ATE282020T1 - Verfahren zur herstellung von 2-aminomalonsäure- derivaten - Google Patents

Verfahren zur herstellung von 2-aminomalonsäure- derivaten

Info

Publication number
ATE282020T1
ATE282020T1 AT98929817T AT98929817T ATE282020T1 AT E282020 T1 ATE282020 T1 AT E282020T1 AT 98929817 T AT98929817 T AT 98929817T AT 98929817 T AT98929817 T AT 98929817T AT E282020 T1 ATE282020 T1 AT E282020T1
Authority
AT
Austria
Prior art keywords
linear
carbon atoms
branched chain
acid derivatives
producing
Prior art date
Application number
AT98929817T
Other languages
English (en)
Inventor
Susumu Hirase
Shigeo Sasaki
Masahiko Yoneta
Ryoji Hirose
Tetsuro Fujita
Original Assignee
Taito Co
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taito Co, Mitsubishi Pharma Corp filed Critical Taito Co
Application granted granted Critical
Publication of ATE282020T1 publication Critical patent/ATE282020T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
AT98929817T 1997-07-03 1998-07-03 Verfahren zur herstellung von 2-aminomalonsäure- derivaten ATE282020T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/JP1997/002299 WO1999001420A1 (en) 1997-07-03 1997-07-03 Process for the preparation of 2-aminomalonic acid derivatives and intermediates used in the process
PCT/JP1998/002998 WO1999001419A1 (en) 1997-07-03 1998-07-03 Processes for producing 2-aminomalonic acid derivatives and 2-amino-1,3-propanediol derivatives, and intermediates for producing the derivatives

Publications (1)

Publication Number Publication Date
ATE282020T1 true ATE282020T1 (de) 2004-11-15

Family

ID=14180796

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98929817T ATE282020T1 (de) 1997-07-03 1998-07-03 Verfahren zur herstellung von 2-aminomalonsäure- derivaten

Country Status (7)

Country Link
US (1) US6284915B2 (de)
EP (1) EP0989113B1 (de)
KR (2) KR100695964B1 (de)
AT (1) ATE282020T1 (de)
CA (2) CA2597702C (de)
ES (1) ES2227848T3 (de)
WO (2) WO1999001420A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2250417A1 (en) 1996-04-02 1997-10-09 Bayer Aktiengesellschaft Substituted phenyl keto enols as pesticides and herbicides
CN100339352C (zh) 1996-08-05 2007-09-26 拜尔公司 2－和2,5－取代的苯基酮烯醇
ATE288414T1 (de) 1998-11-11 2005-02-15 Novartis Pharma Gmbh Herstellung von 2-amino-2(2-(4- alkylphenyl)äthyl)propan-1,3-diolen
AU8533101A (en) 2000-08-31 2002-03-13 Merck & Co Inc Phosphate derivatives as immunoregulatory agents
RU2330839C2 (ru) * 2002-01-11 2008-08-10 Санкио Компани, Лимитед Производные аминоспиртов или производные фосфорных кислот и фармацевтические композиции, содержащие указанные производные
TWI355934B (en) 2004-02-24 2012-01-11 Sankyo Co Pharmaceutical composition for treatment or prophy
JP2006232757A (ja) * 2005-02-25 2006-09-07 Ohara Yakuhin Kogyo Kk フェノキシエチルハライド及びその誘導体の製造法
CN103228617A (zh) 2010-10-01 2013-07-31 斯索恩有限公司 制备盐酸芬戈莫德晶体的方法
US9249265B1 (en) 2014-09-08 2016-02-02 Sirrus, Inc. Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
US9279022B1 (en) 2014-09-08 2016-03-08 Sirrus, Inc. Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
JP2014503474A (ja) 2010-10-20 2014-02-13 バイオフオーミツクス・インコーポレイテツド エネルギー移動手段の存在下での急速回収を用いたメチレンマロナートの合成
US9828324B2 (en) 2010-10-20 2017-11-28 Sirrus, Inc. Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
US10414839B2 (en) 2010-10-20 2019-09-17 Sirrus, Inc. Polymers including a methylene beta-ketoester and products formed therefrom
BR112013010075A2 (pt) 2010-10-28 2017-10-24 Mapi Pharma Ltd compostos intermediários e processo para a preparação de fingolimod
ES2746016T3 (es) 2010-12-28 2020-03-04 Synthon Bv Procedimiento para la preparación de cristales de clorhidrato de fingolimod
US9216943B2 (en) 2011-04-29 2015-12-22 Dr. Reddy's Laboratories Ltd. Preparation of fingolimod and its salts
EP2768917B1 (de) 2011-10-19 2018-12-05 Sirrus, Inc. Multifunktionsmonomere und verfahren zur deren herstellung
ES2640374T3 (es) * 2012-01-25 2017-11-02 Glenmark Generics Limited Proceso para la preparación de fingolimod
CA2869108A1 (en) 2012-03-30 2013-10-03 Bioformix Inc. Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby
JP6345644B2 (ja) 2012-03-30 2018-06-20 シラス・インコーポレイテッド インク配合物およびコーティング配合物ならびにこれらを作製するための重合性の系
US10913875B2 (en) 2012-03-30 2021-02-09 Sirrus, Inc. Composite and laminate articles and polymerizable systems for producing the same
WO2013181600A2 (en) 2012-06-01 2013-12-05 Bioformix Inc. Optical material and articles formed therefrom
CN105008438B (zh) 2012-11-16 2019-10-22 拜奥福米克斯公司 塑料粘结体系及方法
WO2014085570A1 (en) 2012-11-30 2014-06-05 Bioformix, Inc. Composite compositions for electronics applications
WO2014110388A1 (en) 2013-01-11 2014-07-17 Bioformix Inc. Method to obtain methylene malonate via bis(hydroxymethyl) malonate pathway
US9416091B1 (en) 2015-02-04 2016-08-16 Sirrus, Inc. Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9315597B2 (en) 2014-09-08 2016-04-19 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US10501400B2 (en) 2015-02-04 2019-12-10 Sirrus, Inc. Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en) 2015-05-29 2016-05-10 Sirrus, Inc. Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en) 2015-06-01 2015-12-22 Sirrus, Inc. Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
US9518001B1 (en) 2016-05-13 2016-12-13 Sirrus, Inc. High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
US9617377B1 (en) 2016-06-03 2017-04-11 Sirrus, Inc. Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10196481B2 (en) 2016-06-03 2019-02-05 Sirrus, Inc. Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof
US10428177B2 (en) 2016-06-03 2019-10-01 Sirrus, Inc. Water absorbing or water soluble polymers, intermediate compounds, and methods thereof
US9567475B1 (en) 2016-06-03 2017-02-14 Sirrus, Inc. Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3919309A (en) * 1972-08-18 1975-11-11 Sandoz Ag Acyl substituted phenyl alkanoic acids
US3835161A (en) * 1972-10-24 1974-09-10 Realisations Scient S E Res C 3-substituted-4-hydroxy-coumarins
US4051261A (en) * 1974-09-12 1977-09-27 Sandoz, Inc. 1-(p-alkanoylphenyl) alkanols and derivatives
US4035427A (en) * 1975-08-25 1977-07-12 Sandoz, Inc. α-T-butyl-p-xylene-α-α'-diols and hypolipidemic compositions containing same
US4200466A (en) * 1975-09-30 1980-04-29 Konishiroku Photo Industry Co., Ltd. Light-sensitive silver halide photographic materials
JPS52108943A (en) * 1976-03-10 1977-09-12 Teikoku Hormone Mfg Co Ltd Alkyl phenyl ketone derivative
DE3235589A1 (de) * 1982-09-25 1984-03-29 Hoechst Ag, 6230 Frankfurt Benzylether von phenol-mannich-basen, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen, zwischenprodukte und verfahren zu deren herstellung
JPS59190982A (ja) * 1983-04-15 1984-10-29 Hokuriku Seiyaku Co Ltd ４’−フルオロメチル−３−アミノ−２−メチル置換プロピオフエノン誘導体
JPS60116647A (ja) * 1983-11-30 1985-06-24 Nissan Chem Ind Ltd ２−〔４−（置換メチル）フェニル〕脂肪酸エステルの製造法
US4510085A (en) * 1984-04-12 1985-04-09 G.D. Searle & Co. Antihypertensive tetrapeptide amides
JPS61137835A (ja) * 1984-12-07 1986-06-25 Mitsui Petrochem Ind Ltd 芳香族ケトンの製造方法
JPS63159374A (ja) * 1986-12-24 1988-07-02 Nissan Chem Ind Ltd ピリダジノン誘導体および殺虫、殺ダニ、殺線虫剤
IL84944A (en) * 1987-01-19 1992-02-16 Ici Plc Pharmaceutical compositions containing 1,2-dihydro-3h-indazolone derivatives,some new such compounds and their preparation
MX174210B (es) * 1987-02-17 1994-04-28 Pfizer Procedimiento para la preparacion de compuestos arilpiperazinil-alquilenfenil-p-heterociclicos
US5130058A (en) * 1988-07-01 1992-07-14 Tokuyama Soda Kabushiki Kaisha Photochromic compound, process for production thereof, use thereof and composition containing said photochromic compound
JPH0219343A (ja) * 1988-07-07 1990-01-23 Nippon Mining Co Ltd 新規なエステル化合物、これを含む液晶組成物及び光スイッチング素子
JPH054944A (ja) * 1990-09-25 1993-01-14 Nippon Telegr & Teleph Corp <Ntt> 光学活性化合物及びそれを含む液晶組成物
FI940526A0 (fi) * 1991-08-14 1994-02-04 Henkel Corp Kuparin talteenottomenetelmä
EP0627406B1 (de) * 1992-10-21 1998-10-28 Yoshitomi Pharmaceutical Industries, Ltd. 2-amino-1, 3- propandiolverbindung und immunosuppressium
JP3870419B2 (ja) * 1994-08-22 2007-01-17 三菱ウェルファーマ株式会社 ベンゼン化合物およびその医薬としての用途
US5948820A (en) * 1994-08-22 1999-09-07 Yoshitomi Pharmaceutical Industries, Ltd. Benzene compound and pharmaceutical use thereof

Also Published As

Publication number Publication date
KR100555970B1 (ko) 2006-03-06
WO1999001419A1 (en) 1999-01-14
KR20000068437A (ko) 2000-11-25
EP0989113A4 (de) 2001-01-31
ES2227848T3 (es) 2005-04-01
CA2264824A1 (en) 1999-01-14
US6284915B2 (en) 2001-09-04
KR20050109633A (ko) 2005-11-21
CA2597702A1 (en) 1999-01-14
EP0989113A1 (de) 2000-03-29
CA2264824C (en) 2009-06-23
CA2597702C (en) 2010-11-30
KR100695964B1 (ko) 2007-03-16
EP0989113B1 (de) 2004-11-10
JP3632979B2 (ja) 2005-03-30
US20010008945A1 (en) 2001-07-19
WO1999001420A1 (en) 1999-01-14

Similar Documents

Publication Publication Date Title
EP0989113A4 (de) Verfahren zur herstellung von 2-aminomalonsäure-derivaten und 2-amino-1,3-propandiolderivaten und zwischenprodukte zur herstellung dieser verbindungen
DE69415319D1 (de) Verfahren zur herstellung von piperidinderivaten
DE69711391D1 (de) Verbessertes verfahren zum herstellen von geschützten 3,4-dihydroxybuttersäure estern
ATE204870T1 (de) Verfahren zur herstellung von paroxetine
DE69814635D1 (de) Verfahren zur herstellung von 2-hydroxybenzamidderivaten
ATE207055T1 (de) Verfahren zur herstellung von 4-aryl-3- hydroxymethyl-piperidinen
ATE261944T1 (de) Verfahren zur herstellung von carbamoylsubstituierten imidazolderivaten
ATE107295T1 (de) Verfahren zur herstellung von 1,5-benzothiazepin- derivaten.
ATE193281T1 (de) Verfahren zur herstellung von 2-(2- hydroxymethylphenyl)acetamid-derivaten und zwischenprodukte zur herstellung
ATE191461T1 (de) Verfahren zur herstellung von alkoxyimino acetamid-derivaten
ATE138376T1 (de) Verfahren zur herstellung von benzylphthalazinonderivaten und von deren salzen
DE69809888D1 (de) Verfahren zur Herstellung von alpha-Aminoketonen
ATE189453T1 (de) Verfahren zur herstellung von 2-cyanobiphenyl- verbindungen
ATE251135T1 (de) Verfahren zur herstellung von 1-substituierten pyrrol-3-carbonsäure-derivaten
DE69515770D1 (de) Verfahren zur Produktion von Thiophospholipiden des Aether-Typs
DE69410073D1 (de) Verfahren zur Herstellung von 2-Perfluoroalkyl-3-oxazolin-5-one
DE69619402D1 (de) Verfahren zur herstellung von methoximinophenylglyoxylsäure-derivaten
ATE201017T1 (de) Verfahren zur herstellung 6-substituierter 2(1h)- chinoxalinone
ATE155132T1 (de) Verfahren zur herstellung von amino- thiadiazolylacetylhaliden
ATE299498T1 (de) Verfahren zur herstellung von imidazolderivaten
ATE223377T1 (de) Verfahren zur herstellung von difluoracetophenon- derivaten
ATE215931T1 (de) Verfahren zur herstellung von 2- oxopyrrolidinylacetamid-derivaten
ATE206109T1 (de) Verfahren zur herstellung von carbamoylmethylharnstoff-derivaten
ATE244228T1 (de) Verfahren zur herstellung von chloroacetylaminothiazoleaceticsäure derivate
ATE167474T1 (de) Verfahren zur herstellung von n-alkylpyrazolen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0989113

Country of ref document: EP

EEIH Change in the person of patent owner