CO5011071A1 - Inhibicion de las metaloproteinasas de matriz por acidos 2-(w/aroilalquil)-4-biaril-4-oxobutiricos y composiciones farmaceuticas que los contienen - Google Patents

Inhibicion de las metaloproteinasas de matriz por acidos 2-(w/aroilalquil)-4-biaril-4-oxobutiricos y composiciones farmaceuticas que los contienen

Info

Publication number
CO5011071A1
CO5011071A1 CO97025187A CO97025187A CO5011071A1 CO 5011071 A1 CO5011071 A1 CO 5011071A1 CO 97025187 A CO97025187 A CO 97025187A CO 97025187 A CO97025187 A CO 97025187A CO 5011071 A1 CO5011071 A1 CO 5011071A1
Authority
CO
Colombia
Prior art keywords
carbons
alkyl
heteroatom
heteroaryl
aryl
Prior art date
Application number
CO97025187A
Other languages
English (en)
Inventor
William Scott
Margaret A Popp
David S Hartsough
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of CO5011071A1 publication Critical patent/CO5011071A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un compuesto inhibidor de la metaloproteasa de matriz que tienela fórmula generalizada: en la cual v es 1-4, y es 0-2, y cuando y=0 resulta un alquilo de cadena lineal; x es 0-2, w es 0-3, Z es un grupo carbonilo; T se selecciona independientemente desde el grupo que consiste de -F, -Cl, -Br, -I, alquilo de 1-10 carbonos, haloalquilo de 1-10 carbonos, alquenilo de 2-10 carbonos, alquinilo de 2-10 carbonos, -(CH2 )p Q, donde p es 0-4, y alquenilo-Q en donde la fracción de alquenilo comprende 2-4 carbonos y Q se selecciona desde el grupo que consiste de arilo de 6 a 10 carbonos, heteroarilo que comprende 4 a 9 carbonos y por lo menos un heteroátomo de N, O, ó S, -CN; -CHO; -NO2 ; CO2 R2 ; -OCOR2 ; SOR3 ; SO2 R3 ; CON(R2 )2 ; SON(R2 )2 ; -COR2 ; -N(R2 )2 ; N(R2 )COR2 ; -N(R2 )CO2 R3 ; N(R2 )CON(R2 )2 ; -CHN4 ; -OR4 ; y SR4 ; y donde cada R20 es independientemente seleccionado del grupo que consiste de H, alquilo de 1 a 5 carbonos, alcoxi de 1-5 carbonos, ariloxi, halógeno, COOR2 , -CON(R2 )2 , SOR3 , SO2 R3 o COR2 ; R2 representa H, alquilo de 1 a 6 carbonos; arilo de 6-10 carbonos; heteroarilo comprende 4-9 carbonos y por lo menos un heteroátomo de N, O ó S; arilalquilo en donde la porción arilo contiene 6-10 carbonos y la porción alquilo contiene 1-4 carbonos; ó heteroarilalquilo en el cual la porción heteroarilo comprende de 4 a 9 carbonos y por lo menos un heteroátomo de N, O ó S, y la porción alquilo contiene de 1 a 4 carbonos, R3 representa alquilo de 1 a 4 carbonos, arilo de 6 a 10 carbonos, heteroarilo que comprende 4 a 9 carbonos y por lo menos un heteroátomo de N, O ó S, arilalquilo en el cual la porción arilo contiene de 6 a 10 carbonos y la porción alquilo contiene de 1 a 4 carbonos, o heteroarilalquilo en el cual la porción heteroarilo comprende de 4 a 9 carbonos y por lo menos un heteroátomo de N, O ó S, y la porción alquilo contiene de 1 a 4 carbonos, y ...
CO97025187A 1996-05-15 1997-05-09 Inhibicion de las metaloproteinasas de matriz por acidos 2-(w/aroilalquil)-4-biaril-4-oxobutiricos y composiciones farmaceuticas que los contienen CO5011071A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64502996A 1996-05-15 1996-05-15

Publications (1)

Publication Number Publication Date
CO5011071A1 true CO5011071A1 (es) 2001-02-28

Family

ID=24587374

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97025187A CO5011071A1 (es) 1996-05-15 1997-05-09 Inhibicion de las metaloproteinasas de matriz por acidos 2-(w/aroilalquil)-4-biaril-4-oxobutiricos y composiciones farmaceuticas que los contienen

Country Status (22)

Country Link
EP (1) EP0904260B1 (es)
JP (1) JP3524556B2 (es)
CN (1) CN1119313C (es)
AR (1) AR007099A1 (es)
AT (1) ATE224350T1 (es)
AU (1) AU715877B2 (es)
BR (1) BR9709078A (es)
CA (1) CA2254750C (es)
CO (1) CO5011071A1 (es)
DE (1) DE69715619T2 (es)
ES (1) ES2184092T3 (es)
HN (1) HN1997000070A (es)
HR (1) HRP970242A2 (es)
ID (1) ID17938A (es)
PA (1) PA8429601A1 (es)
PE (1) PE66198A1 (es)
SV (1) SV1997000038A (es)
TN (1) TNSN97081A1 (es)
TW (1) TW457231B (es)
WO (1) WO1997043240A1 (es)
YU (1) YU18397A (es)
ZA (1) ZA974028B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6288063B1 (en) 1998-05-27 2001-09-11 Bayer Corporation Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors
EP1031349A1 (en) * 1999-02-25 2000-08-30 Bayer Aktiengesellschaft Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases
EP3126339A1 (de) 2014-04-03 2017-02-08 Bayer Pharma Aktiengesellschaft 2,5-disubstituierte cyclopentancarbonsäuren und ihre verwendung
EP3126358A1 (de) 2014-04-03 2017-02-08 Bayer Pharma Aktiengesellschaft 2,5-disubstituierte cyclopentancarbonsäuren zur behandlung von atemwegserkrankungen
CA2944617A1 (en) 2014-04-03 2015-10-08 Bayer Pharma Aktiengesellschaft Chiral 2,5-disubstituted cyclopentanecarboxylic acid derivatives and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS243570B1 (en) * 1984-08-31 1986-06-12 Miroslav Kuchar Omega-aryloxoalkane acids
GB9101468D0 (en) * 1991-01-23 1991-03-06 Ciba Geigy Coating compositions
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors

Also Published As

Publication number Publication date
BR9709078A (pt) 1999-08-03
AU3010497A (en) 1997-12-05
PA8429601A1 (es) 2000-05-24
TNSN97081A1 (fr) 2005-03-15
TW457231B (en) 2001-10-01
HN1997000070A (es) 1997-09-08
CN1119313C (zh) 2003-08-27
PE66198A1 (es) 1998-10-23
DE69715619T2 (de) 2003-01-16
HRP970242A2 (en) 1998-04-30
DE69715619D1 (de) 2002-10-24
ID17938A (id) 1998-02-12
EP0904260A1 (en) 1999-03-31
ZA974028B (en) 1998-02-19
YU18397A (en) 1999-11-22
JP3524556B2 (ja) 2004-05-10
ES2184092T3 (es) 2003-04-01
AR007099A1 (es) 1999-10-13
WO1997043240A1 (en) 1997-11-20
CA2254750C (en) 2003-09-30
AU715877B2 (en) 2000-02-10
SV1997000038A (es) 1998-09-01
CA2254750A1 (en) 1997-11-20
JP2001509783A (ja) 2001-07-24
EP0904260B1 (en) 2002-09-18
CN1234791A (zh) 1999-11-10
ATE224350T1 (de) 2002-10-15

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