AR029596A1 - Compuestos inhibidores de la trombina que comprenden un grupo aminoisoquinolina - Google Patents

Compuestos inhibidores de la trombina que comprenden un grupo aminoisoquinolina

Info

Publication number
AR029596A1
AR029596A1 ARP010103283A ARP010103283A AR029596A1 AR 029596 A1 AR029596 A1 AR 029596A1 AR P010103283 A ARP010103283 A AR P010103283A AR P010103283 A ARP010103283 A AR P010103283A AR 029596 A1 AR029596 A1 AR 029596A1
Authority
AR
Argentina
Prior art keywords
inhibiting compounds
thrombin
thrombin inhibiting
aminoisoquinoline
group
Prior art date
Application number
ARP010103283A
Other languages
English (en)
Inventor
Johannes Bernardus Ma Rewinkel
Cornelis Marius Timmers
Paolo Giovanni Martino Conti
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of AR029596A1 publication Critical patent/AR029596A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de la formula 1 donde R1 es ciclopentilo, ciclohexilo o un (C3-4) alquilo ramificado; R2 es ciclohexilo o fenilo; R3 es H o metilo; y A es un anillo de 4, 5 o 6 miembros no sustituido y saturado; o una sal farmacéuticamente aceptable del mismo. Los compuestos tienen actividad anticoagulante y pueden usarse para tratar o prevenir enfermedades mediadas por trombina y asociadas con trombina
ARP010103283A 2000-07-12 2001-07-11 Compuestos inhibidores de la trombina que comprenden un grupo aminoisoquinolina AR029596A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00202491 2000-07-12

Publications (1)

Publication Number Publication Date
AR029596A1 true AR029596A1 (es) 2003-07-02

Family

ID=8171793

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010103283A AR029596A1 (es) 2000-07-12 2001-07-11 Compuestos inhibidores de la trombina que comprenden un grupo aminoisoquinolina

Country Status (23)

Country Link
US (1) US6642253B2 (es)
EP (1) EP1303491A1 (es)
JP (1) JP2004502759A (es)
KR (1) KR20030022270A (es)
CN (1) CN1441784A (es)
AR (1) AR029596A1 (es)
AU (1) AU2001278476A1 (es)
BR (1) BR0112338A (es)
CA (1) CA2413035A1 (es)
CZ (1) CZ200392A3 (es)
EC (1) ECSP034422A (es)
HR (1) HRP20030017A2 (es)
HU (1) HUP0301258A2 (es)
IL (1) IL153611A0 (es)
MX (1) MXPA03000337A (es)
NO (1) NO20030145D0 (es)
NZ (1) NZ523553A (es)
PE (1) PE20020209A1 (es)
PL (1) PL359787A1 (es)
RU (1) RU2003104017A (es)
SK (1) SK322003A3 (es)
WO (1) WO2002004423A1 (es)
ZA (1) ZA200300080B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0400651A2 (hu) 2000-11-07 2004-06-28 Bristol-Myers Squibb Company Szerin proteáz inhibitorokként alkalmazható savszármazékok és ezeket tartalmazó gyógyszerkészítmények
US6906192B2 (en) 2000-11-07 2005-06-14 Bristol Myers Squibb Company Processes for the preparation of acid derivatives useful as serine protease inhibitors
TWI389899B (zh) * 2006-08-08 2013-03-21 Msd Oss Bv 具口服活性之凝血酶抑制劑
PL2102164T3 (pl) * 2006-12-27 2011-05-31 Sanofi Aventis Pochodne izochinoliny i izochinolinonu podstawione cykloalkiloaminami
US7927378B2 (en) * 2007-03-05 2011-04-19 Scussel Sbj Systems, Llc Vacuum assisted prosthetic sleeve and socket
CN109810172B (zh) * 2017-11-21 2021-01-01 首都医科大学 异喹啉-3-甲酰-PARGD(aa)aa,其制备,抗静脉血栓活性和应用
CN109810174B (zh) * 2017-11-21 2021-01-01 首都医科大学 异喹啉-3-甲酰-TARGD(aa)aa,其制备,抗静脉血栓活性和应用
CN109810173B (zh) * 2017-11-21 2020-11-27 首都医科大学 二氢异喹啉-3-甲酰-TARGD(aa)aa,其制备,抗静脉血栓活性和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL123986A (en) * 1997-04-24 2011-10-31 Organon Nv Medicinal compounds

Also Published As

Publication number Publication date
PL359787A1 (en) 2004-09-06
ECSP034422A (es) 2003-03-10
WO2002004423A9 (en) 2003-05-15
ZA200300080B (en) 2004-04-05
HUP0301258A2 (hu) 2003-08-28
MXPA03000337A (es) 2004-04-05
IL153611A0 (en) 2003-07-06
NO20030145L (no) 2003-01-10
US6642253B2 (en) 2003-11-04
NO20030145D0 (no) 2003-01-10
BR0112338A (pt) 2003-07-22
HRP20030017A2 (en) 2003-04-30
SK322003A3 (en) 2003-06-03
JP2004502759A (ja) 2004-01-29
CN1441784A (zh) 2003-09-10
CA2413035A1 (en) 2002-01-17
WO2002004423A8 (en) 2003-03-06
RU2003104017A (ru) 2004-08-20
PE20020209A1 (es) 2002-03-19
EP1303491A1 (en) 2003-04-23
AU2001278476A1 (en) 2002-01-21
CZ200392A3 (cs) 2003-05-14
WO2002004423A1 (en) 2002-01-17
KR20030022270A (ko) 2003-03-15
US20030166579A1 (en) 2003-09-04
NZ523553A (en) 2004-04-30

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Legal Events

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FA Abandonment or withdrawal