EP1019525A4 - Chemiluminescence compositions and methods - Google Patents

Chemiluminescence compositions and methods

Info

Publication number
EP1019525A4
EP1019525A4 EP98940778A EP98940778A EP1019525A4 EP 1019525 A4 EP1019525 A4 EP 1019525A4 EP 98940778 A EP98940778 A EP 98940778A EP 98940778 A EP98940778 A EP 98940778A EP 1019525 A4 EP1019525 A4 EP 1019525A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
peroxidase
compounds
double bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP98940778A
Other languages
German (de)
French (fr)
Other versions
EP1019525A1 (en
EP1019525B1 (en
Inventor
Hashem Akhavan-Tafti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lumigen Inc
Original Assignee
Lumigen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lumigen Inc filed Critical Lumigen Inc
Publication of EP1019525A1 publication Critical patent/EP1019525A1/en
Publication of EP1019525A4 publication Critical patent/EP1019525A4/en
Application granted granted Critical
Publication of EP1019525B1 publication Critical patent/EP1019525B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
    • C09K11/07—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials having chemically interreactive components, e.g. reactive chemiluminescent compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)

Abstract

Methods and compositions for generating chemiluminescence on reaction with a peroxidase enzyme are provided as well as compounds to be used in the methods and compositions. The compounds have a C-C double bond substituted at one carbon with two oxygen or sulfur atom-containing groups. The compositions contain the double bond-containing compound and a peroxide in an aqueous solution. Additional components which can be included in the compositions are peroxidase activity enhancers, nonionic surfactants or cationic surfactants to improve detection sensitivity of the peroxidase. The chemiluminescent methods and compositions are useful in assays for peroxidase enzymes and in assays employing enzyme-labeled specific binding pairs.
EP98940778A 1997-09-12 1998-08-12 Chemiluminescence compositions and methods Expired - Lifetime EP1019525B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/928,793 US5922558A (en) 1997-09-12 1997-09-12 Methods and compositions for generating chemiluminescence with a peroxidase
US928793 1997-09-12
PCT/US1998/015813 WO1999014358A1 (en) 1997-09-12 1998-08-12 Chemiluminescence compositions and methods

Publications (3)

Publication Number Publication Date
EP1019525A1 EP1019525A1 (en) 2000-07-19
EP1019525A4 true EP1019525A4 (en) 2003-01-02
EP1019525B1 EP1019525B1 (en) 2004-10-20

Family

ID=25456769

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98940778A Expired - Lifetime EP1019525B1 (en) 1997-09-12 1998-08-12 Chemiluminescence compositions and methods

Country Status (9)

Country Link
US (1) US5922558A (en)
EP (1) EP1019525B1 (en)
JP (1) JP4790905B2 (en)
AT (1) ATE280241T1 (en)
AU (1) AU733086C (en)
CA (1) CA2300096C (en)
DE (1) DE69827152T2 (en)
ES (1) ES2230710T3 (en)
WO (1) WO1999014358A1 (en)

Families Citing this family (32)

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Publication number Priority date Publication date Assignee Title
DE69720332T2 (en) * 1996-01-16 2003-12-04 Lumigen Inc COMPOUNDS, COMPOSITIONS AND METHODS FOR GENERATING CHEMILUMINESCENCE WITH PHOSPHATASE ENZYMS
US6126870A (en) * 1997-09-12 2000-10-03 Lumigen, Inc. Chemiluminescent labeling compounds
US6017769A (en) * 1998-06-17 2000-01-25 Lumigen, Inc. Non-enzymatic methods of generating chemiluminescence from acridan alkenes
US7186568B1 (en) * 2000-06-26 2007-03-06 Lumigen Inc. Electrochemiluminescence from acridan compounds
AU2002215610B2 (en) * 2000-06-26 2004-05-06 Lumigen, Inc. Electrochemiluminescence from acridan compounds
WO2003053934A1 (en) 2001-12-20 2003-07-03 Lumigen, Inc. Improved compounds for generating chemiluminescence with a peroxidase
US6872828B2 (en) 2001-12-20 2005-03-29 Lumigen, Inc. Compounds for generating chemiluminescence with a peroxidase
US7560556B2 (en) * 2001-12-20 2009-07-14 Lumigen, Inc. Assay methods using chemiluminescent detection of peroxidase
US6897036B2 (en) * 2002-06-06 2005-05-24 Lumigen, Inc. Fluorescent detection of peroxidase enzymes
US7390670B2 (en) 2003-02-20 2008-06-24 Lumigen, Inc. Signalling compounds and methods for detecting hydrogen peroxide
US20060205094A1 (en) * 2005-03-14 2006-09-14 Lumigen, Inc. Methods using novel chemiluminescent labels
US7682839B2 (en) * 2005-03-14 2010-03-23 Lumigen, Inc. Methods using novel chemiluminescent labels
WO2006116687A2 (en) * 2005-04-27 2006-11-02 The Trustees Of The University Of Pennsylvania Nanoassays
US7879575B2 (en) * 2005-04-27 2011-02-01 The Trustees Of The University Of Pennsylvania Nanostructures that provide a modified nanoenvironment for the enhancement of luminescence
WO2006116686A2 (en) * 2005-04-27 2006-11-02 The Trustees Of The University Of Pennsylvania Nanostructure enhanced luminescent devices
US7566573B2 (en) * 2005-12-19 2009-07-28 Idexx Laboratories, Inc. Dual standard curve immunoassay
US7799534B2 (en) 2006-05-09 2010-09-21 Beckman Coulter, Inc. Nonseparation assay methods
US7732153B2 (en) 2006-05-09 2010-06-08 Beckman Coulter, Inc. Nonseparation assay methods
US7674629B2 (en) * 2007-03-15 2010-03-09 Saint Louis University Method for improving chemiluminescent signal
WO2009062027A1 (en) * 2007-11-07 2009-05-14 Beckman Coulter, Inc. Nonseparation assay methods using peroxide generating enzymes
CN101178402B (en) * 2007-12-06 2011-08-24 武汉赛欣生物技术有限公司 Preparation method of polyase marker antibody
US20090162876A1 (en) * 2007-12-20 2009-06-25 Abbott Laboratories Myeloperoxidase assays
WO2010062787A1 (en) 2008-11-03 2010-06-03 Washington University Bioluminescence imaging of myeloperoxidase activity in vivo, methods, compositions and apparatuses therefor
WO2010099486A1 (en) 2009-02-27 2010-09-02 Beckman Coulter, Inc. Solution phase homogeneous assays
MX2011009020A (en) 2009-02-27 2011-09-29 Beckman Coulter Inc Non separation assays with selective signal inhibitors.
US20110097723A1 (en) * 2009-09-19 2011-04-28 Qun Liu Methods and reagents for analyte detection
JP6553020B2 (en) 2013-03-15 2019-07-31 ジーピービー デット ホールディングス トゥー エルエルシー Automated immunoassay system for performing diagnostic analysis on allergies and autoimmune diseases
US9383336B2 (en) 2014-04-04 2016-07-05 General Electric Company System and method for flat panel detector gel and blot imaging
CN104761584A (en) * 2015-02-27 2015-07-08 北京利德曼生化股份有限公司 Acridinium ester derivative, synthesis method and application thereof
WO2017045709A1 (en) * 2015-09-16 2017-03-23 General Electric Company System and method for flat panel detector gel and blot imaging
WO2020012390A1 (en) 2018-07-13 2020-01-16 3M Innovative Properties Company Specific binding chemiluminescent assay
CN113295678B (en) * 2021-05-14 2022-11-08 济南迪曼生物科技有限公司 Electrochemiluminescence cleaning fluid

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68911633T2 (en) * 1988-09-30 1994-04-07 Fujirebio Kk Method for determining peroxidase activity using chemiluminescence.
DK0422252T3 (en) * 1989-04-28 1995-09-11 Toray Industries Method for detecting a substance using chemiluminescence
DD296503A5 (en) * 1989-07-13 1991-12-05 �K@�K@������������@�K@�Kk�� CHEMITUMINESCENT COMPOSITIONS, CHEMILUMINESCENCE PROCEDURES AND THEIR USE IN ANALYTICAL TESTS
US5324835A (en) * 1990-03-30 1994-06-28 Biosensor Laboratories Co., Ltd. Pyridazinoquinoxalinones for use as chemiluminescent agents
US5629168A (en) * 1992-02-10 1997-05-13 British Technology Group Limited Chemiluminescent enhancers
US5552298A (en) * 1992-10-23 1996-09-03 Lumigen, Inc. Enzyme-catalyzed chemiluminescence from hydroxyaryl cyclic diacylhydrazide compounds
US5512451A (en) * 1993-04-01 1996-04-30 British Technology Group Limited Enhancement of chemiluminescent reactions
US5491072A (en) * 1993-05-17 1996-02-13 Lumigen, Inc. N-alkylacridan carboxyl derivatives useful for chemiluminescent detection
US5723295A (en) * 1993-05-17 1998-03-03 Lumigen, Inc. Methods, acridan compounds and kits for producing light
US5670644A (en) * 1993-05-17 1997-09-23 Lumigen, Inc. Acridan compounds
US5593845A (en) * 1993-05-17 1997-01-14 Lumigen, Inc. Aryl N-alkylacridancarboxylate derivatives useful for chemiluminescent detection
US5523212A (en) * 1993-05-17 1996-06-04 Lumigen, Inc. Aryl N-alkylacridanthiocarboxylate derivatives useful for chemiluminescent detection
DE19548375A1 (en) * 1995-12-27 1997-07-03 Behringwerke Ag Immunological method of determination
DE69720332T2 (en) * 1996-01-16 2003-12-04 Lumigen Inc COMPOUNDS, COMPOSITIONS AND METHODS FOR GENERATING CHEMILUMINESCENCE WITH PHOSPHATASE ENZYMS
CA2244228A1 (en) * 1996-01-22 1997-07-24 Creative Biomolecules, Inc. Morphogen analogs and methods for producing them

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
ES2230710T3 (en) 2005-05-01
AU733086C (en) 2002-01-03
CA2300096A1 (en) 1999-03-25
WO1999014358A1 (en) 1999-03-25
AU733086B2 (en) 2001-05-03
EP1019525A1 (en) 2000-07-19
EP1019525B1 (en) 2004-10-20
CA2300096C (en) 2010-02-09
ATE280241T1 (en) 2004-11-15
DE69827152D1 (en) 2004-11-25
JP2001516589A (en) 2001-10-02
AU8897598A (en) 1999-04-05
JP4790905B2 (en) 2011-10-12
DE69827152T2 (en) 2006-03-09
US5922558A (en) 1999-07-13

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