BR0011727A - ácidos 3-propil gama-aminobutìricos mono- e dissubstituìdos - Google Patents

ácidos 3-propil gama-aminobutìricos mono- e dissubstituìdos

Info

Publication number
BR0011727A
BR0011727A BR0011727-7A BR0011727A BR0011727A BR 0011727 A BR0011727 A BR 0011727A BR 0011727 A BR0011727 A BR 0011727A BR 0011727 A BR0011727 A BR 0011727A
Authority
BR
Brazil
Prior art keywords
disubstituted
aminobutyric acids
disorders
mono
propyl gamma
Prior art date
Application number
BR0011727-7A
Other languages
English (en)
Inventor
Thomas Richard Belliotti
Justin Stephen Bryans
Ihoezo Victor Ekhato
Augustine Tobi Osuma
Robert Michael Schelkun
Jacob Bradley Schwarz
Andrew John Thorpe
Lawrence David Wise
David Juergen Wustrow
Po-Wai Yuen
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR0011727A publication Critical patent/BR0011727A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/20—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/32—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção: "áCIDOS 3-PROPIL GAMA-AMINOBUTìRICOS MONO- E DISSUBSTITUìDOS". A presente invenção é uma série de ácidos 3-propil gama aminobutíricos mono- e dissubstituídos da Fórmula (I). Os compostos são úteis como agentes terapêuticos no tratamento de epilepsia, ataques de desmaio, hipocinesia, distúrbios cranianos, distúrbios neurodegenerativos, depressão, ansiedade, pânico, dor, distúrbios neuropatológicos, artrite, distúrbios do sono, IBS e dano gástrico. Métodos de preparação de compostos e intermediários úteis são também parte da invenção.
BR0011727-7A 1999-06-10 2000-05-31 ácidos 3-propil gama-aminobutìricos mono- e dissubstituìdos BR0011727A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13848599P 1999-06-10 1999-06-10
PCT/US2000/015070 WO2000076958A2 (en) 1999-06-10 2000-05-31 Mono- and disubstituted 3-propyl gamma-aminobutyric acids

Publications (1)

Publication Number Publication Date
BR0011727A true BR0011727A (pt) 2002-03-05

Family

ID=22482232

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011727-7A BR0011727A (pt) 1999-06-10 2000-05-31 ácidos 3-propil gama-aminobutìricos mono- e dissubstituìdos

Country Status (43)

Country Link
EP (1) EP1192125B9 (pt)
JP (1) JP3904452B2 (pt)
KR (1) KR100694735B1 (pt)
CN (2) CN1310872C (pt)
AP (1) AP1397A (pt)
AR (1) AR033335A1 (pt)
AT (1) ATE419231T1 (pt)
AU (1) AU776723C (pt)
BG (1) BG65561B1 (pt)
BR (1) BR0011727A (pt)
CA (2) CA2689997A1 (pt)
CO (1) CO5200791A1 (pt)
CR (1) CR6529A (pt)
CU (1) CU23101A3 (pt)
CY (1) CY1108827T1 (pt)
CZ (2) CZ301608B6 (pt)
DE (1) DE60041256D1 (pt)
DK (1) DK1192125T3 (pt)
DZ (1) DZ3253A1 (pt)
EA (1) EA004398B1 (pt)
EE (1) EE200100672A (pt)
ES (1) ES2317839T3 (pt)
GE (1) GEP20074142B (pt)
HK (2) HK1046401B (pt)
HR (1) HRP20020025A2 (pt)
HU (1) HUP0201601A3 (pt)
IL (2) IL146969A0 (pt)
IS (1) IS6181A (pt)
MA (1) MA26804A1 (pt)
ME (1) MEP44808A (pt)
MX (1) MXPA01012319A (pt)
NO (2) NO327746B1 (pt)
NZ (1) NZ515668A (pt)
OA (1) OA11962A (pt)
PE (1) PE20010285A1 (pt)
PT (1) PT1192125E (pt)
RS (2) RS50352B (pt)
SI (1) SI1192125T1 (pt)
SK (2) SK287399B6 (pt)
TR (1) TR200103587T2 (pt)
UA (1) UA72519C2 (pt)
WO (1) WO2000076958A2 (pt)
ZA (1) ZA200109711B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7164034B2 (en) 1999-06-10 2007-01-16 Pfizer Inc. Alpha2delta ligands for fibromyalgia and other disorders
US6620829B2 (en) * 2000-10-17 2003-09-16 Warner-Lambert Company Method of treating noninflammatory cartilage damage
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
EP1404324B2 (en) * 2001-06-11 2011-04-06 XenoPort, Inc. Prodrugs of gaba analogs, compositions and uses thereof
ITMI20011308A1 (it) 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
PL371944A1 (en) 2002-01-31 2005-07-11 Warner-Lambert Company Llc Alpha 2 delta ligands to treat tinnitus
NI200300043A (es) 2002-03-28 2003-11-05 Warner Lambert Co AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.
US20030225149A1 (en) * 2002-04-30 2003-12-04 Blazecka Peter G. Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids
US7071339B2 (en) 2002-08-29 2006-07-04 Warner Lambert Company Llc Process for preparing functionalized γ-butyrolactones from mucohalic acid
CA2451267A1 (en) 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
CA2509605C (en) 2002-12-13 2010-10-05 Warner-Lambert Company Llc Alpha-2-delta ligand to treat lower urinary tract symptoms
CA2505788A1 (en) 2002-12-13 2004-07-01 Warner-Lambert Company Llc Pregabalin derivatives for the treatment of fibromyalgia and other disorders
EP1572187A1 (en) * 2002-12-13 2005-09-14 Warner-Lambert Company LLC Pregabalin and derivatives thereof for the treatment of fibromyalgia and other related disorders
ITMI20022658A1 (it) 2002-12-17 2004-06-18 Nicox Sa Farmaci per il dolore cronico.
EP1680125A1 (en) * 2003-07-02 2006-07-19 Warner-Lambert Company LLC Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor
MXPA06002789A (es) 2003-09-12 2006-06-14 Pfizer Combinaciones que comprenden ligandos alfa-2-delta.
MXPA06003396A (es) 2003-09-25 2006-06-08 Warner Lambert Co Profarmacos de aminoacidos con afinidad por la proteina a 2d.
KR100768974B1 (ko) * 2003-09-25 2007-10-22 워너-램버트 캄파니 엘엘씨 알파2델타-단백질에 대한 친화성을 갖는 아미노산
WO2006043171A2 (en) * 2004-10-23 2006-04-27 Warner-Lambert Company Llc Methods of using alpha2delta-1 selective compounds
NZ566240A (en) * 2005-09-15 2011-05-27 Ucb Pharma Sa 4-substituted pyrrolidin-2-ones and their use
US20070141684A1 (en) * 2005-12-21 2007-06-21 Pfizer Inc Preparation of gamma-amino acids having affinity for the alpha-2-delta protein
AR061728A1 (es) * 2006-06-30 2008-09-17 Pfizer Prod Inc Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1
KR20090092307A (ko) 2006-12-22 2009-08-31 레코르다티 아일랜드 리미티드 하요도 장애에 대한 α2δ 리간드 및 ＮＳＡＩＤｓ의 복합 치료
WO2009136375A1 (en) * 2008-05-08 2009-11-12 Pfizer Inc Treatment of interstitial cystitis
WO2011071995A2 (en) 2009-12-08 2011-06-16 Case Western Reserve University Compounds and methods of treating ocular disorders
CN101914031B (zh) * 2010-07-30 2013-08-28 中国广州分析测试中心 普瑞巴林衍生物及其应用
HUE061437T2 (hu) * 2015-10-23 2023-06-28 Navitor Pharm Inc A Sestrin-GATOR2 kölcsönhatás modulátorai és ezek alkalmazásai

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4087544A (en) * 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
WO1992009560A1 (en) * 1990-11-27 1992-06-11 Northwestern University Gaba and l-glutamic acid analogs for antiseizure treatment
CA2134674C (en) * 1992-05-20 2004-12-21 Richard B. Silverman Gaba and l-glutamic acid analogs for antiseizure treatment
US5637767A (en) * 1995-06-07 1997-06-10 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
USRE41920E1 (en) * 1996-07-24 2010-11-09 Warner-Lambert Company Llc Isobutylgaba and its derivatives for the treatment of pain
DE69737719D1 (de) * 1996-10-23 2007-06-21 Warner Lambert Co Substituierte gamma-aminobuttersäurederivate als arzneimittel
GEP20094817B (en) * 1997-10-27 2009-11-10 Warner Lambert Co Cyclic amino acids and derivatives thereof useful as pharmaceutical agents

Also Published As

Publication number Publication date
EE200100672A (et) 2003-02-17
CU23101A3 (es) 2005-12-20
AP2002002388A0 (en) 2002-03-31
CN1196671C (zh) 2005-04-13
HUP0201601A2 (en) 2002-10-28
GEP20074142B (en) 2007-07-10
HK1076626A1 (en) 2006-01-20
CN1310872C (zh) 2007-04-18
NZ515668A (en) 2004-02-27
ES2317839T3 (es) 2009-05-01
MXPA01012319A (es) 2002-07-22
SK17642001A3 (sk) 2002-10-08
UA72519C2 (en) 2005-03-15
HUP0201601A3 (en) 2002-11-28
EP1192125B1 (en) 2008-12-31
CO5200791A1 (es) 2002-09-27
RS50352B (sr) 2009-11-10
JP2003502308A (ja) 2003-01-21
NO20091094L (no) 2001-12-05
WO2000076958A2 (en) 2000-12-21
EP1192125A2 (en) 2002-04-03
NO20015949L (no) 2001-12-05
CZ20014285A3 (cs) 2002-07-17
OA11962A (en) 2006-04-17
CA2689997A1 (en) 2000-12-21
MEP44808A (en) 2011-02-10
BG65561B1 (bg) 2008-12-30
BG106292A (en) 2002-05-31
HRP20020025A2 (en) 2003-12-31
JP3904452B2 (ja) 2007-04-11
AU776723B2 (en) 2004-09-16
DK1192125T3 (da) 2009-02-16
KR100694735B1 (ko) 2007-03-14
YU87001A (sh) 2004-07-15
EP1192125B9 (en) 2009-09-16
CN1660779A (zh) 2005-08-31
ATE419231T1 (de) 2009-01-15
AU776723C (en) 2005-06-02
IS6181A (is) 2001-11-28
DZ3253A1 (fr) 2000-12-21
IL146969A (en) 2008-03-20
PT1192125E (pt) 2009-03-05
WO2000076958A3 (en) 2001-04-12
DE60041256D1 (de) 2009-02-12
ZA200109711B (en) 2003-03-20
KR20020009631A (ko) 2002-02-01
NO327746B1 (no) 2009-09-14
HK1046401B (zh) 2005-12-02
AP1397A (en) 2005-04-19
CR6529A (es) 2003-11-25
AU5311900A (en) 2001-01-02
AR033335A1 (es) 2003-12-17
PE20010285A1 (es) 2001-03-22
SI1192125T1 (sl) 2009-04-30
EA200101134A1 (ru) 2002-06-27
CY1108827T1 (el) 2014-04-09
SK287399B6 (sk) 2010-08-09
PL352431A1 (en) 2003-08-25
SK287247B6 (sk) 2010-04-07
CA2374755C (en) 2010-03-30
RS20090257A (en) 2010-03-02
NO20015949D0 (no) 2001-12-05
CN1355784A (zh) 2002-06-26
CZ301608B6 (cs) 2010-04-28
HK1046401A1 (en) 2003-01-10
EA004398B1 (ru) 2004-04-29
CZ300834B6 (cs) 2009-08-19
IL146969A0 (en) 2002-08-14
CA2374755A1 (en) 2000-12-21
MA26804A1 (fr) 2004-12-20
TR200103587T2 (tr) 2002-04-22

Similar Documents

Publication Publication Date Title
BR0011727A (pt) ácidos 3-propil gama-aminobutìricos mono- e dissubstituìdos
MX9806069A (es) Novedosos amino acidos ciclicos substituidos como agentes farmaceuticos.
GEP20043297B (en) Bicyclic Amino Acids as Pharmaceutical Agents
HRP970560B1 (en) Substituted gamma aminobutyric acids as pharmaceutical agents
GEP20094817B (en) Cyclic amino acids and derivatives thereof useful as pharmaceutical agents
PT888325E (pt) Novos amino acidos ciclicos como agentes farmaceuiticos
ES2169848T3 (es) Nuevos aminoacidos ciclicos coronados como agentes farmaceuticos.
RU94045155A (ru) Способы ингибирования болезни альцгеймера
EA200400881A1 (ru) Азаарилпиперазины
DE69921340D1 (de) Verzweigte alkylpyrrolidin-3-carbonsäuren
ES2185591T3 (es) Amino hererociclos utiles como agentes farmaceuticos.
ECSP003522A (es) Acidos 3- propilgamma- aminobutiricos mono- y, disustituidos
BR0313284A (pt) Utilização terapêutica de derivados de aril-aminoácidos
CA2245647A1 (en) Novel bridged cyclic amino acids as pharmaceutical agents
RU2002113429A (ru) Способ лечения псориаза

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 11 E 13 DA LPI.

B12B Appeal against refusal [chapter 12.2 patent gazette]
B25D Requested change of name of applicant approved

Owner name: WARNER-LAMBERT COMPANY LLC (US)

Free format text: NOME ALTERADO DE: WARNER-LAMBERT COMPANY

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07F Notification of approval that there is no relation to art. 229 of lpi (pipeline patents) [chapter 7.6 patent gazette]

Free format text: NOTIFICACAO DE NAO ANUENCIA RELACIONADA COM O ART. 229 DA LPI

B08L Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 12A, 13A E 14A ANUIDADES.

B08I Publication cancelled [chapter 8.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2258 DE 15/04/2014 POR TER SIDO INDEVIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 12A, 13A, 14A, 15A, 16A, 17A, 18A, 19A E 20A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.