ATE204870T1 - Verfahren zur herstellung von paroxetine - Google Patents
Verfahren zur herstellung von paroxetineInfo
- Publication number
- ATE204870T1 ATE204870T1 AT97108806T AT97108806T ATE204870T1 AT E204870 T1 ATE204870 T1 AT E204870T1 AT 97108806 T AT97108806 T AT 97108806T AT 97108806 T AT97108806 T AT 97108806T AT E204870 T1 ATE204870 T1 AT E204870T1
- Authority
- AT
- Austria
- Prior art keywords
- represented
- general formula
- alkoxycarbonylpiperidine
- paroxetine
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13904896A JP3882224B2 (ja) | 1996-05-31 | 1996-05-31 | パロキセチンの製造方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE204870T1 true ATE204870T1 (de) | 2001-09-15 |
Family
ID=15236260
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97108806T ATE204870T1 (de) | 1996-05-31 | 1997-06-02 | Verfahren zur herstellung von paroxetine |
Country Status (9)
Country | Link |
---|---|
US (2) | US6433179B1 (de) |
EP (1) | EP0810225B1 (de) |
JP (1) | JP3882224B2 (de) |
AT (1) | ATE204870T1 (de) |
CA (1) | CA2205770A1 (de) |
DE (1) | DE69706366T2 (de) |
ES (1) | ES2162156T3 (de) |
PT (1) | PT810225E (de) |
SI (1) | SI0810225T1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3882224B2 (ja) * | 1996-05-31 | 2007-02-14 | 旭硝子株式会社 | パロキセチンの製造方法 |
EP1384711A1 (de) | 1996-06-13 | 2004-01-28 | SUMIKA FINE CHEMICALS Co., Ltd. | Optische Trennung eines Piperidin-Derivates |
SI0994872T1 (de) * | 1997-06-10 | 2001-08-31 | Synthon Bv | |
CH689805A8 (fr) * | 1998-07-02 | 2000-02-29 | Smithkline Beecham Plc | Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant. |
GB9828767D0 (en) * | 1998-12-29 | 1999-02-17 | Smithkline Beecham Plc | Novel process |
GB9914583D0 (en) * | 1999-06-22 | 1999-08-25 | Smithkline Beecham Plc | Novel process |
GB9916187D0 (en) * | 1999-07-09 | 1999-09-08 | Smithkline Beecham Plc | Novel process |
WO2001085688A1 (en) | 2000-05-12 | 2001-11-15 | Synthon B.V. | TOSYLATE SALTS OF 4-(p-FLUOROPHENYL)-PIPERIDINE-3-CARBINOLS |
WO2002006275A1 (en) * | 2000-07-17 | 2002-01-24 | Smithkline Beecham P.L.C. | Novel processes for the preparation of 4-phenylpiperidine derivatives |
US6777554B2 (en) | 2001-02-05 | 2004-08-17 | Teva Pharmaceutical Industries Ltd. | Preparation of N-methylparoxetine and related intermediate compounds |
NL1017421C2 (nl) * | 2001-02-21 | 2002-01-15 | Synthon Bv | Werkwijze voor het vervaardigen van paroxetine. |
JP2005524656A (ja) * | 2002-02-22 | 2005-08-18 | テバ ファーマシューティカル インダストリーズ リミティド | 新規中間物質を用いるパロキセチンの調製 |
US6956121B2 (en) * | 2002-03-01 | 2005-10-18 | Teva Pharmaceutical Industries Ltd. | Preparation of paroxetine involving novel intermediates |
US20090136982A1 (en) | 2005-01-18 | 2009-05-28 | Biocept, Inc. | Cell separation using microchannel having patterned posts |
KR20070116585A (ko) | 2005-01-18 | 2007-12-10 | 바이오셉트 인코포레이티드 | 패턴화된 포스트를 갖는 마이크로채널을 이용하는 세포분리법 |
WO2007015262A2 (en) * | 2005-04-25 | 2007-02-08 | Sun Pharmaceutical Industries Limited | A process for the preparation of (-)-trans-4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl)]piperidine |
AU2006315684A1 (en) * | 2005-11-14 | 2007-05-24 | Auspex Pharmaceuticals, Inc. | Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties |
US20080033050A1 (en) | 2006-08-04 | 2008-02-07 | Richards Patricia Allison Tewe | Method of treating thermoregulatory disfunction with paroxetine |
US9138430B2 (en) * | 2007-12-27 | 2015-09-22 | Mylan Specialty L.P. | Formulation and method for the release of paroxetine in the large intestine |
CN102718756B (zh) * | 2012-07-02 | 2013-11-20 | 浙江尖峰药业有限公司 | 盐酸帕罗西汀化合物及其合成方法 |
CN104447714A (zh) * | 2014-11-18 | 2015-03-25 | 成都医路康医学技术服务有限公司 | 一种盐酸帕罗西汀的生产工艺 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1422263A (en) | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
US4268515A (en) * | 1980-02-04 | 1981-05-19 | Hoechst-Roussel Pharmaceuticals Inc. | Spiro[dihydrobenzofuran-piperidines and-pyrrolidines], pharmaceutical compositions thereof and methods of use thereof |
US4282233B1 (en) * | 1980-06-19 | 2000-09-05 | Schering Corp | Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines |
EP0190496A3 (de) | 1984-12-13 | 1987-05-27 | Beecham Group Plc | Piperidinderivate mit gastro-intestinaler Wirkung |
ES2058061T3 (es) * | 1985-10-25 | 1994-11-01 | Beecham Group Plc | Derivado de piperidina, su preparacion y su uso como medicamento. |
IE66332B1 (en) | 1986-11-03 | 1995-12-27 | Novo Nordisk As | Piperidine compounds and their preparation and use |
US5227379A (en) | 1986-11-03 | 1993-07-13 | Novo Nordisk A/S | Piperidine compounds and their preparation and use |
IL101851A (en) * | 1991-06-13 | 1996-05-14 | Janssen Pharmaceutica Nv | History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition |
JP2607784B2 (ja) | 1991-09-30 | 1997-05-07 | 株式会社神戸製鋼所 | 廻し溶接用エンドタブ |
SK283608B6 (sk) | 1995-02-06 | 2003-10-07 | Smithkline Beecham Plc | Bezvodý hydrochlorid paroxetínu, spôsob jeho výroby a použitie |
JP3882224B2 (ja) * | 1996-05-31 | 2007-02-14 | 旭硝子株式会社 | パロキセチンの製造方法 |
EP1384711A1 (de) | 1996-06-13 | 2004-01-28 | SUMIKA FINE CHEMICALS Co., Ltd. | Optische Trennung eines Piperidin-Derivates |
US5672612A (en) | 1996-09-09 | 1997-09-30 | Pentech Pharmaceuticals, Inc. | Amorphous paroxetine composition |
GB9817195D0 (en) * | 1998-08-07 | 1998-10-07 | Smithkline Beecham Plc | Novel process |
-
1996
- 1996-05-31 JP JP13904896A patent/JP3882224B2/ja not_active Expired - Lifetime
-
1997
- 1997-05-21 CA CA002205770A patent/CA2205770A1/en not_active Abandoned
- 1997-05-21 US US08/861,393 patent/US6433179B1/en not_active Expired - Lifetime
- 1997-06-02 AT AT97108806T patent/ATE204870T1/de not_active IP Right Cessation
- 1997-06-02 EP EP97108806A patent/EP0810225B1/de not_active Expired - Lifetime
- 1997-06-02 PT PT97108806T patent/PT810225E/pt unknown
- 1997-06-02 ES ES97108806T patent/ES2162156T3/es not_active Expired - Lifetime
- 1997-06-02 DE DE69706366T patent/DE69706366T2/de not_active Expired - Lifetime
- 1997-06-02 SI SI9730144T patent/SI0810225T1/xx unknown
-
2002
- 2002-05-30 US US10/157,045 patent/US20020198387A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP3882224B2 (ja) | 2007-02-14 |
PT810225E (pt) | 2001-12-28 |
DE69706366T2 (de) | 2002-05-29 |
ES2162156T3 (es) | 2001-12-16 |
JPH09316072A (ja) | 1997-12-09 |
DE69706366D1 (de) | 2001-10-04 |
CA2205770A1 (en) | 1997-11-30 |
EP0810225B1 (de) | 2001-08-29 |
EP0810225A1 (de) | 1997-12-03 |
SI0810225T1 (en) | 2001-10-31 |
US20020198387A1 (en) | 2002-12-26 |
US6433179B1 (en) | 2002-08-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |