PE86199A1 - Sulfonamida inhibidor de la enzima farnesilo transferasa - Google Patents

Sulfonamida inhibidor de la enzima farnesilo transferasa

Info

Publication number
PE86199A1
PE86199A1 PE1998000508A PE00050898A PE86199A1 PE 86199 A1 PE86199 A1 PE 86199A1 PE 1998000508 A PE1998000508 A PE 1998000508A PE 00050898 A PE00050898 A PE 00050898A PE 86199 A1 PE86199 A1 PE 86199A1
Authority
PE
Peru
Prior art keywords
cells
transferasa
aryl
alkyl
farnesilo
Prior art date
Application number
PE1998000508A
Other languages
English (en)
Inventor
Ronald J Doll
Viyyoor M Girijavallabhan
F George Njoroge
Arthur G Taveras
Bancha Vibulbhan
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE86199A1 publication Critical patent/PE86199A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) O SU SAL, DONDE A ES N o N-OXIDO; CUANDO X ES N o CH SOLO HAY UN ENLACE CON C11 o CUANDO X ES CARBONO Y SE UNE CON UN DOBLE ENLACE AL C11; X1 Y X2 SON BROMO, CLORO, YODO; SOLO UNO DE X3 Y X4 ES H Y EL RESTO SON BROMO, YODO, FLUOR; R5, R6, R7 Y R8 SON H, ALQUILO, ARILO o -CONR20R21; R20 Y R21 SON H, ALQUILO, ALCOXI, ARILO, ENTRE OTROS o R5 Y R6 o R7 Y R8 SON =O O =S; R ES ALQUILO, ARILO, ARILALQUILO, -NR10R11, ENTRE OTROS; R10 Y R11 SON H, ALQUENILO, ALQUILO, ENTRE OTROS. EL COMPUESTO (I) INHIBE A LA ENZIMA FARNESIL RAS TRANSFERASA PUDIENDO SER UTIL PARA INHIBIR EL DESARROLLO ANORMAL DE CELULAS TUMORALES QUE EXPRESAN UN ONCOGEN RAS ACTIVADO, LAS CELULAS INHIBIDAS SON CELULAS DE TUMORES PANCREATICOS, CELULAS DE CANCER DE PULMON, CELULAS TUMORALES DE LEUCEMIA MIELOIDE, CELULAS DE TUMORES FOLICULARES TIROIDEOS
PE1998000508A 1997-06-17 1998-06-15 Sulfonamida inhibidor de la enzima farnesilo transferasa PE86199A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87705097A 1997-06-17 1997-06-17

Publications (1)

Publication Number Publication Date
PE86199A1 true PE86199A1 (es) 1999-09-24

Family

ID=25369146

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000508A PE86199A1 (es) 1997-06-17 1998-06-15 Sulfonamida inhibidor de la enzima farnesilo transferasa

Country Status (14)

Country Link
EP (1) EP0989980A1 (es)
JP (1) JP2002507192A (es)
KR (1) KR20010013826A (es)
CN (1) CN1267290A (es)
AR (1) AR012989A1 (es)
AU (1) AU8253698A (es)
CA (1) CA2293358C (es)
CO (1) CO4940475A1 (es)
HU (1) HUP0004627A2 (es)
IL (1) IL133393A0 (es)
NZ (1) NZ501619A (es)
PE (1) PE86199A1 (es)
WO (1) WO1998057949A1 (es)
ZA (1) ZA985218B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689789B2 (en) 1997-06-17 2004-02-10 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US7517884B2 (en) 1998-03-30 2009-04-14 Kalypsys Inc. Sulfonyl-substituted bicyclic compounds as modulators of PPAR
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
JP2004514717A (ja) * 2000-11-29 2004-05-20 シェーリング　コーポレイション 新規ファルネシルプロテイントランスフェラーゼインヒビター
AR052319A1 (es) 2004-10-29 2007-03-14 Kalypsys Inc Compuestos biciclicos sustituidos por sulfonilo en funcion de moduladores del ppar
BRPI0619282B8 (pt) 2005-10-25 2021-05-25 Kalypsys Inc sal, e composição farmacêutica
WO2008091863A1 (en) 2007-01-23 2008-07-31 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
WO2014130534A1 (en) * 2013-02-19 2014-08-28 Icahn School Of Medicine At Mount Sinai Tricyclic heterocycles as anticancer agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69429440T2 (de) * 1993-10-15 2002-08-08 Schering Corp., Kenilworth Tricyclische sulfonamide-derivate zur inhibierung der g-protein funktion und fur die bekandlung von proliferativen erkrantungen
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
IL117797A0 (en) * 1995-04-07 1996-08-04 Pharmacopeia Inc Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
CO4940475A1 (es) 2000-07-24
CA2293358C (en) 2008-08-05
EP0989980A1 (en) 2000-04-05
ZA985218B (en) 1998-12-15
AU8253698A (en) 1999-01-04
JP2002507192A (ja) 2002-03-05
CA2293358A1 (en) 1998-12-23
IL133393A0 (en) 2001-04-30
HUP0004627A2 (hu) 2001-10-28
NZ501619A (en) 2002-02-01
CN1267290A (zh) 2000-09-20
WO1998057949A1 (en) 1998-12-23
AR012989A1 (es) 2000-11-22
KR20010013826A (ko) 2001-02-26

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed