ATE147071T1 - 1,4-disubstituierte piperidinderivate, ihre herstellung und therapeutische verwendung - Google Patents

1,4-disubstituierte piperidinderivate, ihre herstellung und therapeutische verwendung

Info

Publication number
ATE147071T1
ATE147071T1 AT92401419T AT92401419T ATE147071T1 AT E147071 T1 ATE147071 T1 AT E147071T1 AT 92401419 T AT92401419 T AT 92401419T AT 92401419 T AT92401419 T AT 92401419T AT E147071 T1 ATE147071 T1 AT E147071T1
Authority
AT
Austria
Prior art keywords
preparation
therapeutic use
piperidine derivatives
disubstituted piperidine
general formula
Prior art date
Application number
AT92401419T
Other languages
English (en)
Inventor
Denis Bigg
Jean-Louis Vidaluc
Francis Calmel
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Application granted granted Critical
Publication of ATE147071T1 publication Critical patent/ATE147071T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT92401419T 1991-05-27 1992-05-25 1,4-disubstituierte piperidinderivate, ihre herstellung und therapeutische verwendung ATE147071T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9106327A FR2677019B1 (fr) 1991-05-27 1991-05-27 Nouvelles piperidines disubstituees-1,4, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
ATE147071T1 true ATE147071T1 (de) 1997-01-15

Family

ID=9413134

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92401419T ATE147071T1 (de) 1991-05-27 1992-05-25 1,4-disubstituierte piperidinderivate, ihre herstellung und therapeutische verwendung

Country Status (6)

Country Link
US (1) US5364864A (de)
EP (1) EP0516520B1 (de)
JP (1) JPH05148228A (de)
AT (1) ATE147071T1 (de)
DE (1) DE69216293D1 (de)
FR (1) FR2677019B1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2141763T3 (es) * 1992-03-31 2000-04-01 Glaxo Group Ltd Fenilcarbonatos y fenilureas sustituidos, su preparacion y su uso como antagonistas de 5-ht4.
GB9206989D0 (en) * 1992-03-31 1992-05-13 Glaxo Group Ltd Chemical compounds
FR2750991A1 (fr) * 1996-07-12 1998-01-16 Pf Medicament Nouveaux benzodioxannes et 1-(2h)-benzopyrannes, leur preparation et leur utilisation comme medicament
FR2752732B1 (fr) 1996-08-28 1998-11-20 Pf Medicament Forme galenique a liberation prolongee de milnacipran
IL125658A0 (en) 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
US6339087B1 (en) 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
EP1891954A3 (de) 1998-09-30 2009-01-14 Takeda Pharmaceutical Company Limited Wirkstoffe zur Verbesserung der Exkretionskraft der Harnblase
WO2000031033A1 (en) 1998-11-20 2000-06-02 F. Hoffmann-La Roche Ag Piperidine ccr-3 receptor antagonists
US6239126B1 (en) * 1998-12-17 2001-05-29 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetra-hydropyridine urea derivatives
EP1574508A1 (de) 2004-01-30 2005-09-14 Lonza AG Verfahren zur Herstellung von Acetalen und Ketalen von 3-Amino-5-(hydroxymethyl)-cyclopentan-1,2-diolen, sowie deren Derivaten und Salzen
ATE398616T1 (de) * 2005-02-04 2008-07-15 Ctg Pharma S R L Neue 4-aminochinolinderivate als antimalariamittel
RS52711B (sr) 2005-05-10 2013-08-30 Incyte Corporation Modulatori indolamin 2,3-dioksigenaze i postupci upotrebe istih
EP1971583B1 (de) 2005-12-20 2015-03-25 Incyte Corporation N-hydroxyamidinoheterocyclen als modulatoren der indolamin-2,3-dioxygenase
WO2007095050A2 (en) * 2006-02-09 2007-08-23 Incyte Corporation N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase
US20080146624A1 (en) * 2006-09-19 2008-06-19 Incyte Corporation Amidines as modulators of indoleamine 2,3-dioxygenase
WO2008036642A2 (en) 2006-09-19 2008-03-27 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (es) * 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
WO2008058178A1 (en) * 2006-11-08 2008-05-15 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
PL2315756T3 (pl) 2008-07-08 2015-02-27 Incyte Holdings Corp 1,2,5-oksadiazole jako inhibitory 2,3-dioksygenazy indoloaminy
EP2533645B1 (de) 2010-02-09 2016-07-27 The Johns Hopkins University Verfahren und zusammensetzungen zur verbesserung von kognitiven funktionen
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
EP2968237A4 (de) 2013-03-15 2016-08-31 Univ Johns Hopkins Verfahren und zusammensetzungen zur verbesserung der kognitiven funktion
EP2968220B1 (de) 2013-03-15 2021-05-05 Agenebio, Inc. Verfahren und zusammensetzungen zur verbesserung von kognitiven funktionen
KR102617531B1 (ko) 2013-11-08 2023-12-27 인사이트 홀딩스 코포레이션 인돌아민 2,3-디옥시게나제 억제제의 합성 방법
MX384391B (es) 2015-05-22 2025-03-14 Agenebio Inc Composiciones farmacéuticas de levetiracetam de liberación extendida.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1489879A (en) * 1974-12-20 1977-10-26 Leo Pharm Prod Ltd N'-cyano-n'-3-pyridylguanidines
US4370328A (en) * 1977-11-03 1983-01-25 Pfizer Inc. Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
GB8908063D0 (en) * 1989-04-11 1989-05-24 Beecham Group Plc Novel compounds
US4988688A (en) * 1989-08-02 1991-01-29 Warner-Lambert Company 4-(N-substituted amino)-2-butynyl-1-ureas and thioureas and derivatives thereof as centrally acting muscarinic agents
DK443489D0 (da) * 1989-09-08 1989-09-08 Ferrosan As Substituerede urinstofforbindelser, deres fremstilling og anvendelse
US5006523A (en) * 1989-10-26 1991-04-09 E. R. Squibb & Sons, Inc. Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers
JP2807577B2 (ja) * 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体

Also Published As

Publication number Publication date
FR2677019A1 (fr) 1992-12-04
JPH05148228A (ja) 1993-06-15
FR2677019B1 (fr) 1994-11-25
EP0516520A1 (de) 1992-12-02
EP0516520B1 (de) 1997-01-02
DE69216293D1 (de) 1997-02-13
US5364864A (en) 1994-11-15

Similar Documents

Publication Publication Date Title
DE69216293D1 (de) 1,4-Disubstituierte Piperidinderivate, ihre Herstellung und therapeutische Verwendung
ES2111639T3 (es) Derivados de 3-aminopiperidina y heterociclos relacionados que contienen nitrogeno.
DE59402222D1 (de) Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
KR900700486A (ko) 신규한 벤조피리도 피페리딘, 피페리딜리덴 및 피페라진 화합물, 조성물, 제조방법 및 이용방법
PT807633E (pt) Novas pirimidin-4-onas substituidas em 2,3, e fundidas com heteroarilo em (5,6)
NO933445L (no) Heterocyklisk-cykliske amin-derivater
ES2172580T3 (es) 1,3-oxatiolanos sustituidos con propiedades antiviricas.
DE59203976D1 (de) Hydantoinderivate.
DE69418789D1 (de) 2-(Piperidin-4-yl, Pyridin-4-yl und Tetrahydropyridin-4-yl)-benzofuran-7-carbamat Derivate, ihre Herstellung und Verwendung als Acetylcholinesterase Inhibitoren
DE59208974D1 (de) Neue pyrazinderivative, ihre herstellung und verwendung
DK0587088T3 (da) Substituerede cyclohexan-derivater, fremgangsmåde til deres fremstilling og anvendelsen af forbindelserne til behandling af sygdomme
DE69122866D1 (de) Herstellung von substituierten piperidinen
ES2118294T3 (es) Derivados de aminoquinolina utilizados para el tratamiento de la malaria.
PT992509E (pt) Novos derivados macrolidos
DE69429570D1 (de) Galanthamin Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente
ES2099024A1 (es) Nuevos derivados de 2,2,6,6-tetrametil-4-piperidinol para su uso como estabilizantes a la luz, estabilizantes al calor, y estabilizantes a la oxidacion para materiales organicos.
DE59409248D1 (de) Verwendung von Phenalkylaminen zur Herstellung von cholesterinsenkenden Arzneimitteln
DE69420679D1 (de) Verwendung der 1-4-4-Aryl(oder Heteroaryl)-1-Piperazinylbutyl-1H-Azol-Derivate zur Herstellung von Arzneimitteln zur Behandlung der Störungen der Magensekretion
ATE124039T1 (de) Durch azetidine substituierte derivate von pyridon-carboxylsäure, ihre herstellung und verwendung als arzneimittel.
DE59207425D1 (de) Imidazolylmethyl-Pyridine
FI942468A0 (fi) Kemialliset yhdisteet, niiden valmistus ja käyttö
DK0623620T3 (da) 5-HT3-pyrrolopyrazinderivater
ATE139441T1 (de) Verwendung von 2-iminothiazolidin-4-onderivaten als neuartige arzneimittelwirkstoffe
NZ233618A (en) Optionally heterocyclic substituted pyrrolidone derivatives and pharmaceutical compositions
ATE63309T1 (de) 2,3-dihydro-2-oxo-3-benzofuranylessigs|urederivate und diese enthaltende arzneimittel.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties