WO2001017971A1 - Procede de preparation de derives 2,3-dihydroazepine - Google Patents

Procede de preparation de derives 2,3-dihydroazepine Download PDF

Info

Publication number
WO2001017971A1
WO2001017971A1 PCT/JP2000/006011 JP0006011W WO0117971A1 WO 2001017971 A1 WO2001017971 A1 WO 2001017971A1 JP 0006011 W JP0006011 W JP 0006011W WO 0117971 A1 WO0117971 A1 WO 0117971A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
optionally substituted
ring
hydrogen atom
salt
Prior art date
Application number
PCT/JP2000/006011
Other languages
English (en)
Japanese (ja)
Inventor
Tomomi Ikemoto
Tatsuya Ito
Shoutarou Miura
Kiminori Tomimatsu
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Priority to AU68705/00A priority Critical patent/AU6870500A/en
Publication of WO2001017971A1 publication Critical patent/WO2001017971A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention se rapporte à un procédé simple et peu coûteux de préparation de dérivés 2,3-dihydroazépine représentés par la formule générale (II) ou de sels de ces dérivés. Ce procédé se caractérise en ce qu'il consiste à soumettre des composés de formule générale (I) ou des sels de tels composés à une réaction de fermeture de cycle en présence d'un diester carbonique. Dans lesdites formules, R1 est un groupe accepteur d'électron; R?2, R3, R4, R5, R6 et R7¿ sont chacun hydrogène, halogéno, amino éventuellement substitué, hydroxyle éventuellement substitué, un groupe thiol éventuellement substitué, hydrocarbyle éventuellement substitué ou un groupe hétérocyclique éventuellement substitué, ou bien R?2 et R3, R4 et R5, R2 et R4, ou R6 et R7¿ peuvent être réunis pour former un cycle; R8 est hydrogène ou hydrocarbyle éventuellement substitué; et R9 est hydrocarbyle éventuellement substitué, acyle éventuellement substitué ou sulfonyle substitué.
PCT/JP2000/006011 1999-09-06 2000-09-05 Procede de preparation de derives 2,3-dihydroazepine WO2001017971A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU68705/00A AU6870500A (en) 1999-09-06 2000-09-05 Process for the preparation of 2,3-dihydroazepine derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP25233399 1999-09-06
JP11/252333 1999-09-06

Publications (1)

Publication Number Publication Date
WO2001017971A1 true WO2001017971A1 (fr) 2001-03-15

Family

ID=17235819

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2000/006011 WO2001017971A1 (fr) 1999-09-06 2000-09-05 Procede de preparation de derives 2,3-dihydroazepine

Country Status (2)

Country Link
AU (1) AU6870500A (fr)
WO (1) WO2001017971A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6864367B2 (en) 2000-02-21 2005-03-08 Takeda Chemical Industries, Ltd. Process for producing cyclic compound
US6939885B2 (en) 2002-11-18 2005-09-06 Chemocentryx Aryl sulfonamides
US7227035B2 (en) 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides
US7999109B2 (en) 2002-05-24 2011-08-16 Millennium Pharmaceuticals, Inc. CCR9 inhibitors and methods of use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996022282A1 (fr) * 1995-01-17 1996-07-25 American Cyanamid Company Benzazepine tricycle antagoniste de la vasopressine
EP0897924A1 (fr) * 1996-04-26 1999-02-24 Daiichi Pharmaceutical Co., Ltd. Procede pour la preparation de tetrahydroindolizines
WO1999032468A1 (fr) * 1997-12-19 1999-07-01 Takeda Chemical Industries, Ltd. Derive d'anilide, sa preparation et son utilisation
WO1999032100A2 (fr) * 1997-12-19 1999-07-01 Takeda Chemical Industries, Ltd. Composition pharmaceutique antagoniste de ccr5 et contenant un derive d'anilide

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996022282A1 (fr) * 1995-01-17 1996-07-25 American Cyanamid Company Benzazepine tricycle antagoniste de la vasopressine
EP0897924A1 (fr) * 1996-04-26 1999-02-24 Daiichi Pharmaceutical Co., Ltd. Procede pour la preparation de tetrahydroindolizines
WO1999032468A1 (fr) * 1997-12-19 1999-07-01 Takeda Chemical Industries, Ltd. Derive d'anilide, sa preparation et son utilisation
WO1999032100A2 (fr) * 1997-12-19 1999-07-01 Takeda Chemical Industries, Ltd. Composition pharmaceutique antagoniste de ccr5 et contenant un derive d'anilide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HIROTA TAKASHI ET AL.: "Polycyclic N-hetero compounds. XXI. Synthesis of novel ring system, 4H-imidazo(1',2',:1,6)pyrimido(5,4-d)(1)benzazepine as B-homo-6,11,13,15-tetraazasteroidal analog", HETEROCYCLES, vol. 24, no. 1, 1986, pages 143 - 154, XP002935851 *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7038042B2 (en) 2000-02-21 2006-05-02 Takeda Pharmaceutical Company Limited Process for producing cyclic compound
US6864367B2 (en) 2000-02-21 2005-03-08 Takeda Chemical Industries, Ltd. Process for producing cyclic compound
US7999109B2 (en) 2002-05-24 2011-08-16 Millennium Pharmaceuticals, Inc. CCR9 inhibitors and methods of use thereof
US9035096B2 (en) 2002-05-24 2015-05-19 Millennium Pharmaceuticals, Inc. CCR9 inhibitors and methods of use thereof
US8030517B2 (en) 2002-05-24 2011-10-04 Millennium Pharmaceuticals, Inc. CCR9 inhibitors and methods of use thereof
US7227035B2 (en) 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
US7582661B2 (en) 2002-11-18 2009-09-01 Chemocentryx, Inc. Aryl sulfonamides
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
US7335653B2 (en) 2002-11-18 2008-02-26 Chemocentryx, Inc. Bis-aryl sulfonamides
US8211896B2 (en) 2002-11-18 2012-07-03 Chemocentryx, Inc. Aryl sulfonamides
US8642808B2 (en) 2002-11-18 2014-02-04 Chemocentryx, Inc. Bis-aryl sulfonamides
US6939885B2 (en) 2002-11-18 2005-09-06 Chemocentryx Aryl sulfonamides
US9890148B2 (en) 2002-11-18 2018-02-13 Chemocentryx, Inc. Aryl sulfonamides
US10364240B2 (en) 2002-11-18 2019-07-30 ChemoCentryx. Inc. Aryl sulfonamides
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides

Also Published As

Publication number Publication date
AU6870500A (en) 2001-04-10

Similar Documents

Publication Publication Date Title
CN111386276B (zh) 制备取代的多环吡啶酮衍生物的立体选择性方法
TW201406754A (zh) 雜環化合物之合成
JP4828863B2 (ja) （ｚ）−１−フェニル−１−（ｎ，ｎ−ジエチルアミノカルボニル）−２−フタルイミドメチルシクロプロパンの製造方法
KR20170131508A (ko) 레디파스비르 및 이의 유도체의 제조방법 및 레디파스비르를 제조하기 위한 중간체 화합물
WO2015131773A1 (fr) Dérivés de pipéridine utilisés comme antagonistes du récepteur de l'orexine
CN110741005A (zh) 用于制备1,3-苯并二氧杂环戊烯杂环化合物的方法
US20230278960A1 (en) Novel acridinium salt and method for producing same
WO2020108415A1 (fr) Composé intermédiaire d'un composé inhibiteur de kinase trk et procédé de préparation
WO2001017971A1 (fr) Procede de preparation de derives 2,3-dihydroazepine
CN114685468A (zh) 用于治疗子宫肌瘤的药物的中间体化合物及其制备方法
JP3999128B2 (ja) ベンゾ［ｂ］チオフェン誘導体、およびその製造方法
CN107056681B (zh) 一种托法替布中间体的制备方法
CN106699604B (zh) 一种沙库比曲及其中间体的制备方法
JP4908706B2 (ja) ベンゾフラン誘導体
KR101001129B1 (ko) 디벤즈옥세핀 유도체의 제조 방법
RU2709493C1 (ru) Способ получения роксадустата
WO1996026181A1 (fr) Derives d'aminotetralone et leurs procede de production
WO2022134262A1 (fr) Composé de dipyrrométhène-1-one et procédé de préparation associé
WO2001017947A1 (fr) Procedes de preparation de composes 2,3-dihydroazepine
JP2001151757A (ja) ２，３−ジヒドロアゼピン誘導体の製造法
CN107722007A (zh) 阿哌沙班杂质的制备方法
TWI788573B (zh) 二芳基甲烷化合物之製造方法
US6426417B1 (en) Processes and intermediates useful to make antifolates
US8815870B2 (en) 4-(2-(6-substituted-hexylidene) hydrazinyl)benzonitrile and preparation thereof
CN102531990B (zh) 2-(4-苄氧基-2-氧代-2,5-二氢吡咯-1-基)-乙酰胺及其合成和应用

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AU AZ BA BB BG BR BY BZ CA CN CR CU CZ DM DZ EE GD GE HR HU ID IL IN IS JP KG KR KZ LC LK LR LT LV MA MD MG MK MN MX MZ NO NZ PL RO RU SG SI SK TJ TM TR TT UA US UZ VN YU ZA

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP