KR900700486A - 신규한 벤조피리도 피페리딘, 피페리딜리덴 및 피페라진 화합물, 조성물, 제조방법 및 이용방법 - Google Patents
신규한 벤조피리도 피페리딘, 피페리딜리덴 및 피페라진 화합물, 조성물, 제조방법 및 이용방법Info
- Publication number
- KR900700486A KR900700486A KR1019890702471A KR890702471A KR900700486A KR 900700486 A KR900700486 A KR 900700486A KR 1019890702471 A KR1019890702471 A KR 1019890702471A KR 890702471 A KR890702471 A KR 890702471A KR 900700486 A KR900700486 A KR 900700486A
- Authority
- KR
- South Korea
- Prior art keywords
- piperidylidene
- compositions
- preparation
- new
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18760488A | 1988-04-28 | 1988-04-28 | |
US187,604 | 1988-04-28 | ||
PCT/US1989/001688 WO1989010369A1 (en) | 1988-04-28 | 1989-04-26 | Novel benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use |
Publications (2)
Publication Number | Publication Date |
---|---|
KR900700486A true KR900700486A (ko) | 1990-08-13 |
KR950004004B1 KR950004004B1 (ko) | 1995-04-22 |
Family
ID=22689668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890702471A KR950004004B1 (ko) | 1988-04-28 | 1989-04-26 | 신규한 벤조피리도 피페리딘, 피페리딜리덴 및 피페라진 화합물, 조성물, 제조방법 및 이용방법 |
Country Status (17)
Country | Link |
---|---|
EP (2) | EP0341860B1 (ko) |
JP (1) | JPH0678315B2 (ko) |
KR (1) | KR950004004B1 (ko) |
AT (1) | ATE108453T1 (ko) |
AU (1) | AU629835B2 (ko) |
CA (1) | CA1341044C (ko) |
DE (1) | DE68916699T2 (ko) |
DK (1) | DK256890A (ko) |
ES (1) | ES2056214T3 (ko) |
FI (1) | FI96690C (ko) |
IE (1) | IE64522B1 (ko) |
IL (1) | IL90101A (ko) |
MY (1) | MY106280A (ko) |
NZ (1) | NZ228888A (ko) |
OA (1) | OA09629A (ko) |
WO (1) | WO1989010369A1 (ko) |
ZA (1) | ZA893104B (ko) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5665726A (en) * | 1986-10-31 | 1997-09-09 | Schering Corporation | Benzo[5,6]cycloheptapyridines, compositions and methods of use |
US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
CA2004211A1 (en) * | 1988-11-30 | 1990-05-31 | Masataka Syoji | Piperidine derivatives and hyportensives containing the same |
NZ238629A (en) * | 1990-06-22 | 1993-09-27 | Schering Corp | Bis-benzo- or benzopyrido-cyclohepta (where z is c, o, s or n) piperidine, piperidylidene or piperazine compounds, medicaments and methods of preparation |
EP0552292B1 (en) * | 1990-10-10 | 1995-06-21 | Schering Corporation | Substituted imidazobenzazepines and imidazopyridoazepines |
GB9109557D0 (en) * | 1991-05-02 | 1991-06-26 | Wellcome Found | Chemical compounds |
EP0586560A1 (en) * | 1991-05-23 | 1994-03-16 | Schering Corporation | Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use |
CA2114009A1 (en) * | 1991-07-23 | 1993-02-04 | Jesse K. Wong | Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use |
JP2974529B2 (ja) * | 1992-02-20 | 1999-11-10 | 北陸製薬株式会社 | 両性型三環系化合物 |
DK0635012T3 (da) * | 1992-03-27 | 1996-08-19 | Schering Corp | Bis-aryl-carbinolderivater uden broer, præparater indeholdende disse og fremgangsmåder til anvendelse af disse |
JPH07505394A (ja) * | 1992-03-27 | 1995-06-15 | シェリング・コーポレーション | 橋渡しビスアリールカルビノール誘導体,組成物および使用法 |
US5464840A (en) * | 1993-12-06 | 1995-11-07 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
US5538986A (en) * | 1993-12-06 | 1996-07-23 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
US5574173A (en) * | 1993-12-06 | 1996-11-12 | Schering Corporation | Tricyclic derivatives, compositions and methods of use |
US6524832B1 (en) | 1994-02-04 | 2003-02-25 | Arch Development Corporation | DNA damaging agents in combination with tyrosine kinase inhibitors |
US5801175A (en) | 1995-04-07 | 1998-09-01 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
US6323206B1 (en) | 1996-07-12 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
PE92098A1 (es) * | 1996-07-31 | 1998-12-31 | Schering Corp | N-cianoiminas triciclicas utiles como inhibidores de transferasa de proteina farnesilo |
CH688412A5 (de) * | 1997-03-11 | 1997-09-15 | Cilag Ag | Verfahren zur Herstellung von 1,4-disubstituierten Piperidinverbindungen. |
WO1998057962A1 (en) * | 1997-06-17 | 1998-12-23 | Schering Corporation | Benzo(5,6)cyclohepta(1,2b)pyridine derivatives useful for inhibition of farnesyl protein transferase |
US6051582A (en) * | 1997-06-17 | 2000-04-18 | Schering Corporation | Compounds useful for inhibition of farnesyl protein transferase |
US5925648A (en) * | 1997-07-29 | 1999-07-20 | Schering Corporation | Tricyclic N-cyanoimines useful as inhibitors of a farnesyl-protein transferase |
US6632455B2 (en) | 1997-12-22 | 2003-10-14 | Schering Corporation | Molecular dispersion composition with enhanced bioavailability |
US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
ID26618A (id) | 1998-01-21 | 2001-01-25 | Millennium Pharm Inc | Antagonis-antagonis reseptor kemokin dan metode penggunaannya |
US6433165B1 (en) | 1998-01-21 | 2002-08-13 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
US7271176B2 (en) | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
DE69934435T2 (de) * | 1998-10-20 | 2007-09-27 | University Of North Carolina At Chapel Hill | Methoden zum befeuchten der nasenschleimhaut |
US6316462B1 (en) | 1999-04-09 | 2001-11-13 | Schering Corporation | Methods of inducing cancer cell death and tumor regression |
US6455554B1 (en) | 1999-06-07 | 2002-09-24 | Targacept, Inc. | Oxopyridinyl pharmaceutical compositions and methods for use |
WO2001009137A1 (en) * | 1999-07-28 | 2001-02-08 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
MY117975A (en) | 2000-09-20 | 2004-08-30 | Schering Corp | Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists |
US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
NZ596484A (en) | 2001-11-21 | 2013-05-31 | Millennium Pharm Inc | Chemokine receptor antagonists and methods of use thereof |
ES2211315B1 (es) | 2002-11-12 | 2005-10-16 | Almirall Prodesfarma, S.A. | Nuevos compuestos triciclicos. |
TWI291467B (en) | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4282233B1 (en) * | 1980-06-19 | 2000-09-05 | Schering Corp | Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines |
AU570306B2 (en) * | 1984-02-15 | 1988-03-10 | Schering Corporation | 8-chloro-6, 11-dihydro-11-(4-piperidylidene)-5h-benzo (5,6) cyclohepta (1,2-b) pyridine and its salts. |
DE3677842D1 (de) * | 1985-05-13 | 1991-04-11 | Schering Corp | Verfahren zur herstellung von piperidyliden-dihydrodibenzo(a,d)zykloheptenen und deren azoderivate, so hergestellte verbindungen und ihre anwendung zur vorbereitung von heilmitteln. |
US4804666A (en) * | 1985-08-14 | 1989-02-14 | Schering Corporation | Antiallergic 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines |
US4826853A (en) * | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
-
1989
- 1989-04-26 AT AT89304169T patent/ATE108453T1/de not_active IP Right Cessation
- 1989-04-26 JP JP1505871A patent/JPH0678315B2/ja not_active Expired - Lifetime
- 1989-04-26 KR KR1019890702471A patent/KR950004004B1/ko not_active IP Right Cessation
- 1989-04-26 EP EP89304169A patent/EP0341860B1/en not_active Expired - Lifetime
- 1989-04-26 EP EP89905928A patent/EP0411048A1/en active Pending
- 1989-04-26 NZ NZ228888A patent/NZ228888A/en unknown
- 1989-04-26 CA CA000597849A patent/CA1341044C/en not_active Expired - Fee Related
- 1989-04-26 ZA ZA893104A patent/ZA893104B/xx unknown
- 1989-04-26 AU AU37344/89A patent/AU629835B2/en not_active Ceased
- 1989-04-26 DE DE68916699T patent/DE68916699T2/de not_active Expired - Fee Related
- 1989-04-26 ES ES89304169T patent/ES2056214T3/es not_active Expired - Lifetime
- 1989-04-26 WO PCT/US1989/001688 patent/WO1989010369A1/en active IP Right Grant
- 1989-04-26 MY MYPI89000537A patent/MY106280A/en unknown
- 1989-04-27 IE IE137989A patent/IE64522B1/en not_active IP Right Cessation
- 1989-04-27 IL IL9010189A patent/IL90101A/en not_active IP Right Cessation
-
1990
- 1990-10-25 DK DK256890A patent/DK256890A/da not_active Application Discontinuation
- 1990-10-26 FI FI905280A patent/FI96690C/fi not_active IP Right Cessation
- 1990-10-26 OA OA59879A patent/OA09629A/en unknown
Also Published As
Publication number | Publication date |
---|---|
IE64522B1 (en) | 1995-08-09 |
FI96690B (fi) | 1996-04-30 |
DE68916699T2 (de) | 1994-12-01 |
IL90101A0 (en) | 1989-12-15 |
NZ228888A (en) | 1991-12-23 |
JPH03504012A (ja) | 1991-09-05 |
FI96690C (fi) | 1996-08-12 |
EP0341860A1 (en) | 1989-11-15 |
FI905280A0 (fi) | 1990-10-26 |
ATE108453T1 (de) | 1994-07-15 |
CA1341044C (en) | 2000-07-04 |
EP0341860B1 (en) | 1994-07-13 |
AU629835B2 (en) | 1992-10-15 |
AU3734489A (en) | 1989-11-24 |
DK256890A (da) | 1990-12-21 |
OA09629A (en) | 1993-04-30 |
JPH0678315B2 (ja) | 1994-10-05 |
IL90101A (en) | 1996-11-14 |
WO1989010369A1 (en) | 1989-11-02 |
MY106280A (en) | 1995-04-29 |
EP0411048A1 (en) | 1991-02-06 |
ES2056214T3 (es) | 1994-10-01 |
ZA893104B (en) | 1989-12-27 |
KR950004004B1 (ko) | 1995-04-22 |
DE68916699D1 (de) | 1994-08-18 |
DK256890D0 (da) | 1990-10-25 |
IE891379L (en) | 1989-10-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 19980331 Year of fee payment: 4 |
|
LAPS | Lapse due to unpaid annual fee |