PE92098A1 - N-cianoiminas triciclicas utiles como inhibidores de transferasa de proteina farnesilo - Google Patents

N-cianoiminas triciclicas utiles como inhibidores de transferasa de proteina farnesilo

Info

Publication number
PE92098A1
PE92098A1 PE1997000654A PE00065497A PE92098A1 PE 92098 A1 PE92098 A1 PE 92098A1 PE 1997000654 A PE1997000654 A PE 1997000654A PE 00065497 A PE00065497 A PE 00065497A PE 92098 A1 PE92098 A1 PE 92098A1
Authority
PE
Peru
Prior art keywords
cyanoimines
tricyclic
protein transferase
farnesilo
useful
Prior art date
Application number
PE1997000654A
Other languages
English (en)
Inventor
Ronald J Doll
Alan B Cooper
James J-S Wang
Jagdish A Desai
Viyyoor M Girijavallabhan
Anil K Saksena
Raymond G Lovey
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE92098A1 publication Critical patent/PE92098A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: UNO DE a, b, c Y d ES N o NR9, EN DONDE R9 ES O, CH3O o (CH2)n-CO2H; n ES 1; 2 o 3; LOS REMANENTES DE a, b, c Y d SON CR1 o CR2; DE PREFERENCIA a ES NITROGENO; R1 Y R2 SON H, HALOGENO o CF3, ENTRE OTROS; R3 Y R4 SON H o R1 Y R2 o R3 Y R4 CONFORMAN UN ANILLO C5-C7 SATURADO O INSATURADO; R5, R6, R7 Y R8 SON DE PREFERENCIA HIDROGENO; "X" ES N, CH o C; "Z" ES ALQUILO, OR40 o SR40, ENTRE OTROS, DE PREFERENCIA "Z" ES NHR4O, EN DONDE: R40 ES UN HETEROARILALQUILO COMO N-OXIDO DE 3 o 4 METIL PIRIDILO; DE PREFERENCIA EN UN COMPUESTO DE FORMULA (I) EXISTE UN ENLACE SIMPLE EN EL CARBONO 11, "X" ES CARBONO Y LAS POSICIONES 3, 8 Y 10 ESTAN SUSTITUIDAS EN EL ANILLO CON HALOGENO. ESTOS COMPUESTOS ACTUAN INHIBIENDO LA ENZIMA TRANSFERASA DE PROTEINA FARNESILO RAS (FTasa) Y LA FORMACION DE LA PROTEINA RAS RESPONSABLE DEL DESARROLLO ANORMAL DE CELULAS, EN DONDE LA PROTEINA RAS ES ACTIVADA COMO RESULTADO DE LA MUTACION ONCOGENICA OCURRIDA EN GENES DIFERENTES DEL GEN RAS, POR LO QUE SERIAN UTILES EN EL TRATAMIENTO DE TUMORES PANCREATICOS, PULMONARES, DE LEUCEMIA MIELOIDE, FOLICULARES DE TIROIDES, MIELODISPLASTICAS, DE CARCINOMA EPIDERMICO, DE CARCINOMA DE VEJIGA O DEL COLON, ENTRE OTROS
PE1997000654A 1996-07-31 1997-07-22 N-cianoiminas triciclicas utiles como inhibidores de transferasa de proteina farnesilo PE92098A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69052296A 1996-07-31 1996-07-31

Publications (1)

Publication Number Publication Date
PE92098A1 true PE92098A1 (es) 1998-12-31

Family

ID=24772812

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1997000654A PE92098A1 (es) 1996-07-31 1997-07-22 N-cianoiminas triciclicas utiles como inhibidores de transferasa de proteina farnesilo

Country Status (13)

Country Link
EP (1) EP0915869B1 (es)
JP (1) JP3153555B2 (es)
CN (1) CN1117745C (es)
AT (1) ATE240313T1 (es)
AU (1) AU3737097A (es)
CA (1) CA2261724C (es)
CO (1) CO4900031A1 (es)
DE (1) DE69722002T2 (es)
ES (1) ES2194207T3 (es)
ID (1) ID19401A (es)
PE (1) PE92098A1 (es)
WO (1) WO1998004545A1 (es)
ZA (1) ZA976754B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200101755T2 (tr) * 1998-12-18 2001-09-21 Schering Corporation Trisiklik farnezil protein transferaz inhibitörleri.
AR033680A1 (es) * 2000-08-30 2004-01-07 Schering Corp Compuestos triciclicos utiles como inhibidores de la farnesil proteino transferasa y su uso para la manufactura de medicamentos como agentes antitumorales
CN102731476A (zh) * 2012-05-29 2012-10-17 安徽宏业药业有限公司 含氰胍结构的苯并环庚基吡啶衍生物、制备方法、药物组合物及其医药用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
ES2056214T3 (es) * 1988-04-28 1994-10-01 Schering Corp Compuestos de benzopirido-piperidina, -piperidilideno y -piperazina, composiciones, metodos de preparacion y metodos de uso.
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
ES2164716T3 (es) * 1993-10-15 2002-03-01 Schering Corp Compuestos triciclicos de carbamato utiles para inhibir la funcion de la proteina-g y para el tratamiento de enfermedades proliferativas.

Also Published As

Publication number Publication date
ES2194207T3 (es) 2003-11-16
EP0915869A1 (en) 1999-05-19
WO1998004545A1 (en) 1998-02-05
JP2000500783A (ja) 2000-01-25
CA2261724A1 (en) 1998-02-05
EP0915869B1 (en) 2003-05-14
CN1226246A (zh) 1999-08-18
CA2261724C (en) 2003-05-13
DE69722002D1 (de) 2003-06-18
CO4900031A1 (es) 2000-03-27
CN1117745C (zh) 2003-08-13
ZA976754B (en) 1998-02-02
ID19401A (id) 1998-07-09
JP3153555B2 (ja) 2001-04-09
ATE240313T1 (de) 2003-05-15
DE69722002T2 (de) 2004-04-01
AU3737097A (en) 1998-02-20

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