CA2293358A1 - Tricyclic sulfonamide inhibitors of farnesyl-protein transferase - Google Patents

Tricyclic sulfonamide inhibitors of farnesyl-protein transferase Download PDF

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Publication number
CA2293358A1
CA2293358A1 CA002293358A CA2293358A CA2293358A1 CA 2293358 A1 CA2293358 A1 CA 2293358A1 CA 002293358 A CA002293358 A CA 002293358A CA 2293358 A CA2293358 A CA 2293358A CA 2293358 A1 CA2293358 A1 CA 2293358A1
Authority
CA
Canada
Prior art keywords
protein transferase
farnesyl
sulfonamide inhibitors
tricyclic sulfonamide
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002293358A
Other languages
French (fr)
Other versions
CA2293358C (en
Inventor
F. George Njoroge
Bancha Vibulbhan
Arthur G. Taveras
Ronald J. Doll
Viyyoor M. Girijavallabhan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corporation
F. George Njoroge
Bancha Vibulbhan
Arthur G. Taveras
Ronald J. Doll
Viyyoor M. Girijavallabhan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation, F. George Njoroge, Bancha Vibulbhan, Arthur G. Taveras, Ronald J. Doll, Viyyoor M. Girijavallabhan filed Critical Schering Corporation
Publication of CA2293358A1 publication Critical patent/CA2293358A1/en
Application granted granted Critical
Publication of CA2293358C publication Critical patent/CA2293358C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Novel tricyclic sulfonamide compounds of formula (1.0) and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel sulfonamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
CA002293358A 1997-06-17 1998-06-15 Tricyclic sulfonamide inhibitors of farnesyl-protein transferase Expired - Fee Related CA2293358C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87705097A 1997-06-17 1997-06-17
US08/877,050 1997-06-17
PCT/US1998/011508 WO1998057949A1 (en) 1997-06-17 1998-06-15 Novel tricyclic sulfonamide inhibitors of farnesyl-protein transferase

Publications (2)

Publication Number Publication Date
CA2293358A1 true CA2293358A1 (en) 1998-12-23
CA2293358C CA2293358C (en) 2008-08-05

Family

ID=25369146

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002293358A Expired - Fee Related CA2293358C (en) 1997-06-17 1998-06-15 Tricyclic sulfonamide inhibitors of farnesyl-protein transferase

Country Status (14)

Country Link
EP (1) EP0989980A1 (en)
JP (1) JP2002507192A (en)
KR (1) KR20010013826A (en)
CN (1) CN1267290A (en)
AR (1) AR012989A1 (en)
AU (1) AU8253698A (en)
CA (1) CA2293358C (en)
CO (1) CO4940475A1 (en)
HU (1) HUP0004627A2 (en)
IL (1) IL133393A0 (en)
NZ (1) NZ501619A (en)
PE (1) PE86199A1 (en)
WO (1) WO1998057949A1 (en)
ZA (1) ZA985218B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689789B2 (en) 1997-06-17 2004-02-10 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US7517884B2 (en) 1998-03-30 2009-04-14 Kalypsys Inc. Sulfonyl-substituted bicyclic compounds as modulators of PPAR
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
EP1337522B1 (en) * 2000-11-29 2007-08-29 Schering Corporation farnesyl protein transferase inhibitors
WO2006055187A1 (en) 2004-10-29 2006-05-26 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as modulators of ppar
HUE040020T2 (en) 2005-10-25 2019-02-28 Kalypsys Inc Salts of modulators of ppar and methods of treating metabolic disorders
US20080176861A1 (en) 2007-01-23 2008-07-24 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
US9796717B2 (en) * 2013-02-19 2017-10-24 Icahn School Of Medicine At Mount Sinai Tricyclic heterocycles as anticancer agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE210653T1 (en) * 1993-10-15 2001-12-15 Schering Corp TRICYCLIC SULFONAMIDE DERIVATIVES FOR INHIBITING G-PROTEIN FUNCTION AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES
IL117797A0 (en) * 1995-04-07 1996-08-04 Pharmacopeia Inc Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
HUP0004627A2 (en) 2001-10-28
CN1267290A (en) 2000-09-20
WO1998057949A1 (en) 1998-12-23
PE86199A1 (en) 1999-09-24
KR20010013826A (en) 2001-02-26
CO4940475A1 (en) 2000-07-24
AR012989A1 (en) 2000-11-22
NZ501619A (en) 2002-02-01
JP2002507192A (en) 2002-03-05
CA2293358C (en) 2008-08-05
EP0989980A1 (en) 2000-04-05
ZA985218B (en) 1998-12-15
IL133393A0 (en) 2001-04-30
AU8253698A (en) 1999-01-04

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EEER Examination request
MKLA Lapsed