CY1115484T1 - Ενωσεις, συνθεσεις και μεθοδοι για την θεραπεια αμυλοειδικων ασθενειων και συνουκλεϊνοπαθειων, οπως νοσος alzheimer, διαβητης τυπου 2 και νοσος parkinson - Google Patents

Ενωσεις, συνθεσεις και μεθοδοι για την θεραπεια αμυλοειδικων ασθενειων και συνουκλεϊνοπαθειων, οπως νοσος alzheimer, διαβητης τυπου 2 και νοσος parkinson

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Publication number
CY1115484T1
CY1115484T1 CY20141100440T CY141100440T CY1115484T1 CY 1115484 T1 CY1115484 T1 CY 1115484T1 CY 20141100440 T CY20141100440 T CY 20141100440T CY 141100440 T CY141100440 T CY 141100440T CY 1115484 T1 CY1115484 T1 CY 1115484T1
Authority
CY
Cyprus
Prior art keywords
disease
alzheimer
treatment
diabetes
type
Prior art date
Application number
CY20141100440T
Other languages
English (en)
Inventor
Alan D Snow
Beth P Nguyen
Gerardo M Castillo
Virginia J Sanders
Thomas P Lake
Lesley Larsen
David S Larsen
Rex T Weavers
Stephen D Lorimer
David L COFFEN (deceased)
Original Assignee
Proteotech, Inc.
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Publication date
Application filed by Proteotech, Inc. filed Critical Proteotech, Inc.
Publication of CY1115484T1 publication Critical patent/CY1115484T1/el

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    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings
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Abstract

Ενώσεις δι- και τρι-διυδροξυαρυλίου και τα μεθυλενοδιοξυ ανάλογα τους και φαρμακευτικά αποδεκτοί εστέρες, η σύνθεση τους, φαρμακευτικές συνθέσεις που τις περιέχουν και χρήση τους στην θεραπεία αμυλοειδικών ασθενειών, ειδικότερα Αβ αμυλοείδωση, όπως παρατηρείται στην νόσο Alzheimer, ΙΑΡΡ αμυλοείδωση, όπως παρατηρείται στον διαβήτη τύπου 2, και συνουκλεϊνοπάθειες, όπως παρατηρούνται στην νόσο Parkinson, και παρασκευή φαρμάκων για τέτοια θεραπεία.
CY20141100440T 2002-05-31 2014-06-18 Ενωσεις, συνθεσεις και μεθοδοι για την θεραπεια αμυλοειδικων ασθενειων και συνουκλεϊνοπαθειων, οπως νοσος alzheimer, διαβητης τυπου 2 και νοσος parkinson CY1115484T1 (el)

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US40910002P 2002-09-09 2002-09-09
US41227202P 2002-09-20 2002-09-20
US43588002P 2002-12-20 2002-12-20
US46310403P 2003-04-14 2003-04-14
EP12166370.2A EP2527315B1 (en) 2002-05-31 2003-05-30 Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes and Parkinson's disease

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US20130137775A1 (en) * 2002-05-31 2013-05-30 Alan D. Snow Compositions and methods for the treatment of systemic aa amyloid diseases
US7601876B2 (en) * 2002-05-31 2009-10-13 Proteotech, Inc. Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis
ES2473581T3 (es) * 2002-05-31 2014-07-07 Proteotech Inc. Compuestos, composiciones y métodos para el tratamiento de amiloidosis y sinucleinopat�as tales como la enfermedad de Alzheimer, la diabetes de tipo 2 y la enfermedad de Parkinson
US8227643B2 (en) * 2002-05-31 2012-07-24 Proteotech, Inc. Sirtuin 1 and the treatment of neurodegenerative diseases
US20140005240A1 (en) * 2002-05-31 2014-01-02 Alan D. Snow Compounds and compositions for use as modulators of tau aggregation and alleviation of tauopathies
US20070276034A1 (en) * 2002-05-31 2007-11-29 Luke Esposito Compounds, compositions and methods for the treatment of synucleinopathies
US8829198B2 (en) * 2007-10-31 2014-09-09 Proteotech Inc Compounds, compositions and methods for the treatment of beta-amyloid diseases and synucleinopathies
WO2004037751A2 (en) * 2002-08-29 2004-05-06 Temple University - Of The Commonwealth System Of Higher Education Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof
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AU2003249678A1 (en) 2003-12-19
US8163957B2 (en) 2012-04-24
SI2527315T1 (sl) 2014-06-30
PT1511710E (pt) 2014-02-26
US8586585B2 (en) 2013-11-19
PT2527315E (pt) 2014-06-24
US9051253B2 (en) 2015-06-09
EP2527315A1 (en) 2012-11-28
CA2486869A1 (en) 2003-12-11
ES2447417T3 (es) 2014-03-12
JP5179533B2 (ja) 2013-04-10
SI1511710T1 (sl) 2014-04-30
ES2473581T3 (es) 2014-07-07
US20120225890A1 (en) 2012-09-06
CA2486869C (en) 2011-09-13
US7514583B2 (en) 2009-04-07
US20140038980A1 (en) 2014-02-06
EP1511710B1 (en) 2013-11-20

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