DE69707860T2 - Verfahren zur herstellung von tetrahydroindolizinen - Google Patents

Verfahren zur herstellung von tetrahydroindolizinen

Info

Publication number
DE69707860T2
DE69707860T2 DE69707860T DE69707860T DE69707860T2 DE 69707860 T2 DE69707860 T2 DE 69707860T2 DE 69707860 T DE69707860 T DE 69707860T DE 69707860 T DE69707860 T DE 69707860T DE 69707860 T2 DE69707860 T2 DE 69707860T2
Authority
DE
Germany
Prior art keywords
compound
tetrahydroindolizines
producing
solvent
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69707860T
Other languages
English (en)
Other versions
DE69707860D1 (de
Inventor
Shinji Kamihara
Kazuaki Kanai
Shigeru Noguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69707860D1 publication Critical patent/DE69707860D1/de
Publication of DE69707860T2 publication Critical patent/DE69707860T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
DE69707860T 1996-04-26 1997-04-24 Verfahren zur herstellung von tetrahydroindolizinen Expired - Fee Related DE69707860T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10725196 1996-04-26
JP10725296 1996-04-26
PCT/JP1997/001428 WO1997041124A1 (fr) 1996-04-26 1997-04-24 Procede pour la preparation de tetrahydroindolizines

Publications (2)

Publication Number Publication Date
DE69707860D1 DE69707860D1 (de) 2001-12-06
DE69707860T2 true DE69707860T2 (de) 2002-04-11

Family

ID=26447288

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69707860T Expired - Fee Related DE69707860T2 (de) 1996-04-26 1997-04-24 Verfahren zur herstellung von tetrahydroindolizinen

Country Status (11)

Country Link
US (2) US6172230B1 (de)
EP (1) EP0897924B1 (de)
KR (1) KR20000064811A (de)
CN (2) CN1087296C (de)
AT (1) ATE207921T1 (de)
AU (1) AU2406097A (de)
DE (1) DE69707860T2 (de)
DK (1) DK0897924T3 (de)
ES (1) ES2166991T3 (de)
PT (1) PT897924E (de)
WO (1) WO1997041124A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6870500A (en) * 1999-09-06 2001-04-10 Takeda Chemical Industries Ltd. Process for the preparation of 2,3-dihydroazepine derivatives
JP4566187B2 (ja) 2003-02-21 2010-10-20 中外製薬株式会社 六環式化合物の調製法
CA2563502A1 (en) 2004-04-09 2005-10-20 Chugai Seiyaku Kabushiki Kaisha Novel water-soluble prodrug
TW200744603A (en) 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
US20210341341A1 (en) * 2018-06-29 2021-11-04 Tecnimed S.R.L. Infrared thermometer
CN110204482A (zh) * 2019-05-23 2019-09-06 久泰能源(准格尔)有限公司 一种4-羟基吡啶-2,6-二羧酸的制备方法
CN114341162A (zh) 2019-07-10 2022-04-12 赛博克萨2公司 作为治疗剂的细胞毒素的肽缀合物
CA3146385A1 (en) 2019-07-10 2021-01-14 Cybrexa 3, Inc. Peptide conjugates of microtubule-targeting agents as therapeutics

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4304728A (en) * 1979-04-05 1981-12-08 Lilly Industries Limited 6-Substituted pyranone compounds and their use as pharmaceuticals
US5244903A (en) * 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US4894456A (en) * 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5227380A (en) * 1987-03-31 1993-07-13 Research Triangle Institute Pharmaceutical compositions and methods employing camptothecins
US5106742A (en) * 1987-03-31 1992-04-21 Wall Monroe E Camptothecin analogs as potent inhibitors of topoisomerase I
US5364858A (en) * 1987-03-31 1994-11-15 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5122526A (en) * 1987-03-31 1992-06-16 Research Triangle Institute Camptothecin and analogs thereof and pharmaceutical compositions and method using them

Also Published As

Publication number Publication date
PT897924E (pt) 2002-03-28
CN1373130A (zh) 2002-10-09
US6172230B1 (en) 2001-01-09
KR20000064811A (ko) 2000-11-06
ES2166991T3 (es) 2002-05-01
EP0897924A1 (de) 1999-02-24
CN1216992A (zh) 1999-05-19
ATE207921T1 (de) 2001-11-15
EP0897924B1 (de) 2001-10-31
EP0897924A4 (de) 1999-07-07
DE69707860D1 (de) 2001-12-06
WO1997041124A1 (fr) 1997-11-06
AU2406097A (en) 1997-11-19
US6337400B1 (en) 2002-01-08
CN1087296C (zh) 2002-07-10
DK0897924T3 (da) 2001-11-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee