ATE402940T1 - Verfahren zur herstellung von 3-cephem- verbindungen - Google Patents
Verfahren zur herstellung von 3-cephem- verbindungenInfo
- Publication number
- ATE402940T1 ATE402940T1 AT98947899T AT98947899T ATE402940T1 AT E402940 T1 ATE402940 T1 AT E402940T1 AT 98947899 T AT98947899 T AT 98947899T AT 98947899 T AT98947899 T AT 98947899T AT E402940 T1 ATE402940 T1 AT E402940T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- producing
- cephem compounds
- chem
- electron
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- FZEVMBJWXHDLDB-ZCFIWIBFSA-N (6r)-5-thia-1-azabicyclo[4.2.0]oct-2-en-8-one Chemical class S1CC=CN2C(=O)C[C@H]21 FZEVMBJWXHDLDB-ZCFIWIBFSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000006244 carboxylic acid protecting group Chemical group 0.000 abstract 1
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 150000002989 phenols Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9303765A JPH11124384A (ja) | 1997-10-17 | 1997-10-17 | ３−セフェム化合物の製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE402940T1 true ATE402940T1 (de) | 2008-08-15 |
Family
ID=17925019
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04028497T ATE554094T1 (de) | 1997-10-17 | 1998-10-16 | Verfahren zur herstellung von 3-cephem- verbindungen |
| AT98947899T ATE402940T1 (de) | 1997-10-17 | 1998-10-16 | Verfahren zur herstellung von 3-cephem- verbindungen |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04028497T ATE554094T1 (de) | 1997-10-17 | 1998-10-16 | Verfahren zur herstellung von 3-cephem- verbindungen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6448393B1 (de) |
| EP (2) | EP1028118B1 (de) |
| JP (1) | JPH11124384A (de) |
| KR (1) | KR100420739B1 (de) |
| CN (1) | CN1155603C (de) |
| AT (2) | ATE554094T1 (de) |
| AU (1) | AU9462298A (de) |
| ES (2) | ES2382546T3 (de) |
| WO (1) | WO1999020631A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4383557B2 (ja) * | 1998-07-01 | 2009-12-16 | 大塚化学株式会社 | ３−セフェム化合物の製造方法 |
| WO2007013043A2 (en) * | 2005-07-29 | 2007-02-01 | Ranbaxy Laboratories Limited | Processes for the preparation of 7-amino-3-vinyl cephalosporanic acid |
| CN101792453B (zh) * | 2010-03-17 | 2012-04-18 | 河北九派制药有限公司 | 一种7-氨基-3-磺酸基四氮唑硫甲基头孢烷酸的制备方法 |
| CN102633813A (zh) * | 2012-04-17 | 2012-08-15 | 黑龙江豪运精细化工有限公司 | 一种头孢唑林钠中间体tda的制备方法 |
| CN104910188B (zh) * | 2015-05-26 | 2017-07-04 | 齐鲁安替制药有限公司 | 一种头孢唑林酸的合成方法 |
| CN105131018B (zh) * | 2015-09-23 | 2017-12-26 | 浙江华方药业股份有限公司 | 一种头孢替唑酸的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6011917B2 (ja) * | 1981-04-09 | 1985-03-28 | 山之内製薬株式会社 | 新規なセファロスポリン化合物 |
| JP2501785B2 (ja) * | 1984-07-09 | 1996-05-29 | 明治製菓株式会社 | 新規セフアロスポリン系化合物 |
| AU5258786A (en) * | 1985-01-31 | 1986-08-07 | Yamanouchi Pharmaceutical Co., Ltd. | 3-pyridinio thio methyl cephalosporins |
| JPH064638B2 (ja) * | 1985-05-17 | 1994-01-19 | 大塚化学株式会社 | β−ラクタム誘導体の製造方法 |
| US5070194A (en) * | 1985-05-17 | 1991-12-03 | Otsuka Kagaku Kabushiki Kaisha | Method for production of β-lactam derivatives |
| JPH064645B2 (ja) * | 1985-11-27 | 1994-01-19 | 明治製菓株式会社 | 新規セフアロスポリン誘導体およびそれを含む抗菌剤 |
| GB8616002D0 (en) * | 1986-07-01 | 1986-08-06 | Fujisawa Pharmaceutical Co | Cephem compounds |
| CA1283404C (en) * | 1986-07-01 | 1991-04-23 | Shigeru Sanai | Cephalosporin compounds, processes for their preparation and antibacterial agents |
| JPH0651706B2 (ja) * | 1986-08-18 | 1994-07-06 | 科研製薬株式会社 | 新規なセファロスポリン化合物 |
| GB9006728D0 (en) * | 1990-03-26 | 1990-05-23 | Beecham Group Plc | Novel compounds |
| ATE216701T1 (de) * | 1989-09-04 | 2002-05-15 | Pfizer | Antibakterielle cephalosporin-derivate |
| GB9104238D0 (en) * | 1990-03-16 | 1991-04-17 | Ici Pharma | 3-tetrazolylthiomethyl cephalosporin antibiotics |
-
1997
- 1997-10-17 JP JP9303765A patent/JPH11124384A/ja active Pending
-
1998
- 1998-10-16 ES ES04028497T patent/ES2382546T3/es not_active Expired - Lifetime
- 1998-10-16 AT AT04028497T patent/ATE554094T1/de active
- 1998-10-16 EP EP98947899A patent/EP1028118B1/de not_active Expired - Lifetime
- 1998-10-16 US US09/529,530 patent/US6448393B1/en not_active Expired - Lifetime
- 1998-10-16 AT AT98947899T patent/ATE402940T1/de active
- 1998-10-16 AU AU94622/98A patent/AU9462298A/en not_active Abandoned
- 1998-10-16 ES ES98947899T patent/ES2310011T3/es not_active Expired - Lifetime
- 1998-10-16 EP EP04028497A patent/EP1512689B1/de not_active Expired - Lifetime
- 1998-10-16 WO PCT/JP1998/004676 patent/WO1999020631A1/ja not_active Ceased
- 1998-10-16 KR KR10-2000-7004008A patent/KR100420739B1/ko not_active Expired - Fee Related
- 1998-10-16 CN CNB98809245XA patent/CN1155603C/zh not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1028118B1 (de) | 2008-07-30 |
| ES2382546T3 (es) | 2012-06-11 |
| US6448393B1 (en) | 2002-09-10 |
| AU9462298A (en) | 1999-05-10 |
| WO1999020631A1 (en) | 1999-04-29 |
| ATE554094T1 (de) | 2012-05-15 |
| EP1512689B1 (de) | 2012-04-18 |
| JPH11124384A (ja) | 1999-05-11 |
| CN1270594A (zh) | 2000-10-18 |
| EP1028118A4 (de) | 2003-01-22 |
| CN1155603C (zh) | 2004-06-30 |
| EP1028118A1 (de) | 2000-08-16 |
| ES2310011T3 (es) | 2008-12-16 |
| EP1512689A1 (de) | 2005-03-09 |
| KR100420739B1 (ko) | 2004-03-02 |
| KR20010031117A (ko) | 2001-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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