ATE138376T1 - Verfahren zur herstellung von benzylphthalazinonderivaten und von deren salzen - Google Patents
Verfahren zur herstellung von benzylphthalazinonderivaten und von deren salzenInfo
- Publication number
- ATE138376T1 ATE138376T1 AT91120268T AT91120268T ATE138376T1 AT E138376 T1 ATE138376 T1 AT E138376T1 AT 91120268 T AT91120268 T AT 91120268T AT 91120268 T AT91120268 T AT 91120268T AT E138376 T1 ATE138376 T1 AT E138376T1
- Authority
- AT
- Austria
- Prior art keywords
- salts
- producing
- chem
- general formula
- benzylphthalazinone
- Prior art date
Links
- JUCCMEHWBGPJKS-UHFFFAOYSA-N 4-benzyl-2h-phthalazin-1-one Chemical class C12=CC=CC=C2C(=O)NN=C1CC1=CC=CC=C1 JUCCMEHWBGPJKS-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 229940125715 antihistaminic agent Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2322399A JPH04198180A (ja) | 1990-11-28 | 1990-11-28 | ベンジルフタラゾン誘導体の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE138376T1 true ATE138376T1 (de) | 1996-06-15 |
Family
ID=18143233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91120268T ATE138376T1 (de) | 1990-11-28 | 1991-11-27 | Verfahren zur herstellung von benzylphthalazinonderivaten und von deren salzen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5216151A (de) |
| EP (1) | EP0488209B1 (de) |
| JP (1) | JPH04198180A (de) |
| AT (1) | ATE138376T1 (de) |
| CA (1) | CA2056334C (de) |
| DE (1) | DE69119714T2 (de) |
| ES (1) | ES2089097T3 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4207234A1 (de) * | 1992-03-07 | 1993-09-09 | Asta Medica Ag | Neue aminocarbonsaeure-derivate mit antiallergischer/antiasthmatischer wirkung und verfahren zu deren herstellung |
| US20070275921A1 (en) * | 1996-06-06 | 2007-11-29 | Isis Pharmaceuticals, Inc. | Oligomeric Compounds That Facilitate Risc Loading |
| US20070020298A1 (en) * | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid |
| US20070020299A1 (en) | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
| US12370352B2 (en) | 2007-06-28 | 2025-07-29 | Cydex Pharmaceuticals, Inc. | Nasal and ophthalmic delivery of aqueous corticosteroid solutions |
| ES2493641T3 (es) * | 2007-06-28 | 2014-09-12 | Cydex Pharmaceuticals, Inc. | Administración nasal de soluciones acuosas de corticosteroides |
| CN101987844B (zh) * | 2009-08-04 | 2013-04-03 | 铜陵凯顺生物科技有限公司 | 一种4-(4-氯苄基)-2-(六氢-1-甲基-1h-氮卓-4-基)-1-(2h)-酞嗪盐酸盐的合成方法 |
| CN118271291B (zh) * | 2024-04-01 | 2024-12-27 | 广东先强药业有限公司 | 一种高纯度盐酸氮卓斯汀的制备方法及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3813384A (en) * | 1972-01-17 | 1974-05-28 | Asta Werke Ag Chem Fab | Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof |
| ATE49205T1 (de) * | 1984-09-14 | 1990-01-15 | Asta Pharma Ag | Substituierte benzylphthalazinon-derivate. |
| US4939140A (en) * | 1985-11-07 | 1990-07-03 | Pfizer Inc. | Heterocyclic oxophthalazinyl acetic acids |
| ATE60598T1 (de) * | 1985-11-11 | 1991-02-15 | Asta Pharma Ag | 4-benzyl-1-(2h)-phthalazinon-derivate. |
| EP0289939A1 (de) * | 1987-05-08 | 1988-11-09 | ASTA Pharma AG | Neue 4-Benzyl-1-(2H)-phthalazinon-Derivate mit einem Aminosäurerest |
| DE3850044D1 (de) * | 1987-11-13 | 1994-07-14 | Asta Medica Ag | Azelastin-Embonat, Verfahren zu seiner Herstellung und pharmazeutische Zubereitungen, die als Wirkstoff Azelastin-Embonat enthalten. |
| EP0396069B1 (de) * | 1989-05-05 | 1994-06-22 | ASTA Medica Aktiengesellschaft | Salze des Azelastins mit verbesserter Löslichkeit |
-
1990
- 1990-11-28 JP JP2322399A patent/JPH04198180A/ja active Pending
-
1991
- 1991-11-27 AT AT91120268T patent/ATE138376T1/de active
- 1991-11-27 DE DE69119714T patent/DE69119714T2/de not_active Expired - Fee Related
- 1991-11-27 EP EP91120268A patent/EP0488209B1/de not_active Expired - Lifetime
- 1991-11-27 CA CA002056334A patent/CA2056334C/en not_active Expired - Fee Related
- 1991-11-27 ES ES91120268T patent/ES2089097T3/es not_active Expired - Lifetime
- 1991-11-29 US US07/800,259 patent/US5216151A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2089097T3 (es) | 1996-10-01 |
| US5216151A (en) | 1993-06-01 |
| DE69119714D1 (de) | 1996-06-27 |
| EP0488209B1 (de) | 1996-05-22 |
| DE69119714T2 (de) | 1996-10-31 |
| CA2056334A1 (en) | 1992-05-29 |
| JPH04198180A (ja) | 1992-07-17 |
| EP0488209A1 (de) | 1992-06-03 |
| CA2056334C (en) | 1999-06-01 |
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