ZA985218B - Novel sulfonamide inhibitors of farnesyl-protein transferase - Google Patents
Novel sulfonamide inhibitors of farnesyl-protein transferaseInfo
- Publication number
- ZA985218B ZA985218B ZA985218A ZA985218A ZA985218B ZA 985218 B ZA985218 B ZA 985218B ZA 985218 A ZA985218 A ZA 985218A ZA 985218 A ZA985218 A ZA 985218A ZA 985218 B ZA985218 B ZA 985218B
- Authority
- ZA
- South Africa
- Prior art keywords
- farnesyl
- protein transferase
- novel sulfonamide
- sulfonamide inhibitors
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87705097A | 1997-06-17 | 1997-06-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA985218B true ZA985218B (en) | 1998-12-15 |
Family
ID=25369146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA985218A ZA985218B (en) | 1997-06-17 | 1998-06-15 | Novel sulfonamide inhibitors of farnesyl-protein transferase |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0989980A1 (en) |
JP (1) | JP2002507192A (en) |
KR (1) | KR20010013826A (en) |
CN (1) | CN1267290A (en) |
AR (1) | AR012989A1 (en) |
AU (1) | AU8253698A (en) |
CA (1) | CA2293358C (en) |
CO (1) | CO4940475A1 (en) |
HU (1) | HUP0004627A2 (en) |
IL (1) | IL133393A0 (en) |
NZ (1) | NZ501619A (en) |
PE (1) | PE86199A1 (en) |
WO (1) | WO1998057949A1 (en) |
ZA (1) | ZA985218B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6689789B2 (en) | 1997-06-17 | 2004-02-10 | Schering Corporation | Compounds useful for inhibition of farnesyl protein transferase |
US7517884B2 (en) | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
US7342016B2 (en) | 2000-08-30 | 2008-03-11 | Schering Corporation | Farnesyl protein transferase inhibitors as antitumor agents |
EP1337522B1 (en) * | 2000-11-29 | 2007-08-29 | Schering Corporation | farnesyl protein transferase inhibitors |
WO2006055187A1 (en) | 2004-10-29 | 2006-05-26 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as modulators of ppar |
HUE040020T2 (en) | 2005-10-25 | 2019-02-28 | Kalypsys Inc | Salts of modulators of ppar and methods of treating metabolic disorders |
US20080176861A1 (en) | 2007-01-23 | 2008-07-24 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
US9796717B2 (en) * | 2013-02-19 | 2017-10-24 | Icahn School Of Medicine At Mount Sinai | Tricyclic heterocycles as anticancer agents |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE210653T1 (en) * | 1993-10-15 | 2001-12-15 | Schering Corp | TRICYCLIC SULFONAMIDE DERIVATIVES FOR INHIBITING G-PROTEIN FUNCTION AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES |
IL117797A0 (en) * | 1995-04-07 | 1996-08-04 | Pharmacopeia Inc | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases and pharmaceutical compositions comprising them |
-
1998
- 1998-06-15 IL IL13339398A patent/IL133393A0/en unknown
- 1998-06-15 CA CA002293358A patent/CA2293358C/en not_active Expired - Fee Related
- 1998-06-15 WO PCT/US1998/011508 patent/WO1998057949A1/en not_active Application Discontinuation
- 1998-06-15 CN CN98808186A patent/CN1267290A/en active Pending
- 1998-06-15 HU HU0004627A patent/HUP0004627A2/en unknown
- 1998-06-15 AU AU82536/98A patent/AU8253698A/en not_active Abandoned
- 1998-06-15 EP EP98932718A patent/EP0989980A1/en not_active Withdrawn
- 1998-06-15 KR KR1019997011846A patent/KR20010013826A/en not_active Application Discontinuation
- 1998-06-15 NZ NZ501619A patent/NZ501619A/en unknown
- 1998-06-15 ZA ZA985218A patent/ZA985218B/en unknown
- 1998-06-15 PE PE1998000508A patent/PE86199A1/en not_active Application Discontinuation
- 1998-06-15 JP JP54752198A patent/JP2002507192A/en active Pending
- 1998-06-16 AR ARP980102859A patent/AR012989A1/en unknown
- 1998-06-16 CO CO98034142A patent/CO4940475A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
HUP0004627A2 (en) | 2001-10-28 |
CN1267290A (en) | 2000-09-20 |
WO1998057949A1 (en) | 1998-12-23 |
PE86199A1 (en) | 1999-09-24 |
CA2293358A1 (en) | 1998-12-23 |
KR20010013826A (en) | 2001-02-26 |
CO4940475A1 (en) | 2000-07-24 |
AR012989A1 (en) | 2000-11-22 |
NZ501619A (en) | 2002-02-01 |
JP2002507192A (en) | 2002-03-05 |
CA2293358C (en) | 2008-08-05 |
EP0989980A1 (en) | 2000-04-05 |
IL133393A0 (en) | 2001-04-30 |
AU8253698A (en) | 1999-01-04 |
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