PT1511710E - Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson - Google Patents

Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson Download PDF

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PT1511710E
PT1511710E PT37563434T PT03756343T PT1511710E PT 1511710 E PT1511710 E PT 1511710E PT 37563434 T PT37563434 T PT 37563434T PT 03756343 T PT03756343 T PT 03756343T PT 1511710 E PT1511710 E PT 1511710E
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disease
synucleinopathies
parkinson
alzheimer
diabetes
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PT37563434T
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English (en)
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Alan D Snow
Thomas P Lake
Beth P Nguyen
Virginia J Sanders
Gerardo M Castillo
Lesley Larsen
Rex T Weavers
Stephen D Lorimer
David L Coffen
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Proteotech Inc
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Publication of PT1511710E publication Critical patent/PT1511710E/pt

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    • C07C49/245Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
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PT37563434T 2002-05-31 2003-05-30 Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson PT1511710E (pt)

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Families Citing this family (83)

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Publication number Priority date Publication date Assignee Title
US20070208087A1 (en) 2001-11-02 2007-09-06 Sanders Virginia J Compounds, compositions and methods for the treatment of inflammatory diseases
US20140005240A1 (en) * 2002-05-31 2014-01-02 Alan D. Snow Compounds and compositions for use as modulators of tau aggregation and alleviation of tauopathies
US20130137775A1 (en) * 2002-05-31 2013-05-30 Alan D. Snow Compositions and methods for the treatment of systemic aa amyloid diseases
US20070276034A1 (en) * 2002-05-31 2007-11-29 Luke Esposito Compounds, compositions and methods for the treatment of synucleinopathies
US8227643B2 (en) * 2002-05-31 2012-07-24 Proteotech, Inc. Sirtuin 1 and the treatment of neurodegenerative diseases
US20110104055A1 (en) * 2002-05-31 2011-05-05 Alan Snow Substituted n-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies
US8829198B2 (en) * 2007-10-31 2014-09-09 Proteotech Inc Compounds, compositions and methods for the treatment of beta-amyloid diseases and synucleinopathies
US7601876B2 (en) * 2002-05-31 2009-10-13 Proteotech, Inc. Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis
PT1511710E (pt) * 2002-05-31 2014-02-26 Proteotech Inc Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson
JP2006512306A (ja) * 2002-08-29 2006-04-13 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション アリール及びヘテロアリールプロペンアミド、それらの誘導体並びにそれらの治療用途
RU2333203C2 (ru) 2002-12-25 2008-09-10 Дайити Фармасьютикал Ко., Лтд. Диаминовые производные
JP4630267B2 (ja) * 2002-12-25 2011-02-09 第一三共株式会社 ジアミン誘導体
US8916598B2 (en) 2003-05-30 2014-12-23 Proteotech Inc Compounds, compositions, and methods for the treatment of β-amyloid diseases and synucleinopathies
US20090227647A1 (en) * 2008-03-05 2009-09-10 Thomas Lake Compounds, Compositions and Methods for the Treatment of Islet Amyloid Polypeptide (IAPP) Accumulation in Diabetes
US20100331380A1 (en) * 2009-06-29 2010-12-30 Esposito Luke A Compounds, Compositions, and Methods for the Treatment of Beta-Amyloid Diseases and Synucleinopathies
RU2381213C2 (ru) * 2004-05-12 2010-02-10 Протеотек, Инк. Замещенные n-арилбензамиды и родственные соединения для лечения амилоидных заболеваний и синуклеинопатии
EP1757591A4 (en) * 2004-05-26 2010-05-05 Eisai R&D Man Co Ltd ZIMTSÄUREAMIDVERBINDUNG
GB0415181D0 (en) 2004-07-06 2004-08-11 School Of Pharmacy The Univers Compounds for use in the treatment of infection
DE102004041496A1 (de) * 2004-08-27 2006-03-02 Symrise Gmbh & Co. Kg Hydroxybenzoesäureamide und deren Verwendung zur Maskierung von bitterem Geschmack
WO2006034003A2 (en) * 2004-09-17 2006-03-30 Whitehead Institute For Biomedical Research Compounds, compositions and methods of inhibiting a-synuclein toxicity
JPWO2006046575A1 (ja) * 2004-10-26 2008-05-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 シンナミド化合物の非晶質体
FR2892923B1 (fr) * 2005-11-08 2009-01-16 Engelhard Lyon Sa Utilisatiion des derives de l'acide para-coumarique ou para- hydroxycinnamique dans des compositions cosmetiques ou dermatologiques.
EP3006424A1 (en) * 2005-11-11 2016-04-13 The Scripps Research Institute Histone deacetylase inhibitors as therapeutics for neurological diseases
US20090270623A1 (en) * 2005-11-18 2009-10-29 Naoyuki Shimomura Process for production of cinnamide derivative
JPWO2007058304A1 (ja) * 2005-11-18 2009-05-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 シンナミド化合物の塩またはそれらの溶媒和物
TWI370130B (en) * 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
NZ568050A (en) * 2005-11-24 2010-09-30 Eisai R&D Man Co Ltd Morpholine type cinnamide compound
AU2006324167A1 (en) 2005-12-13 2007-06-21 Wyeth Dibenzonaphthyridine derivatives and methods of use thereof
JP2009084155A (ja) * 2006-01-16 2009-04-23 Kanazawa Univ レビー小体病治療薬及びレビー小体病予防薬
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
SA07280403B1 (ar) * 2006-07-28 2010-12-01 إيساي أر أند دي منجمنت كو. ليمتد ملح رباعي لمركب سيناميد
US8058309B2 (en) * 2006-12-04 2011-11-15 Novotyr Therapeutics Ltd. Protein kinase modulators and therapeutic uses thereof
US20120083528A1 (en) * 2006-12-04 2012-04-05 Novotyr Therapeutics Ltd. Novel protein kinase modulators and therapeutic uses thereof
TW200848054A (en) * 2007-02-28 2008-12-16 Eisai R&D Man Co Ltd Two cyclic oxomorpholine derivatives
WO2008140111A1 (ja) * 2007-05-16 2008-11-20 Eisai R & D Management Co., Ltd. シンナミド誘導体のワンポット製造方法
WO2009026658A1 (en) * 2007-08-29 2009-03-05 The University Of Sydney Ppar agonists
US7935815B2 (en) * 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
AU2008292390B2 (en) 2007-08-31 2013-04-04 Eisai R & D Management Co., Ltd. Polycyclic compound
GB0719559D0 (en) * 2007-10-05 2007-11-14 Senexis Ltd Compounds
EP2239265A1 (en) * 2008-01-28 2010-10-13 Eisai R&D Management Co., Ltd. Crystalline cinnamide compounds or salts thereof
US20110027725A1 (en) * 2008-04-04 2011-02-03 Kiyoharu Tsutsumi Polyol compound for photoresist
ES2537529T3 (es) * 2008-06-05 2015-06-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Novedosos moduladores de la señalización de proteínas cinasas
PT2307381T (pt) * 2008-06-09 2021-03-15 Univ Muenchen Ludwig Maximilians Novas drogas para inibir a agregação de proteínas envolvidas em doenças relacionadas com a agregação de proteínas e/ou doenças neurodegenerativas
WO2010043631A1 (en) * 2008-10-17 2010-04-22 Universite Libre De Bruxelles Di-vanilloyl and tri-vanilloyl derivatives for use in anti-cancer therapy
WO2011061744A2 (en) 2009-11-19 2011-05-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Novel arylated camphenes, processes for their preparation and uses thereof
WO2011119869A1 (en) * 2010-03-24 2011-09-29 Medical University Of South Carolina Compositions and methods for the treatment of degenerative diseases
WO2011118812A1 (ja) * 2010-03-26 2011-09-29 国立大学法人北海道大学 神経変性疾患治療薬
EP2566333A4 (en) 2010-05-07 2014-04-02 Univ Leland Stanford Junior IDENTIFICATION OF STABILIZERS OF MULTIMEDER PROTEINS
SG185515A1 (en) * 2010-05-13 2012-12-28 Amgen Inc Nitrogen heterocyclic compounds useful as pde10 inhibitors
KR101164869B1 (ko) * 2010-06-16 2012-07-19 한국해양연구원 페놀계 화합물, 그 제조방법 및 이를 포함하는 항균 조성물
EP2428503B1 (de) * 2010-09-10 2014-12-10 Justus-Liebig-Universität Gießen Synthese von tripodalen Catecholderivaten mit einem flexiblen Grundgerüst zur Funktionalisierung von Oberflächen
WO2012068405A2 (en) 2010-11-17 2012-05-24 Isis Pharmaceuticals, Inc. Modulation of alpha synuclein expression
US20120251448A1 (en) * 2011-03-03 2012-10-04 Hefti Franz F Compounds for Use in the Detection of Neurodegenerative Diseases
WO2012118935A1 (en) * 2011-03-03 2012-09-07 Proteotech Inc Compounds for the treatment of neurodegenerative diseases
JP2012246224A (ja) * 2011-05-25 2012-12-13 Suntory Holdings Ltd 抗認知症および学習記憶改善剤
US9169255B2 (en) 2011-10-27 2015-10-27 Proteo Tech Inc. Caffeinated compounds and compositions for treatment of amyloid diseases and synucleinopathies
WO2013078413A1 (en) * 2011-11-22 2013-05-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Modulators of lipid storage
WO2013106328A1 (en) * 2012-01-09 2013-07-18 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes for treatment of early onset alzheimer's disease
WO2013128927A1 (ja) * 2012-02-29 2013-09-06 国立大学法人東京医科歯科大学 新規アンドロゲン受容体アンタゴニスト
GB201208775D0 (en) 2012-05-18 2012-07-04 Uni I Oslo Chemical compounds
JP6291158B2 (ja) * 2012-11-21 2018-03-14 サントリーホールディングス株式会社 抗認知症および学習記憶改善剤
MX2015012559A (es) * 2013-03-15 2016-07-18 Techfields Pharma Co Ltd Novedosos fármacos de alta penetración y sus composiciones para el tratamiento de enfermedades de parkinson.
KR101467673B1 (ko) 2013-03-26 2014-12-04 계명대학교 산학협력단 신규한 페놀산 유도체 및 이의 항산화제로서의 용도
WO2014162320A2 (en) * 2013-04-04 2014-10-09 Sphaera Pharma Pvt. Ltd. Novel analogues of epicatechin and related polyphenols
CN104276973B (zh) * 2013-07-05 2017-05-10 中国科学院大连化学物理研究所 一种羟基肉桂酸胺类生物碱及其制备和应用
WO2015008206A1 (en) 2013-07-14 2015-01-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Igf-1r signaling pathway inhibitors useful in the treatment of neurodegenerative diseases
WO2016013030A2 (en) 2014-07-23 2016-01-28 Sphaera Pharma Pvt. Ltd. Hydroxysteroid compounds, their intermediates, process of preparation, composition and uses thereof
EP3253733B1 (en) 2015-02-05 2020-04-29 TyrNovo Ltd. Combinations of irs/stat3 dual modulators and anti-cancer agents for treating cancer
GB2541910B (en) 2015-09-03 2021-10-27 Thermographic Measurements Ltd Thermochromic composition
BR112018004249A2 (pt) * 2015-09-04 2018-12-04 Shin Poong Pharmaceutical Co., Ltd. composto, e, composição para prevenção ou tratamento de doenças trombóticas.
US10300155B2 (en) 2015-12-31 2019-05-28 Washington University Alpha-synuclein ligands
AU2017244139A1 (en) * 2016-03-31 2018-09-13 Merck Patent Gmbh Compounds for the inhibition of cyclophilins and uses thereof
JP7067745B2 (ja) 2016-06-21 2022-05-16 スフェラ ファーマ ピーブイティー リミテッド (+)-エピカテキン及びその類似体の有用性
WO2018119395A1 (en) * 2016-12-23 2018-06-28 Aquinnah Pharmaceuticals, Inc. Compouns, compositions and methods of use
NZ755597A (en) 2017-02-17 2023-06-30 Eidos Therapeutics Inc Processes for preparing ag-10, its intermediates, and salts thereof
CN109400573B (zh) * 2017-08-17 2023-04-11 中国人民解放军第二军医大学 苯并[d][1,3]二氧杂环戊烯类化合物、制备方法及其应用
JP6987104B2 (ja) * 2017-12-28 2021-12-22 テックフィールズ ファーマ カンパニー リミテッド パ−キンソン病治療用の新規高透過薬物及びその組成物
CN111836624A (zh) 2018-01-12 2020-10-27 百时美施贵宝公司 靶向α-突触核蛋白的反义寡核苷酸及其用途
JP2021518381A (ja) 2018-03-23 2021-08-02 エイドス セラピューティクス,インコーポレイティド Ag10を使用するttrアミロイドーシスの治療方法
US11260047B2 (en) 2018-08-17 2022-03-01 Eidos Therapeutics, Inc. Formulations of AG10
CA3129243A1 (en) * 2019-02-07 2020-08-13 Alsatech, Inc. Polyvalent derivatives of emoxypine
CA3148602A1 (en) * 2019-08-02 2021-02-11 Acelot, Inc. Small molecule drugs and related methods for treatment of diseases related to tdp-43, alpha-synuclein, huntingtin's protein and tau protein oligomer formation
CN112830884B (zh) * 2019-11-22 2024-06-14 深圳市高盈医药科技开发有限公司 一种丹参素衍生物及其制备方法及其医药用途

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US197692A (en) * 1877-11-27 Improvement in car-axles
US111309A (en) * 1871-01-31 Improvement in hat-supporters and ventilators combined
US47032A (en) * 1865-03-28 Improvement in buck-saw frames
US168753A (en) * 1875-10-11 Improvement in hemmer attachments for sewing-machines
US86067A (en) * 1869-01-19 Improvement in piston steam-valves
US151506A (en) * 1874-06-02 Improvement in friction-gearings
US150948A (en) * 1874-05-19 Improvement in carving-tools
US17998A (en) * 1857-08-11 sturtevant
US153734A (en) * 1874-08-04 Improvement in weather-strips
US13648A (en) * 1855-10-09 Variable exhaust of locomotive-engines
US119934A (en) * 1871-10-17 Improvement in cotton-presses
US2769817A (en) 1951-06-07 1956-11-06 Nat Drug Co Therapeutic substituted chalcones
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3803120A (en) * 1971-09-28 1974-04-09 Hoffmann La Roche Di-and tripeptides of 3-(3,4-dihydroxyphenyl)-alanine
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
FR2302745A1 (fr) * 1975-03-07 1976-10-01 Screen Esters heterosidiques d'acide cafeique, leurs procedes de preparation e
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4710384A (en) 1986-07-28 1987-12-01 Avner Rotman Sustained release tablets made from microcapsules
JP2587842B2 (ja) 1987-12-09 1997-03-05 株式会社ニチレイ 神経疾患治療・予防剤
EP0324521A3 (en) * 1988-01-11 1991-11-27 Duphar International Research B.V Method of treating haematologic diseases and pharmaceutical compositions to be used therefor
US5166180A (en) 1988-01-11 1992-11-24 Duphar International Research B.V. Method of treating hematologic diseases and pharmaceutical composition to be used therefor
US5061629A (en) 1988-01-26 1991-10-29 Hoffman-La Roche Inc. Production of 2-hydroxy substituted arylalkanoic acids and esters by enzymatic hydrolysis
JPH01291242A (ja) * 1988-05-18 1989-11-22 Tosoh Corp 新規感光剤含有ポジ型フォトレジスト組成物
DE3822449A1 (de) 1988-07-02 1990-01-04 Henkel Kgaa Oxidationshaarfaerbemittel mit neuen kupplern
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5478579A (en) 1991-02-06 1995-12-26 Biodyn Medical Research, Inc. Method for treatment of osteoporosis
EP0515128A1 (en) 1991-05-23 1992-11-25 Konica Corporation Silver halide color photographic light-sensitive material
GB2264707A (en) 1991-06-18 1993-09-08 Roger Michael Marchbanks Acridine derivatives for treating alzheimer's disease
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5958883A (en) 1992-09-23 1999-09-28 Board Of Regents Of The University Of Washington Office Of Technology Animal models of human amyloidoses
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US5643562A (en) 1993-03-29 1997-07-01 Queen's University Of Kingston Method for treating amyloidosis
US5840294A (en) 1993-03-29 1998-11-24 Queen's University At Kingston Method for treating amyloidosis
US5552415A (en) 1993-12-21 1996-09-03 Eli Lilly And Company Method of inhibiting Alzheimer's Disease
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US5610185A (en) * 1995-02-17 1997-03-11 The United States Of America As Represented By The Department Of Health And Human Services Method for the treatment of hyperproliferative epithelial skin diseases by topical application of hydroxylated aromatic protein cross-linking compounds
EP0937137A4 (en) 1996-06-06 2002-10-23 Univ Washington PERLECAN EXPRESSIVE TRANSGENIC ANIMALS AND METHOD FOR IDENTIFYING COMPOUNDS FOR TREATING AMYLOIDOSIS
US6432636B1 (en) 1996-08-26 2002-08-13 University Of Washington Diagnostic applications of perlecan domain I splice variants
FR2753098B1 (fr) 1996-09-06 1998-11-27 Sod Conseils Rech Applic Composition pharmaceutique comprenant au moins un inhibiteur de no synthase et au moins un piegeur des formes reactives de l'oxygene
US5703129A (en) 1996-09-30 1997-12-30 Bristol-Myers Squibb Company 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production
ES2215220T3 (es) 1996-10-07 2004-10-01 MERCK &amp; CO., INC. Derivados de sordarina.
US6933280B2 (en) 1996-10-08 2005-08-23 Gerardo Castillo Peptides for the treatment of Alzheimer's disease and other beta-amyloid protein fibrillogenesis disorders
CA2268029C (en) 1996-10-08 2008-11-25 University Of Washington Therapeutic and diagnostic applications of laminin and laminin-derived protein fragments
JPH10175852A (ja) 1996-10-15 1998-06-30 Dokutaazu Kosumeteikusu:Kk 津液改善剤及びそれを含有する経口投与用組成物
JPH10175854A (ja) 1996-10-18 1998-06-30 Dokutaazu Kosumeteikusu:Kk 津液改善用皮膚外用剤
US6635632B1 (en) * 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
GB9702310D0 (en) 1997-02-05 1997-03-26 Univ Hertfordshire Invention
JPH10245342A (ja) 1997-03-03 1998-09-14 Mitsui Norin Kk β−アミロイド蛋白の神経細胞毒性低減剤
WO1998039653A1 (en) 1997-03-06 1998-09-11 University Of Washington Methods for producing pure perlecan and other heparan sulfate proteoglycans
CA2289531C (en) 1997-05-15 2009-09-29 University Of Washington Composition and methods for treating alzheimer's disease and other amyloidoses
US6346280B1 (en) 1997-05-15 2002-02-12 University Of Washington Composition and methods for inhibiting the formation of brain amyloid deposits
US6264994B1 (en) 1997-05-15 2001-07-24 University Of Washington Compositions for treating alzheimer's disease and other amyloidoses
US20030017998A1 (en) 1997-05-16 2003-01-23 Snow Alan D. Proanthocyanidins for the treatment of amyloid and alpha-synuclein diseases
CA2301725C (en) 1997-08-28 2008-11-18 University Of Washington Specific saccharide compositions and methods for treating alzheimer's disease and other amyloidoses
US6432639B1 (en) * 1997-09-10 2002-08-13 Dna Sciences Laboratories, Inc. Isolated CYP3A4 nucleic acid molecules and detection methods
AU3083899A (en) 1998-03-13 1999-09-27 University Of Washington (in vitro) formation of congophilic maltese-cross amyloid plaques to identify anti-plaque therapeutics for the treatment of alzheimer's and prion diseases
EP1077695A2 (en) 1998-05-22 2001-02-28 Avanir Pharmaceuticals COMPOUNDS HAVING IgE AFFECTING PROPERTIES
US6767898B2 (en) 1998-08-28 2004-07-27 University Of Washington Methods for using specific saccharides for treating alzheimer's disease and other amyloidoses
WO2000012102A1 (en) 1998-08-31 2000-03-09 Proteotech, Inc. Blended compositions for treatment of alzheimer's disease and other amyloidoses
US6255498B1 (en) * 1998-10-16 2001-07-03 Millennium Pharmaceuticals, Inc. Method for synthesizing diaryl-substituted heterocyclic compounds, including tetrahydrofurans
WO2000057707A1 (en) 1999-03-15 2000-10-05 Proteotech, Inc. Methods of treating alzheimer's disease and other amyloidoses using hypericum perforatum and derivatives thereof
AU3888100A (en) 1999-03-15 2000-10-04 Proteotech, Inc. Therapeutic and diagnostic applications of p400: a newly discovered beta-amyloidbinding protein present in human biological fluids
WO2000055167A1 (fr) * 1999-03-17 2000-09-21 Shionogi & Co., Ltd. Derives de 2-pyridinethiol et reactifs permettant la mesure de l'activite de la nag contenant ceux-ci
US6562836B1 (en) * 1999-05-24 2003-05-13 Queen's University Of Kingston Methods and compounds for inhibiting amyloid deposits
WO2001021160A2 (en) 1999-09-23 2001-03-29 Axxima Pharmaceuticals Aktiengesellschaft Carboxymide and aniline derivatives as selective inhibitors of pathogens
US20010047032A1 (en) 1999-12-30 2001-11-29 Castillo Gerardo M. Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases
JP2003519192A (ja) 1999-12-30 2003-06-17 プロテオテック・インコーポレーテッド アルツハイマー病におけるアミロイド症および他のアミロイド症の治療のためのカテキンおよび緑茶抽出物
JP2003520854A (ja) 2000-01-27 2003-07-08 サイトビア インコーポレイテッド カスパーゼのアクチベーターおよびアポトーシスのインデューサーとしての置換ニコチンアミドおよび類似物およびそれらの使用
AU2001230026A1 (en) 2000-02-04 2001-08-14 Novo-Nordisk A/S 2,4-diaminothiazole derivatives
US7205008B2 (en) 2000-03-15 2007-04-17 Proteotech, Inc. Methods of treating Alzheimer's disease and other amyloidoses using Hypericum perforatum and derivatives thereof
JP2001341424A (ja) 2000-05-31 2001-12-11 Asahi Kasei Corp ウレアウレタン化合物顕色剤用増感剤
DE10030891A1 (de) * 2000-06-23 2002-01-03 Haarmann & Reimer Gmbh 3,4-Dihydroxybenzyl-substituierte Kohlensäurederivate und ihre Verwendung als Antioxidantien in kosmetischen und pharmazeutischen Präparaten
US6472436B1 (en) * 2000-07-17 2002-10-29 The Salk Institute For Biological Studies Methods for protecting cells from amyloid toxicity and for inhibiting amyloid protein production
AU2002239765A1 (en) 2000-11-03 2002-06-03 Proteotech, Inc. Antibody pti-hs7 for treatment of alzheimer's disease and other amyloidoses and parkinson's disease
AU3976402A (en) 2000-11-03 2002-06-03 Proteotech Inc Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from uncaria tomentosa and related plants
WO2002042329A2 (en) 2000-11-21 2002-05-30 Diadexus, Inc. Compositions and methods relating to prostate specific genes and proteins
US20020128208A1 (en) 2000-12-15 2002-09-12 Snyder James P. Nonpeptide agonists and antagonists of vasopressin receptors
US20020151506A1 (en) 2000-12-29 2002-10-17 Castillo Gerardo M. Catechins for the treatment of fibrillogenesis in Alzheimer's disease, Parkinson's disease, systemic AA amyloidosis, and other amyloid disorders
SE0100374D0 (sv) 2001-02-07 2001-02-07 Pharmacia Ab Novel compositions of potassium channel openers and protein kinase c inhibitors and use thereof
WO2002076381A2 (en) 2001-03-15 2002-10-03 Proteotech, Inc. Proanthocyanidins for the treatment of amyloid and alpha-synuclein diseases
ATE517617T1 (de) 2001-12-10 2011-08-15 Yansheng Dr Du Behandlung von parkinson erkrankung mit kape
PT1511710E (pt) * 2002-05-31 2014-02-26 Proteotech Inc Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson
US7601876B2 (en) * 2002-05-31 2009-10-13 Proteotech, Inc. Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis
US20070276034A1 (en) * 2002-05-31 2007-11-29 Luke Esposito Compounds, compositions and methods for the treatment of synucleinopathies
AU2003249244A1 (en) 2002-07-15 2004-02-02 Combinatorx, Incorporated Methods for the treatment of neoplasms

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