RU94045155A - Способы ингибирования болезни альцгеймера - Google Patents

Способы ингибирования болезни альцгеймера

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Publication number
RU94045155A
RU94045155A RU94045155/14A RU94045155A RU94045155A RU 94045155 A RU94045155 A RU 94045155A RU 94045155/14 A RU94045155/14 A RU 94045155/14A RU 94045155 A RU94045155 A RU 94045155A RU 94045155 A RU94045155 A RU 94045155A
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RU
Russia
Prior art keywords
compound
formula
treatment
methods
alzheimer
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RU94045155/14A
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English (en)
Other versions
RU2128992C1 (ru
Inventor
Корнелиус Мэй Патрик
Us]
Original Assignee
Эли Лилли энд Компани (US)
Эли Лилли Энд Компани
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Application filed by Эли Лилли энд Компани (US), Эли Лилли Энд Компани filed Critical Эли Лилли энд Компани (US)
Publication of RU94045155A publication Critical patent/RU94045155A/ru
Application granted granted Critical
Publication of RU2128992C1 publication Critical patent/RU2128992C1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

Данное изобретение включает способы ингибирования болезни Альцгеймера, состоящие во введении человеку при необходимости лечения эффективного количества соединения формулы I, приведенной в описании.Данное изобретение предлагает также способы увеличения выделения в головной мозг TGF-бета, включающие введение человеку при необходимости лечения эффективного количества соединения формулы 1. Данное изобретение предлагает также способы ингибирования нейротоксичности, проводимой бета-амилоидными пептидами, или воспалительной реакции, связанной с болезнью Альцгеймера (БА), включающие введение человеку при необходимости лечения эффективного количества соединения формулы 1

Claims (1)

  1. Данное изобретение включает способы ингибирования болезни Альцгеймера, состоящие во введении человеку при необходимости лечения эффективного количества соединения формулы I, приведенной в описании.Данное изобретение предлагает также способы увеличения выделения в головной мозг TGF-бета, включающие введение человеку при необходимости лечения эффективного количества соединения формулы 1. Данное изобретение предлагает также способы ингибирования нейротоксичности, проводимой бета-амилоидными пептидами, или воспалительной реакции, связанной с болезнью Альцгеймера (БА), включающие введение человеку при необходимости лечения эффективного количества соединения формулы 1.
RU94045155A 1993-12-21 1994-12-19 Средство для ингибирования нейротоксичности, вызываемой бета-амилоидными пептидами RU2128992C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/171,387 US5552415A (en) 1993-12-21 1993-12-21 Method of inhibiting Alzheimer's Disease
US08/171,387 1993-12-21
US08/171387 1993-12-21

Publications (2)

Publication Number Publication Date
RU94045155A true RU94045155A (ru) 1996-11-10
RU2128992C1 RU2128992C1 (ru) 1999-04-20

Family

ID=22623556

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94045155A RU2128992C1 (ru) 1993-12-21 1994-12-19 Средство для ингибирования нейротоксичности, вызываемой бета-амилоидными пептидами

Country Status (14)

Country Link
US (3) US5552415A (ru)
EP (1) EP0659418A1 (ru)
JP (1) JPH07215854A (ru)
KR (1) KR950016738A (ru)
CN (2) CN1087937C (ru)
AU (1) AU688815B2 (ru)
CA (1) CA2138495A1 (ru)
CZ (1) CZ288984B6 (ru)
HU (1) HUT71465A (ru)
IL (1) IL112050A (ru)
NO (1) NO944928L (ru)
NZ (1) NZ270177A (ru)
RU (1) RU2128992C1 (ru)
ZA (1) ZA9410095B (ru)

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Also Published As

Publication number Publication date
NO944928L (no) 1995-06-22
HUT71465A (en) 1995-11-28
US5686476A (en) 1997-11-11
CN1294913A (zh) 2001-05-16
NO944928D0 (no) 1994-12-19
ZA9410095B (en) 1996-06-19
AU8154694A (en) 1995-06-29
CN1108098A (zh) 1995-09-13
CZ322094A3 (en) 1995-09-13
CA2138495A1 (en) 1995-06-22
IL112050A (en) 1999-03-12
US5552415A (en) 1996-09-03
AU688815B2 (en) 1998-03-19
KR950016738A (ko) 1995-07-20
JPH07215854A (ja) 1995-08-15
CN1087937C (zh) 2002-07-24
US5652259A (en) 1997-07-29
IL112050A0 (en) 1995-03-15
CZ288984B6 (cs) 2001-10-17
NZ270177A (en) 1997-08-22
EP0659418A1 (en) 1995-06-28
HU9403668D0 (en) 1995-02-28
RU2128992C1 (ru) 1999-04-20

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