CY1108827T1 - Μονο-υποκατεστημενα 3-προπυλο γαμμα-αμινοβουτυρικα οξεα - Google Patents
Μονο-υποκατεστημενα 3-προπυλο γαμμα-αμινοβουτυρικα οξεαInfo
- Publication number
- CY1108827T1 CY1108827T1 CY20091100228T CY091100228T CY1108827T1 CY 1108827 T1 CY1108827 T1 CY 1108827T1 CY 20091100228 T CY20091100228 T CY 20091100228T CY 091100228 T CY091100228 T CY 091100228T CY 1108827 T1 CY1108827 T1 CY 1108827T1
- Authority
- CY
- Cyprus
- Prior art keywords
- disorders
- acids
- propylum
- aminobutic
- gamma
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/20—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/32—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Η παρούσα εφεύρεση είναι μια σειρά νέων μονο- και διϋποκατεστημένων 3-προπυλο γάμα αμινοβουτυρικών οξέων του Τύπου (I). Οι ενώσεις είναι χρήσιμες ως θεραπευτικοί παράγοντες στην αντιμετώπιση επιληψίας, κρίσεων αδυναμίας, υποκινησίας, κρανιακών διαταραχών, νευροεκφυλιστικών διαταραχών, κατάθλιψης, άγχους, πανικού, πόνου, νευροπαθολογικών διαταραχών, αρθρίτιδας, διαταραχών του ύπνου, IBS, και γαστρικής βλάβης. Μέθοδοι παρασκευής των ενώσεων και χρήσιμων ενδιαμέσων είναι επίσης μέρος της εφεύρεσης.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13848599P | 1999-06-10 | 1999-06-10 | |
EP00938022A EP1192125B9 (en) | 1999-06-10 | 2000-05-31 | Mono-substituted 3-propyl gamma-aminobutyric acids |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108827T1 true CY1108827T1 (el) | 2014-04-09 |
Family
ID=22482232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100228T CY1108827T1 (el) | 1999-06-10 | 2009-02-26 | Μονο-υποκατεστημενα 3-προπυλο γαμμα-αμινοβουτυρικα οξεα |
Country Status (43)
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7164034B2 (en) | 1999-06-10 | 2007-01-16 | Pfizer Inc. | Alpha2delta ligands for fibromyalgia and other disorders |
US6620829B2 (en) | 2000-10-17 | 2003-09-16 | Warner-Lambert Company | Method of treating noninflammatory cartilage damage |
KR100958552B1 (ko) * | 2001-06-11 | 2010-05-17 | 제노포트 인코포레이티드 | Gaba 유사체의 프로드러그, 이의 조성물 및 용도 |
US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
ITMI20011308A1 (it) | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per il dolore cronico |
KR20040081478A (ko) * | 2002-01-31 | 2004-09-21 | 워너-램버트 캄파니 엘엘씨 | 이명을 치료하기 위한 알파 2 델타 리간드 |
NI200300043A (es) | 2002-03-28 | 2003-11-05 | Warner Lambert Co | AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA. |
US20030225149A1 (en) | 2002-04-30 | 2003-12-04 | Blazecka Peter G. | Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids |
US7071339B2 (en) | 2002-08-29 | 2006-07-04 | Warner Lambert Company Llc | Process for preparing functionalized γ-butyrolactones from mucohalic acid |
EP1572188A1 (en) | 2002-12-13 | 2005-09-14 | Warner-Lambert Company LLC | Pregabalin derivatives for the treatment of fibromyalgia and other disorders |
MXPA05006209A (es) * | 2002-12-13 | 2005-08-19 | Warner Lambert Co | Pregabalina y sus derivados para el tratamiento de fibromialgia y otros trastornos relacionados. |
CA2451267A1 (en) | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
CA2509605C (en) | 2002-12-13 | 2010-10-05 | Warner-Lambert Company Llc | Alpha-2-delta ligand to treat lower urinary tract symptoms |
ITMI20022658A1 (it) | 2002-12-17 | 2004-06-18 | Nicox Sa | Farmaci per il dolore cronico. |
WO2005002585A1 (en) * | 2003-07-02 | 2005-01-13 | Warner-Lambert Company Llc | Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor |
ATE449633T1 (de) | 2003-09-12 | 2009-12-15 | Pfizer | Kombinationen aus alpha-2-delta liganden und serotonin / noradrenalin-wiederaufnahmehemmern |
CA2540208A1 (en) * | 2003-09-25 | 2005-04-07 | Warner-Lambert Company Llc | Amino acids with affinity for the alpha2delta-protein |
BRPI0414819A (pt) | 2003-09-25 | 2006-11-14 | Warner Lambert Co | pró-fármacos de aminoácidos com afinidade para a proteìna alfa2delta |
WO2006043171A2 (en) * | 2004-10-23 | 2006-04-27 | Warner-Lambert Company Llc | Methods of using alpha2delta-1 selective compounds |
JP2009507870A (ja) * | 2005-09-15 | 2009-02-26 | ユセベ ファルマ ソシエテ アノニム | 4−置換ピロリジン−2−オン及びそれらの使用 |
US20070141684A1 (en) * | 2005-12-21 | 2007-06-21 | Pfizer Inc | Preparation of gamma-amino acids having affinity for the alpha-2-delta protein |
AR061728A1 (es) * | 2006-06-30 | 2008-09-17 | Pfizer Prod Inc | Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1 |
EA017171B1 (ru) | 2006-12-22 | 2012-10-30 | Рекордати Айерленд Лимитед | КОМБИНИРОВАННАЯ ТЕРАПИЯ ЗАБОЛЕВАНИЙ НИЖНИХ МОЧЕВЫВОДЯЩИХ ПУТЕЙ С ИСПОЛЬЗОВАНИЕМ ЛИГАНДОВ αδ И НЕСТЕРОИДНЫХ ПРОТИВОВОСПАЛИТЕЛЬНЫХ ПРЕПАРАТОВ (НПВП) |
WO2009136375A1 (en) * | 2008-05-08 | 2009-11-12 | Pfizer Inc | Treatment of interstitial cystitis |
EP2509596B1 (en) | 2009-12-08 | 2019-08-28 | Case Western Reserve University | Gamma aminoacids for treating ocular disorders |
CN101914031B (zh) * | 2010-07-30 | 2013-08-28 | 中国广州分析测试中心 | 普瑞巴林衍生物及其应用 |
PT3364958T (pt) * | 2015-10-23 | 2023-04-10 | Navitor Pharm Inc | Moduladores de interação sestrina-gator2 e utilizações dos mesmos |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
US6197819B1 (en) * | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
AU9137091A (en) * | 1990-11-27 | 1992-06-25 | Northwestern University | Gaba and l-glutamic acid analogs for antiseizure treatment |
DK0641330T3 (da) * | 1992-05-20 | 2001-12-03 | Univ Northwestern | Gaba- og L-glutaminsyreanaloger til antikrampeanfaldsbehandling |
US5637767A (en) * | 1995-06-07 | 1997-06-10 | Warner-Lambert Company | Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
DK0934061T6 (en) * | 1996-07-24 | 2015-01-26 | Warner Lambert Co | Isobutylgaba and its derivatives for the treatment of pain |
US6153650A (en) * | 1996-10-23 | 2000-11-28 | Warner-Lambert Company | Substituted gamma aminobutyric acids as pharmaceutical agents |
KR100589066B1 (ko) * | 1997-10-27 | 2006-06-13 | 워너-램버트 캄파니 엘엘씨 | 약제로서 유용한 시클릭 아미노산 및 그의 유도체 |
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2000
- 2000-05-31 CA CA2689997A patent/CA2689997A1/en not_active Abandoned
- 2000-05-31 PT PT00938022T patent/PT1192125E/pt unknown
- 2000-05-31 MX MXPA01012319A patent/MXPA01012319A/es active IP Right Grant
- 2000-05-31 GE GE4667A patent/GEP20074142B/en unknown
- 2000-05-31 AP APAP/P/2002/002388A patent/AP1397A/en active
- 2000-05-31 OA OA1200100326A patent/OA11962A/en unknown
- 2000-05-31 JP JP2001503818A patent/JP3904452B2/ja not_active Expired - Fee Related
- 2000-05-31 TR TR2001/03587T patent/TR200103587T2/xx unknown
- 2000-05-31 AU AU53119/00A patent/AU776723C/en not_active Ceased
- 2000-05-31 CA CA2374755A patent/CA2374755C/en not_active Expired - Fee Related
- 2000-05-31 CN CNB2005100037011A patent/CN1310872C/zh not_active Expired - Fee Related
- 2000-05-31 SK SK1764-2001A patent/SK287247B6/sk not_active IP Right Cessation
- 2000-05-31 EA EA200101134A patent/EA004398B1/ru not_active IP Right Cessation
- 2000-05-31 SK SK5045-2009A patent/SK287399B6/sk not_active IP Right Cessation
- 2000-05-31 EE EEP200100672A patent/EE200100672A/xx unknown
- 2000-05-31 DE DE60041256T patent/DE60041256D1/de not_active Expired - Lifetime
- 2000-05-31 DZ DZ003253A patent/DZ3253A1/fr active
- 2000-05-31 DK DK00938022T patent/DK1192125T3/da active
- 2000-05-31 ME MEP-448/08A patent/MEP44808A/xx unknown
- 2000-05-31 CZ CZ20014285A patent/CZ300834B6/cs not_active IP Right Cessation
- 2000-05-31 KR KR1020017015841A patent/KR100694735B1/ko not_active IP Right Cessation
- 2000-05-31 WO PCT/US2000/015070 patent/WO2000076958A2/en active Application Filing
- 2000-05-31 HU HU0201601A patent/HUP0201601A3/hu unknown
- 2000-05-31 CN CNB00808730XA patent/CN1196671C/zh not_active Expired - Fee Related
- 2000-05-31 RS RSP-2009/0257A patent/RS20090257A/sr unknown
- 2000-05-31 ES ES00938022T patent/ES2317839T3/es not_active Expired - Lifetime
- 2000-05-31 IL IL14696900A patent/IL146969A0/xx active IP Right Grant
- 2000-05-31 BR BR0011727-7A patent/BR0011727A/pt not_active IP Right Cessation
- 2000-05-31 CZ CZ20080760A patent/CZ301608B6/cs not_active IP Right Cessation
- 2000-05-31 NZ NZ515668A patent/NZ515668A/xx not_active IP Right Cessation
- 2000-05-31 SI SI200031015T patent/SI1192125T1/sl unknown
- 2000-05-31 UA UA2001128283A patent/UA72519C2/uk unknown
- 2000-05-31 EP EP00938022A patent/EP1192125B9/en not_active Expired - Lifetime
- 2000-05-31 AT AT00938022T patent/ATE419231T1/de not_active IP Right Cessation
- 2000-05-31 RS YUP-870/01A patent/RS50352B/sr unknown
- 2000-06-07 AR ARP000102808A patent/AR033335A1/es active IP Right Grant
- 2000-06-09 PE PE2000000577A patent/PE20010285A1/es not_active Application Discontinuation
- 2000-06-09 CO CO00043067A patent/CO5200791A1/es not_active Application Discontinuation
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2001
- 2001-11-26 ZA ZA200109711A patent/ZA200109711B/en unknown
- 2001-11-28 IS IS6181A patent/IS6181A/is unknown
- 2001-12-05 NO NO20015949A patent/NO327746B1/no not_active IP Right Cessation
- 2001-12-06 CU CU20010291A patent/CU23101A3/es not_active IP Right Cessation
- 2001-12-06 IL IL146969A patent/IL146969A/en not_active IP Right Cessation
- 2001-12-07 CR CR6529A patent/CR6529A/es not_active Application Discontinuation
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2002
- 2002-01-02 MA MA26462A patent/MA26804A1/fr unknown
- 2002-01-09 BG BG106292A patent/BG65561B1/bg unknown
- 2002-01-10 HR HR20020025A patent/HRP20020025A2/hr not_active Application Discontinuation
- 2002-10-30 HK HK02107862.8A patent/HK1046401B/zh not_active IP Right Cessation
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2005
- 2005-09-29 HK HK05108612A patent/HK1076626A1/xx not_active IP Right Cessation
-
2009
- 2009-02-26 CY CY20091100228T patent/CY1108827T1/el unknown
- 2009-03-13 NO NO20091094A patent/NO20091094L/no not_active Application Discontinuation
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