CO4940475A1 - Novedosos inhibidores de sulfonamida de la farnesil-protein transferasa - Google Patents
Novedosos inhibidores de sulfonamida de la farnesil-protein transferasaInfo
- Publication number
- CO4940475A1 CO4940475A1 CO98034142A CO98034142A CO4940475A1 CO 4940475 A1 CO4940475 A1 CO 4940475A1 CO 98034142 A CO98034142 A CO 98034142A CO 98034142 A CO98034142 A CO 98034142A CO 4940475 A1 CO4940475 A1 CO 4940475A1
- Authority
- CO
- Colombia
- Prior art keywords
- hydrogen
- heterocycloalkyl
- cycloalkyl
- aryl
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de fórmula 1: o una sal o solvato farmacéuticamente aceptable de los mismos, en los cuales: A representa N o N- óxido; X representa N, CH o C, de tal manera que cuando X es N o CH, haya un solo enlace con el átomo de carbono 11 representando por la línea plena; o cuando X es C, haya un doble enlace con el átomo de carbono 11, representando por la líneas plena y de puntos; X1 y X2 son independientemente seleccionados entre bromo, yodo y cloro; X3 y X4 son independientemente seleccionados entre bromo, yodo, fluoro o hidrógeno, siempre que solo uno de X3 y X4 sea hidrógeno; cada uno de R5 , R6 , R7 y R8 representa independientemente hidrógeno, alquilo, arilo -CONR20 R21 , donde R20 y R21 representan independientemente hidrógeno, alquilo, alcoxi, arilo, aralquilo, heteroarilo, heteroarialquilo, cicloalquilo, cicloalquialquilo, heterocicloalquilo y heterocicloalquialquilo, y además donde R5 se puede combinar con R6 para representar =O o =S y/o R7 se puede combinar con R8 para representar =O o =S; R puede representar alquilo, arilo, arialquilo, heteroarilo, heteroarilalquilo, cicloalquilo, cicloalquilalquilo, heterocicloalquilo, heterocicloalquinalquilo o -NR10 R11 , donde R10 R11 puede representar independientemente hidrógeno, alquenilo, alquilo, arilo, aralquilo, heteroarilo, heteroarialquilo, cicloalquilo, cicloalquilalquilo, heterocicloalquilo o heterocicloalquilalquilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87705097A | 1997-06-17 | 1997-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4940475A1 true CO4940475A1 (es) | 2000-07-24 |
Family
ID=25369146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO98034142A CO4940475A1 (es) | 1997-06-17 | 1998-06-16 | Novedosos inhibidores de sulfonamida de la farnesil-protein transferasa |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0989980A1 (es) |
| JP (1) | JP2002507192A (es) |
| KR (1) | KR20010013826A (es) |
| CN (1) | CN1267290A (es) |
| AR (1) | AR012989A1 (es) |
| AU (1) | AU8253698A (es) |
| CA (1) | CA2293358C (es) |
| CO (1) | CO4940475A1 (es) |
| HU (1) | HUP0004627A2 (es) |
| IL (1) | IL133393A0 (es) |
| NZ (1) | NZ501619A (es) |
| PE (1) | PE86199A1 (es) |
| WO (1) | WO1998057949A1 (es) |
| ZA (1) | ZA985218B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6689789B2 (en) | 1997-06-17 | 2004-02-10 | Schering Corporation | Compounds useful for inhibition of farnesyl protein transferase |
| US7517884B2 (en) | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| US7342016B2 (en) | 2000-08-30 | 2008-03-11 | Schering Corporation | Farnesyl protein transferase inhibitors as antitumor agents |
| JP2004514717A (ja) * | 2000-11-29 | 2004-05-20 | シェーリング コーポレイション | 新規ファルネシルプロテイントランスフェラーゼインヒビター |
| BRPI0516435B1 (pt) | 2004-10-29 | 2021-09-21 | Kalypsys , Inc | Composto, e composição farmacêutica |
| EP1940815B1 (en) | 2005-10-25 | 2018-08-15 | Kalypsys, Inc. | Salts of modulators of ppar and methods of treating metabolic disorders |
| WO2008091863A1 (en) | 2007-01-23 | 2008-07-31 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
| MX2015010407A (es) * | 2013-02-19 | 2015-10-26 | Icahn School Med Mount Sinai | Heterociclos triciclicos como agentes anticancer. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA947969B (en) * | 1993-10-15 | 1996-07-12 | Schering Corp | Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
| IL117797A0 (en) * | 1995-04-07 | 1996-08-04 | Pharmacopeia Inc | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
-
1998
- 1998-06-15 JP JP54752198A patent/JP2002507192A/ja active Pending
- 1998-06-15 ZA ZA985218A patent/ZA985218B/xx unknown
- 1998-06-15 EP EP98932718A patent/EP0989980A1/en not_active Withdrawn
- 1998-06-15 CA CA002293358A patent/CA2293358C/en not_active Expired - Fee Related
- 1998-06-15 WO PCT/US1998/011508 patent/WO1998057949A1/en not_active Application Discontinuation
- 1998-06-15 KR KR1019997011846A patent/KR20010013826A/ko not_active Application Discontinuation
- 1998-06-15 CN CN98808186A patent/CN1267290A/zh active Pending
- 1998-06-15 PE PE1998000508A patent/PE86199A1/es not_active Application Discontinuation
- 1998-06-15 HU HU0004627A patent/HUP0004627A2/hu unknown
- 1998-06-15 NZ NZ501619A patent/NZ501619A/en unknown
- 1998-06-15 AU AU82536/98A patent/AU8253698A/en not_active Abandoned
- 1998-06-15 IL IL13339398A patent/IL133393A0/xx unknown
- 1998-06-16 CO CO98034142A patent/CO4940475A1/es unknown
- 1998-06-16 AR ARP980102859A patent/AR012989A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ501619A (en) | 2002-02-01 |
| PE86199A1 (es) | 1999-09-24 |
| ZA985218B (en) | 1998-12-15 |
| WO1998057949A1 (en) | 1998-12-23 |
| IL133393A0 (en) | 2001-04-30 |
| CN1267290A (zh) | 2000-09-20 |
| AU8253698A (en) | 1999-01-04 |
| CA2293358A1 (en) | 1998-12-23 |
| EP0989980A1 (en) | 2000-04-05 |
| CA2293358C (en) | 2008-08-05 |
| HUP0004627A2 (hu) | 2001-10-28 |
| KR20010013826A (ko) | 2001-02-26 |
| JP2002507192A (ja) | 2002-03-05 |
| AR012989A1 (es) | 2000-11-22 |
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