PE86199A1 - SULFONAMIDE ENZYME INHIBITOR FARNESILO TRANSFERASA - Google Patents

SULFONAMIDE ENZYME INHIBITOR FARNESILO TRANSFERASA

Info

Publication number
PE86199A1
PE86199A1 PE1998000508A PE00050898A PE86199A1 PE 86199 A1 PE86199 A1 PE 86199A1 PE 1998000508 A PE1998000508 A PE 1998000508A PE 00050898 A PE00050898 A PE 00050898A PE 86199 A1 PE86199 A1 PE 86199A1
Authority
PE
Peru
Prior art keywords
cells
transferasa
aryl
alkyl
farnesilo
Prior art date
Application number
PE1998000508A
Other languages
Spanish (es)
Inventor
Ronald J Doll
Viyyoor M Girijavallabhan
F George Njoroge
Arthur G Taveras
Bancha Vibulbhan
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE86199A1 publication Critical patent/PE86199A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) O SU SAL, DONDE A ES N o N-OXIDO; CUANDO X ES N o CH SOLO HAY UN ENLACE CON C11 o CUANDO X ES CARBONO Y SE UNE CON UN DOBLE ENLACE AL C11; X1 Y X2 SON BROMO, CLORO, YODO; SOLO UNO DE X3 Y X4 ES H Y EL RESTO SON BROMO, YODO, FLUOR; R5, R6, R7 Y R8 SON H, ALQUILO, ARILO o -CONR20R21; R20 Y R21 SON H, ALQUILO, ALCOXI, ARILO, ENTRE OTROS o R5 Y R6 o R7 Y R8 SON =O O =S; R ES ALQUILO, ARILO, ARILALQUILO, -NR10R11, ENTRE OTROS; R10 Y R11 SON H, ALQUENILO, ALQUILO, ENTRE OTROS. EL COMPUESTO (I) INHIBE A LA ENZIMA FARNESIL RAS TRANSFERASA PUDIENDO SER UTIL PARA INHIBIR EL DESARROLLO ANORMAL DE CELULAS TUMORALES QUE EXPRESAN UN ONCOGEN RAS ACTIVADO, LAS CELULAS INHIBIDAS SON CELULAS DE TUMORES PANCREATICOS, CELULAS DE CANCER DE PULMON, CELULAS TUMORALES DE LEUCEMIA MIELOIDE, CELULAS DE TUMORES FOLICULARES TIROIDEOSIT REFERS TO A COMPOUND OF FORMULA (I) OR ITS SALT, WHERE A IS N or N-OXIDE; WHEN X IS N or CH THERE IS ONLY ONE LINK TO C11 or WHEN X IS CARBON AND JOINS WITH A DOUBLE LINK TO C11; X1 AND X2 ARE JOKE, CHLORINE, IODINE; ONLY ONE OF X3 AND X4 IS H AND THE REST IS BROMO, IODINE, FLUORIDE; R5, R6, R7, and R8 ARE H, ALKYL, ARYL, or -CONR20R21; R20 AND R21 ARE H, ALKYL, ALCOXY, ARYL, AMONG OTHERS or R5 AND R6 or R7 AND R8 SON = O O = S; R IS ALKYL, ARYL, ARYALKYL, -NR10R11, AMONG OTHERS; R10 AND R11 ARE H, ALQUENILO, ALQUILO, AMONG OTHERS. THE COMPOUND (I) INHIBITS THE ENZYME FARNESIL RAS TRANSFERASA MAY BE USEFUL TO INHIBIT THE ABNORMAL DEVELOPMENT OF TUMOR CELLS THAT EXPRESS AN ONCOGEN RAS ACTIVATED, THE CELLS OF CELLULAR CELLS, CANCELL CELLS, , THYROID FOLICULAR TUMOR CELLS

PE1998000508A 1997-06-17 1998-06-15 SULFONAMIDE ENZYME INHIBITOR FARNESILO TRANSFERASA PE86199A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87705097A 1997-06-17 1997-06-17

Publications (1)

Publication Number Publication Date
PE86199A1 true PE86199A1 (en) 1999-09-24

Family

ID=25369146

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000508A PE86199A1 (en) 1997-06-17 1998-06-15 SULFONAMIDE ENZYME INHIBITOR FARNESILO TRANSFERASA

Country Status (14)

Country Link
EP (1) EP0989980A1 (en)
JP (1) JP2002507192A (en)
KR (1) KR20010013826A (en)
CN (1) CN1267290A (en)
AR (1) AR012989A1 (en)
AU (1) AU8253698A (en)
CA (1) CA2293358C (en)
CO (1) CO4940475A1 (en)
HU (1) HUP0004627A2 (en)
IL (1) IL133393A0 (en)
NZ (1) NZ501619A (en)
PE (1) PE86199A1 (en)
WO (1) WO1998057949A1 (en)
ZA (1) ZA985218B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689789B2 (en) 1997-06-17 2004-02-10 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US7494999B2 (en) 2004-10-29 2009-02-24 Kalypsys, Inc Sulfonyl-substituted bicyclic compounds as modulators of PPAR
US7517884B2 (en) 1998-03-30 2009-04-14 Kalypsys Inc. Sulfonyl-substituted bicyclic compounds as modulators of PPAR
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
MXPA03004878A (en) * 2000-11-29 2003-08-19 Schering Corp 0ovel farnesyl protein transferase inhibitors.
WO2007051095A1 (en) 2005-10-25 2007-05-03 Kalypsys, Inc. Salts of modulators of ppar and methods of treating metabolic disorders
WO2008091863A1 (en) 2007-01-23 2008-07-31 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
CA2901493A1 (en) * 2013-02-19 2014-08-28 Icahn School Of Medicine At Mount Sinai Tricyclic heterocycles as anticancer agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ275646A (en) * 1993-10-15 1998-02-26 Schering Corp Tricyclic sulphonamide derivatives and medicaments
IL117797A0 (en) * 1995-04-07 1996-08-04 Pharmacopeia Inc Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
JP2002507192A (en) 2002-03-05
HUP0004627A2 (en) 2001-10-28
IL133393A0 (en) 2001-04-30
AU8253698A (en) 1999-01-04
CA2293358A1 (en) 1998-12-23
NZ501619A (en) 2002-02-01
EP0989980A1 (en) 2000-04-05
CO4940475A1 (en) 2000-07-24
AR012989A1 (en) 2000-11-22
CA2293358C (en) 2008-08-05
CN1267290A (en) 2000-09-20
WO1998057949A1 (en) 1998-12-23
KR20010013826A (en) 2001-02-26
ZA985218B (en) 1998-12-15

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed