CR6529A - Acidos 3-propil-gama-aminobutiricos mono y disustituidos - Google Patents

Acidos 3-propil-gama-aminobutiricos mono y disustituidos

Info

Publication number
CR6529A
CR6529A CR6529A CR6529A CR6529A CR 6529 A CR6529 A CR 6529A CR 6529 A CR6529 A CR 6529A CR 6529 A CR6529 A CR 6529A CR 6529 A CR6529 A CR 6529A
Authority
CR
Costa Rica
Prior art keywords
acids
disustituted
aminobutiric
propil
range
Prior art date
Application number
CR6529A
Other languages
English (en)
Inventor
Richard Belliotti Thomas
Stephen Briñas Justin
Victor Ekhato Ihoezo
Tobi Osuma Augustine
Michael Schelkun Robert
Bradley Schwarz Jacob
John Thorpe Andrew
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of CR6529A publication Critical patent/CR6529A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/20—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/32—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPUESTOS DE LA FORMULA I O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS, EN LA CUAL R1 ES HIDROGENO, ALQUILO DE CADENA RECTA O RAMIFICADA DE 1 A 6 ATOMOS DE CARBONO O FENILO, R2 ES ALQUILO DE CADENA RECTA O RAMIFICADA DE 2 A 8 ATOMOS DE CARBONO, CICLOALQUILO, ALQUILALCOXI, OH DE ALQUILO, ALQUILFENILO, ALQUILFENOXI, FENILO O FENILO SUBSTITUIDO Y R3 ES ES ALQUILO DE CADENA RECTA O RAMIFICADA DE 1 A 6 ATOMOS DE CARBONO O FENILO CUANDO R2 ES METILO.
CR6529A 1999-06-10 2001-12-07 Acidos 3-propil-gama-aminobutiricos mono y disustituidos CR6529A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13848599P 1999-06-10 1999-06-10

Publications (1)

Publication Number Publication Date
CR6529A true CR6529A (es) 2003-11-25

Family

ID=22482232

Family Applications (1)

Application Number Title Priority Date Filing Date
CR6529A CR6529A (es) 1999-06-10 2001-12-07 Acidos 3-propil-gama-aminobutiricos mono y disustituidos

Country Status (43)

Country Link
EP (1) EP1192125B9 (es)
JP (1) JP3904452B2 (es)
KR (1) KR100694735B1 (es)
CN (2) CN1196671C (es)
AP (1) AP1397A (es)
AR (1) AR033335A1 (es)
AT (1) ATE419231T1 (es)
AU (1) AU776723C (es)
BG (1) BG65561B1 (es)
BR (1) BR0011727A (es)
CA (2) CA2374755C (es)
CO (1) CO5200791A1 (es)
CR (1) CR6529A (es)
CU (1) CU23101A3 (es)
CY (1) CY1108827T1 (es)
CZ (2) CZ300834B6 (es)
DE (1) DE60041256D1 (es)
DK (1) DK1192125T3 (es)
DZ (1) DZ3253A1 (es)
EA (1) EA004398B1 (es)
EE (1) EE200100672A (es)
ES (1) ES2317839T3 (es)
GE (1) GEP20074142B (es)
HK (2) HK1046401B (es)
HR (1) HRP20020025A2 (es)
HU (1) HUP0201601A3 (es)
IL (2) IL146969A0 (es)
IS (1) IS6181A (es)
MA (1) MA26804A1 (es)
ME (1) MEP44808A (es)
MX (1) MXPA01012319A (es)
NO (2) NO327746B1 (es)
NZ (1) NZ515668A (es)
OA (1) OA11962A (es)
PE (1) PE20010285A1 (es)
PT (1) PT1192125E (es)
RS (2) RS20090257A (es)
SI (1) SI1192125T1 (es)
SK (2) SK287399B6 (es)
TR (1) TR200103587T2 (es)
UA (1) UA72519C2 (es)
WO (1) WO2000076958A2 (es)
ZA (1) ZA200109711B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7164034B2 (en) 1999-06-10 2007-01-16 Pfizer Inc. Alpha2delta ligands for fibromyalgia and other disorders
US6620829B2 (en) 2000-10-17 2003-09-16 Warner-Lambert Company Method of treating noninflammatory cartilage damage
EP2085087A1 (en) * 2001-06-11 2009-08-05 Xenoport, Inc. Prodrugs of gaba analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
ITMI20011308A1 (it) 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
AU2003201716B2 (en) 2002-01-31 2008-04-17 Warner-Lambert Company Llc Alpha 2 delta ligands to treat tinnitus
NI200300043A (es) 2002-03-28 2003-11-05 Warner Lambert Co AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.
US20030225149A1 (en) 2002-04-30 2003-12-04 Blazecka Peter G. Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids
US7071339B2 (en) 2002-08-29 2006-07-04 Warner Lambert Company Llc Process for preparing functionalized γ-butyrolactones from mucohalic acid
WO2004054565A1 (en) * 2002-12-13 2004-07-01 Warner-Lambert Company Llc Pregabalin and derivates thereof for the treatment of fibromyalgia and other related disorders
KR20090118994A (ko) 2002-12-13 2009-11-18 워너-램버트 캄파니 엘엘씨 하부요로증상을 치료하기 위한 알파-2-델타 리간드
PL377520A1 (pl) 2002-12-13 2006-02-06 Warner-Lambert Company Llc Pochodne pregabaliny przeznaczone do leczenia fibromialgii i innych zaburzeń
CA2451267A1 (en) 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
ITMI20022658A1 (it) 2002-12-17 2004-06-18 Nicox Sa Farmaci per il dolore cronico.
WO2005002585A1 (en) * 2003-07-02 2005-01-13 Warner-Lambert Company Llc Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor
CA2537402C (en) 2003-09-12 2009-05-05 Pfizer Inc. Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
MXPA06003396A (es) 2003-09-25 2006-06-08 Warner Lambert Co Profarmacos de aminoacidos con afinidad por la proteina a 2d.
OA13258A (en) * 2003-09-25 2007-01-31 Warner Lambert Co Amino acids with affinity for the alpha2delta-protein.
WO2006043171A2 (en) * 2004-10-23 2006-04-27 Warner-Lambert Company Llc Methods of using alpha2delta-1 selective compounds
JP2009507870A (ja) * 2005-09-15 2009-02-26 ユセベ ファルマ ソシエテ アノニム ４−置換ピロリジン−２−オン及びそれらの使用
US20070141684A1 (en) * 2005-12-21 2007-06-21 Pfizer Inc Preparation of gamma-amino acids having affinity for the alpha-2-delta protein
AR061728A1 (es) * 2006-06-30 2008-09-17 Pfizer Prod Inc Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1
UA94979C2 (uk) 2006-12-22 2011-06-25 Рекордати Айеленд Лимитед КОМБІНОВАНА ТЕРАПІЯ ПОРУШЕНЬ НИЖНІХ СЕЧОВИВІДНИХ ШЛЯХІВ ЛІГАНДАМИ α2δ І НПЗП
WO2009136375A1 (en) * 2008-05-08 2009-11-12 Pfizer Inc Treatment of interstitial cystitis
WO2011071995A2 (en) 2009-12-08 2011-06-16 Case Western Reserve University Compounds and methods of treating ocular disorders
CN101914031B (zh) * 2010-07-30 2013-08-28 中国广州分析测试中心 普瑞巴林衍生物及其应用
MX2018004674A (es) * 2015-10-23 2018-09-11 Navitor Pharm Inc Moduladores de interacción de sestrina-gator2 y sus usos.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087544A (en) * 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
AU9137091A (en) * 1990-11-27 1992-06-25 Northwestern University Gaba and l-glutamic acid analogs for antiseizure treatment
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
SK283281B6 (sk) * 1992-05-20 2003-05-02 Northwestern University Deriváty gamaaminomaslovej kyseliny, spôsoby a medziprodukty na ich výrobu, ich použitie a farmaceutické prostriedky
US5637767A (en) * 1995-06-07 1997-06-10 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
NZ332762A (en) * 1996-07-24 2000-09-29 Warner Lambert Co Isobutylgaba and its derivatives for the treatment of pain
NZ334898A (en) * 1996-10-23 2000-09-29 Warner Lambert Co Substituted gamma aminobutyric acids as pharamceutical agents
PL199500B1 (pl) * 1997-10-27 2008-09-30 Warner Lambert Co Cykliczne aminokwasy, kompozycja farmaceutyczna i zastosowanie cyklicznych aminokwasów

Also Published As

Publication number Publication date
AR033335A1 (es) 2003-12-17
OA11962A (en) 2006-04-17
DZ3253A1 (fr) 2000-12-21
DK1192125T3 (da) 2009-02-16
NO20091094L (no) 2001-12-05
CN1310872C (zh) 2007-04-18
PT1192125E (pt) 2009-03-05
CA2689997A1 (en) 2000-12-21
CZ300834B6 (cs) 2009-08-19
ES2317839T3 (es) 2009-05-01
HUP0201601A2 (en) 2002-10-28
IL146969A (en) 2008-03-20
HK1076626A1 (en) 2006-01-20
AU5311900A (en) 2001-01-02
AU776723C (en) 2005-06-02
ZA200109711B (en) 2003-03-20
CN1660779A (zh) 2005-08-31
EA004398B1 (ru) 2004-04-29
TR200103587T2 (tr) 2002-04-22
UA72519C2 (en) 2005-03-15
YU87001A (sh) 2004-07-15
JP2003502308A (ja) 2003-01-21
KR100694735B1 (ko) 2007-03-14
BG106292A (en) 2002-05-31
CO5200791A1 (es) 2002-09-27
AP1397A (en) 2005-04-19
WO2000076958A2 (en) 2000-12-21
BR0011727A (pt) 2002-03-05
NO20015949L (no) 2001-12-05
EP1192125A2 (en) 2002-04-03
KR20020009631A (ko) 2002-02-01
EP1192125B9 (en) 2009-09-16
NZ515668A (en) 2004-02-27
CA2374755C (en) 2010-03-30
HUP0201601A3 (en) 2002-11-28
JP3904452B2 (ja) 2007-04-11
SI1192125T1 (sl) 2009-04-30
EA200101134A1 (ru) 2002-06-27
MXPA01012319A (es) 2002-07-22
IL146969A0 (en) 2002-08-14
CY1108827T1 (el) 2014-04-09
AU776723B2 (en) 2004-09-16
CN1355784A (zh) 2002-06-26
EP1192125B1 (en) 2008-12-31
PE20010285A1 (es) 2001-03-22
DE60041256D1 (de) 2009-02-12
BG65561B1 (bg) 2008-12-30
AP2002002388A0 (en) 2002-03-31
EE200100672A (et) 2003-02-17
PL352431A1 (en) 2003-08-25
SK287247B6 (sk) 2010-04-07
CZ301608B6 (cs) 2010-04-28
MEP44808A (en) 2011-02-10
HK1046401B (zh) 2005-12-02
HK1046401A1 (en) 2003-01-10
NO20015949D0 (no) 2001-12-05
WO2000076958A3 (en) 2001-04-12
GEP20074142B (en) 2007-07-10
IS6181A (is) 2001-11-28
RS20090257A (en) 2010-03-02
RS50352B (sr) 2009-11-10
CZ20014285A3 (cs) 2002-07-17
SK287399B6 (sk) 2010-08-09
SK17642001A3 (sk) 2002-10-08
CN1196671C (zh) 2005-04-13
HRP20020025A2 (en) 2003-12-31
CU23101A3 (es) 2005-12-20
MA26804A1 (fr) 2004-12-20
ATE419231T1 (de) 2009-01-15
CA2374755A1 (en) 2000-12-21
NO327746B1 (no) 2009-09-14

Similar Documents

Publication Publication Date Title
CR6529A (es) Acidos 3-propil-gama-aminobutiricos mono y disustituidos
NO2022019I1 (no) Eribulin eller et farmasøytisk akseptabelt salt derav - forlenget SPC
DE60336850D1 (en) Substituierte arylcyclopropylacetamide als glucokinaseaktivatoren
ATE297203T1 (de) Antithrombotische mitteln
AR039387A2 (es) Compuestos antibioticos de azalida
ATE306261T1 (de) Antithrombosemittel
JO2654B1 (en) Multiple aryl caroxa amides are useful as lipid - lowering agents
CO5070677A1 (es) Composicion topica para aclarar o reducir la pigmentacion que contiene derivados de resorcinol
YU35697A (en) Substituted 6,6-hetero-bicyclic derivatives
ATE283253T1 (de) Substituierte aminopropoxyarylderivate als lxr agonisten
DK0749424T3 (da) Naphthalenderivater som prostaglandin-I2-agonister
EA200100310A1 (ru) Кислородсодержащие гетероциклические соединения
ATE172463T1 (de) Pyrrolocarbazol
PT1181294E (pt) Novos derivados e analogos da galantamina
PT1044186E (pt) Composto 2-benzilamino-2-fenil-acetamida substituidos
ATE308540T1 (de) Antithrombosemittel
DE60041001D1 (de) Substituierte homopiperidylbenzimidazolanaloga als fundusrelaxantien
HRP20010885B1 (en) Ethanesulfonyl-piperidine derivatives
BR0112338A (pt) Composto, composição farmacêutica, e, uso de um composto
MY133207A (en) Substituted benzolactam compaunds
CO5140085A1 (es) Derivados terapeuticos de benzamida
CO5560539A2 (es) Derivados de 2-hidroxi-2-metil-3,3,3-trifluoropropanamida n-fenilo sustituida que elevan la actividad de piruvato deshidrogenasa
IL153780A0 (en) Dimethylbenzene derivatives
EP1632228A4 (en) MEDICINAL COMPOSITION CONTAINING TRIAZOLE COMPOUND
SE9800932D0 (sv) New compunds

Legal Events

Date Code Title Description
FC Refusal