MXPA03000337A - Inhibidores de trombina que comprenden un grupo aminoisoquinolina. - Google Patents

Inhibidores de trombina que comprenden un grupo aminoisoquinolina.

Info

Publication number
MXPA03000337A
MXPA03000337A MXPA03000337A MXPA03000337A MXPA03000337A MX PA03000337 A MXPA03000337 A MX PA03000337A MX PA03000337 A MXPA03000337 A MX PA03000337A MX PA03000337 A MXPA03000337 A MX PA03000337A MX PA03000337 A MXPA03000337 A MX PA03000337A
Authority
MX
Mexico
Prior art keywords
thrombin inhibitors
thrombin
aminoisoquinoline
group
aminoisoquinoline group
Prior art date
Application number
MXPA03000337A
Other languages
English (en)
Inventor
Cornelis Marius Timmers
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of MXPA03000337A publication Critical patent/MXPA03000337A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invencion se refiere a un compuesto que tiene la formula (I) en donde R1 es ciclopentilo, ciclohexilo o alquilo ramificado (3-4C), R2 es ciclohexilo o fenilo; R3 es H o metilo; y A es un anillo de 4, 5 o 6 miembros saturado no substituido; o una sal farmaceuticamente aceptable del mismo. Los compuestos de la invencion tienen actividad anticoagulante y pueden utilizarse en el tratamiento o prevencion de enfermedades asociadas a trombina y mediadas por trombina.
MXPA03000337A 2000-07-12 2001-07-09 Inhibidores de trombina que comprenden un grupo aminoisoquinolina. MXPA03000337A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00202491 2000-07-12
PCT/EP2001/007887 WO2002004423A1 (en) 2000-07-12 2001-07-09 Thrombin inhibitors comprising an aminoisoquinoline group

Publications (1)

Publication Number Publication Date
MXPA03000337A true MXPA03000337A (es) 2004-04-05

Family

ID=8171793

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03000337A MXPA03000337A (es) 2000-07-12 2001-07-09 Inhibidores de trombina que comprenden un grupo aminoisoquinolina.

Country Status (23)

Country Link
US (1) US6642253B2 (es)
EP (1) EP1303491A1 (es)
JP (1) JP2004502759A (es)
KR (1) KR20030022270A (es)
CN (1) CN1441784A (es)
AR (1) AR029596A1 (es)
AU (1) AU2001278476A1 (es)
BR (1) BR0112338A (es)
CA (1) CA2413035A1 (es)
CZ (1) CZ200392A3 (es)
EC (1) ECSP034422A (es)
HR (1) HRP20030017A2 (es)
HU (1) HUP0301258A2 (es)
IL (1) IL153611A0 (es)
MX (1) MXPA03000337A (es)
NO (1) NO20030145D0 (es)
NZ (1) NZ523553A (es)
PE (1) PE20020209A1 (es)
PL (1) PL359787A1 (es)
RU (1) RU2003104017A (es)
SK (1) SK322003A3 (es)
WO (1) WO2002004423A1 (es)
ZA (1) ZA200300080B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6906192B2 (en) 2000-11-07 2005-06-14 Bristol Myers Squibb Company Processes for the preparation of acid derivatives useful as serine protease inhibitors
EP1332131A2 (en) 2000-11-07 2003-08-06 Bristol-Myers Squibb Company Acid derivatives useful as serine protease inhibitors
TWI389899B (zh) * 2006-08-08 2013-03-21 Msd Oss Bv 具口服活性之凝血酶抑制劑
RS51655B (en) * 2006-12-27 2011-10-31 Sanofi-Aventis Isoquinoline derivatives and isoquinolinone derivatives substituted by cycloalkylamine
US7927378B2 (en) * 2007-03-05 2011-04-19 Scussel Sbj Systems, Llc Vacuum assisted prosthetic sleeve and socket
CN109810172B (zh) * 2017-11-21 2021-01-01 首都医科大学 异喹啉-3-甲酰-PARGD(aa)aa,其制备,抗静脉血栓活性和应用
CN109810173B (zh) * 2017-11-21 2020-11-27 首都医科大学 二氢异喹啉-3-甲酰-TARGD(aa)aa,其制备,抗静脉血栓活性和应用
CN109810174B (zh) * 2017-11-21 2021-01-01 首都医科大学 异喹啉-3-甲酰-TARGD(aa)aa,其制备,抗静脉血栓活性和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL123986A (en) 1997-04-24 2011-10-31 Organon Nv Medicinal compounds

Also Published As

Publication number Publication date
RU2003104017A (ru) 2004-08-20
BR0112338A (pt) 2003-07-22
WO2002004423A9 (en) 2003-05-15
US6642253B2 (en) 2003-11-04
KR20030022270A (ko) 2003-03-15
ECSP034422A (es) 2003-03-10
NO20030145L (no) 2003-01-10
AR029596A1 (es) 2003-07-02
US20030166579A1 (en) 2003-09-04
CN1441784A (zh) 2003-09-10
EP1303491A1 (en) 2003-04-23
PL359787A1 (en) 2004-09-06
IL153611A0 (en) 2003-07-06
ZA200300080B (en) 2004-04-05
CA2413035A1 (en) 2002-01-17
HUP0301258A2 (hu) 2003-08-28
PE20020209A1 (es) 2002-03-19
AU2001278476A1 (en) 2002-01-21
NZ523553A (en) 2004-04-30
WO2002004423A8 (en) 2003-03-06
CZ200392A3 (cs) 2003-05-14
WO2002004423A1 (en) 2002-01-17
JP2004502759A (ja) 2004-01-29
SK322003A3 (en) 2003-06-03
HRP20030017A2 (en) 2003-04-30
NO20030145D0 (no) 2003-01-10

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