ATE224350T1 - Inhibition der matrix metalloproteasen durch 2- (omega-aroylalkyl)-4-biaryl-4-oxobutansäuren - Google Patents
Inhibition der matrix metalloproteasen durch 2- (omega-aroylalkyl)-4-biaryl-4-oxobutansäurenInfo
- Publication number
- ATE224350T1 ATE224350T1 AT97924788T AT97924788T ATE224350T1 AT E224350 T1 ATE224350 T1 AT E224350T1 AT 97924788 T AT97924788 T AT 97924788T AT 97924788 T AT97924788 T AT 97924788T AT E224350 T1 ATE224350 T1 AT E224350T1
- Authority
- AT
- Austria
- Prior art keywords
- oxobutanic
- aroylalkyl
- biaryl
- omega
- inhibition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64502996A | 1996-05-15 | 1996-05-15 | |
PCT/US1997/008608 WO1997043240A1 (en) | 1996-05-15 | 1997-05-12 | INHIBITION OF MATRIX METALLOPROTEASES BY 2-(φ-AROYLALKYL)-4-BIARYL-OXOBUTYRIC ACIDS |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE224350T1 true ATE224350T1 (de) | 2002-10-15 |
Family
ID=24587374
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97924788T ATE224350T1 (de) | 1996-05-15 | 1997-05-12 | Inhibition der matrix metalloproteasen durch 2- (omega-aroylalkyl)-4-biaryl-4-oxobutansäuren |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0904260B1 (de) |
JP (1) | JP3524556B2 (de) |
CN (1) | CN1119313C (de) |
AR (1) | AR007099A1 (de) |
AT (1) | ATE224350T1 (de) |
AU (1) | AU715877B2 (de) |
BR (1) | BR9709078A (de) |
CA (1) | CA2254750C (de) |
CO (1) | CO5011071A1 (de) |
DE (1) | DE69715619T2 (de) |
ES (1) | ES2184092T3 (de) |
HN (1) | HN1997000070A (de) |
HR (1) | HRP970242A2 (de) |
ID (1) | ID17938A (de) |
PA (1) | PA8429601A1 (de) |
PE (1) | PE66198A1 (de) |
SV (1) | SV1997000038A (de) |
TN (1) | TNSN97081A1 (de) |
TW (1) | TW457231B (de) |
WO (1) | WO1997043240A1 (de) |
YU (1) | YU18397A (de) |
ZA (1) | ZA974028B (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6288063B1 (en) | 1998-05-27 | 2001-09-11 | Bayer Corporation | Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors |
EP1031349A1 (de) * | 1999-02-25 | 2000-08-30 | Bayer Aktiengesellschaft | Verwendung von substituierten 4-Biarylbuttersäuren und 5-Biarylpentansäuren zur Behandlung von zerebralen Krankheiten |
CN106661008A (zh) | 2014-04-03 | 2017-05-10 | 拜耳制药股份公司 | 用于治疗呼吸道疾病的2,5‑二取代的环戊烷甲酸 |
EP3126339A1 (de) | 2014-04-03 | 2017-02-08 | Bayer Pharma Aktiengesellschaft | 2,5-disubstituierte cyclopentancarbonsäuren und ihre verwendung |
CN106458938A (zh) | 2014-04-03 | 2017-02-22 | 拜耳制药股份公司 | 手性2,5‑二取代的环戊烷甲酸衍生物及其用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS243570B1 (en) * | 1984-08-31 | 1986-06-12 | Miroslav Kuchar | Omega-aryloxoalkane acids |
GB9101468D0 (en) * | 1991-01-23 | 1991-03-06 | Ciba Geigy | Coating compositions |
US5789434A (en) * | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
-
1997
- 1997-05-09 TN TNTNSN97081A patent/TNSN97081A1/fr unknown
- 1997-05-09 HR HR08/645,029A patent/HRP970242A2/xx not_active Application Discontinuation
- 1997-05-09 ZA ZA9704028A patent/ZA974028B/xx unknown
- 1997-05-09 CO CO97025187A patent/CO5011071A1/es unknown
- 1997-05-12 DE DE69715619T patent/DE69715619T2/de not_active Expired - Fee Related
- 1997-05-12 SV SV1997000038A patent/SV1997000038A/es not_active Application Discontinuation
- 1997-05-12 HN HN1997000070A patent/HN1997000070A/es unknown
- 1997-05-12 CA CA002254750A patent/CA2254750C/en not_active Expired - Fee Related
- 1997-05-12 AT AT97924788T patent/ATE224350T1/de not_active IP Right Cessation
- 1997-05-12 TW TW086106287A patent/TW457231B/zh not_active IP Right Cessation
- 1997-05-12 WO PCT/US1997/008608 patent/WO1997043240A1/en active IP Right Grant
- 1997-05-12 CN CN97196453A patent/CN1119313C/zh not_active Expired - Fee Related
- 1997-05-12 JP JP54119597A patent/JP3524556B2/ja not_active Expired - Fee Related
- 1997-05-12 YU YU18397A patent/YU18397A/sr unknown
- 1997-05-12 PE PE1997000364A patent/PE66198A1/es not_active Application Discontinuation
- 1997-05-12 AR ARP970101979A patent/AR007099A1/es unknown
- 1997-05-12 ES ES97924788T patent/ES2184092T3/es not_active Expired - Lifetime
- 1997-05-12 EP EP97924788A patent/EP0904260B1/de not_active Expired - Lifetime
- 1997-05-12 AU AU30104/97A patent/AU715877B2/en not_active Ceased
- 1997-05-12 BR BR9709078A patent/BR9709078A/pt not_active IP Right Cessation
- 1997-05-12 PA PA19978429601A patent/PA8429601A1/es unknown
- 1997-05-14 ID IDP971608A patent/ID17938A/id unknown
Also Published As
Publication number | Publication date |
---|---|
AR007099A1 (es) | 1999-10-13 |
HRP970242A2 (en) | 1998-04-30 |
JP3524556B2 (ja) | 2004-05-10 |
CN1234791A (zh) | 1999-11-10 |
CA2254750C (en) | 2003-09-30 |
TW457231B (en) | 2001-10-01 |
AU715877B2 (en) | 2000-02-10 |
HN1997000070A (es) | 1997-09-08 |
ID17938A (id) | 1998-02-12 |
WO1997043240A1 (en) | 1997-11-20 |
DE69715619D1 (de) | 2002-10-24 |
YU18397A (en) | 1999-11-22 |
CO5011071A1 (es) | 2001-02-28 |
CA2254750A1 (en) | 1997-11-20 |
CN1119313C (zh) | 2003-08-27 |
BR9709078A (pt) | 1999-08-03 |
DE69715619T2 (de) | 2003-01-16 |
PA8429601A1 (es) | 2000-05-24 |
TNSN97081A1 (fr) | 2005-03-15 |
SV1997000038A (es) | 1998-09-01 |
JP2001509783A (ja) | 2001-07-24 |
ES2184092T3 (es) | 2003-04-01 |
EP0904260B1 (de) | 2002-09-18 |
AU3010497A (en) | 1997-12-05 |
ZA974028B (en) | 1998-02-19 |
EP0904260A1 (de) | 1999-03-31 |
PE66198A1 (es) | 1998-10-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EE200000573A (et) | Asendatud indoolalkaanhapped | |
BR9509802A (pt) | Inibidores de metaloproteases de matriz | |
DE69621021D1 (de) | Inhibitoren der plättchenaggregation | |
NO932620D0 (no) | Amindiol-proteaseinhibitorer | |
NO990184D0 (no) | Fosfintbaserte inhibitorer for mtriks-metalloproteaser | |
ATE238984T1 (de) | Sulfonylaminocarbonsäuren | |
ID18145A (id) | Asam fosfinik amida sebagai inhibitor metaloprotease matriks | |
BR9612707A (pt) | Composiç o detergente compreendendo uma enzima pectinesterase | |
NO20003256D0 (no) | ACE inhibitor-MMP inhibitor kombinasjoner | |
ATE275123T1 (de) | Hemmung von matrixmetalloproteasen durch 2- substituierte-4-(4-substituiertphenyl)-4- oxobutansäuren | |
EE04281B1 (et) | 8-metoksükinoloonkarboksüülhapete valmistamismeetod | |
EE9900180A (et) | Asendatud 4-bifenüül-4-hüdroksübutaanhappe derivaadid metalloproteaasimaatriksi inhibiitoritena | |
DE69715619D1 (de) | Inhibition der matrix metalloproteasen durch 2-(omega-aroylalkyl)-4-biaryl-4-oxobutansäuren | |
DE69806543D1 (de) | Verringerung der Metallkorrosivität von organischen Säuren | |
ID17424A (id) | Penghambat matriks metaloproteasa oleh senyawa-senyawa fenetil tersubstitusi | |
FI971901A (fi) | Konstruktioelementti rakenteita varten | |
MX9100121A (es) | Inhibidores de proteasas asparticas | |
HRP970246B1 (en) | Substituted oxobutric acids as matrix metalloprotease inhibitors | |
DE69401967D1 (de) | Abspaltbare Hydroxycarbonsäuren | |
DE69705405D1 (de) | Neue formen der organischen salze des n'n-diacetylcystins | |
IT1269226B (it) | Procedimento di colata | |
ID19267A (id) | Senyawa baru yang bermanfaat sebagai inhibitor matriks metaloprotease | |
FI960371A (fi) | Tiatsolijohdannaisia lipoksigenaasi-inhibiittoreina | |
NO931841D0 (no) | Forbedrede matriksmetallproteasehemmere | |
NO931844D0 (no) | Forbedrede matriks metallproteasehemmere |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |