- 1997-05-12 JP JP54097997A patent/JP3305328B2/ja not_active Expired - Fee Related
- 1997-05-12 TW TW086106288A patent/TW363056B/zh active
- 1997-05-12 AU AU29385/97A patent/AU727899B2/en not_active Ceased
- 1997-05-12 EP EP97923621A patent/EP0907632B1/en not_active Expired - Lifetime
- 1997-05-12 AT AT97923621T patent/ATE229497T1/de not_active IP Right Cessation
- 1997-05-12 PA PA19978429801A patent/PA8429801A1/es unknown
- 1997-05-12 CA CA002253870A patent/CA2253870C/en not_active Expired - Fee Related
- 1997-05-12 PE PE1997000366A patent/PE66298A1/es not_active Application Discontinuation
- 1997-05-12 WO PCT/US1997/007919 patent/WO1997043247A1/en active IP Right Grant
- 1997-05-12 SV SV1997000037A patent/SV1997000037A/es not_active Application Discontinuation
- 1997-05-12 DE DE69717811T patent/DE69717811T2/de not_active Expired - Fee Related
- 1997-05-12 YU YU18497A patent/YU18497A/sr unknown
- 1997-05-12 DK DK97923621T patent/DK0907632T3/da active
- 1997-05-12 ES ES97923621T patent/ES2188943T3/es not_active Expired - Lifetime
- 1997-05-12 CN CN97196457A patent/CN1124255C/zh not_active Expired - Fee Related
- 1997-05-12 PT PT97923621T patent/PT907632E/pt unknown
- 1997-05-12 HN HN1997000071A patent/HN1997000071A/es unknown
- 1997-05-12 AR ARP970101980A patent/AR007100A1/es unknown
- 1997-05-14 ID IDP971605A patent/ID17424A/id unknown
Also Published As
Publication number | Publication date |
---|---|
PA8429801A1 (es) | 2000-05-24 |
PE66298A1 (es) | 1998-10-23 |
YU18497A (en) | 1999-11-22 |
JPH11510517A (ja) | 1999-09-14 |
JP3305328B2 (ja) | 2002-07-22 |
ATE229497T1 (de) | 2002-12-15 |
TW363056B (en) | 1999-07-01 |
DE69717811T2 (de) | 2003-05-28 |
CA2253870A1 (en) | 1997-11-20 |
WO1997043247A1 (en) | 1997-11-20 |
TNSN97082A1 (fr) | 2005-03-15 |
CN1225624A (zh) | 1999-08-11 |
CN1124255C (zh) | 2003-10-15 |
HN1997000071A (es) | 1997-06-18 |
SV1997000037A (es) | 1999-01-14 |
CO5070565A1 (es) | 2001-08-28 |
ES2188943T3 (es) | 2003-07-01 |
CA2253870C (en) | 2004-01-06 |
EP0907632A1 (en) | 1999-04-14 |
HRP970243A2 (en) | 1998-04-30 |
EP0907632B1 (en) | 2002-12-11 |
ZA974029B (en) | 1998-02-19 |
AR007100A1 (es) | 1999-10-13 |
ID17424A (id) | 1997-12-24 |
PT907632E (pt) | 2003-04-30 |
AU727899B2 (en) | 2001-01-04 |
DK0907632T3 (da) | 2003-04-07 |
DE69717811D1 (en) | 2003-01-23 |
AU2938597A (en) | 1997-12-05 |
HRP970243B1 (en) | 2002-06-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB36 | Technical and formal requirements: requirement - article 36 of industrial property law | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |