NO944928L - Fremgangsmåter for inhibering av Alzheimers sykdom - Google Patents

Fremgangsmåter for inhibering av Alzheimers sykdom

Info

Publication number
NO944928L
NO944928L NO944928A NO944928A NO944928L NO 944928 L NO944928 L NO 944928L NO 944928 A NO944928 A NO 944928A NO 944928 A NO944928 A NO 944928A NO 944928 L NO944928 L NO 944928L
Authority
NO
Norway
Prior art keywords
methods
disease
human
compound
formula
Prior art date
Application number
NO944928A
Other languages
English (en)
Other versions
NO944928D0 (no
Inventor
Patrick Cornelious May
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO944928D0 publication Critical patent/NO944928D0/no
Publication of NO944928L publication Critical patent/NO944928L/no

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32Antioestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Det er beskrevet fremgangsmåter for Inhibering av Alzheimers sykdom Innbefattende administrering til et menneske som har behov for dette, av en effektiv mengde av en forbindelse av formel I OCH2CHi¿R2 (D hvor R1 og R3 uavhengig av hverandre betyr hydrogen, O O II II ' -CH3, -C-fCj-Cfc alkyl), eller -C-Ar, hvor Ar er eventuelt substituert fenyl; R2 er valgt fra gruppen bestående av pyrrolldin, heksametylenimino og piperidino; eller et farmasøytisk akseptabelt salt eller solvat derav. Det er videre beskrevet fremgangsmåter for å øke TGF-e ekspresjonen i hjernen, som Innbefatter administrering til et menneske som har behov for dette av en effektiv mengde av en forbindelse av formel I. Det er videre beskrevet fremgangsmåter for å inhlbere e-amyloidpeptidformidlet neurotokslsitet eller inflammatorisk respons forbundet med Alzheimers sykdom (AD) som Innbefatter administrering til et menneske som har behov for dette av en effektiv mengde av en forbindelse av formel I.
NO944928A 1993-12-21 1994-12-19 Fremgangsmåter for inhibering av Alzheimers sykdom NO944928L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/171,387 US5552415A (en) 1993-12-21 1993-12-21 Method of inhibiting Alzheimer's Disease

Publications (2)

Publication Number Publication Date
NO944928D0 NO944928D0 (no) 1994-12-19
NO944928L true NO944928L (no) 1995-06-22

Family

ID=22623556

Family Applications (1)

Application Number Title Priority Date Filing Date
NO944928A NO944928L (no) 1993-12-21 1994-12-19 Fremgangsmåter for inhibering av Alzheimers sykdom

Country Status (14)

Country Link
US (3) US5552415A (no)
EP (1) EP0659418A1 (no)
JP (1) JPH07215854A (no)
KR (1) KR950016738A (no)
CN (2) CN1087937C (no)
AU (1) AU688815B2 (no)
CA (1) CA2138495A1 (no)
CZ (1) CZ288984B6 (no)
HU (1) HUT71465A (no)
IL (1) IL112050A (no)
NO (1) NO944928L (no)
NZ (1) NZ270177A (no)
RU (1) RU2128992C1 (no)
ZA (1) ZA9410095B (no)

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Also Published As

Publication number Publication date
CA2138495A1 (en) 1995-06-22
US5652259A (en) 1997-07-29
US5686476A (en) 1997-11-11
AU688815B2 (en) 1998-03-19
NZ270177A (en) 1997-08-22
CN1294913A (zh) 2001-05-16
AU8154694A (en) 1995-06-29
RU2128992C1 (ru) 1999-04-20
IL112050A (en) 1999-03-12
HUT71465A (en) 1995-11-28
JPH07215854A (ja) 1995-08-15
HU9403668D0 (en) 1995-02-28
CN1108098A (zh) 1995-09-13
CN1087937C (zh) 2002-07-24
ZA9410095B (en) 1996-06-19
IL112050A0 (en) 1995-03-15
US5552415A (en) 1996-09-03
EP0659418A1 (en) 1995-06-28
KR950016738A (ko) 1995-07-20
CZ322094A3 (en) 1995-09-13
NO944928D0 (no) 1994-12-19
CZ288984B6 (cs) 2001-10-17
RU94045155A (ru) 1996-11-10

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