DK0897924T3 - Fremgangsmåde til fremstilling af tetrahydroindoliziner - Google Patents

Fremgangsmåde til fremstilling af tetrahydroindoliziner

Info

Publication number
DK0897924T3
DK0897924T3 DK97919674T DK97919674T DK0897924T3 DK 0897924 T3 DK0897924 T3 DK 0897924T3 DK 97919674 T DK97919674 T DK 97919674T DK 97919674 T DK97919674 T DK 97919674T DK 0897924 T3 DK0897924 T3 DK 0897924T3
Authority
DK
Denmark
Prior art keywords
compound
preparation
solvent
useful
alkyl group
Prior art date
Application number
DK97919674T
Other languages
English (en)
Inventor
Shinji Kamihara
Kazuaki Kanai
Shigeru Noguchi
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Application granted granted Critical
Publication of DK0897924T3 publication Critical patent/DK0897924T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK97919674T 1996-04-26 1997-04-24 Fremgangsmåde til fremstilling af tetrahydroindoliziner DK0897924T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10725196 1996-04-26
JP10725296 1996-04-26
PCT/JP1997/001428 WO1997041124A1 (fr) 1996-04-26 1997-04-24 Procede pour la preparation de tetrahydroindolizines

Publications (1)

Publication Number Publication Date
DK0897924T3 true DK0897924T3 (da) 2001-11-19

Family

ID=26447288

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97919674T DK0897924T3 (da) 1996-04-26 1997-04-24 Fremgangsmåde til fremstilling af tetrahydroindoliziner

Country Status (11)

Country Link
US (2) US6172230B1 (da)
EP (1) EP0897924B1 (da)
KR (1) KR20000064811A (da)
CN (2) CN1087296C (da)
AT (1) ATE207921T1 (da)
AU (1) AU2406097A (da)
DE (1) DE69707860T2 (da)
DK (1) DK0897924T3 (da)
ES (1) ES2166991T3 (da)
PT (1) PT897924E (da)
WO (1) WO1997041124A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001017971A1 (fr) * 1999-09-06 2001-03-15 Takeda Chemical Industries, Ltd. Procede de preparation de derives 2,3-dihydroazepine
WO2004073601A2 (en) 2003-02-21 2004-09-02 Chugai Seiyaku Kabushiki Kaisha Process for the preparation of hexacyclic camptothecin derivatives
CN1964979B (zh) 2004-04-09 2011-07-27 中外制药株式会社 新颖的水溶性前药
TW200744603A (en) 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
US12098961B2 (en) * 2018-06-29 2024-09-24 Tecnimed S.R.L. Non-contact infrared thermometer
CN110204482A (zh) * 2019-05-23 2019-09-06 久泰能源(准格尔)有限公司 一种4-羟基吡啶-2,6-二羧酸的制备方法
TW202116778A (zh) 2019-07-10 2021-05-01 美商斯布雷克薩二號公司 作為治療劑之細胞毒素之肽結合物
EP3996749A1 (en) 2019-07-10 2022-05-18 Cybrexa 3, Inc. Peptide conjugates of microtubule-targeting agents as therapeutics

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4304728A (en) * 1979-04-05 1981-12-08 Lilly Industries Limited 6-Substituted pyranone compounds and their use as pharmaceuticals
US5244903A (en) * 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5364858A (en) * 1987-03-31 1994-11-15 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US4894456A (en) * 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5122526A (en) * 1987-03-31 1992-06-16 Research Triangle Institute Camptothecin and analogs thereof and pharmaceutical compositions and method using them
US4981968A (en) 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5227380A (en) * 1987-03-31 1993-07-13 Research Triangle Institute Pharmaceutical compositions and methods employing camptothecins
US5106742A (en) * 1987-03-31 1992-04-21 Wall Monroe E Camptothecin analogs as potent inhibitors of topoisomerase I

Also Published As

Publication number Publication date
ES2166991T3 (es) 2002-05-01
PT897924E (pt) 2002-03-28
WO1997041124A1 (fr) 1997-11-06
EP0897924A1 (en) 1999-02-24
US6337400B1 (en) 2002-01-08
AU2406097A (en) 1997-11-19
DE69707860D1 (de) 2001-12-06
CN1216992A (zh) 1999-05-19
ATE207921T1 (de) 2001-11-15
EP0897924A4 (en) 1999-07-07
EP0897924B1 (en) 2001-10-31
CN1087296C (zh) 2002-07-10
KR20000064811A (ko) 2000-11-06
DE69707860T2 (de) 2002-04-11
US6172230B1 (en) 2001-01-09
CN1373130A (zh) 2002-10-09

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