DE69706366T2 - Verfahren zur Herstellung von Paroxetine - Google Patents

Verfahren zur Herstellung von Paroxetine

Info

Publication number
DE69706366T2
DE69706366T2 DE69706366T DE69706366T DE69706366T2 DE 69706366 T2 DE69706366 T2 DE 69706366T2 DE 69706366 T DE69706366 T DE 69706366T DE 69706366 T DE69706366 T DE 69706366T DE 69706366 T2 DE69706366 T2 DE 69706366T2
Authority
DE
Germany
Prior art keywords
represented
general formula
paroxetine
alkoxycarbonylpiperidine
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69706366T
Other languages
English (en)
Other versions
DE69706366D1 (de
Inventor
Shu-Zhong Wang
Yasushi Matsumura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AGC Inc
Original Assignee
Asahi Glass Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Glass Co Ltd filed Critical Asahi Glass Co Ltd
Application granted granted Critical
Publication of DE69706366D1 publication Critical patent/DE69706366D1/de
Publication of DE69706366T2 publication Critical patent/DE69706366T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE69706366T 1996-05-31 1997-06-02 Verfahren zur Herstellung von Paroxetine Expired - Lifetime DE69706366T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13904896A JP3882224B2 (ja) 1996-05-31 1996-05-31 パロキセチンの製造方法

Publications (2)

Publication Number Publication Date
DE69706366D1 DE69706366D1 (de) 2001-10-04
DE69706366T2 true DE69706366T2 (de) 2002-05-29

Family

ID=15236260

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69706366T Expired - Lifetime DE69706366T2 (de) 1996-05-31 1997-06-02 Verfahren zur Herstellung von Paroxetine

Country Status (9)

Country Link
US (2) US6433179B1 (de)
EP (1) EP0810225B1 (de)
JP (1) JP3882224B2 (de)
AT (1) ATE204870T1 (de)
CA (1) CA2205770A1 (de)
DE (1) DE69706366T2 (de)
ES (1) ES2162156T3 (de)
PT (1) PT810225E (de)
SI (1) SI0810225T1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3882224B2 (ja) * 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
ES2331937T3 (es) 1996-06-13 2010-01-20 Sumitomo Chemical Company, Limited Derivados de piperidina como intermediarios para la preparacion de paroxetina y procedimiento de preparacion de los mismos.
PT994872E (pt) 1997-06-10 2001-09-28 Synthon Bv Composto de 4-fenilpiperidina
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
GB9828767D0 (en) * 1998-12-29 1999-02-17 Smithkline Beecham Plc Novel process
GB9914583D0 (en) * 1999-06-22 1999-08-25 Smithkline Beecham Plc Novel process
GB9916187D0 (en) * 1999-07-09 1999-09-08 Smithkline Beecham Plc Novel process
AU2000246280A1 (en) 2000-05-12 2001-11-20 Synthon B.V. Tosylate salts of 4-(p-fluorophenyl)-piperidine-3-carbinols
AU2001270858A1 (en) * 2000-07-17 2002-01-30 Smithkline Beecham Plc Novel processes for the preparation of 4-phenylpiperidine derivatives
US6777554B2 (en) 2001-02-05 2004-08-17 Teva Pharmaceutical Industries Ltd. Preparation of N-methylparoxetine and related intermediate compounds
NL1017421C2 (nl) * 2001-02-21 2002-01-15 Synthon Bv Werkwijze voor het vervaardigen van paroxetine.
JP2005524656A (ja) * 2002-02-22 2005-08-18 テバ ファーマシューティカル インダストリーズ リミティド 新規中間物質を用いるパロキセチンの調製
US6956121B2 (en) * 2002-03-01 2005-10-18 Teva Pharmaceutical Industries Ltd. Preparation of paroxetine involving novel intermediates
ES2437845T3 (es) 2005-01-18 2014-01-14 Biocept, Inc. Separación de células usando un microcanal que tiene pilares con una configuración
US20090136982A1 (en) 2005-01-18 2009-05-28 Biocept, Inc. Cell separation using microchannel having patterned posts
WO2007015262A2 (en) * 2005-04-25 2007-02-08 Sun Pharmaceutical Industries Limited A process for the preparation of (-)-trans-4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl)]piperidine
US20070112031A1 (en) * 2005-11-14 2007-05-17 Gant Thomas G Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties
US20080033050A1 (en) 2006-08-04 2008-02-07 Richards Patricia Allison Tewe Method of treating thermoregulatory disfunction with paroxetine
US9138430B2 (en) * 2007-12-27 2015-09-22 Mylan Specialty L.P. Formulation and method for the release of paroxetine in the large intestine
CN102718756B (zh) * 2012-07-02 2013-11-20 浙江尖峰药业有限公司 盐酸帕罗西汀化合物及其合成方法
CN104447714A (zh) * 2014-11-18 2015-03-25 成都医路康医学技术服务有限公司 一种盐酸帕罗西汀的生产工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
US4268515A (en) * 1980-02-04 1981-05-19 Hoechst-Roussel Pharmaceuticals Inc. Spiro[dihydrobenzofuran-piperidines and-pyrrolidines], pharmaceutical compositions thereof and methods of use thereof
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
EP0190496A3 (de) 1984-12-13 1987-05-27 Beecham Group Plc Piperidinderivate mit gastro-intestinaler Wirkung
ES2058061T3 (es) * 1985-10-25 1994-11-01 Beecham Group Plc Derivado de piperidina, su preparacion y su uso como medicamento.
IE66332B1 (en) 1986-11-03 1995-12-27 Novo Nordisk As Piperidine compounds and their preparation and use
US5227379A (en) 1986-11-03 1993-07-13 Novo Nordisk A/S Piperidine compounds and their preparation and use
IL101851A (en) * 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition
JP2607784B2 (ja) 1991-09-30 1997-05-07 株式会社神戸製鋼所 廻し溶接用エンドタブ
AR001982A1 (es) 1995-02-06 1998-01-07 Smithkline Beecham Plc Clorhidrato de paroxetina anhidratado, y procedimiento para su preparacion
JP3882224B2 (ja) * 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
ES2331937T3 (es) 1996-06-13 2010-01-20 Sumitomo Chemical Company, Limited Derivados de piperidina como intermediarios para la preparacion de paroxetina y procedimiento de preparacion de los mismos.
US5672612A (en) 1996-09-09 1997-09-30 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
GB9817195D0 (en) * 1998-08-07 1998-10-07 Smithkline Beecham Plc Novel process

Also Published As

Publication number Publication date
SI0810225T1 (en) 2001-10-31
CA2205770A1 (en) 1997-11-30
US6433179B1 (en) 2002-08-13
JP3882224B2 (ja) 2007-02-14
ATE204870T1 (de) 2001-09-15
DE69706366D1 (de) 2001-10-04
EP0810225A1 (de) 1997-12-03
PT810225E (pt) 2001-12-28
JPH09316072A (ja) 1997-12-09
ES2162156T3 (es) 2001-12-16
EP0810225B1 (de) 2001-08-29
US20020198387A1 (en) 2002-12-26

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